YGL053W / PRM8

Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL053W / PRM8

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-3.51|P-value:1.14E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.66|P-value:5.82E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.13|P-value:4.96E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.08|P-value:6.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.32|P-value:2.39E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.30|P-value:2.56E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.00|P-value:8.17E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.43|P-value:1.53E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-5.20|P-value:2.40E-8 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.26|P-value:3.14E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.00|P-value:7.94E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.60|P-value:7.76E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-2.97|P-value:9.22E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.09|P-value:5.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.20|P-value:5.06E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.20|P-value:3.82E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.20|P-value:2.29E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.63|P-value:6.90E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.04|P-value:6.86E-4 ID:SGTC_1715|Compound:st032160|FD-Score:7.66|P-value:3.87E-16 ID:SGTC_1724|Compound:st037281|FD-Score:8.81|P-value:9.60E-21 ID:SGTC_1763|Compound:st044482|FD-Score:3.09|P-value:5.70E-4 ID:SGTC_1772|Compound:st048439|FD-Score:2.96|P-value:9.22E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.18|P-value:4.14E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.01|P-value:7.73E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.05|P-value:1.02E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.69|P-value:5.20E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.01|P-value:1.26E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.24|P-value:3.28E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.08|P-value:4.64E-8 ID:SGTC_2171|Compound:5739187|FD-Score:-3.40|P-value:1.77E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.97|P-value:1.46E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.11|P-value:5.31E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.94|P-value:2.13E-10 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.21|P-value:2.13E-8 ID:SGTC_2459|Compound:5811157|FD-Score:-4.43|P-value:1.66E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.19|P-value:4.01E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.10|P-value:5.65E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-5.66|P-value:1.35E-9 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.01|P-value:7.77E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.51|P-value:1.12E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.36|P-value:2.30E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.42|P-value:1.66E-6 ID:SGTC_2840|Compound:9008771|FD-Score:3.44|P-value:1.48E-4 ID:SGTC_3004|Compound:9076122|FD-Score:5.53|P-value:3.11E-9 ID:SGTC_3007|Compound:9078383|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-4.11|P-value:8.02E-6 ID:SGTC_3016|Compound:9080866|FD-Score:5.56|P-value:2.56E-9 ID:SGTC_3018|Compound:9082602|FD-Score:5.81|P-value:5.03E-10 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.51|P-value:1.14E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.66|P-value:5.82E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.13|P-value:4.96E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.08|P-value:6.00E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.32|P-value:2.39E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.30|P-value:2.56E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.00|P-value:8.17E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.43|P-value:1.53E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-5.20|P-value:2.40E-8 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.26|P-value:3.14E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.00|P-value:7.94E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.60|P-value:7.76E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-2.97|P-value:9.22E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.09|P-value:5.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.20|P-value:5.06E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.20|P-value:3.82E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.20|P-value:2.29E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.63|P-value:6.90E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.04|P-value:6.86E-4 ID:SGTC_1715|Compound:st032160|FD-Score:7.66|P-value:3.87E-16 ID:SGTC_1724|Compound:st037281|FD-Score:8.81|P-value:9.60E-21 ID:SGTC_1763|Compound:st044482|FD-Score:3.09|P-value:5.70E-4 ID:SGTC_1772|Compound:st048439|FD-Score:2.96|P-value:9.22E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.18|P-value:4.14E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.01|P-value:7.73E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.05|P-value:1.02E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.69|P-value:5.20E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.01|P-value:1.26E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.24|P-value:3.28E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.08|P-value:4.64E-8 ID:SGTC_2171|Compound:5739187|FD-Score:-3.40|P-value:1.77E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.97|P-value:1.46E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.11|P-value:5.31E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.94|P-value:2.13E-10 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.21|P-value:2.13E-8 ID:SGTC_2459|Compound:5811157|FD-Score:-4.43|P-value:1.66E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.19|P-value:4.01E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.10|P-value:5.65E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-5.66|P-value:1.35E-9 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.01|P-value:7.77E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.51|P-value:1.12E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.36|P-value:2.30E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.42|P-value:1.66E-6 ID:SGTC_2840|Compound:9008771|FD-Score:3.44|P-value:1.48E-4 ID:SGTC_3004|Compound:9076122|FD-Score:5.53|P-value:3.11E-9 ID:SGTC_3007|Compound:9078383|FD-Score:3.45|P-value:1.42E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-4.11|P-value:8.02E-6 ID:SGTC_3016|Compound:9080866|FD-Score:5.56|P-value:2.56E-9 ID:SGTC_3018|Compound:9082602|FD-Score:5.81|P-value:5.03E-10

Top fitness defect scores for YGL053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1724 st037281 8.81 8.3 µM 9.60E-21 2 6.03E-19
2 SGTC_1715 st032160 7.66 10.2 µM 3.87E-16 10 9.01E-15
3 SGTC_2410 aloe-emodin-8-o-glycoside 5.94 46.3 µM 2.13E-10 mitochondrial processes 5 1.44E-9
4 SGTC_3018 9082602 5.81 49.5 µM 5.03E-10 32 3.15E-9
5 SGTC_3016 9080866 5.56 49.5 µM 2.56E-9 4 1.38E-8
6 SGTC_3004 9076122 5.53 71.4 µM 3.11E-9 6 1.64E-8
7 SGTC_2419 paclitaxel 5.21 166.5 µM 2.13E-8 12 9.42E-8
8 SGTC_1514 1189-1591 5.20 158.0 µM 2.29E-8 17 1.00E-7
9 SGTC_2167 5876490 5.08 200.0 µM 4.64E-8 12 1.91E-7
10 SGTC_2758 dehydroepiandrosterone 4.42 69.3 µM 1.66E-6 29 4.92E-6
11 SGTC_1872 amphotericin b 4.05 148.0 nM 1.02E-5 RNA pol III & RNase P/MRP 26 2.56E-5
12 SGTC_1916 st067606 4.01 49.2 µM 1.26E-5 37 3.09E-5
13 SGTC_2245 6637752 3.97 200.0 µM 1.46E-5 16 3.54E-5
14 SGTC_1876 myriocin 3.69 605.0 nM 5.20E-5 43 1.13E-4
15 SGTC_470 aa-861 3.66 153.0 µM 5.82E-5 sphingolipid biosynthesis & PDR1 67 1.25E-4
16 SGTC_1004 4084-0029 3.60 199.0 µM 7.76E-5 25 1.62E-4
17 SGTC_2710 st078562 3.51 53.7 µM 1.12E-4 32 2.25E-4
18 SGTC_3007 9078383 3.45 71.4 µM 1.42E-4 35 2.80E-4
19 SGTC_2840 9008771 3.44 71.4 µM 1.48E-4 16 2.92E-4
20 SGTC_910 3454-3003 3.43 490.0 µM 1.53E-4 30 3.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 8.28E-12 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.108 3.45E-10 YMR306C-A_d YMR306C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.07E-9 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096 2.95E-8 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.095 3.29E-8 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.095 3.95E-8 YGL028C SCW11 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
0.093 6.24E-8 YBR222C PCS60 hom Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
0.092 8.57E-8 YDR488C PAC11 hom Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.092 1.03E-7 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.091 1.15E-7 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.091 1.24E-7 YPL079W RPL21B hom Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication
0.091 1.52E-7 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.087 4.37E-7 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.087 4.52E-7 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.086 5.35E-7 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol