YGL028C / SCW11

Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL028C / SCW11

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:4.08|P-value:4.04E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.58|P-value:2.42E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.98|P-value:5.92E-5 ID:SGTC_289|Compound:k017-0060|FD-Score:3.70|P-value:1.79E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.82|P-value:1.57E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.30|P-value:7.19E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.39|P-value:5.37E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.55|P-value:5.48E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.33|P-value:6.48E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.25|P-value:2.04E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.75|P-value:2.23E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.36|P-value:1.09E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.72|P-value:1.46E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.95|P-value:6.66E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.98|P-value:5.35E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.45|P-value:8.63E-6 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.23|P-value:9.04E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.48|P-value:3.88E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.38|P-value:5.52E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.63|P-value:2.27E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.85|P-value:8.89E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.41|P-value:4.47E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.46|P-value:4.23E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.99|P-value:5.73E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.78|P-value:1.32E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-4.08|P-value:3.55E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_2287|Compound:7945887|FD-Score:5.12|P-value:3.63E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.24|P-value:1.81E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.25|P-value:8.67E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.48|P-value:7.36E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.27|P-value:1.84E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:4.08|P-value:4.04E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.58|P-value:2.42E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.98|P-value:5.92E-5 ID:SGTC_289|Compound:k017-0060|FD-Score:3.70|P-value:1.79E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.82|P-value:1.57E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.39|P-value:5.33E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.30|P-value:7.19E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.39|P-value:5.37E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.55|P-value:5.48E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.33|P-value:6.48E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.25|P-value:2.04E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.75|P-value:2.23E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.36|P-value:1.09E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.72|P-value:1.46E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.95|P-value:6.66E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.98|P-value:5.35E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.45|P-value:8.63E-6 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.23|P-value:9.04E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.48|P-value:3.88E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.38|P-value:5.52E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.63|P-value:2.27E-4 ID:SGTC_1643|Compound:st009866|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.85|P-value:8.89E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.41|P-value:4.47E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.46|P-value:4.23E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.99|P-value:5.73E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.78|P-value:1.32E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-4.08|P-value:3.55E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_2287|Compound:7945887|FD-Score:5.12|P-value:3.63E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.24|P-value:1.81E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.25|P-value:8.67E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.48|P-value:3.96E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.48|P-value:7.36E-6 ID:SGTC_3294|Compound:9122953|FD-Score:4.27|P-value:1.84E-5

Top fitness defect scores for YGL028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2287 7945887 5.12 168.8 µM 3.63E-7 2 1.50E-7
2 SGTC_375 3970-0961 4.82 9.3 µM 1.57E-6 tubulin folding & SWR complex 8 7.12E-7
3 SGTC_1130 3454-2858 4.75 15.9 µM 2.23E-6 NEO1 61 1.04E-6
4 SGTC_1046 2001-0062 4.55 216.0 µM 5.48E-6 9 2.69E-6
5 SGTC_3016 9080866 4.48 49.5 µM 7.36E-6 17 3.68E-6
6 SGTC_1429 4049-0205 4.45 9.5 µM 8.63E-6 4 4.36E-6
7 SGTC_3294 9122953 4.27 26.3 µM 1.84E-5 tubulin folding & SWR complex 19 9.76E-6
8 SGTC_1127 asiatic acid 4.25 681.4 nM 2.04E-5 18 1.09E-5
9 SGTC_34 0469-0683 4.08 81.8 µM 4.04E-5 SWF1 & branched chain AA biosynthesis 24 2.25E-5
10 SGTC_1763 st044482 3.99 94.5 µM 5.73E-5 copper-dependent oxidative stress 21 3.27E-5
11 SGTC_273 hydroxyurea 3.98 18.1 mM 5.92E-5 heme biosynthesis & mitochondrial translocase 37 3.38E-5
12 SGTC_1249 0481-0015 3.95 10.2 µM 6.66E-5 21 3.83E-5
13 SGTC_1931 st074438 3.78 57.1 µM 1.32E-4 24 7.92E-5
14 SGTC_289 k017-0060 3.70 526.0 µM 1.79E-4 6 1.09E-4
15 SGTC_1616 st002734 3.63 56.1 µM 2.27E-4 38 1.41E-4
16 SGTC_873 0591-4978 3.52 488.0 µM 3.39E-4 26 2.16E-4
17 SGTC_2280 7785178 3.52 200.0 µM 3.39E-4 16 2.16E-4
18 SGTC_1442 4112-3290 3.48 3.0 µM 3.88E-4 27 2.50E-4
19 SGTC_2934 9036370 3.48 36.9 µM 3.96E-4 48 2.55E-4
20 SGTC_1724 st037281 3.46 8.3 µM 4.23E-4 60 2.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.85E-10 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.106 6.36E-10 YCR045C RRT12 hom Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores
0.106 8.12E-10 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.098 1.48E-8 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.095 3.06E-8 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.095 3.95E-8 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.091 1.18E-7 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.091 1.24E-7 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.089 2.17E-7 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.089 2.66E-7 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.085 7.46E-7 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.085 8.49E-7 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.083 1.69E-6 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.082 1.86E-6 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.081 2.79E-6 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W