YGL043W / DST1

General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL043W / DST1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.71|P-value:1.03E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.91|P-value:3.39E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:5.89|P-value:1.46E-9 ID:SGTC_72|Compound:0744-0168|FD-Score:9.77|P-value:3.41E-23 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.66|P-value:1.22E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.28|P-value:4.49E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.57|P-value:2.06E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.46|P-value:3.56E-6 ID:SGTC_172|Compound:1112-0046|FD-Score:8.22|P-value:5.74E-17 ID:SGTC_174|Compound:3553-0389|FD-Score:6.70|P-value:7.52E-12 ID:SGTC_178|Compound:4092-0806|FD-Score:12.50|P-value:1.14E-36 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.96|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.51|P-value:2.82E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:4.29|P-value:7.75E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:4.15|P-value:1.48E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:4.11|P-value:1.76E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:6.73|P-value:5.83E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:4.74|P-value:8.90E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.43|P-value:4.03E-6 ID:SGTC_232|Compound:clozapine|FD-Score:3.35|P-value:3.69E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.58|P-value:1.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.60|P-value:1.34E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.57|P-value:1.50E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.49|P-value:2.03E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.52|P-value:1.88E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.10|P-value:9.21E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.64|P-value:1.13E-11 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.26|P-value:4.85E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.83|P-value:5.72E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:-4.26|P-value:8.10E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.72|P-value:8.38E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.34|P-value:3.69E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.04|P-value:2.35E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.11|P-value:1.73E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:-4.20|P-value:1.06E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.56|P-value:2.15E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-4.46|P-value:3.17E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.31|P-value:7.23E-6 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.59|P-value:1.93E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.72|P-value:9.14E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.91|P-value:3.87E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.97|P-value:3.14E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.09|P-value:9.33E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.96|P-value:3.38E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.88|P-value:4.68E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.60|P-value:1.47E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.29|P-value:4.33E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.95|P-value:1.00E-9 ID:SGTC_1643|Compound:st009866|FD-Score:3.27|P-value:4.96E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.99|P-value:7.84E-10 ID:SGTC_1731|Compound:st035964|FD-Score:-3.36|P-value:3.35E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.08|P-value:9.27E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.20|P-value:6.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.82|P-value:1.56E-15 ID:SGTC_1760|Compound:st045453|FD-Score:5.46|P-value:1.87E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.26|P-value:5.78E-8 ID:SGTC_1801|Compound:st050089|FD-Score:5.57|P-value:1.02E-8 ID:SGTC_1803|Compound:st050068|FD-Score:5.42|P-value:2.38E-8 ID:SGTC_1818|Compound:st052136|FD-Score:4.71|P-value:1.04E-6 ID:SGTC_1868|Compound:st057644|FD-Score:-3.09|P-value:8.76E-4 ID:SGTC_1870|Compound:st057514|FD-Score:10.30|P-value:2.11E-25 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.22|P-value:1.78E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_1941|Compound:st076221|FD-Score:6.37|P-value:7.03E-11 ID:SGTC_2116|Compound:5511452|FD-Score:3.73|P-value:8.67E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.72|P-value:8.54E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.84|P-value:2.06E-9 ID:SGTC_2348|Compound:9022543|FD-Score:5.37|P-value:3.06E-8 ID:SGTC_2430|Compound:5571206|FD-Score:3.19|P-value:6.67E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.09|P-value:8.95E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.31|P-value:1.02E-10 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-4.45|P-value:3.38E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.65|P-value:1.11E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.74|P-value:7.76E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.48|P-value:2.13E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.22|P-value:1.07E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.08|P-value:1.53E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.57|P-value:1.52E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.51|P-value:2.02E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.21|P-value:5.85E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.37|P-value:3.29E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.30|P-value:1.31E-25 ID:SGTC_3111|Compound:9122088|FD-Score:3.09|P-value:9.40E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.84|P-value:5.47E-5 ID:SGTC_3152|Compound:9099253|FD-Score:8.95|P-value:9.05E-20 ID:SGTC_3204|Compound:9114183|FD-Score:-3.43|P-value:2.64E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.23|P-value:5.68E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.67|P-value:1.12E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.53|P-value:2.56E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:4.71|P-value:1.03E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.91|P-value:3.39E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:5.89|P-value:1.46E-9 ID:SGTC_72|Compound:0744-0168|FD-Score:9.77|P-value:3.41E-23 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.66|P-value:1.22E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.28|P-value:4.49E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.57|P-value:2.06E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:4.46|P-value:3.56E-6 ID:SGTC_172|Compound:1112-0046|FD-Score:8.22|P-value:5.74E-17 ID:SGTC_174|Compound:3553-0389|FD-Score:6.70|P-value:7.52E-12 ID:SGTC_178|Compound:4092-0806|FD-Score:12.50|P-value:1.14E-36 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.96|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.51|P-value:2.82E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:4.29|P-value:7.75E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:4.15|P-value:1.48E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:4.11|P-value:1.76E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:6.73|P-value:5.83E-12 ID:SGTC_214|Compound:4373-3496|FD-Score:4.74|P-value:8.90E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.43|P-value:4.03E-6 ID:SGTC_232|Compound:clozapine|FD-Score:3.35|P-value:3.69E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.58|P-value:1.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.60|P-value:1.34E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.57|P-value:1.50E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.49|P-value:2.03E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.52|P-value:1.88E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.10|P-value:9.21E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.64|P-value:1.13E-11 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.26|P-value:4.85E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.83|P-value:5.72E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:-4.26|P-value:8.10E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.72|P-value:8.38E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.27|P-value:5.05E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.34|P-value:3.69E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.04|P-value:2.35E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.11|P-value:1.73E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:-4.20|P-value:1.06E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.10|P-value:8.64E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.56|P-value:2.15E-6 ID:SGTC_917|Compound:harmaline|FD-Score:-4.46|P-value:3.17E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.31|P-value:7.23E-6 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.59|P-value:1.93E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.72|P-value:9.14E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.91|P-value:3.87E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.97|P-value:3.14E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.09|P-value:9.33E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.40|P-value:3.08E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.96|P-value:3.38E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.88|P-value:4.68E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.60|P-value:1.47E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.29|P-value:4.33E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.95|P-value:1.00E-9 ID:SGTC_1643|Compound:st009866|FD-Score:3.27|P-value:4.96E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.99|P-value:7.84E-10 ID:SGTC_1731|Compound:st035964|FD-Score:-3.36|P-value:3.35E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.08|P-value:9.27E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.20|P-value:6.39E-4 ID:SGTC_1754|Compound:st042065|FD-Score:7.82|P-value:1.56E-15 ID:SGTC_1760|Compound:st045453|FD-Score:5.46|P-value:1.87E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.26|P-value:5.78E-8 ID:SGTC_1801|Compound:st050089|FD-Score:5.57|P-value:1.02E-8 ID:SGTC_1803|Compound:st050068|FD-Score:5.42|P-value:2.38E-8 ID:SGTC_1818|Compound:st052136|FD-Score:4.71|P-value:1.04E-6 ID:SGTC_1868|Compound:st057644|FD-Score:-3.09|P-value:8.76E-4 ID:SGTC_1870|Compound:st057514|FD-Score:10.30|P-value:2.11E-25 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.22|P-value:1.78E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_1941|Compound:st076221|FD-Score:6.37|P-value:7.03E-11 ID:SGTC_2116|Compound:5511452|FD-Score:3.73|P-value:8.67E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.72|P-value:8.54E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.84|P-value:2.06E-9 ID:SGTC_2348|Compound:9022543|FD-Score:5.37|P-value:3.06E-8 ID:SGTC_2430|Compound:5571206|FD-Score:3.19|P-value:6.67E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.09|P-value:8.95E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.31|P-value:1.02E-10 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-4.45|P-value:3.38E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.65|P-value:1.11E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.74|P-value:7.76E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.48|P-value:2.13E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.22|P-value:1.07E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.08|P-value:1.53E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.57|P-value:1.52E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.51|P-value:2.02E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.21|P-value:5.85E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.37|P-value:3.29E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.30|P-value:1.31E-25 ID:SGTC_3111|Compound:9122088|FD-Score:3.09|P-value:9.40E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.84|P-value:5.47E-5 ID:SGTC_3152|Compound:9099253|FD-Score:8.95|P-value:9.05E-20 ID:SGTC_3204|Compound:9114183|FD-Score:-3.43|P-value:2.64E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.23|P-value:5.68E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.67|P-value:1.12E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.53|P-value:2.56E-6

Top fitness defect scores for YGL043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_178 4092-0806 12.50 87.5 µM 1.14E-36 ergosterol depletion effects on membrane 7 4.34E-36
2 SGTC_3037 9091026 10.30 49.5 µM 1.31E-25 NEO1-PIK1 3 3.20E-25
3 SGTC_1870 st057514 10.30 26.5 µM 2.11E-25 RSC & ERG11 1 5.11E-25
4 SGTC_72 0744-0168 9.77 198.4 µM 3.41E-23 RPP1 & pyrimidine depletion 2 7.57E-23
5 SGTC_3152 9099253 8.95 49.5 µM 9.05E-20 NEO1-PIK1 29 1.76E-19
6 SGTC_172 1112-0046 8.22 2.6 µM 5.74E-17 NEO1 5 1.00E-16
7 SGTC_1754 st042065 7.82 16.1 µM 1.56E-15 NEO1-PIK1 57 2.57E-15
8 SGTC_212 3807-4682 6.73 38.8 µM 5.83E-12 tubulin folding & SWR complex 21 8.38E-12
9 SGTC_174 3553-0389 6.70 74.3 µM 7.52E-12 2 1.08E-11
10 SGTC_528 3492-0019 6.64 172.0 µM 1.13E-11 calcium & mitochondrial duress 105 1.60E-11
11 SGTC_1941 st076221 6.37 61.8 µM 7.03E-11 sphingolipid biosynthesis & PDR1 28 9.70E-11
12 SGTC_2499 avocadenofuran 6.31 51.5 µM 1.02E-10 6 1.40E-10
13 SGTC_1875 nocodazole 6.22 6.0 µM 1.78E-10 tubulin folding & SWR complex 27 2.43E-10
14 SGTC_1712 st032288 5.99 53.4 µM 7.84E-10 calcium & mitochondrial duress 76 1.04E-9
15 SGTC_1495 4469-0029 5.95 237.0 µM 1.00E-9 53 1.33E-9
16 SGTC_61 0978-8327 5.89 98.6 µM 1.46E-9 ergosterol biosynthesis 7 1.92E-9
17 SGTC_2344 7990960 5.84 77.0 µM 2.06E-9 5 2.69E-9
18 SGTC_1801 st050089 5.57 28.4 µM 1.02E-8 NEO1-PIK1 55 1.30E-8
19 SGTC_1760 st045453 5.46 10.4 µM 1.87E-8 NEO1-PIK1 96 2.35E-8
20 SGTC_1803 st050068 5.42 52.4 µM 2.38E-8 NEO1-PIK1 101 2.99E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 2.02E-76 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.304 1.24E-72 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.297 3.48E-69 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.282 1.33E-62 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.279 8.03E-61 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.278 1.68E-60 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.275 3.17E-59 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.269 9.50E-57 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.269 2.38E-56 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.265 4.93E-55 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.262 8.52E-54 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.262 1.08E-53 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.260 7.25E-53 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.253 2.65E-50 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.250 3.72E-49 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria