YGL054C / ERV14

COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL054C / ERV14

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:5.01|P-value:5.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.14|P-value:3.98E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.03|P-value:5.18E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:11.90|P-value:1.01E-15 ID:SGTC_119|Compound:0121-0043|FD-Score:8.55|P-value:7.13E-9 ID:SGTC_124|Compound:0136-0217|FD-Score:6.93|P-value:2.42E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.70|P-value:9.33E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:7.01|P-value:1.85E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.43|P-value:1.17E-8 ID:SGTC_232|Compound:clozapine|FD-Score:7.63|P-value:2.29E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:8.54|P-value:7.41E-9 ID:SGTC_264|Compound:promethazine|FD-Score:5.90|P-value:5.37E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:5.90|P-value:5.34E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:5.74|P-value:8.46E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:7.28|P-value:7.52E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:5.20|P-value:3.41E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.74|P-value:2.93E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.68|P-value:9.71E-5 ID:SGTC_443|Compound:clozapine|FD-Score:5.67|P-value:1.00E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.17|P-value:3.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.67|P-value:1.67E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:5.19|P-value:3.50E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:6.69|P-value:5.16E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:8.16|P-value:3.22E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:9.31|P-value:3.09E-10 ID:SGTC_537|Compound:1334-0398|FD-Score:8.89|P-value:1.79E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:5.56|P-value:1.36E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.07|P-value:4.64E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:8.72|P-value:3.66E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:8.69|P-value:4.16E-9 ID:SGTC_804|Compound:1595-0054|FD-Score:5.69|P-value:9.52E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:11.50|P-value:8.57E-15 ID:SGTC_863|Compound:0466-0191|FD-Score:5.16|P-value:3.77E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:11.40|P-value:1.64E-14 ID:SGTC_888|Compound:0916-0002|FD-Score:10.60|P-value:7.80E-13 ID:SGTC_900|Compound:1112-0045|FD-Score:7.31|P-value:6.81E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:4.75|P-value:9.86E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.90|P-value:2.64E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:9.00|P-value:1.15E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:6.18|P-value:2.42E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:9.48|P-value:1.47E-10 ID:SGTC_957|Compound:1187-1561|FD-Score:5.11|P-value:4.25E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:7.06|P-value:1.58E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.72|P-value:4.81E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.40|P-value:2.03E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.81|P-value:8.63E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.34|P-value:2.36E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:8.43|P-value:1.15E-8 ID:SGTC_1103|Compound:duloxetine|FD-Score:6.49|P-value:9.76E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.14|P-value:2.70E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:7.75|P-value:1.49E-7 ID:SGTC_1187|Compound:1391-0724|FD-Score:6.32|P-value:1.62E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.88|P-value:5.72E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.01|P-value:5.73E-8 ID:SGTC_1394|Compound:3474-0001|FD-Score:6.06|P-value:3.46E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:5.55|P-value:1.39E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:10.70|P-value:4.49E-13 ID:SGTC_1458|Compound:k015-0034|FD-Score:-4.91|P-value:2.71E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:5.22|P-value:3.26E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.18|P-value:2.40E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:-4.72|P-value:4.44E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:6.66|P-value:5.71E-6 ID:SGTC_1627|Compound:st003713|FD-Score:8.80|P-value:2.62E-9 ID:SGTC_1665|Compound:st014639|FD-Score:5.35|P-value:2.32E-4 ID:SGTC_1666|Compound:st014829|FD-Score:8.93|P-value:1.54E-9 ID:SGTC_1687|Compound:st020778|FD-Score:11.30|P-value:1.98E-14 ID:SGTC_1694|Compound:st024011|FD-Score:7.41|P-value:4.84E-7 ID:SGTC_1754|Compound:st042065|FD-Score:5.91|P-value:5.22E-5 ID:SGTC_1760|Compound:st045453|FD-Score:9.02|P-value:1.05E-9 ID:SGTC_1781|Compound:st038725|FD-Score:11.40|P-value:1.28E-14 ID:SGTC_1826|Compound:st055655|FD-Score:9.15|P-value:6.03E-10 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.99|P-value:5.63E-4 ID:SGTC_1933|Compound:st074711|FD-Score:5.08|P-value:4.60E-4 ID:SGTC_1991|Compound:st073000|FD-Score:8.50|P-value:8.62E-9 ID:SGTC_1993|Compound:st073995|FD-Score:4.94|P-value:6.43E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.55|P-value:1.39E-4 ID:SGTC_2028|Compound:5153890|FD-Score:7.09|P-value:1.46E-6 ID:SGTC_2036|Compound:5160441|FD-Score:10.90|P-value:1.60E-13 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:9.15|P-value:6.04E-10 ID:SGTC_2257|Compound:7960413|FD-Score:11.50|P-value:9.04E-15 ID:SGTC_2421|Compound:5690543|FD-Score:-4.52|P-value:7.03E-4 ID:SGTC_2472|Compound:5377652|FD-Score:5.67|P-value:1.01E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.11|P-value:4.25E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:-5.88|P-value:1.94E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:5.04|P-value:5.07E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.88|P-value:2.83E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.24|P-value:8.80E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.65|P-value:5.24E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.95|P-value:6.17E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:7.92|P-value:7.97E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.28|P-value:1.79E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:5.21|P-value:3.28E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:7.10|P-value:1.39E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.85|P-value:3.18E-6 ID:SGTC_2699|Compound:st077704|FD-Score:7.51|P-value:3.49E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:7.26|P-value:8.12E-7 ID:SGTC_2724|Compound:maprotiline|FD-Score:9.66|P-value:6.64E-11 ID:SGTC_2734|Compound:clemastine|FD-Score:5.40|P-value:2.05E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.06|P-value:4.67E-8 ID:SGTC_2837|Compound:9008476|FD-Score:-5.45|P-value:6.58E-5 ID:SGTC_2851|Compound:9015922|FD-Score:7.19|P-value:1.02E-6 ID:SGTC_2881|Compound:9058953|FD-Score:4.85|P-value:7.78E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.93|P-value:6.47E-4 ID:SGTC_2951|Compound:9072950|FD-Score:6.10|P-value:3.06E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-4.57|P-value:6.34E-4 ID:SGTC_3025|Compound:9087895|FD-Score:6.25|P-value:1.98E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.76|P-value:7.94E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.74|P-value:8.24E-5 ID:SGTC_3174|Compound:9107204|FD-Score:5.86|P-value:6.02E-5 ID:SGTC_3237|Compound:9133362|FD-Score:7.28|P-value:7.63E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:5.01|P-value:5.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.14|P-value:3.98E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.03|P-value:5.18E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:11.90|P-value:1.01E-15 ID:SGTC_119|Compound:0121-0043|FD-Score:8.55|P-value:7.13E-9 ID:SGTC_124|Compound:0136-0217|FD-Score:6.93|P-value:2.42E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.70|P-value:9.33E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:7.01|P-value:1.85E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.43|P-value:1.17E-8 ID:SGTC_232|Compound:clozapine|FD-Score:7.63|P-value:2.29E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:8.54|P-value:7.41E-9 ID:SGTC_264|Compound:promethazine|FD-Score:5.90|P-value:5.37E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:5.90|P-value:5.34E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:5.74|P-value:8.46E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:7.28|P-value:7.52E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:5.20|P-value:3.41E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-5.74|P-value:2.93E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.68|P-value:9.71E-5 ID:SGTC_443|Compound:clozapine|FD-Score:5.67|P-value:1.00E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.17|P-value:3.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.67|P-value:1.67E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:5.19|P-value:3.50E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:6.69|P-value:5.16E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:8.16|P-value:3.22E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:9.31|P-value:3.09E-10 ID:SGTC_537|Compound:1334-0398|FD-Score:8.89|P-value:1.79E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:5.56|P-value:1.36E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.07|P-value:4.64E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:8.72|P-value:3.66E-9 ID:SGTC_788|Compound:1182-0090|FD-Score:8.69|P-value:4.16E-9 ID:SGTC_804|Compound:1595-0054|FD-Score:5.69|P-value:9.52E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:11.50|P-value:8.57E-15 ID:SGTC_863|Compound:0466-0191|FD-Score:5.16|P-value:3.77E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:11.40|P-value:1.64E-14 ID:SGTC_888|Compound:0916-0002|FD-Score:10.60|P-value:7.80E-13 ID:SGTC_900|Compound:1112-0045|FD-Score:7.31|P-value:6.81E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:4.75|P-value:9.86E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.90|P-value:2.64E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:9.00|P-value:1.15E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:6.18|P-value:2.42E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:9.48|P-value:1.47E-10 ID:SGTC_957|Compound:1187-1561|FD-Score:5.11|P-value:4.25E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:7.06|P-value:1.58E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.72|P-value:4.81E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.40|P-value:2.03E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:4.81|P-value:8.63E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.34|P-value:2.36E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:8.43|P-value:1.15E-8 ID:SGTC_1103|Compound:duloxetine|FD-Score:6.49|P-value:9.76E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.14|P-value:2.70E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:7.75|P-value:1.49E-7 ID:SGTC_1187|Compound:1391-0724|FD-Score:6.32|P-value:1.62E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:5.88|P-value:5.72E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.01|P-value:5.73E-8 ID:SGTC_1394|Compound:3474-0001|FD-Score:6.06|P-value:3.46E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:5.55|P-value:1.39E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:10.70|P-value:4.49E-13 ID:SGTC_1458|Compound:k015-0034|FD-Score:-4.91|P-value:2.71E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:5.22|P-value:3.26E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.18|P-value:2.40E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:-4.72|P-value:4.44E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:6.66|P-value:5.71E-6 ID:SGTC_1627|Compound:st003713|FD-Score:8.80|P-value:2.62E-9 ID:SGTC_1665|Compound:st014639|FD-Score:5.35|P-value:2.32E-4 ID:SGTC_1666|Compound:st014829|FD-Score:8.93|P-value:1.54E-9 ID:SGTC_1687|Compound:st020778|FD-Score:11.30|P-value:1.98E-14 ID:SGTC_1694|Compound:st024011|FD-Score:7.41|P-value:4.84E-7 ID:SGTC_1754|Compound:st042065|FD-Score:5.91|P-value:5.22E-5 ID:SGTC_1760|Compound:st045453|FD-Score:9.02|P-value:1.05E-9 ID:SGTC_1781|Compound:st038725|FD-Score:11.40|P-value:1.28E-14 ID:SGTC_1826|Compound:st055655|FD-Score:9.15|P-value:6.03E-10 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.99|P-value:5.63E-4 ID:SGTC_1933|Compound:st074711|FD-Score:5.08|P-value:4.60E-4 ID:SGTC_1991|Compound:st073000|FD-Score:8.50|P-value:8.62E-9 ID:SGTC_1993|Compound:st073995|FD-Score:4.94|P-value:6.43E-4 ID:SGTC_2006|Compound:4011487|FD-Score:5.55|P-value:1.39E-4 ID:SGTC_2028|Compound:5153890|FD-Score:7.09|P-value:1.46E-6 ID:SGTC_2036|Compound:5160441|FD-Score:10.90|P-value:1.60E-13 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:9.15|P-value:6.04E-10 ID:SGTC_2257|Compound:7960413|FD-Score:11.50|P-value:9.04E-15 ID:SGTC_2421|Compound:5690543|FD-Score:-4.52|P-value:7.03E-4 ID:SGTC_2472|Compound:5377652|FD-Score:5.67|P-value:1.01E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.11|P-value:4.25E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:-5.88|P-value:1.94E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:5.04|P-value:5.07E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.88|P-value:2.83E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.24|P-value:8.80E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.65|P-value:5.24E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.95|P-value:6.17E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:7.92|P-value:7.97E-8 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.28|P-value:1.79E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:5.21|P-value:3.28E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:7.10|P-value:1.39E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.85|P-value:3.18E-6 ID:SGTC_2699|Compound:st077704|FD-Score:7.51|P-value:3.49E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:7.26|P-value:8.12E-7 ID:SGTC_2724|Compound:maprotiline|FD-Score:9.66|P-value:6.64E-11 ID:SGTC_2734|Compound:clemastine|FD-Score:5.40|P-value:2.05E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.06|P-value:4.67E-8 ID:SGTC_2837|Compound:9008476|FD-Score:-5.45|P-value:6.58E-5 ID:SGTC_2851|Compound:9015922|FD-Score:7.19|P-value:1.02E-6 ID:SGTC_2881|Compound:9058953|FD-Score:4.85|P-value:7.78E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.93|P-value:6.47E-4 ID:SGTC_2951|Compound:9072950|FD-Score:6.10|P-value:3.06E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-4.57|P-value:6.34E-4 ID:SGTC_3025|Compound:9087895|FD-Score:6.25|P-value:1.98E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.76|P-value:7.94E-5 ID:SGTC_3152|Compound:9099253|FD-Score:5.74|P-value:8.24E-5 ID:SGTC_3174|Compound:9107204|FD-Score:5.86|P-value:6.02E-5 ID:SGTC_3237|Compound:9133362|FD-Score:7.28|P-value:7.63E-7

Top fitness defect scores for YGL054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_109 0132-0036 11.90 33.7 µM 1.01E-15 2 5.90E-33
2 SGTC_841 0251-0215 11.50 91.2 µM 8.57E-15 10 6.46E-31
3 SGTC_2257 7960413 11.50 200.0 µM 9.04E-15 NEO1-PIK1 1 7.27E-31
4 SGTC_1781 st038725 11.40 66.3 µM 1.28E-14 NEO1 13 1.56E-30
5 SGTC_887 0885-0007 11.40 9.6 µM 1.64E-14 endomembrane recycling 5 2.70E-30
6 SGTC_1687 st020778 11.30 55.4 µM 1.98E-14 41 4.06E-30
7 SGTC_2036 5160441 10.90 105.0 µM 1.60E-13 NEO1 18 3.98E-28
8 SGTC_1450 4112-4260 10.70 37.6 µM 4.49E-13 calcium & mitochondrial duress 5 3.80E-27
9 SGTC_888 0916-0002 10.60 7.0 µM 7.80E-13 NEO1 9 1.27E-26
10 SGTC_2724 maprotiline 9.66 69.6 µM 6.64E-11 ERG2 2 2.17E-22
11 SGTC_954 1189-0853 9.48 2.9 µM 1.47E-10 endomembrane recycling 4 1.24E-21
12 SGTC_535 2293-4129 9.31 48.2 µM 3.09E-10 NEO1 9 6.27E-21
13 SGTC_1826 st055655 9.15 41.6 µM 6.03E-10 ERG2 6 2.72E-20
14 SGTC_2232 chlorophetanol 9.15 41.5 µM 6.04E-10 TRP & mitochondrial translation 14 2.73E-20
15 SGTC_1760 st045453 9.02 10.4 µM 1.05E-9 NEO1-PIK1 39 9.24E-20
16 SGTC_945 3381-0768 9.00 11.3 µM 1.15E-9 endomembrane recycling 1 1.13E-19
17 SGTC_1666 st014829 8.93 29.0 µM 1.54E-9 calcium & mitochondrial duress 7 2.11E-19
18 SGTC_537 1334-0398 8.89 209.0 µM 1.79E-9 2 2.94E-19
19 SGTC_1627 st003713 8.80 25.6 µM 2.62E-9 calcium & mitochondrial duress 11 6.78E-19
20 SGTC_768 0384-0033 8.72 77.3 µM 3.66E-9 fatty acid desaturase (OLE1) 17 1.42E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.339 7.14E-91 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.315 4.56E-78 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.315 1.11E-77 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.300 1.56E-70 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.296 1.46E-68 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.294 1.38E-67 YMR202W ERG2 hom C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
0.288 5.09E-65 YKL126W YPK1 hom Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
0.284 6.03E-63 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.278 2.89E-60 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.275 5.16E-59 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.270 6.52E-57 YKL212W SAC1 hom Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
0.267 2.01E-55 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.266 2.90E-55 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.262 9.79E-54 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.259 2.90E-52 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication