YGL033W / HOP2

Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL033W / HOP2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.45|P-value:1.17E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.89|P-value:3.57E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:4.68|P-value:5.49E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:5.21|P-value:8.18E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:4.23|P-value:2.32E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.80|P-value:8.09E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:5.32|P-value:5.43E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.85|P-value:7.33E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:9.69|P-value:6.29E-16 ID:SGTC_159|Compound:3970-0959|FD-Score:5.57|P-value:2.06E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:3.90|P-value:6.38E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:8.76|P-value:2.31E-13 ID:SGTC_214|Compound:4373-3496|FD-Score:4.48|P-value:1.06E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.13|P-value:1.19E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.94|P-value:5.65E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.57|P-value:2.09E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:6.52|P-value:3.67E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:4.36|P-value:1.58E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.14|P-value:3.30E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.61|P-value:7.03E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.04|P-value:3.08E-9 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.73|P-value:1.08E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.82|P-value:7.87E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:27.30|P-value:1.43E-112 ID:SGTC_568|Compound:1193-0097|FD-Score:5.03|P-value:1.64E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.63|P-value:6.51E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.13|P-value:1.10E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.97|P-value:5.14E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.28|P-value:2.01E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.21|P-value:8.36E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.12|P-value:3.34E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.04|P-value:3.06E-9 ID:SGTC_927|Compound:2425-1185|FD-Score:4.62|P-value:6.64E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.33|P-value:1.75E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.93|P-value:5.85E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.89|P-value:2.66E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.24|P-value:2.27E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.87|P-value:2.83E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.86|P-value:7.03E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.82|P-value:3.41E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.77|P-value:4.04E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-4.20|P-value:2.74E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.74|P-value:9.91E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-4.31|P-value:1.95E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.04|P-value:4.18E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-5.00|P-value:1.90E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.83|P-value:8.14E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.10|P-value:3.49E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.05|P-value:4.08E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.80|P-value:8.40E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.69|P-value:5.25E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.30|P-value:1.91E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.95|P-value:5.67E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.70|P-value:5.15E-5 ID:SGTC_2294|Compound:7971431|FD-Score:5.68|P-value:1.33E-6 ID:SGTC_2296|Compound:7971656|FD-Score:-5.84|P-value:7.31E-7 ID:SGTC_2300|Compound:7976697|FD-Score:-6.25|P-value:1.28E-7 ID:SGTC_2384|Compound:9036245|FD-Score:4.41|P-value:1.35E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.22|P-value:7.88E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.15|P-value:3.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.86|P-value:1.29E-13 ID:SGTC_2584|Compound:androsterone|FD-Score:7.33|P-value:7.19E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:26.50|P-value:3.16E-106 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.72|P-value:4.86E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.87|P-value:6.10E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:5.45|P-value:3.32E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:5.23|P-value:7.78E-6 ID:SGTC_2815|Compound:7968870|FD-Score:7.16|P-value:1.66E-9 ID:SGTC_2838|Compound:9002687|FD-Score:-3.83|P-value:8.07E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.48|P-value:1.06E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.77|P-value:9.58E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.31|P-value:1.82E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.81|P-value:3.56E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.73|P-value:2.78E-13 ID:SGTC_3321|Compound:9137793|FD-Score:5.79|P-value:8.51E-7 ID:SGTC_3328|Compound:9140624|FD-Score:-4.29|P-value:2.07E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.45|P-value:1.17E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.89|P-value:3.57E-11 ID:SGTC_70|Compound:0141-0289|FD-Score:4.68|P-value:5.49E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:5.21|P-value:8.18E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:4.23|P-value:2.32E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.80|P-value:8.09E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:5.32|P-value:5.43E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.85|P-value:7.33E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:9.69|P-value:6.29E-16 ID:SGTC_159|Compound:3970-0959|FD-Score:5.57|P-value:2.06E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:3.90|P-value:6.38E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:8.76|P-value:2.31E-13 ID:SGTC_214|Compound:4373-3496|FD-Score:4.48|P-value:1.06E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.13|P-value:1.19E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.94|P-value:5.65E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.57|P-value:2.09E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:6.52|P-value:3.67E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:4.36|P-value:1.58E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.14|P-value:3.30E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.61|P-value:7.03E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.04|P-value:3.08E-9 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.73|P-value:1.08E-6 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.82|P-value:7.87E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:27.30|P-value:1.43E-112 ID:SGTC_568|Compound:1193-0097|FD-Score:5.03|P-value:1.64E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.63|P-value:6.51E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:5.13|P-value:1.10E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.97|P-value:5.14E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.28|P-value:2.01E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.21|P-value:8.36E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.12|P-value:3.34E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.04|P-value:3.06E-9 ID:SGTC_927|Compound:2425-1185|FD-Score:4.62|P-value:6.64E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:4.33|P-value:1.75E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.93|P-value:5.85E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.89|P-value:2.66E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:4.24|P-value:2.27E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.87|P-value:2.83E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.86|P-value:7.03E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.82|P-value:3.41E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.77|P-value:4.04E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:-4.20|P-value:2.74E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.74|P-value:9.91E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-4.31|P-value:1.95E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.04|P-value:4.18E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-5.00|P-value:1.90E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.83|P-value:8.14E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.10|P-value:3.49E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.05|P-value:4.08E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.80|P-value:8.40E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.69|P-value:5.25E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.30|P-value:1.91E-4 ID:SGTC_2144|Compound:5628481|FD-Score:-3.95|P-value:5.67E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.70|P-value:5.15E-5 ID:SGTC_2294|Compound:7971431|FD-Score:5.68|P-value:1.33E-6 ID:SGTC_2296|Compound:7971656|FD-Score:-5.84|P-value:7.31E-7 ID:SGTC_2300|Compound:7976697|FD-Score:-6.25|P-value:1.28E-7 ID:SGTC_2384|Compound:9036245|FD-Score:4.41|P-value:1.35E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.22|P-value:7.88E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.15|P-value:3.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.86|P-value:1.29E-13 ID:SGTC_2584|Compound:androsterone|FD-Score:7.33|P-value:7.19E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:26.50|P-value:3.16E-106 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.72|P-value:4.86E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.87|P-value:6.10E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:5.45|P-value:3.32E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:5.23|P-value:7.78E-6 ID:SGTC_2815|Compound:7968870|FD-Score:7.16|P-value:1.66E-9 ID:SGTC_2838|Compound:9002687|FD-Score:-3.83|P-value:8.07E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.48|P-value:1.06E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.77|P-value:9.58E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.31|P-value:1.82E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.81|P-value:3.56E-5 ID:SGTC_3311|Compound:9131146|FD-Score:8.73|P-value:2.78E-13 ID:SGTC_3321|Compound:9137793|FD-Score:5.79|P-value:8.51E-7 ID:SGTC_3328|Compound:9140624|FD-Score:-4.29|P-value:2.07E-4

Top fitness defect scores for YGL033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 27.30 2.6 nM 1.43E-112 cell wall 1 3.76E-164
2 SGTC_2619 obliquin 26.50 87.9 µM 3.16E-106 cell wall 3 7.64E-155
3 SGTC_149 3970-0822 9.69 46.1 µM 6.29E-16 tubulin folding & SWR complex 11 1.74E-22
4 SGTC_2582 agaric acid 8.86 100.0 µM 1.29E-13 redox potentiating 85 4.12E-19
5 SGTC_212 3807-4682 8.76 38.8 µM 2.31E-13 tubulin folding & SWR complex 12 9.69E-19
6 SGTC_3311 9131146 8.73 2.9 µM 2.78E-13 cell wall 24 1.27E-18
7 SGTC_58 0957-0393 7.89 9.0 µM 3.57E-11 cell wall 127 1.50E-15
8 SGTC_2584 androsterone 7.33 48.7 µM 7.19E-10 cell wall 31 1.19E-13
9 SGTC_2815 7968870 7.16 71.4 µM 1.66E-9 3 4.03E-13
10 SGTC_916 4466-0038 7.04 42.0 nM 3.06E-9 cell wall 17 9.83E-13
11 SGTC_453 enantio-paf c16 7.04 10.0 µM 3.08E-9 24 9.91E-13
12 SGTC_312 4092-0653 6.52 6.8 µM 3.67E-8 ergosterol depletion effects on membrane 32 3.63E-11
13 SGTC_2751 anetholtrithion 5.87 17.2 µM 6.10E-7 5 2.15E-9
14 SGTC_116 0155-0182 5.80 31.8 µM 8.09E-7 mitochondrial response to ROS 27 3.24E-9
15 SGTC_3321 9137793 5.79 26.8 µM 8.51E-7 cell wall 33 3.48E-9
16 SGTC_464 bw-b 70c 5.73 158.0 µM 1.08E-6 3 4.95E-9
17 SGTC_2294 7971431 5.68 200.0 µM 1.33E-6 2 6.62E-9
18 SGTC_159 3970-0959 5.57 50.0 µM 2.06E-6 31 1.25E-8
19 SGTC_310 1273-0058 5.57 1.1 µM 2.09E-6 mitochondrial stress 156 1.28E-8
20 SGTC_2756 carbadox 5.45 75.1 µM 3.32E-6 22 2.50E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.499 2.04E-210 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.484 2.91E-196 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.477 4.89E-190 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.460 1.10E-175 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.417 3.44E-141 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.406 1.80E-133 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.391 1.15E-122 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.375 1.64E-112 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.360 2.69E-103 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.354 1.80E-99 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.349 4.80E-97 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.345 1.80E-94 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.327 1.20E-84 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.321 3.89E-81 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.300 9.51E-71 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization