YGL047W / ALG13

Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL047W / ALG13

Click on Significant Values for Screen Details ID:SGTC_142|Compound:0335-0849|FD-Score:3.14|P-value:9.34E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.13|P-value:9.93E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.53|P-value:2.40E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.21|P-value:7.40E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:5.14|P-value:1.98E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:3.39|P-value:3.98E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.16|P-value:8.89E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.55|P-value:3.53E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.68|P-value:1.91E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.35|P-value:1.07E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.98|P-value:4.29E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.95|P-value:5.83E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.04|P-value:3.35E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.22|P-value:8.43E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.67|P-value:1.44E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.48|P-value:2.94E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.15|P-value:9.12E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.15|P-value:9.06E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.93|P-value:5.78E-7 ID:SGTC_2047|Compound:4141938|FD-Score:-4.02|P-value:4.30E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.30|P-value:5.48E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.78|P-value:1.14E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.51|P-value:2.63E-4 ID:SGTC_2106|Compound:5357045|FD-Score:5.53|P-value:2.44E-8 ID:SGTC_2118|Compound:5526350|FD-Score:3.43|P-value:3.46E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.88|P-value:6.41E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.73|P-value:1.15E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.38|P-value:4.22E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_2477|Compound:5967686|FD-Score:6.73|P-value:1.62E-11 ID:SGTC_2484|Compound:5809818|FD-Score:-3.56|P-value:2.60E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.14|P-value:2.14E-5 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.28|P-value:6.99E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.14|P-value:9.51E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.56|P-value:2.17E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.01|P-value:3.78E-7 ID:SGTC_2782|Compound:7736369|FD-Score:4.53|P-value:3.92E-6 ID:SGTC_2784|Compound:7567673|FD-Score:4.11|P-value:2.47E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.31|P-value:5.38E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.17|P-value:8.65E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.27|P-value:1.27E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.14|P-value:9.34E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.13|P-value:9.93E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.53|P-value:2.40E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.21|P-value:7.40E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.14|P-value:9.40E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:5.14|P-value:1.98E-7 ID:SGTC_607|Compound:4491-0986|FD-Score:3.39|P-value:3.98E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.16|P-value:8.89E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.55|P-value:3.53E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.68|P-value:1.91E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.35|P-value:1.07E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.98|P-value:4.29E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.95|P-value:5.83E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.04|P-value:3.35E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.22|P-value:8.43E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.67|P-value:1.44E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.48|P-value:2.94E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.15|P-value:9.12E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.54|P-value:2.30E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.15|P-value:9.06E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.93|P-value:5.78E-7 ID:SGTC_2047|Compound:4141938|FD-Score:-4.02|P-value:4.30E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.30|P-value:5.48E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.78|P-value:1.14E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.51|P-value:2.63E-4 ID:SGTC_2106|Compound:5357045|FD-Score:5.53|P-value:2.44E-8 ID:SGTC_2118|Compound:5526350|FD-Score:3.43|P-value:3.46E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.88|P-value:6.41E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.73|P-value:1.15E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.38|P-value:4.22E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_2477|Compound:5967686|FD-Score:6.73|P-value:1.62E-11 ID:SGTC_2484|Compound:5809818|FD-Score:-3.56|P-value:2.60E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.14|P-value:2.14E-5 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.28|P-value:6.99E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.14|P-value:9.51E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.56|P-value:2.17E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.01|P-value:3.78E-7 ID:SGTC_2782|Compound:7736369|FD-Score:4.53|P-value:3.92E-6 ID:SGTC_2784|Compound:7567673|FD-Score:4.11|P-value:2.47E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.31|P-value:5.38E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.17|P-value:8.65E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.27|P-value:1.27E-5

Top fitness defect scores for YGL047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2477 5967686 6.73 25.2 µM 1.62E-11 1 8.25E-12 1.74
2 SGTC_2106 5357045 5.53 167.3 µM 2.44E-8 2 1.58E-8 1.04
3 SGTC_565 1418-0001 5.14 44.5 µM 1.98E-7 3 1.36E-7 0.47
4 SGTC_2779 methotrexate 5.01 400.0 µM 3.78E-7 9 2.67E-7 0.17
5 SGTC_1952 st077036 4.93 64.1 µM 5.78E-7 8 4.13E-7 0.16
6 SGTC_946 3434-1334 4.68 87.4 µM 1.91E-6 5 1.42E-6 0.03
7 SGTC_939 1165-0479 4.55 45.3 µM 3.53E-6 4 2.67E-6 0.01
8 SGTC_2782 7736369 4.53 71.4 µM 3.92E-6 5 2.97E-6 0.11
9 SGTC_3238 9133470 4.27 49.5 µM 1.27E-5 3 9.94E-6 0.20
10 SGTC_2616 abietic acid 4.14 100.0 µM 2.14E-5 3 1.71E-5 0.04
11 SGTC_2784 7567673 4.11 72.7 µM 2.47E-5 iron homeostasis 13 1.98E-5 0.20
12 SGTC_1158 4092-0494 4.04 91.8 µM 3.35E-5 3 2.71E-5 0.09
13 SGTC_1054 3429-0080 3.98 167.0 µM 4.29E-5 5 3.50E-5 0.17
14 SGTC_2122 5258151 3.88 111.7 µM 6.41E-5 5 5.28E-5 0.04
15 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.73 49.5 µM 1.15E-4 26 9.64E-5 0.23
16 SGTC_1338 1486-1223 3.67 76.0 µM 1.44E-4 2 1.21E-4 0.01
17 SGTC_2444 5485484 3.65 36.4 µM 1.53E-4 12 1.30E-4 0.36
18 SGTC_2769 toremifene 3.61 3.7 µM 1.82E-4 9 1.55E-4 0.07
19 SGTC_2608 thymoquinone 3.58 42.7 µM 2.04E-4 6 1.74E-4 0.21
20 SGTC_2828 7998861 3.56 71.4 µM 2.13E-4 4 1.82E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.33E-21 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.114 3.06E-11 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.111 1.10E-10 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.098 1.15E-8 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.098 1.23E-8 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.096 2.53E-8 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.094 4.22E-8 YER168C CCA1 het ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.093 5.94E-8 YPL126W NAN1 het U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
0.092 9.24E-8 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.090 1.98E-7 YIR030C DCG1 hom Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
0.087 4.88E-7 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication
0.083 1.45E-6 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.080 3.88E-6 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.080 4.09E-6 YDR365C ESF1 het Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
0.077 7.22E-6 YJL032W_d YJL032W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase