YGL034C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL034C / YGL034C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.56|P-value:3.67E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.58|P-value:6.81E-6 ID:SGTC_229|Compound:benomyl|FD-Score:4.06|P-value:5.83E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.36|P-value:7.26E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.25|P-value:3.03E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:3.80|P-value:1.58E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.19|P-value:3.45E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.68|P-value:2.39E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.28|P-value:9.42E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.28|P-value:9.37E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:6.77|P-value:6.08E-11 ID:SGTC_998|Compound:3996-0085|FD-Score:3.72|P-value:2.12E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-4.15|P-value:3.43E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.09|P-value:5.21E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.60|P-value:6.43E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.29|P-value:1.12E-9 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.90|P-value:9.08E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.62|P-value:2.97E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.39|P-value:1.55E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.92|P-value:1.02E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.34|P-value:6.66E-4 ID:SGTC_1614|Compound:st002383|FD-Score:4.01|P-value:7.13E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.92|P-value:8.43E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.44|P-value:1.28E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.12|P-value:3.03E-9 ID:SGTC_1762|Compound:st045503|FD-Score:4.00|P-value:7.43E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.45|P-value:5.45E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.67|P-value:3.89E-6 ID:SGTC_2069|Compound:5228469|FD-Score:-4.85|P-value:1.65E-6 ID:SGTC_2099|Compound:5377090|FD-Score:3.51|P-value:4.40E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.50|P-value:3.87E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.59|P-value:2.84E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-5.12|P-value:4.76E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.43|P-value:5.76E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.28|P-value:2.44E-5 ID:SGTC_2556|Compound:citropten|FD-Score:4.99|P-value:1.08E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:6.28|P-value:1.23E-9 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.05|P-value:5.12E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.38|P-value:6.91E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.61|P-value:5.94E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.59|P-value:6.70E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:4.30|P-value:2.26E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.84|P-value:1.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.75|P-value:1.88E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.19|P-value:3.53E-5 ID:SGTC_2957|Compound:9076800|FD-Score:6.01|P-value:5.65E-9 ID:SGTC_2962|Compound:9082311|FD-Score:3.27|P-value:9.87E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.99|P-value:6.45E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.44|P-value:5.54E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.56|P-value:3.67E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.58|P-value:6.81E-6 ID:SGTC_229|Compound:benomyl|FD-Score:4.06|P-value:5.83E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.36|P-value:7.26E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.25|P-value:3.03E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:3.80|P-value:1.58E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.19|P-value:3.45E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.68|P-value:2.39E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.28|P-value:9.42E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.28|P-value:9.37E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:6.77|P-value:6.08E-11 ID:SGTC_998|Compound:3996-0085|FD-Score:3.72|P-value:2.12E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-4.15|P-value:3.43E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.09|P-value:5.21E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.60|P-value:6.43E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.29|P-value:1.12E-9 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.90|P-value:9.08E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.62|P-value:2.97E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.39|P-value:1.55E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.92|P-value:1.02E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.34|P-value:6.66E-4 ID:SGTC_1614|Compound:st002383|FD-Score:4.01|P-value:7.13E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.92|P-value:8.43E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.44|P-value:1.28E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.12|P-value:3.03E-9 ID:SGTC_1762|Compound:st045503|FD-Score:4.00|P-value:7.43E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.45|P-value:5.45E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.67|P-value:3.89E-6 ID:SGTC_2069|Compound:5228469|FD-Score:-4.85|P-value:1.65E-6 ID:SGTC_2099|Compound:5377090|FD-Score:3.51|P-value:4.40E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.50|P-value:3.87E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.59|P-value:2.84E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-5.12|P-value:4.76E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.43|P-value:5.76E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.28|P-value:2.44E-5 ID:SGTC_2556|Compound:citropten|FD-Score:4.99|P-value:1.08E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:6.28|P-value:1.23E-9 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.05|P-value:5.12E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.38|P-value:6.91E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.61|P-value:5.94E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.59|P-value:6.70E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:4.30|P-value:2.26E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.84|P-value:1.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.75|P-value:1.88E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.19|P-value:3.53E-5 ID:SGTC_2957|Compound:9076800|FD-Score:6.01|P-value:5.65E-9 ID:SGTC_2962|Compound:9082311|FD-Score:3.27|P-value:9.87E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.99|P-value:6.45E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.44|P-value:5.54E-4

Top fitness defect scores for YGL034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 6.77 1.8 µM 6.08E-11 28 6.38E-12
2 SGTC_1179 1021-1431 6.29 9.3 µM 1.12E-9 13 1.57E-10
3 SGTC_2557 derrustone 6.28 83.8 µM 1.23E-9 4 1.74E-10
4 SGTC_1754 st042065 6.12 16.1 µM 3.03E-9 NEO1-PIK1 97 4.70E-10
5 SGTC_2957 9076800 6.01 11.5 µM 5.65E-9 5 9.34E-10
6 SGTC_669 0108-0021 5.25 26.2 µM 3.03E-7 fatty acid desaturase (OLE1) 30 7.46E-8
7 SGTC_2556 citropten 4.99 84.6 µM 1.08E-6 9 3.02E-7
8 SGTC_2592 piperlongumine 4.61 83.3 µM 5.94E-6 TSC3-RPN4 17 1.97E-6
9 SGTC_1178 0988-0033 4.60 191.0 µM 6.43E-6 18 2.15E-6
10 SGTC_2593 nobiletin 4.59 86.2 µM 6.70E-6 15 2.25E-6
11 SGTC_15 0266-0086 4.58 27.1 µM 6.81E-6 endomembrane recycling 40 2.29E-6
12 SGTC_1712 st032288 4.44 53.4 µM 1.28E-5 calcium & mitochondrial duress 155 4.58E-6
13 SGTC_1438 4092-1045 4.39 4.0 µM 1.55E-5 3 5.65E-6
14 SGTC_2605 digitonin 4.30 300.0 nM 2.26E-5 20 8.58E-6
15 SGTC_2543 pimpinellin 4.28 60.7 µM 2.44E-5 Golgi 9 9.32E-6
16 SGTC_795 0685-0265 4.19 78.0 µM 3.45E-5 excess fatty acid 17 1.36E-5
17 SGTC_2757 clomiphene 4.19 4.2 µM 3.53E-5 fatty acid desaturase (OLE1) 32 1.40E-5
18 SGTC_1174 0739-0097 4.09 51.1 µM 5.21E-5 redox potentiating 28 2.15E-5
19 SGTC_229 benomyl 4.06 22.9 µM 5.83E-5 tubulin folding & SWR complex 29 2.43E-5
20 SGTC_1614 st002383 4.01 48.6 µM 7.13E-5 cell wall signaling 15 3.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.15E-30 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.194 6.62E-30 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.177 5.09E-25 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.167 1.87E-22 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.164 1.05E-21 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.159 1.53E-20 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.156 1.24E-19 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.151 1.46E-18 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.147 1.13E-17 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.136 2.78E-15 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.136 2.96E-15 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.133 9.92E-15 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.132 1.52E-14 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.130 3.75E-14 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.129 7.06E-14 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication