YGL035C / MIG1

Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL035C / MIG1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.81|P-value:1.62E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.33|P-value:9.84E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:5.12|P-value:6.37E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.89|P-value:1.39E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.94|P-value:1.48E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.01|P-value:7.44E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.60|P-value:3.40E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.02|P-value:7.12E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:4.31|P-value:2.29E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.52|P-value:4.45E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.08|P-value:5.71E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.94|P-value:9.88E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.69|P-value:2.48E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.03|P-value:7.07E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:4.42|P-value:1.44E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.76|P-value:1.54E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.41|P-value:1.54E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.89|P-value:3.27E-11 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.75|P-value:2.62E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.91|P-value:1.08E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.79|P-value:2.95E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.53|P-value:3.53E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.70|P-value:1.36E-13 ID:SGTC_690|Compound:glyoxal|FD-Score:4.12|P-value:5.01E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:7.12|P-value:7.24E-12 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.36|P-value:6.10E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.90|P-value:1.13E-8 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.85|P-value:2.23E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:4.78|P-value:3.03E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.16|P-value:4.15E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.35|P-value:7.94E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.02|P-value:7.31E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.43|P-value:5.97E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.33|P-value:8.39E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.34|P-value:2.03E-5 ID:SGTC_1712|Compound:st032288|FD-Score:11.20|P-value:1.06E-26 ID:SGTC_1722|Compound:st034304|FD-Score:3.43|P-value:5.98E-4 ID:SGTC_1754|Compound:st042065|FD-Score:9.62|P-value:3.32E-20 ID:SGTC_1760|Compound:st045453|FD-Score:10.30|P-value:5.42E-23 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.87|P-value:2.01E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.99|P-value:8.24E-5 ID:SGTC_1800|Compound:st050079|FD-Score:5.49|P-value:1.01E-7 ID:SGTC_1801|Compound:st050089|FD-Score:7.20|P-value:4.39E-12 ID:SGTC_1803|Compound:st050068|FD-Score:7.55|P-value:4.04E-13 ID:SGTC_2021|Compound:4019055|FD-Score:13.20|P-value:1.82E-36 ID:SGTC_2022|Compound:5136654|FD-Score:5.99|P-value:6.82E-9 ID:SGTC_2036|Compound:5160441|FD-Score:5.19|P-value:4.48E-7 ID:SGTC_2038|Compound:4100038|FD-Score:4.80|P-value:2.83E-6 ID:SGTC_2046|Compound:4110841|FD-Score:4.55|P-value:8.28E-6 ID:SGTC_2305|Compound:7443522|FD-Score:3.56|P-value:3.83E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.34|P-value:2.14E-7 ID:SGTC_2329|Compound:6138490|FD-Score:4.30|P-value:2.36E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.44|P-value:4.69E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-4.30|P-value:1.89E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.61|P-value:3.32E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.66|P-value:4.00E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.81|P-value:1.62E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.33|P-value:9.74E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.76|P-value:1.89E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.35|P-value:2.01E-7 ID:SGTC_2802|Compound:7925815|FD-Score:-3.81|P-value:1.26E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.76|P-value:3.39E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-3.36|P-value:6.24E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.33|P-value:8.38E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.15|P-value:4.34E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.37|P-value:7.40E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.12|P-value:4.93E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.30|P-value:9.19E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.67|P-value:5.06E-6 ID:SGTC_3249|Compound:9135183|FD-Score:3.63|P-value:3.01E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.81|P-value:1.62E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:6.33|P-value:9.84E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:5.12|P-value:6.37E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.89|P-value:1.39E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.94|P-value:1.48E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.01|P-value:7.44E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.60|P-value:3.40E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.02|P-value:7.12E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:4.31|P-value:2.29E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.52|P-value:4.45E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.08|P-value:5.71E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:3.94|P-value:9.88E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.69|P-value:2.48E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.03|P-value:7.07E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:4.42|P-value:1.44E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.76|P-value:1.54E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.41|P-value:1.54E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.89|P-value:3.27E-11 