YGL030W / RPL30

Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL030W / RPL30

Click on Significant Values for Screen Details ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.14|P-value:6.50E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.55|P-value:5.30E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.63|P-value:4.08E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.69|P-value:3.37E-4 ID:SGTC_264|Compound:promethazine|FD-Score:7.05|P-value:2.69E-11 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.75|P-value:1.69E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.37|P-value:9.63E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.41|P-value:8.54E-4 ID:SGTC_394|Compound:menadione|FD-Score:-4.18|P-value:3.27E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.75|P-value:2.73E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.09|P-value:8.06E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.96|P-value:1.16E-6 ID:SGTC_529|Compound:4076-0302|FD-Score:3.88|P-value:1.71E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:4.87|P-value:3.24E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:3.58|P-value:4.87E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.25|P-value:4.35E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:5.92|P-value:1.91E-8 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.54|P-value:5.53E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.43|P-value:5.11E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:5.13|P-value:9.97E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:8.05|P-value:3.17E-14 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.01|P-value:1.72E-6 ID:SGTC_1189|Compound:1431-2119|FD-Score:9.03|P-value:1.88E-17 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.55|P-value:3.39E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.18|P-value:5.62E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.42|P-value:8.18E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.13|P-value:6.83E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.86|P-value:1.11E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.66|P-value:2.27E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.56|P-value:3.21E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.95|P-value:1.33E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.08|P-value:8.23E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.93|P-value:8.63E-5 ID:SGTC_1925|Compound:st057770|FD-Score:6.00|P-value:1.24E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.17|P-value:5.95E-5 ID:SGTC_1931|Compound:st074438|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-4.58|P-value:6.32E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.80|P-value:2.31E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.33|P-value:6.93E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.96|P-value:7.73E-5 ID:SGTC_2297|Compound:7971671|FD-Score:6.25|P-value:3.18E-9 ID:SGTC_2303|Compound:7774051|FD-Score:-3.40|P-value:5.56E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.70|P-value:3.67E-6 ID:SGTC_2437|Compound:5741531|FD-Score:3.39|P-value:9.11E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.38|P-value:5.91E-4 ID:SGTC_2448|Compound:5185112|FD-Score:7.40|P-value:2.88E-12 ID:SGTC_2485|Compound:5633444|FD-Score:4.08|P-value:8.25E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:-3.45|P-value:4.66E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.46|P-value:4.61E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.51|P-value:1.50E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.55|P-value:1.34E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.01|P-value:1.07E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.00|P-value:6.56E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.48|P-value:4.21E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.74|P-value:2.83E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.75|P-value:2.73E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.78|P-value:4.89E-6 ID:SGTC_2794|Compound:7785382|FD-Score:-4.48|P-value:9.40E-6 ID:SGTC_2798|Compound:7813637|FD-Score:7.62|P-value:6.51E-13 ID:SGTC_2868|Compound:9035608|FD-Score:3.55|P-value:5.41E-4 ID:SGTC_2887|Compound:9044784|FD-Score:5.23|P-value:6.22E-7 ID:SGTC_2893|Compound:9048488|FD-Score:3.44|P-value:7.71E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.86|P-value:1.84E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-5.50|P-value:8.22E-8 ID:SGTC_2928|Compound:9011484|FD-Score:-4.02|P-value:6.11E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.44|P-value:7.62E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.76|P-value:5.13E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.27|P-value:3.93E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-3.63|P-value:2.51E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.66|P-value:2.30E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.14|P-value:6.50E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.55|P-value:5.30E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.63|P-value:4.08E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.69|P-value:3.37E-4 ID:SGTC_264|Compound:promethazine|FD-Score:7.05|P-value:2.69E-11 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.75|P-value:1.69E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.37|P-value:9.63E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.41|P-value:8.54E-4 ID:SGTC_394|Compound:menadione|FD-Score:-4.18|P-value:3.27E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.75|P-value:2.73E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.09|P-value:8.06E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.96|P-value:1.16E-6 ID:SGTC_529|Compound:4076-0302|FD-Score:3.88|P-value:1.71E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:4.87|P-value:3.24E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:3.58|P-value:4.87E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.25|P-value:4.35E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:5.92|P-value:1.91E-8 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.54|P-value:5.53E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.43|P-value:5.11E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:5.13|P-value:9.97E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:8.05|P-value:3.17E-14 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.01|P-value:1.72E-6 ID:SGTC_1189|Compound:1431-2119|FD-Score:9.03|P-value:1.88E-17 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.55|P-value:3.39E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.18|P-value:5.62E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.42|P-value:8.18E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.13|P-value:6.83E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.86|P-value:1.11E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.66|P-value:2.27E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.56|P-value:3.21E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.95|P-value:1.33E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.08|P-value:8.23E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.93|P-value:8.63E-5 ID:SGTC_1925|Compound:st057770|FD-Score:6.00|P-value:1.24E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.17|P-value:5.95E-5 ID:SGTC_1931|Compound:st074438|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-4.58|P-value:6.32E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.80|P-value:2.31E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.33|P-value:6.93E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.96|P-value:7.73E-5 ID:SGTC_2297|Compound:7971671|FD-Score:6.25|P-value:3.18E-9 ID:SGTC_2303|Compound:7774051|FD-Score:-3.40|P-value:5.56E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.70|P-value:3.67E-6 ID:SGTC_2437|Compound:5741531|FD-Score:3.39|P-value:9.11E-4 ID:SGTC_2447|Compound:5741742|FD-Score:-3.38|P-value:5.91E-4 ID:SGTC_2448|Compound:5185112|FD-Score:7.40|P-value:2.88E-12 ID:SGTC_2485|Compound:5633444|FD-Score:4.08|P-value:8.25E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:-3.45|P-value:4.66E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.46|P-value:4.61E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.51|P-value:1.50E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.55|P-value:1.34E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.01|P-value:1.07E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.00|P-value:6.56E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.48|P-value:4.21E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.74|P-value:2.83E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.75|P-value:2.73E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.78|P-value:4.89E-6 ID:SGTC_2794|Compound:7785382|FD-Score:-4.48|P-value:9.40E-6 ID:SGTC_2798|Compound:7813637|FD-Score:7.62|P-value:6.51E-13 ID:SGTC_2868|Compound:9035608|FD-Score:3.55|P-value:5.41E-4 ID:SGTC_2887|Compound:9044784|FD-Score:5.23|P-value:6.22E-7 ID:SGTC_2893|Compound:9048488|FD-Score:3.44|P-value:7.71E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.86|P-value:1.84E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-5.50|P-value:8.22E-8 ID:SGTC_2928|Compound:9011484|FD-Score:-4.02|P-value:6.11E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.44|P-value:7.62E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.76|P-value:5.13E-6 ID:SGTC_3033|Compound:9090887|FD-Score:4.27|P-value:3.93E-5 ID:SGTC_3328|Compound:9140624|FD-Score:-3.63|P-value:2.51E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.66|P-value:2.30E-4

Top fitness defect scores for YGL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1189 1431-2119 9.03 7.3 µM 1.88E-17 1 8.53E-20 1.46
2 SGTC_1137 ixabepilone 8.05 100.0 µM 3.17E-14 1 4.06E-16 2.13
3 SGTC_2798 7813637 7.62 45.5 µM 6.51E-13 2 1.28E-14 1.91
4 SGTC_2448 5185112 7.40 27.2 µM 2.88E-12 1 6.96E-14 1.24
5 SGTC_264 promethazine 7.05 12.5 mM 2.69E-11 DNA intercalators 8 8.89E-13 0.43
6 SGTC_2297 7971671 6.25 152.3 µM 3.18E-9 RNA processing & uracil transport 2 2.05E-10 0.45
7 SGTC_1925 st057770 6.00 10.1 µM 1.24E-8 TSC3-RPN4 1 9.76E-10 1.73
8 SGTC_747 3448-8087 5.92 38.7 µM 1.91E-8 1 1.59E-9 0.80
9 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 5.55 100.0 µM 1.34E-7 2 1.47E-8 0.82
10 SGTC_2887 9044784 5.23 58.4 µM 6.22E-7 fatty acid desaturase (OLE1) 10 8.49E-8 0.12
11 SGTC_1136 pergolide 5.13 1.1 µM 9.97E-7 9 1.46E-7 0.70
12 SGTC_1187 1391-0724 5.01 117.0 µM 1.72E-6 amide catabolism 1 2.72E-7 0.82
13 SGTC_537 1334-0398 4.87 209.0 µM 3.24E-6 2 5.61E-7 0.68
14 SGTC_2785 7756463 4.78 72.7 µM 4.89E-6 9 8.95E-7 0.01
15 SGTC_3027 9089541 4.76 49.5 µM 5.13E-6 fatty acid desaturase (OLE1) 11 9.45E-7 0.02
16 SGTC_1931 st074438 4.60 57.1 µM 1.06E-5 5 2.16E-6 0.22
17 SGTC_2572 astragaloside iv 4.51 100.0 µM 1.50E-5 2 3.22E-6 0.11
18 SGTC_3033 9090887 4.27 49.5 µM 3.93E-5 fatty acid desaturase (OLE1) 11 9.68E-6 0.20
19 SGTC_641 4092-0595 4.25 30.0 µM 4.35E-5 8 1.09E-5 0.15
20 SGTC_1466 k213-0079 4.18 57.5 µM 5.62E-5 9 1.46E-5 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.37E-33 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.192 2.97E-29 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.181 3.68E-26 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.174 2.64E-24 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.164 9.91E-22 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.156 1.51E-19 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.155 1.83E-19 YPL142C_d YPL142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
0.145 3.19E-17 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.141 2.98E-16 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.139 5.64E-16 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.138 1.06E-15 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.137 1.48E-15 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.131 3.09E-14 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.117 1.20E-11 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117 1.31E-11 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin