YGL032C / AGA2

Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL032C / AGA2

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:4.09|P-value:1.12E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.62|P-value:8.64E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.25|P-value:3.77E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:4.34|P-value:3.37E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:4.37|P-value:2.86E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:4.83|P-value:2.69E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.54|P-value:1.23E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.46|P-value:1.68E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.11|P-value:6.42E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-5.65|P-value:1.99E-9 ID:SGTC_504|Compound:lovastatin|FD-Score:-4.20|P-value:6.07E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:3.10|P-value:6.47E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.45|P-value:1.73E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.04|P-value:7.74E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.19|P-value:4.71E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.63|P-value:8.39E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.16|P-value:5.36E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.54|P-value:1.22E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.80|P-value:3.99E-5 ID:SGTC_1695|Compound:st026914|FD-Score:5.58|P-value:3.60E-9 ID:SGTC_1922|Compound:5578187|FD-Score:-4.43|P-value:1.99E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.21|P-value:4.19E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.03|P-value:1.49E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.07|P-value:6.93E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.98|P-value:1.82E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.22|P-value:4.21E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.61|P-value:9.27E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.14|P-value:5.62E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.60|P-value:9.55E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_2880|Compound:9042983|FD-Score:6.07|P-value:1.45E-10 ID:SGTC_2881|Compound:9058953|FD-Score:3.85|P-value:3.30E-5 ID:SGTC_2977|Compound:9011197|FD-Score:5.18|P-value:3.90E-8 ID:SGTC_2993|Compound:9054257|FD-Score:3.01|P-value:9.06E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.12|P-value:6.05E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.61|P-value:9.04E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.79|P-value:4.30E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.00|P-value:8.77E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:4.09|P-value:1.12E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.62|P-value:8.64E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.25|P-value:3.77E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:4.34|P-value:3.37E-6 ID:SGTC_349|Compound:k015-0014|FD-Score:4.37|P-value:2.86E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:4.83|P-value:2.69E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.54|P-value:1.23E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.46|P-value:1.68E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.11|P-value:6.42E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-5.65|P-value:1.99E-9 ID:SGTC_504|Compound:lovastatin|FD-Score:-4.20|P-value:6.07E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:3.10|P-value:6.47E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.45|P-value:1.73E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.04|P-value:7.74E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.19|P-value:4.71E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.63|P-value:8.39E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.16|P-value:5.36E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.54|P-value:1.22E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.80|P-value:3.99E-5 ID:SGTC_1695|Compound:st026914|FD-Score:5.58|P-value:3.60E-9 ID:SGTC_1922|Compound:5578187|FD-Score:-4.43|P-value:1.99E-6 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.21|P-value:4.19E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.03|P-value:1.49E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.07|P-value:6.93E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.98|P-value:1.82E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.22|P-value:4.21E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.61|P-value:9.27E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.14|P-value:5.62E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.60|P-value:9.55E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_2880|Compound:9042983|FD-Score:6.07|P-value:1.45E-10 ID:SGTC_2881|Compound:9058953|FD-Score:3.85|P-value:3.30E-5 ID:SGTC_2977|Compound:9011197|FD-Score:5.18|P-value:3.90E-8 ID:SGTC_2993|Compound:9054257|FD-Score:3.01|P-value:9.06E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.12|P-value:6.05E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.61|P-value:9.04E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.79|P-value:4.30E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.00|P-value:8.77E-4

Top fitness defect scores for YGL032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2880 9042983 6.07 58.4 µM 1.45E-10 fatty acid desaturase (OLE1) 6 6.23E-10
2 SGTC_1695 st026914 5.58 34.5 µM 3.60E-9 1 1.23E-8
3 SGTC_2977 9011197 5.18 71.4 µM 3.90E-8 8 1.13E-7
4 SGTC_355 1311-2252 4.83 105.0 µM 2.69E-7 7 6.79E-7
5 SGTC_349 k015-0014 4.37 24.0 µM 2.86E-6 11 6.10E-6
6 SGTC_258 haloperidol 4.34 50.8 µM 3.37E-6 fatty acid desaturase (OLE1) 23 7.11E-6
7 SGTC_13 0199-0087 4.09 65.0 µM 1.12E-5 ERG2 8 2.18E-5
8 SGTC_2099 5377090 4.03 177.4 µM 1.49E-5 18 2.84E-5
9 SGTC_2303 7774051 3.98 200.0 µM 1.82E-5 18 3.43E-5
10 SGTC_2881 9058953 3.85 52.0 µM 3.30E-5 21 5.96E-5
11 SGTC_1575 cyproterone acetate 3.80 48.0 µM 3.99E-5 27 7.10E-5
12 SGTC_3218 9131285 3.79 49.5 µM 4.30E-5 endomembrane recycling 54 7.62E-5
13 SGTC_175 3793-3120 3.73 23.7 µM 5.45E-5 18 9.50E-5
14 SGTC_1070 indatraline 3.63 8.8 µM 8.39E-5 60S ribosome export 34 1.42E-4
15 SGTC_115 0527-0192 3.62 112.0 µM 8.64E-5 90 1.46E-4
16 SGTC_3205 9113483 3.61 49.5 µM 9.04E-5 42 1.52E-4
17 SGTC_2567 aureobasidin a 3.61 60.0 nM 9.27E-5 109 1.56E-4
18 SGTC_2650 prasterone 3.60 100.0 µM 9.55E-5 18 1.60E-4
19 SGTC_140 0062-0056 3.57 502.5 µM 1.06E-4 32 1.76E-4
20 SGTC_1250 0485-0349 3.54 40.2 µM 1.22E-4 48 2.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.49E-12 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.111 9.91E-11 YGR277C CAB4 het Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
0.097 1.99E-8 YHR068W DYS1 het Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
0.092 8.76E-8 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.092 1.10E-7 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.088 3.10E-7 YFR005C SAD1 het Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
0.084 1.12E-6 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.084 1.15E-6 YNL109W_d YNL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C
0.082 2.27E-6 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.082 2.28E-6 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.074 1.70E-5 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.072 2.76E-5 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.071 3.82E-5 YLR198C_d YLR198C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
0.070 4.62E-5 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.070 4.79E-5 YIR030C DCG1 hom Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain