YGL025C / PGD1

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL025C / PGD1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:5.16|P-value:7.34E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:4.64|P-value:3.20E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:8.29|P-value:5.08E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:13.00|P-value:4.62E-22 ID:SGTC_70|Compound:0141-0289|FD-Score:6.07|P-value:3.94E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:7.89|P-value:3.08E-9 ID:SGTC_100|Compound:0086-0128|FD-Score:14.70|P-value:9.27E-28 ID:SGTC_119|Compound:0121-0043|FD-Score:5.44|P-value:3.15E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:8.72|P-value:6.47E-11 ID:SGTC_146|Compound:3448-8650|FD-Score:7.58|P-value:1.17E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:4.53|P-value:4.33E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.91|P-value:1.52E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:9.86|P-value:1.86E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:4.83|P-value:1.88E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:5.87|P-value:7.64E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.12|P-value:8.27E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:6.59|P-value:6.09E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:5.34|P-value:4.24E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:6.78|P-value:2.99E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:6.39|P-value:1.26E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:15.10|P-value:2.94E-29 ID:SGTC_336|Compound:4111-0029|FD-Score:4.33|P-value:7.26E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:4.28|P-value:8.13E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.76|P-value:1.11E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.71|P-value:2.41E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-4.74|P-value:2.23E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.01|P-value:4.88E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:4.46|P-value:5.24E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.57|P-value:3.92E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.48|P-value:4.97E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:10.80|P-value:7.94E-16 ID:SGTC_455|Compound:paf C-16|FD-Score:6.09|P-value:3.62E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.58|P-value:3.39E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.87|P-value:7.62E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:10.20|P-value:2.41E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:4.45|P-value:5.30E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:5.10|P-value:8.82E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:8.93|P-value:2.29E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:5.13|P-value:7.95E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:12.10|P-value:2.79E-19 ID:SGTC_598|Compound:3937-0236|FD-Score:8.70|P-value:7.10E-11 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.84|P-value:1.69E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:6.59|P-value:6.16E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:4.55|P-value:4.11E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:12.30|P-value:5.14E-20 ID:SGTC_703|Compound:3875-0075|FD-Score:5.52|P-value:2.39E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.43|P-value:5.65E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:13.30|P-value:5.98E-23 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.48|P-value:4.49E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.26|P-value:5.39E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:6.12|P-value:3.29E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:4.22|P-value:9.57E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:5.11|P-value:8.45E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.33|P-value:7.32E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.23|P-value:9.43E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.22|P-value:2.29E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:4.60|P-value:3.56E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.52|P-value:4.00E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-4.52|P-value:4.01E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.72|P-value:2.55E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.58|P-value:3.73E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:8.68|P-value:8.05E-11 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.66|P-value:3.03E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.28|P-value:8.23E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.52|P-value:2.40E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.60|P-value:1.66E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:13.10|P-value:2.00E-22 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.07|P-value:3.86E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.40|P-value:6.02E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.39|P-value:6.23E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.36|P-value:6.64E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.40|P-value:6.02E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.31|P-value:7.04E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:5.83|P-value:8.90E-6 ID:SGTC_1643|Compound:st009866|FD-Score:5.78|P-value:1.03E-5 ID:SGTC_1687|Compound:st020778|FD-Score:15.60|P-value:8.80E-31 ID:SGTC_1694|Compound:st024011|FD-Score:14.10|P-value:1.34E-25 ID:SGTC_1700|Compound:st030840|FD-Score:14.00|P-value:3.38E-25 ID:SGTC_1738|Compound:st035555|FD-Score:7.31|P-value:3.66E-8 ID:SGTC_1739|Compound:st037196|FD-Score:-4.36|P-value:6.14E-4 ID:SGTC_1766|Compound:st045414|FD-Score:7.95|P-value:2.32E-9 ID:SGTC_1818|Compound:st052136|FD-Score:-4.71|P-value:2.40E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.00|P-value:1.09E-7 ID:SGTC_1876|Compound:myriocin|FD-Score:4.63|P-value:3.30E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.25|P-value:8.86E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.51|P-value:4.53E-4 ID:SGTC_2009|Compound:4012297|FD-Score:6.33|P-value:1.57E-6 ID:SGTC_2090|Compound:5301565|FD-Score:4.63|P-value:3.27E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.32|P-value:7.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.39|P-value:6.21E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-7.87|P-value:2.80E-9 ID:SGTC_2335|Compound:9018011|FD-Score:6.45|P-value:1.02E-6 ID:SGTC_2337|Compound:9009472|FD-Score:-4.88|P-value:1.50E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.33|P-value:7.17E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.59|P-value:3.65E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.93|P-value:1.66E-7 ID:SGTC_2459|Compound:5811157|FD-Score:4.35|P-value:6.85E-4 ID:SGTC_2482|Compound:5981709|FD-Score:6.88|P-value:2.05E-7 ID:SGTC_2508|Compound:celastrol|FD-Score:4.35|P-value:6.95E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.17|P-value:7.11E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.88|P-value:6.68E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:9.40|P-value:2.16E-12 ID:SGTC_2671|Compound:danthron|FD-Score:13.30|P-value:3.83E-23 ID:SGTC_2679|Compound:rapamycin|FD-Score:-10.20|P-value:2.05E-14 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.34|P-value:4.23E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:9.11|P-value:9.42E-12 ID:SGTC_2810|Compound:7959871|FD-Score:10.50|P-value:4.96E-15 ID:SGTC_2820|Compound:7989630|FD-Score:5.63|P-value:1.68E-5 ID:SGTC_2833|Compound:9001315|FD-Score:6.05|P-value:4.20E-6 ID:SGTC_2932|Compound:9016711|FD-Score:4.34|P-value:7.15E-4 ID:SGTC_2980|Compound:9014342|FD-Score:10.20|P-value:2.53E-14 ID:SGTC_3025|Compound:9087895|FD-Score:7.15|P-value:7.00E-8 ID:SGTC_3071|Compound:9117417|FD-Score:-5.19|P-value:6.03E-5 ID:SGTC_3078|Compound:9116413|FD-Score:5.02|P-value:1.09E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-4.30|P-value:7.11E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-7.25|P-value:3.95E-8 ID:SGTC_3174|Compound:9107204|FD-Score:4.92|P-value:1.48E-4 ID:SGTC_3200|Compound:9114385|FD-Score:6.31|P-value:1.68E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-5.31|P-value:4.20E-5 ID:SGTC_3237|Compound:9133362|FD-Score:4.51|P-value:4.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.51|P-value:2.21E-5 ID:SGTC_3284|Compound:9108171|FD-Score:6.07|P-value:3.85E-6 ID:SGTC_3307|Compound:9126885|FD-Score:5.34|P-value:4.28E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:5.16|P-value:7.34E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:4.64|P-value:3.20E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:8.29|P-value:5.08E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:13.00|P-value:4.62E-22 ID:SGTC_70|Compound:0141-0289|FD-Score:6.07|P-value:3.94E-6 ID:SGTC_90|Compound:0870-0863|FD-Score:7.89|P-value:3.08E-9 ID:SGTC_100|Compound:0086-0128|FD-Score:14.70|P-value:9.27E-28 ID:SGTC_119|Compound:0121-0043|FD-Score:5.44|P-value:3.15E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:8.72|P-value:6.47E-11 ID:SGTC_146|Compound:3448-8650|FD-Score:7.58|P-value:1.17E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:4.53|P-value:4.33E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.91|P-value:1.52E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:9.86|P-value:1.86E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:4.83|P-value:1.88E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:5.87|P-value:7.64E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.12|P-value:8.27E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:6.59|P-value:6.09E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:5.34|P-value:4.24E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:6.78|P-value:2.99E-7 ID:SGTC_315|Compound:k915-0449|FD-Score:6.39|P-value:1.26E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:15.10|P-value:2.94E-29 ID:SGTC_336|Compound:4111-0029|FD-Score:4.33|P-value:7.26E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:4.28|P-value:8.13E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.76|P-value:1.11E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.71|P-value:2.41E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-4.74|P-value:2.23E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:6.01|P-value:4.88E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:4.46|P-value:5.24E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.57|P-value:3.92E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.48|P-value:4.97E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:10.80|P-value:7.94E-16 ID:SGTC_455|Compound:paf C-16|FD-Score:6.09|P-value:3.62E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.58|P-value:3.39E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.87|P-value:7.62E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:10.20|P-value:2.41E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:4.45|P-value:5.30E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:5.10|P-value:8.82E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:8.93|P-value:2.29E-11 ID:SGTC_548|Compound:1436-0017|FD-Score:5.13|P-value:7.95E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:12.10|P-value:2.79E-19 ID:SGTC_598|Compound:3937-0236|FD-Score:8.70|P-value:7.10E-11 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.84|P-value:1.69E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:6.59|P-value:6.16E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:4.55|P-value:4.11E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:12.30|P-value:5.14E-20 ID:SGTC_703|Compound:3875-0075|FD-Score:5.52|P-value:2.39E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.43|P-value:5.65E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:13.30|P-value:5.98E-23 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.48|P-value:4.49E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.26|P-value:5.39E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:6.12|P-value:3.29E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:4.22|P-value:9.57E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:5.11|P-value:8.45E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.33|P-value:7.32E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.23|P-value:9.43E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.22|P-value:2.29E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:4.60|P-value:3.56E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.52|P-value:4.00E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-4.52|P-value:4.01E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.72|P-value:2.55E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.58|P-value:3.73E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:8.68|P-value:8.05E-11 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.66|P-value:3.03E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.28|P-value:8.23E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.52|P-value:2.40E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.60|P-value:1.66E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:13.10|P-value:2.00E-22 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.07|P-value:3.86E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.40|P-value:6.02E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.39|P-value:6.23E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.36|P-value:6.64E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.40|P-value:6.02E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.31|P-value:7.04E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:5.83|P-value:8.90E-6 ID:SGTC_1643|Compound:st009866|FD-Score:5.78|P-value:1.03E-5 ID:SGTC_1687|Compound:st020778|FD-Score:15.60|P-value:8.80E-31 ID:SGTC_1694|Compound:st024011|FD-Score:14.10|P-value:1.34E-25 ID:SGTC_1700|Compound:st030840|FD-Score:14.00|P-value:3.38E-25 ID:SGTC_1738|Compound:st035555|FD-Score:7.31|P-value:3.66E-8 ID:SGTC_1739|Compound:st037196|FD-Score:-4.36|P-value:6.14E-4 ID:SGTC_1766|Compound:st045414|FD-Score:7.95|P-value:2.32E-9 ID:SGTC_1818|Compound:st052136|FD-Score:-4.71|P-value:2.40E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.00|P-value:1.09E-7 ID:SGTC_1876|Compound:myriocin|FD-Score:4.63|P-value:3.30E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.25|P-value:8.86E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.51|P-value:4.53E-4 ID:SGTC_2009|Compound:4012297|FD-Score:6.33|P-value:1.57E-6 ID:SGTC_2090|Compound:5301565|FD-Score:4.63|P-value:3.27E-4 ID:SGTC_2135|Compound:5326629|FD-Score:4.32|P-value:7.46E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.39|P-value:6.21E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-7.87|P-value:2.80E-9 ID:SGTC_2335|Compound:9018011|FD-Score:6.45|P-value:1.02E-6 ID:SGTC_2337|Compound:9009472|FD-Score:-4.88|P-value:1.50E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.33|P-value:7.17E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.59|P-value:3.65E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.93|P-value:1.66E-7 ID:SGTC_2459|Compound:5811157|FD-Score:4.35|P-value:6.85E-4 ID:SGTC_2482|Compound:5981709|FD-Score:6.88|P-value:2.05E-7 ID:SGTC_2508|Compound:celastrol|FD-Score:4.35|P-value:6.95E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:5.17|P-value:7.11E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.88|P-value:6.68E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:9.40|P-value:2.16E-12 ID:SGTC_2671|Compound:danthron|FD-Score:13.30|P-value:3.83E-23 ID:SGTC_2679|Compound:rapamycin|FD-Score:-10.20|P-value:2.05E-14 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.34|P-value:4.23E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:9.11|P-value:9.42E-12 ID:SGTC_2810|Compound:7959871|FD-Score:10.50|P-value:4.96E-15 ID:SGTC_2820|Compound:7989630|FD-Score:5.63|P-value:1.68E-5 ID:SGTC_2833|Compound:9001315|FD-Score:6.05|P-value:4.20E-6 ID:SGTC_2932|Compound:9016711|FD-Score:4.34|P-value:7.15E-4 ID:SGTC_2980|Compound:9014342|FD-Score:10.20|P-value:2.53E-14 ID:SGTC_3025|Compound:9087895|FD-Score:7.15|P-value:7.00E-8 ID:SGTC_3071|Compound:9117417|FD-Score:-5.19|P-value:6.03E-5 ID:SGTC_3078|Compound:9116413|FD-Score:5.02|P-value:1.09E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-4.30|P-value:7.11E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-7.25|P-value:3.95E-8 ID:SGTC_3174|Compound:9107204|FD-Score:4.92|P-value:1.48E-4 ID:SGTC_3200|Compound:9114385|FD-Score:6.31|P-value:1.68E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-5.31|P-value:4.20E-5 ID:SGTC_3237|Compound:9133362|FD-Score:4.51|P-value:4.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.51|P-value:2.21E-5 ID:SGTC_3284|Compound:9108171|FD-Score:6.07|P-value:3.85E-6 ID:SGTC_3307|Compound:9126885|FD-Score:5.34|P-value:4.28E-5

Top fitness defect scores for YGL025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 15.60 55.4 µM 8.80E-31 17 7.17E-55
2 SGTC_318 1488-0629 15.10 67.2 µM 2.94E-29 copper-dependent oxidative stress 1 4.39E-52
3 SGTC_100 0086-0128 14.70 49.6 µM 9.27E-28 copper-dependent oxidative stress 3 2.43E-49
4 SGTC_1694 st024011 14.10 44.9 µM 1.34E-25 ERG2 5 2.17E-45
5 SGTC_1700 st030840 14.00 7.9 µM 3.38E-25 PDR1 3 1.18E-44
6 SGTC_2671 danthron 13.30 100.0 µM 3.83E-23 DNA damage response 2 6.70E-41
7 SGTC_725 1497-0963 13.30 19.0 µM 5.98E-23 copper-dependent oxidative stress 1 1.51E-40
8 SGTC_1287 0971-0001 13.10 34.6 µM 2.00E-22 sphingolipid biosynthesis & PDR1 7 1.37E-39
9 SGTC_43 0570-0105 13.00 72.5 µM 4.62E-22 ERG2 5 6.34E-39
10 SGTC_664 1222-0054 12.30 14.9 µM 5.14E-20 sphingolipid biosynthesis & PDR1 6 3.48E-35
11 SGTC_562 3772-2733 12.10 112.0 µM 2.79E-19 ERG2 5 7.62E-34
12 SGTC_453 enantio-paf c16 10.80 10.0 µM 7.94E-16 5 1.54E-27
13 SGTC_2810 7959871 10.50 45.5 µM 4.96E-15 copper-dependent oxidative stress 3 4.36E-26
14 SGTC_505 gw-5074 10.20 63.9 µM 2.41E-14 13 7.78E-25
15 SGTC_2980 9014342 10.20 25.3 µM 2.53E-14 6 8.49E-25
16 SGTC_157 1348-1695 9.86 65.8 µM 1.86E-13 iron homeostasis 12 3.24E-23
17 SGTC_2615 purpurogallin-4-carboxylic acid 9.40 100.0 µM 2.16E-12 redox potentiating 9 2.81E-21
18 SGTC_2752 diclazuril 9.11 33.1 µM 9.42E-12 28 4.11E-20
19 SGTC_543 3844-1095 8.93 191.0 µM 2.29E-11 ERG2 5 2.06E-19
20 SGTC_134 0269-0018 8.72 6.9 µM 6.47E-11 49 1.37E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.514 3.96E-225 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.380 1.97E-115 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.298 1.23E-69 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.267 1.37E-55 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.264 1.32E-54 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.263 3.87E-54 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.252 8.80E-50 YGR064W_d YGR064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
0.251 3.21E-49 YNL235C_d YNL235C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
0.247 6.93E-48 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.214 4.76E-36 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.212 1.71E-35 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.203 1.53E-32 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.198 7.01E-31 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.188 6.12E-28 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.187 1.03E-27 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs