YGL045W / RIM8

Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL045W / RIM8

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.74|P-value:7.34E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.90|P-value:2.12E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:-4.13|P-value:2.17E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.40|P-value:9.06E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.82|P-value:2.98E-14 ID:SGTC_63|Compound:0099-0242|FD-Score:6.52|P-value:1.45E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:3.90|P-value:4.55E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.01|P-value:9.96E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:3.91|P-value:4.32E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.09|P-value:7.25E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:12.70|P-value:1.23E-27 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.96|P-value:3.76E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.00|P-value:3.30E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.57|P-value:5.07E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.04|P-value:2.90E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:12.30|P-value:8.37E-26 ID:SGTC_383|Compound:2324-0395|FD-Score:4.60|P-value:4.54E-5 ID:SGTC_447|Compound:ml7|FD-Score:4.62|P-value:4.20E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.86|P-value:1.77E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.45|P-value:1.11E-10 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.52|P-value:1.33E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.63|P-value:9.89E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:11.90|P-value:1.71E-24 ID:SGTC_526|Compound:4469-0568|FD-Score:6.07|P-value:1.19E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:14.60|P-value:8.44E-36 ID:SGTC_547|Compound:1120-0019|FD-Score:3.67|P-value:9.02E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.93|P-value:2.20E-7 ID:SGTC_623|Compound:k072-0108|FD-Score:3.95|P-value:3.84E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-4.01|P-value:3.19E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.34|P-value:1.11E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.36|P-value:1.03E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.22|P-value:1.64E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.96|P-value:1.22E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:7.02|P-value:1.15E-9 ID:SGTC_768|Compound:0384-0033|FD-Score:5.38|P-value:2.32E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:5.59|P-value:9.88E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:5.83|P-value:3.52E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:10.50|P-value:2.68E-19 ID:SGTC_902|Compound:1120-0002|FD-Score:3.82|P-value:5.75E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.76|P-value:4.34E-9 ID:SGTC_917|Compound:harmaline|FD-Score:7.51|P-value:7.93E-11 ID:SGTC_978|Compound:1416-0512|FD-Score:10.10|P-value:5.44E-18 ID:SGTC_993|Compound:3909-8757|FD-Score:3.90|P-value:4.54E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.82|P-value:3.59E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.00|P-value:1.29E-9 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.01|P-value:1.01E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.37|P-value:1.01E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.70|P-value:8.21E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:5.11|P-value:6.88E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:6.80|P-value:3.47E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:15.30|P-value:4.22E-39 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.23|P-value:4.28E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:11.70|P-value:1.43E-23 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.06|P-value:8.38E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.07|P-value:2.69E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.03|P-value:9.40E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.88|P-value:2.82E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.35|P-value:3.16E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:19.80|P-value:2.50E-64 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.00|P-value:1.63E-7 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.46|P-value:7.22E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.95|P-value:3.87E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.95|P-value:3.81E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.94|P-value:4.01E-4 ID:SGTC_1754|Compound:st042065|FD-Score:10.20|P-value:2.57E-18 ID:SGTC_1760|Compound:st045453|FD-Score:8.29|P-value:8.63E-13 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.40|P-value:6.18E-16 ID:SGTC_1797|Compound:st048695|FD-Score:7.23|P-value:3.83E-10 ID:SGTC_1800|Compound:st050079|FD-Score:3.99|P-value:3.45E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.92|P-value:2.35E-7 ID:SGTC_1884|Compound:5633444|FD-Score:8.80|P-value:3.45E-14 ID:SGTC_1991|Compound:st073000|FD-Score:6.13|P-value:8.88E-8 ID:SGTC_2005|Compound:4024620|FD-Score:-3.90|P-value:4.53E-4 ID:SGTC_2006|Compound:4011487|FD-Score:7.74|P-value:2.17E-11 ID:SGTC_2007|Compound:4011539|FD-Score:-4.23|P-value:1.58E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.73|P-value:2.83E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.17|P-value:5.40E-6 ID:SGTC_2036|Compound:5160441|FD-Score:5.18|P-value:5.23E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.41|P-value:8.58E-5 ID:SGTC_2201|Compound:6605497|FD-Score:6.02|P-value:1.48E-7 ID:SGTC_2218|Compound:6965428|FD-Score:-4.80|P-value:2.14E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.27|P-value:3.00E-10 ID:SGTC_2257|Compound:7960413|FD-Score:5.10|P-value:7.11E-6 ID:SGTC_2289|Compound:7946404|FD-Score:5.05|P-value:8.41E-6 ID:SGTC_2300|Compound:7976697|FD-Score:9.93|P-value:1.42E-17 ID:SGTC_2322|Compound:7413319|FD-Score:6.56|P-value:1.16E-8 ID:SGTC_2389|Compound:9091542|FD-Score:8.57|P-value:1.45E-13 ID:SGTC_2409|Compound:alverine citrate|FD-Score:11.40|P-value:1.25E-22 ID:SGTC_2466|Compound:5983409|FD-Score:4.95|P-value:1.27E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.94|P-value:1.31E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:5.18|P-value:5.07E-6 ID:SGTC_2511|Compound:berberine|FD-Score:9.64|P-value:1.13E-16 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.64|P-value:9.73E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.73|P-value:7.41E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.95|P-value:3.87E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:7.66|P-value:3.38E-11 ID:SGTC_2586|Compound:curcumin|FD-Score:5.62|P-value:8.49E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.64|P-value:7.78E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:9.26|P-value:1.59E-15 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.84|P-value:1.87E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:21.00|P-value:5.33E-72 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:9.87|P-value:2.22E-17 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.60|P-value:1.10E-35 ID:SGTC_2756|Compound:carbadox|FD-Score:13.10|P-value:3.13E-29 ID:SGTC_2765|Compound:myclobutanil|FD-Score:7.23|P-value:3.71E-10 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.45|P-value:7.66E-5 ID:SGTC_2784|Compound:7567673|FD-Score:4.08|P-value:2.54E-4 ID:SGTC_2790|Compound:5423970|FD-Score:8.21|P-value:1.37E-12 ID:SGTC_2816|Compound:7982706|FD-Score:6.64|P-value:7.80E-9 ID:SGTC_2880|Compound:9042983|FD-Score:4.26|P-value:1.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.13|P-value:2.25E-12 ID:SGTC_2925|Compound:9010536|FD-Score:13.50|P-value:9.56E-31 ID:SGTC_2928|Compound:9011484|FD-Score:10.60|P-value:7.27E-20 ID:SGTC_2948|Compound:9070189|FD-Score:4.03|P-value:3.03E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.02|P-value:3.11E-4 ID:SGTC_2965|Compound:9082772|FD-Score:6.58|P-value:1.08E-8 ID:SGTC_2991|Compound:9074669|FD-Score:6.34|P-value:3.32E-8 ID:SGTC_2993|Compound:9054257|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.55|P-value:5.29E-5 ID:SGTC_3018|Compound:9082602|FD-Score:6.48|P-value:1.70E-8 ID:SGTC_3019|Compound:9081971|FD-Score:3.64|P-value:9.61E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.17|P-value:7.62E-8 ID:SGTC_3110|Compound:9122132|FD-Score:3.78|P-value:6.39E-4 ID:SGTC_3152|Compound:9099253|FD-Score:25.80|P-value:5.19E-107 ID:SGTC_3212|Compound:9128307|FD-Score:7.91|P-value:8.11E-12 ID:SGTC_3296|Compound:9122258|FD-Score:4.19|P-value:1.82E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.63|P-value:1.22E-16 ID:SGTC_3324|Compound:9138759|FD-Score:3.94|P-value:4.01E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.74|P-value:7.34E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:6.90|P-value:2.12E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:-4.13|P-value:2.17E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:4.40|P-value:9.06E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.82|P-value:2.98E-14 ID:SGTC_63|Compound:0099-0242|FD-Score:6.52|P-value:1.45E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:3.90|P-value:4.55E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.01|P-value:9.96E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:3.91|P-value:4.32E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.09|P-value:7.25E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:12.70|P-value:1.23E-27 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.96|P-value:3.76E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.00|P-value:3.30E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.57|P-value:5.07E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.04|P-value:2.90E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:12.30|P-value:8.37E-26 ID:SGTC_383|Compound:2324-0395|FD-Score:4.60|P-value:4.54E-5 ID:SGTC_447|Compound:ml7|FD-Score:4.62|P-value:4.20E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.86|P-value:1.77E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.45|P-value:1.11E-10 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.52|P-value:1.33E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.63|P-value:9.89E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:11.90|P-value:1.71E-24 ID:SGTC_526|Compound:4469-0568|FD-Score:6.07|P-value:1.19E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:14.60|P-value:8.44E-36 ID:SGTC_547|Compound:1120-0019|FD-Score:3.67|P-value:9.02E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.93|P-value:2.20E-7 ID:SGTC_623|Compound:k072-0108|FD-Score:3.95|P-value:3.84E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-4.01|P-value:3.19E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.34|P-value:1.11E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.36|P-value:1.03E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.22|P-value:1.64E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.96|P-value:1.22E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:7.02|P-value:1.15E-9 ID:SGTC_768|Compound:0384-0033|FD-Score:5.38|P-value:2.32E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:5.59|P-value:9.88E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:5.83|P-value:3.52E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:10.50|P-value:2.68E-19 ID:SGTC_902|Compound:1120-0002|FD-Score:3.82|P-value:5.75E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.76|P-value:4.34E-9 ID:SGTC_917|Compound:harmaline|FD-Score:7.51|P-value:7.93E-11 ID:SGTC_978|Compound:1416-0512|FD-Score:10.10|P-value:5.44E-18 ID:SGTC_993|Compound:3909-8757|FD-Score:3.90|P-value:4.54E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.82|P-value:3.59E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.00|P-value:1.29E-9 ID:SGTC_1005|Compound:4092-0690|FD-Score:5.01|P-value:1.01E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.37|P-value:1.01E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.70|P-value:8.21E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:5.11|P-value:6.88E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:6.80|P-value:3.47E-9 ID:SGTC_1044|Compound:1222-0021|FD-Score:15.30|P-value:4.22E-39 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.23|P-value:4.28E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:11.70|P-value:1.43E-23 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.06|P-value:8.38E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.07|P-value:2.69E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:5.03|P-value:9.40E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.88|P-value:2.82E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.35|P-value:3.16E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:19.80|P-value:2.50E-64 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.00|P-value:1.63E-7 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.46|P-value:7.22E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.95|P-value:3.87E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.95|P-value:3.81E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.94|P-value:4.01E-4 ID:SGTC_1754|Compound:st042065|FD-Score:10.20|P-value:2.57E-18 ID:SGTC_1760|Compound:st045453|FD-Score:8.29|P-value:8.63E-13 ID:SGTC_1788|Compound:fluconazole|FD-Score:9.40|P-value:6.18E-16 ID:SGTC_1797|Compound:st048695|FD-Score:7.23|P-value:3.83E-10 ID:SGTC_1800|Compound:st050079|FD-Score:3.99|P-value:3.45E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.92|P-value:2.35E-7 ID:SGTC_1884|Compound:5633444|FD-Score:8.80|P-value:3.45E-14 ID:SGTC_1991|Compound:st073000|FD-Score:6.13|P-value:8.88E-8 ID:SGTC_2005|Compound:4024620|FD-Score:-3.90|P-value:4.53E-4 ID:SGTC_2006|Compound:4011487|FD-Score:7.74|P-value:2.17E-11 ID:SGTC_2007|Compound:4011539|FD-Score:-4.23|P-value:1.58E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.73|P-value:2.83E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.17|P-value:5.40E-6 ID:SGTC_2036|Compound:5160441|FD-Score:5.18|P-value:5.23E-6 ID:SGTC_2038|Compound:4100038|FD-Score:4.41|P-value:8.58E-5 ID:SGTC_2201|Compound:6605497|FD-Score:6.02|P-value:1.48E-7 ID:SGTC_2218|Compound:6965428|FD-Score:-4.80|P-value:2.14E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.27|P-value:3.00E-10 ID:SGTC_2257|Compound:7960413|FD-Score:5.10|P-value:7.11E-6 ID:SGTC_2289|Compound:7946404|FD-Score:5.05|P-value:8.41E-6 ID:SGTC_2300|Compound:7976697|FD-Score:9.93|P-value:1.42E-17 ID:SGTC_2322|Compound:7413319|FD-Score:6.56|P-value:1.16E-8 ID:SGTC_2389|Compound:9091542|FD-Score:8.57|P-value:1.45E-13 ID:SGTC_2409|Compound:alverine citrate|FD-Score:11.40|P-value:1.25E-22 ID:SGTC_2466|Compound:5983409|FD-Score:4.95|P-value:1.27E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.94|P-value:1.31E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:5.18|P-value:5.07E-6 ID:SGTC_2511|Compound:berberine|FD-Score:9.64|P-value:1.13E-16 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.64|P-value:9.73E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.73|P-value:7.41E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.95|P-value:3.87E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:7.66|P-value:3.38E-11 ID:SGTC_2586|Compound:curcumin|FD-Score:5.62|P-value:8.49E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.64|P-value:7.78E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:9.26|P-value:1.59E-15 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.84|P-value:1.87E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:21.00|P-value:5.33E-72 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:9.87|P-value:2.22E-17 ID:SGTC_2752|Compound:diclazuril|FD-Score:14.60|P-value:1.10E-35 ID:SGTC_2756|Compound:carbadox|FD-Score:13.10|P-value:3.13E-29 ID:SGTC_2765|Compound:myclobutanil|FD-Score:7.23|P-value:3.71E-10 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.45|P-value:7.66E-5 ID:SGTC_2784|Compound:7567673|FD-Score:4.08|P-value:2.54E-4 ID:SGTC_2790|Compound:5423970|FD-Score:8.21|P-value:1.37E-12 ID:SGTC_2816|Compound:7982706|FD-Score:6.64|P-value:7.80E-9 ID:SGTC_2880|Compound:9042983|FD-Score:4.26|P-value:1.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:8.13|P-value:2.25E-12 ID:SGTC_2925|Compound:9010536|FD-Score:13.50|P-value:9.56E-31 ID:SGTC_2928|Compound:9011484|FD-Score:10.60|P-value:7.27E-20 ID:SGTC_2948|Compound:9070189|FD-Score:4.03|P-value:3.03E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.02|P-value:3.11E-4 ID:SGTC_2965|Compound:9082772|FD-Score:6.58|P-value:1.08E-8 ID:SGTC_2991|Compound:9074669|FD-Score:6.34|P-value:3.32E-8 ID:SGTC_2993|Compound:9054257|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.55|P-value:5.29E-5 ID:SGTC_3018|Compound:9082602|FD-Score:6.48|P-value:1.70E-8 ID:SGTC_3019|Compound:9081971|FD-Score:3.64|P-value:9.61E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.17|P-value:7.62E-8 ID:SGTC_3110|Compound:9122132|FD-Score:3.78|P-value:6.39E-4 ID:SGTC_3152|Compound:9099253|FD-Score:25.80|P-value:5.19E-107 ID:SGTC_3212|Compound:9128307|FD-Score:7.91|P-value:8.11E-12 ID:SGTC_3296|Compound:9122258|FD-Score:4.19|P-value:1.82E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.63|P-value:1.22E-16 ID:SGTC_3324|Compound:9138759|FD-Score:3.94|P-value:4.01E-4

Top fitness defect scores for YGL045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3152 9099253 25.80 49.5 µM 5.19E-107 NEO1-PIK1 1 1.04E-146
2 SGTC_2688 kanamycin b 21.00 96.7 µM 5.33E-72 calcium & mitochondrial duress 1 1.84E-98
3 SGTC_1317 1273-0028 19.80 910.0 nM 2.50E-64 azole & statin 3 6.83E-88
4 SGTC_1044 1222-0021 15.30 1.8 µM 4.22E-39 heme biosynthesis & mitochondrial translocase 1 3.82E-53
5 SGTC_528 3492-0019 14.60 172.0 µM 8.44E-36 calcium & mitochondrial duress 18 1.34E-48
6 SGTC_2752 diclazuril 14.60 33.1 µM 1.10E-35 10 1.92E-48
7 SGTC_2925 9010536 13.50 32.5 µM 9.56E-31 azole & statin 1 1.21E-41
8 SGTC_2756 carbadox 13.10 75.1 µM 3.13E-29 2 1.47E-39
9 SGTC_227 fluconazole 12.70 33.5 µM 1.23E-27 azole & statin 9 2.31E-37
10 SGTC_363 0455-0021 12.30 3.1 µM 8.37E-26 azole & statin 6 7.65E-35
11 SGTC_525 k781-2675 11.90 26.7 µM 1.71E-24 redox potentiating 3 4.86E-33
12 SGTC_1083 didemethylchlorpromazine sulfoxide 11.70 707.4 nM 1.43E-23 redox potentiating 4 8.97E-32
13 SGTC_2409 alverine citrate 11.40 64.0 µM 1.25E-22 4 1.78E-30
14 SGTC_2928 9011484 10.60 9.8 µM 7.27E-20 heme biosynthesis & mitochondrial translocase 1 1.12E-26
15 SGTC_862 0452-0056 10.50 10.2 µM 2.68E-19 azole & statin 4 6.75E-26
16 SGTC_1754 st042065 10.20 16.1 µM 2.57E-18 NEO1-PIK1 24 1.51E-24
17 SGTC_978 1416-0512 10.10 87.4 µM 5.44E-18 redox potentiating 1 4.23E-24
18 SGTC_2300 7976697 9.93 71.6 µM 1.42E-17 ERG2 5 1.58E-23
19 SGTC_2697 mebhydrolin 9.87 72.4 µM 2.22E-17 NEO1 16 2.93E-23
20 SGTC_2511 berberine 9.64 10.5 µM 1.13E-16 60S ribosome export 1 2.73E-22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.653 0 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.610 0 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.568 9.97E-286 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.554 1.27E-268 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.540 1.70E-252 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.539 1.45E-252 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.471 2.57E-184 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.452 1.55E-168 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.413 4.70E-138 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.374 6.62E-112 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.354 1.49E-99 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.349 1.29E-96 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.348 7.35E-96 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.329 1.48E-85 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.303 4.22E-72 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth