YGL031C / RPL24A

Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL031C / RPL24A

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:5.85|P-value:7.19E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:3.98|P-value:5.70E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.97|P-value:5.98E-5 ID:SGTC_269|Compound:exalamide|FD-Score:3.23|P-value:8.94E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.27|P-value:7.10E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.30|P-value:6.95E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.11|P-value:3.43E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.51|P-value:6.04E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:3.34|P-value:6.13E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:5.62|P-value:2.47E-8 ID:SGTC_593|Compound:1203-0218|FD-Score:3.39|P-value:5.21E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.99|P-value:5.49E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.62|P-value:2.23E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.62|P-value:2.12E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.34|P-value:6.11E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.44|P-value:4.35E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:5.03|P-value:5.31E-7 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.93|P-value:6.41E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.14|P-value:2.97E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:5.00|P-value:6.34E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:5.63|P-value:2.35E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.16|P-value:2.79E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.59|P-value:3.00E-8 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:7.80|P-value:1.89E-14 ID:SGTC_1519|Compound:esterone|FD-Score:7.50|P-value:1.65E-13 ID:SGTC_1612|Compound:st002233|FD-Score:4.22|P-value:2.13E-5 ID:SGTC_1619|Compound:st003326|FD-Score:4.92|P-value:9.44E-7 ID:SGTC_1733|Compound:st037357|FD-Score:3.84|P-value:1.00E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.62|P-value:2.26E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.90|P-value:1.04E-6 ID:SGTC_2048|Compound:5246248|FD-Score:4.12|P-value:3.31E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.95|P-value:6.58E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-3.57|P-value:2.46E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.82|P-value:9.95E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.22|P-value:9.25E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.33|P-value:1.25E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.25|P-value:8.17E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.24|P-value:8.00E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.18|P-value:9.74E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.13|P-value:3.12E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.85|P-value:9.49E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.45|P-value:4.22E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.41|P-value:4.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.23|P-value:8.69E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:5.85|P-value:7.19E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:3.98|P-value:5.70E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.97|P-value:5.98E-5 ID:SGTC_269|Compound:exalamide|FD-Score:3.23|P-value:8.94E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.27|P-value:7.10E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.30|P-value:6.95E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.11|P-value:3.43E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.51|P-value:6.04E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:3.34|P-value:6.13E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:5.62|P-value:2.47E-8 ID:SGTC_593|Compound:1203-0218|FD-Score:3.39|P-value:5.21E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.99|P-value:5.49E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.62|P-value:2.23E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.62|P-value:2.12E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.34|P-value:6.11E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.44|P-value:4.35E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:5.03|P-value:5.31E-7 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.93|P-value:6.41E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:4.14|P-value:2.97E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:5.00|P-value:6.34E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:5.63|P-value:2.35E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.16|P-value:2.79E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.59|P-value:3.00E-8 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:7.80|P-value:1.89E-14 ID:SGTC_1519|Compound:esterone|FD-Score:7.50|P-value:1.65E-13 ID:SGTC_1612|Compound:st002233|FD-Score:4.22|P-value:2.13E-5 ID:SGTC_1619|Compound:st003326|FD-Score:4.92|P-value:9.44E-7 ID:SGTC_1733|Compound:st037357|FD-Score:3.84|P-value:1.00E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.62|P-value:2.26E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.90|P-value:1.04E-6 ID:SGTC_2048|Compound:5246248|FD-Score:4.12|P-value:3.31E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.95|P-value:6.58E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-3.57|P-value:2.46E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-3.82|P-value:9.95E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.22|P-value:9.25E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.33|P-value:1.25E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.25|P-value:8.17E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.24|P-value:8.00E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.18|P-value:9.74E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.13|P-value:3.12E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.85|P-value:9.49E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.45|P-value:4.22E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-3.41|P-value:4.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.23|P-value:8.69E-4

Top fitness defect scores for YGL031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1349 flufenamic acid 7.80 69.0 µM 1.89E-14 1 3.10E-15
2 SGTC_1519 esterone 7.50 74.0 µM 1.65E-13 DNA intercalators 1 3.08E-14
3 SGTC_25 0118-0223 5.85 35.7 µM 7.19E-9 1 2.53E-9
4 SGTC_1156 4092-0367 5.63 4.9 µM 2.35E-8 4 8.88E-9
5 SGTC_570 0987-0065 5.62 62.6 µM 2.47E-8 60S ribosome export 2 9.35E-9
6 SGTC_1263 0774-1208 5.59 64.8 µM 3.00E-8 12 1.15E-8
7 SGTC_765 1319-0117 5.03 244.0 µM 5.31E-7 60S ribosome export 2 2.41E-7
8 SGTC_1078 idebenone 5.00 36.1 µM 6.34E-7 Golgi 19 2.91E-7
9 SGTC_1619 st003326 4.92 88.7 µM 9.44E-7 60S ribosome export 5 4.44E-7
10 SGTC_1745 st081495 4.90 74.0 µM 1.04E-6 RNA processing & uracil transport 41 4.89E-7
11 SGTC_545 4218-0007 4.51 221.0 µM 6.04E-6 14 3.17E-6
12 SGTC_1612 st002233 4.22 45.4 µM 2.13E-5 13 1.20E-5
13 SGTC_1170 0310-0127 4.16 64.8 µM 2.79E-5 19 1.60E-5
14 SGTC_1023 4482-3888 4.14 16.0 µM 2.97E-5 TSC3-RPN4 14 1.71E-5
15 SGTC_2845 9003024 4.13 43.0 µM 3.12E-5 amide catabolism 38 1.80E-5
16 SGTC_2048 5246248 4.12 200.0 µM 3.31E-5 4 1.92E-5
17 SGTC_464 bw-b 70c 4.11 158.0 µM 3.43E-5 19 1.99E-5
18 SGTC_627 1391-0720 3.99 175.0 µM 5.49E-5 13 3.28E-5
19 SGTC_118 0083-0097 3.98 135.3 µM 5.70E-5 translation 130 3.41E-5
20 SGTC_179 1273-0063 3.97 6.8 µM 5.98E-5 21 3.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.54E-8 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.094 5.34E-8 YBR182C SMP1 hom Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication
0.080 3.05E-6 YGL084C GUP1 hom Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
0.080 3.29E-6 YJL144W YJL144W hom Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress
0.075 1.46E-5 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.075 1.53E-5 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.072 3.06E-5 YDR114C_p YDR114C_p hom Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
0.069 6.63E-5 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.068 7.26E-5 YOL043C NTG2 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
0.068 7.55E-5 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.068 8.73E-5 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.066 1.26E-4 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.066 1.41E-4 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.065 1.68E-4 YCR028C-A RIM1 hom Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
0.065 1.73E-4 YPL203W TPK2 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase