YGL051W / MST27

Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL051W / MST27

Click on Significant Values for Screen Details ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.96|P-value:3.52E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.81|P-value:6.44E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.20|P-value:1.34E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:2.74|P-value:9.05E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.84|P-value:5.69E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.83|P-value:1.85E-8 ID:SGTC_782|Compound:0083-0095|FD-Score:4.30|P-value:4.64E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.77|P-value:7.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.55|P-value:2.60E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:2.74|P-value:9.08E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.88|P-value:5.25E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:2.89|P-value:5.00E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.77|P-value:8.00E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.00|P-value:2.53E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.31|P-value:8.10E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:2.79|P-value:7.33E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.15|P-value:1.52E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:2.72|P-value:9.72E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-2.98|P-value:3.14E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.64|P-value:6.12E-8 ID:SGTC_2013|Compound:4024628|FD-Score:2.95|P-value:3.96E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.21|P-value:1.15E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.93|P-value:3.89E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.41|P-value:4.76E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.57|P-value:2.37E-5 ID:SGTC_2337|Compound:9009472|FD-Score:4.09|P-value:1.58E-6 ID:SGTC_2477|Compound:5967686|FD-Score:-3.24|P-value:1.02E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.44|P-value:4.07E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.66|P-value:1.53E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.36|P-value:6.39E-5 ID:SGTC_3300|Compound:9124615|FD-Score:2.72|P-value:9.86E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-2.96|P-value:3.52E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:-2.81|P-value:6.44E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.20|P-value:1.34E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:2.74|P-value:9.05E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.84|P-value:5.69E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.83|P-value:1.85E-8 ID:SGTC_782|Compound:0083-0095|FD-Score:4.30|P-value:4.64E-7 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.77|P-value:7.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.55|P-value:2.60E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:2.74|P-value:9.08E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.88|P-value:5.25E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:2.89|P-value:5.00E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.77|P-value:8.00E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.00|P-value:2.53E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.31|P-value:8.10E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:2.79|P-value:7.33E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.15|P-value:1.52E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:2.72|P-value:9.72E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-2.98|P-value:3.14E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.64|P-value:6.12E-8 ID:SGTC_2013|Compound:4024628|FD-Score:2.95|P-value:3.96E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.21|P-value:1.15E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.93|P-value:3.89E-4 ID:SGTC_2326|Compound:6164455|FD-Score:-3.41|P-value:4.76E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.57|P-value:2.37E-5 ID:SGTC_2337|Compound:9009472|FD-Score:4.09|P-value:1.58E-6 ID:SGTC_2477|Compound:5967686|FD-Score:-3.24|P-value:1.02E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.44|P-value:4.07E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.66|P-value:1.53E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.36|P-value:6.39E-5 ID:SGTC_3300|Compound:9124615|FD-Score:2.72|P-value:9.86E-4

Top fitness defect scores for YGL051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_430 0958-0115 4.83 16.4 µM 1.85E-8 12 6.95E-7
2 SGTC_1618 st003135 4.64 44.5 µM 6.12E-8 8 1.75E-6
3 SGTC_782 0083-0095 4.30 30.5 µM 4.64E-7 17 8.42E-6
4 SGTC_2337 9009472 4.09 200.0 µM 1.58E-6 28 2.17E-5
5 SGTC_1383 3049-0032 4.00 20.7 µM 2.53E-6 60S ribosome export 20 3.14E-5
6 SGTC_2781 5567276 3.66 71.4 µM 1.53E-5 62 1.27E-4
7 SGTC_2336 9001819 3.57 198.7 µM 2.37E-5 heme biosynthesis & mitochondrial translocase 71 1.79E-4
8 SGTC_1124 fisetin 3.55 1.2 µM 2.60E-5 47 1.92E-4
9 SGTC_2797 7859098 3.36 81.8 µM 6.39E-5 47 3.87E-4
10 SGTC_1411 3909-8223 3.31 150.0 µM 8.10E-5 27 4.66E-4
11 SGTC_307 1501-1223 3.20 22.3 µM 1.34E-4 29 6.89E-4
12 SGTC_2013 4024628 2.95 200.0 µM 3.96E-4 95 0.00161
13 SGTC_1167 k781-0610 2.89 148.0 µM 5.00E-4 RNA processing & uracil transport 74 0.00193
14 SGTC_1142 3253-1408 2.88 9.8 µM 5.25E-4 48 0.00201
15 SGTC_1457 k015-0032 2.79 57.3 µM 7.33E-4 112 0.00261
16 SGTC_1270 0831-1170 2.77 17.3 µM 8.00E-4 68 0.00279
17 SGTC_332 4112-0506 2.74 40.9 µM 9.05E-4 74 0.00308
18 SGTC_1139 k015-0024 2.74 46.9 µM 9.08E-4 PDR1 52 0.00308
19 SGTC_1482 3346-2049 2.72 8.5 µM 9.72E-4 88 0.00325
20 SGTC_3300 9124615 2.72 50.5 µM 9.86E-4 98 0.00329

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.20E-16 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.120 3.37E-12 YLL057C JLP1 hom Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
0.119 4.38E-12 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.111 1.28E-10 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.109 2.28E-10 YDR022C ATG31 hom Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
0.103 2.31E-9 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.103 2.59E-9 YLR227C ADY4 hom Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
0.102 3.51E-9 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.102 3.41E-9 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.102 3.61E-9 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.101 4.43E-9 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.101 5.33E-9 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.099 8.47E-9 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.098 1.45E-8 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.094 4.73E-8 YLR361C DCR2 hom Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START