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.75|P-value:2.62E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.91|P-value:1.08E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:4.79|P-value:2.95E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.53|P-value:3.53E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.70|P-value:1.36E-13 ID:SGTC_690|Compound:glyoxal|FD-Score:4.12|P-value:5.01E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:7.12|P-value:7.24E-12 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.36|P-value:6.10E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.90|P-value:1.13E-8 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.85|P-value:2.23E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:4.78|P-value:3.03E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.16|P-value:4.15E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.35|P-value:7.94E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.02|P-value:7.31E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.43|P-value:5.97E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.33|P-value:8.39E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.34|P-value:2.03E-5 ID:SGTC_1712|Compound:st032288|FD-Score:11.20|P-value:1.06E-26 ID:SGTC_1722|Compound:st034304|FD-Score:3.43|P-value:5.98E-4 ID:SGTC_1754|Compound:st042065|FD-Score:9.62|P-value:3.32E-20 ID:SGTC_1760|Compound:st045453|FD-Score:10.30|P-value:5.42E-23 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.87|P-value:2.01E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.99|P-value:8.24E-5 ID:SGTC_1800|Compound:st050079|FD-Score:5.49|P-value:1.01E-7 ID:SGTC_1801|Compound:st050089|FD-Score:7.20|P-value:4.39E-12 ID:SGTC_1803|Compound:st050068|FD-Score:7.55|P-value:4.04E-13 ID:SGTC_2021|Compound:4019055|FD-Score:13.20|P-value:1.82E-36 ID:SGTC_2022|Compound:5136654|FD-Score:5.99|P-value:6.82E-9 ID:SGTC_2036|Compound:5160441|FD-Score:5.19|P-value:4.48E-7 ID:SGTC_2038|Compound:4100038|FD-Score:4.80|P-value:2.83E-6 ID:SGTC_2046|Compound:4110841|FD-Score:4.55|P-value:8.28E-6 ID:SGTC_2305|Compound:7443522|FD-Score:3.56|P-value:3.83E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.34|P-value:2.14E-7 ID:SGTC_2329|Compound:6138490|FD-Score:4.30|P-value:2.36E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.44|P-value:4.69E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-4.30|P-value:1.89E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.61|P-value:3.32E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.66|P-value:4.00E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:3.81|P-value:1.62E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.33|P-value:9.74E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.76|P-value:1.89E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.35|P-value:2.01E-7 ID:SGTC_2802|Compound:7925815|FD-Score:-3.81|P-value:1.26E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.76|P-value:3.39E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-3.36|P-value:6.24E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.46|P-value:5.42E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.33|P-value:8.38E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.15|P-value:4.34E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.37|P-value:7.40E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.12|P-value:4.93E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.30|P-value:9.19E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.67|P-value:5.06E-6 ID:SGTC_3249|Compound:9135183|FD-Score:3.63|P-value:3.01E-4

Top fitness defect scores for YGL035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 13.20 173.0 µM 1.82E-36 endomembrane recycling 2 3.63E-40
2 SGTC_1712 st032288 11.20 53.4 µM 1.06E-26 calcium & mitochondrial duress 16 2.21E-29
3 SGTC_1760 st045453 10.30 10.4 µM 5.42E-23 NEO1-PIK1 32 2.75E-25
4 SGTC_1754 st042065 9.62 16.1 µM 3.32E-20 NEO1-PIK1 32 3.29E-22
5 SGTC_528 3492-0019 7.70 172.0 µM 1.36E-13 calcium & mitochondrial duress 80 6.63E-15
6 SGTC_1803 st050068 7.55 52.4 µM 4.04E-13 NEO1-PIK1 46 2.21E-14
7 SGTC_1801 st050089 7.20 28.4 µM 4.39E-12 NEO1-PIK1 35 3.08E-13
8 SGTC_902 1120-0002 7.12 2.1 µM 7.24E-12 azole & statin 11 5.36E-13
9 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 6.89 150.0 µM 3.27E-11 Golgi 13 2.84E-12
10 SGTC_2752 diclazuril 6.33 33.1 µM 9.74E-10 53 1.21E-10
11 SGTC_15 0266-0086 6.33 27.1 µM 9.84E-10 endomembrane recycling 15 1.22E-10
12 SGTC_2022 5136654 5.99 200.0 µM 6.82E-9 9 1.03E-9
13 SGTC_1045 1348-1485 5.90 165.0 µM 1.13E-8 4 1.80E-9
14 SGTC_1800 st050079 5.49 29.1 µM 1.01E-7 NEO1-PIK1 57 2.04E-8
15 SGTC_2784 7567673 5.35 72.7 µM 2.01E-7 iron homeostasis 9 4.35E-8
16 SGTC_2322 7413319 5.34 38.2 µM 2.14E-7 ERAD & cell cycle 82 4.66E-8
17 SGTC_2036 5160441 5.19 105.0 µM 4.48E-7 NEO1 52 1.06E-7
18 SGTC_43 0570-0105 5.12 72.5 µM 6.37E-7 ERG2 50 1.56E-7
19 SGTC_156 3474-0145 4.94 5.6 µM 1.48E-6 endomembrane recycling 34 3.96E-7
20 SGTC_1788 fluconazole 4.87 20.0 µM 2.01E-6 azole & statin 43 5.54E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.409 6.61E-136 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.383 1.45E-117 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.376 3.37E-113 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.360 3.39E-103 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.352 1.05E-98 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.352 3.12E-98 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.346 6.22E-95 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.333 1.83E-87 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.326 7.93E-84 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.324 8.27E-83 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.324 1.29E-82 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.322 5.91E-82 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.320 1.04E-80 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.319 2.86E-80 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.317 2.71E-79 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH