YGL055W / OLE1

Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL055W / OLE1

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:7.05|P-value:1.57E-11 ID:SGTC_68|Compound:0986-0284|FD-Score:4.15|P-value:4.95E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:5.63|P-value:5.77E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:14.10|P-value:1.29E-40 ID:SGTC_200|Compound:k038-0079|FD-Score:3.49|P-value:5.42E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:5.96|P-value:1.04E-8 ID:SGTC_258|Compound:haloperidol|FD-Score:10.00|P-value:1.43E-21 ID:SGTC_278|Compound:4092-0821|FD-Score:4.20|P-value:4.00E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:6.43|P-value:7.10E-10 ID:SGTC_363|Compound:0455-0021|FD-Score:3.34|P-value:8.87E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.34|P-value:2.57E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:3.66|P-value:2.99E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.25|P-value:9.05E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:6.52|P-value:3.98E-10 ID:SGTC_649|Compound:1123-0311|FD-Score:7.68|P-value:2.15E-13 ID:SGTC_688|Compound:0527-0193|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:9.00|P-value:9.80E-18 ID:SGTC_710|Compound:3448-4187|FD-Score:5.10|P-value:7.96E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:4.83|P-value:2.80E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:7.93|P-value:3.72E-14 ID:SGTC_747|Compound:3448-8087|FD-Score:4.88|P-value:2.30E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:4.43|P-value:1.57E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.81|P-value:1.30E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.54|P-value:4.65E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:11.50|P-value:8.41E-28 ID:SGTC_914|Compound:3820-6779|FD-Score:4.07|P-value:6.82E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.42|P-value:5.05E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.26|P-value:3.83E-7 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.46|P-value:1.43E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:15.60|P-value:1.27E-49 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.33|P-value:2.43E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:9.24|P-value:1.33E-18 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.02|P-value:8.09E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:14.50|P-value:4.28E-43 ID:SGTC_1168|Compound:k815-0004|FD-Score:-4.44|P-value:1.07E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.31|P-value:7.37E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.91|P-value:1.94E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.82|P-value:1.69E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.56|P-value:9.34E-6 ID:SGTC_1343|Compound:1487-0095|FD-Score:9.58|P-value:7.26E-20 ID:SGTC_1354|Compound:1498-1681|FD-Score:-4.06|P-value:4.93E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.70|P-value:2.59E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:5.35|P-value:2.41E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:-6.60|P-value:1.49E-10 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.72|P-value:4.67E-6 ID:SGTC_1435|Compound:4092-0789|FD-Score:7.18|P-value:6.51E-12 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.76|P-value:2.16E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.71|P-value:2.55E-4 ID:SGTC_1646|Compound:st011709|FD-Score:5.86|P-value:1.72E-8 ID:SGTC_1649|Compound:st011737|FD-Score:7.43|P-value:1.27E-12 ID:SGTC_1667|Compound:st014849|FD-Score:6.00|P-value:8.11E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:-5.34|P-value:1.61E-7 ID:SGTC_1750|Compound:st081859|FD-Score:11.80|P-value:4.36E-29 ID:SGTC_1755|Compound:st041960|FD-Score:4.50|P-value:1.19E-5 ID:SGTC_1825|Compound:st052143|FD-Score:4.94|P-value:1.68E-6 ID:SGTC_1826|Compound:st055655|FD-Score:-3.76|P-value:1.55E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.55|P-value:9.51E-6 ID:SGTC_1830|Compound:st055982|FD-Score:3.86|P-value:1.46E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.99|P-value:1.37E-6 ID:SGTC_1936|Compound:st074407|FD-Score:3.74|P-value:2.26E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.87|P-value:1.01E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.99|P-value:9.20E-5 ID:SGTC_1999|Compound:st074831|FD-Score:9.27|P-value:1.06E-18 ID:SGTC_2006|Compound:4011487|FD-Score:4.51|P-value:1.14E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.68|P-value:4.51E-8 ID:SGTC_2028|Compound:5153890|FD-Score:3.57|P-value:4.13E-4 ID:SGTC_2038|Compound:4100038|FD-Score:8.94|P-value:1.62E-17 ID:SGTC_2047|Compound:4141938|FD-Score:3.42|P-value:6.88E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.89|P-value:1.31E-4 ID:SGTC_2050|Compound:5263056|FD-Score:22.60|P-value:1.41E-101 ID:SGTC_2105|Compound:5350118|FD-Score:6.65|P-value:1.88E-10 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.93|P-value:1.82E-6 ID:SGTC_2239|Compound:6685329|FD-Score:4.17|P-value:4.60E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.03|P-value:7.74E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.26|P-value:3.23E-5 ID:SGTC_2385|Compound:9074692|FD-Score:7.55|P-value:5.30E-13 ID:SGTC_2440|Compound:5628896|FD-Score:3.48|P-value:5.53E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.61|P-value:3.66E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.89|P-value:1.34E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:11.30|P-value:1.08E-26 ID:SGTC_2725|Compound:haloperidol|FD-Score:13.80|P-value:3.04E-39 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.41|P-value:6.97E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:9.17|P-value:2.57E-18 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.64|P-value:4.51E-6 ID:SGTC_2792|Compound:7535235|FD-Score:4.32|P-value:2.54E-5 ID:SGTC_2825|Compound:7998094|FD-Score:8.13|P-value:8.94E-15 ID:SGTC_2838|Compound:9002687|FD-Score:6.90|P-value:3.84E-11 ID:SGTC_2880|Compound:9042983|FD-Score:9.95|P-value:2.87E-21 ID:SGTC_2887|Compound:9044784|FD-Score:9.44|P-value:2.47E-19 ID:SGTC_2893|Compound:9048488|FD-Score:5.12|P-value:7.39E-7 ID:SGTC_2910|Compound:7948405|FD-Score:7.41|P-value:1.40E-12 ID:SGTC_2938|Compound:9059746|FD-Score:5.12|P-value:7.44E-7 ID:SGTC_2952|Compound:9073731|FD-Score:4.06|P-value:6.95E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.97|P-value:1.53E-6 ID:SGTC_2993|Compound:9054257|FD-Score:19.60|P-value:3.96E-77 ID:SGTC_3027|Compound:9089541|FD-Score:5.44|P-value:1.57E-7 ID:SGTC_3033|Compound:9090887|FD-Score:7.06|P-value:1.44E-11 ID:SGTC_3041|Compound:9091929|FD-Score:5.70|P-value:4.05E-8 ID:SGTC_3045|Compound:9092950|FD-Score:3.38|P-value:7.69E-4 ID:SGTC_3054|Compound:9094397|FD-Score:8.41|P-value:1.05E-15 ID:SGTC_3056|Compound:9094900|FD-Score:4.67|P-value:5.75E-6 ID:SGTC_3071|Compound:9117417|FD-Score:14.40|P-value:1.02E-42 ID:SGTC_3081|Compound:9117243|FD-Score:11.00|P-value:1.94E-25 ID:SGTC_3126|Compound:9127922|FD-Score:18.00|P-value:4.16E-65 ID:SGTC_3145|Compound:9085516|FD-Score:5.44|P-value:1.57E-7 ID:SGTC_3155|Compound:9099265|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.86|P-value:2.44E-6 ID:SGTC_3214|Compound:9129694|FD-Score:4.95|P-value:1.62E-6 ID:SGTC_3310|Compound:9130229|FD-Score:4.39|P-value:1.89E-5 ID:SGTC_3334|Compound:9142812|FD-Score:7.49|P-value:8.18E-13 ID:SGTC_3335|Compound:9143315|FD-Score:3.58|P-value:4.05E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:7.05|P-value:1.57E-11 ID:SGTC_68|Compound:0986-0284|FD-Score:4.15|P-value:4.95E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:5.63|P-value:5.77E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:14.10|P-value:1.29E-40 ID:SGTC_200|Compound:k038-0079|FD-Score:3.49|P-value:5.42E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:5.96|P-value:1.04E-8 ID:SGTC_258|Compound:haloperidol|FD-Score:10.00|P-value:1.43E-21 ID:SGTC_278|Compound:4092-0821|FD-Score:4.20|P-value:4.00E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:6.43|P-value:7.10E-10 ID:SGTC_363|Compound:0455-0021|FD-Score:3.34|P-value:8.87E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.34|P-value:2.57E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:3.66|P-value:2.99E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.25|P-value:9.05E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:6.52|P-value:3.98E-10 ID:SGTC_649|Compound:1123-0311|FD-Score:7.68|P-value:2.15E-13 ID:SGTC_688|Compound:0527-0193|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:9.00|P-value:9.80E-18 ID:SGTC_710|Compound:3448-4187|FD-Score:5.10|P-value:7.96E-7 ID:SGTC_720|Compound:r052-1644|FD-Score:4.83|P-value:2.80E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:7.93|P-value:3.72E-14 ID:SGTC_747|Compound:3448-8087|FD-Score:4.88|P-value:2.30E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:4.43|P-value:1.57E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.81|P-value:1.30E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.54|P-value:4.65E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:11.50|P-value:8.41E-28 ID:SGTC_914|Compound:3820-6779|FD-Score:4.07|P-value:6.82E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.42|P-value:5.05E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.26|P-value:3.83E-7 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.46|P-value:1.43E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:15.60|P-value:1.27E-49 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.33|P-value:2.43E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:9.24|P-value:1.33E-18 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.02|P-value:8.09E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:14.50|P-value:4.28E-43 ID:SGTC_1168|Compound:k815-0004|FD-Score:-4.44|P-value:1.07E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.31|P-value:7.37E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.91|P-value:1.94E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.82|P-value:1.69E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.56|P-value:9.34E-6 ID:SGTC_1343|Compound:1487-0095|FD-Score:9.58|P-value:7.26E-20 ID:SGTC_1354|Compound:1498-1681|FD-Score:-4.06|P-value:4.93E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.70|P-value:2.59E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:5.35|P-value:2.41E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:-6.60|P-value:1.49E-10 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.72|P-value:4.67E-6 ID:SGTC_1435|Compound:4092-0789|FD-Score:7.18|P-value:6.51E-12 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.76|P-value:2.16E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.71|P-value:2.55E-4 ID:SGTC_1646|Compound:st011709|FD-Score:5.86|P-value:1.72E-8 ID:SGTC_1649|Compound:st011737|FD-Score:7.43|P-value:1.27E-12 ID:SGTC_1667|Compound:st014849|FD-Score:6.00|P-value:8.11E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:-5.34|P-value:1.61E-7 ID:SGTC_1750|Compound:st081859|FD-Score:11.80|P-value:4.36E-29 ID:SGTC_1755|Compound:st041960|FD-Score:4.50|P-value:1.19E-5 ID:SGTC_1825|Compound:st052143|FD-Score:4.94|P-value:1.68E-6 ID:SGTC_1826|Compound:st055655|FD-Score:-3.76|P-value:1.55E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.55|P-value:9.51E-6 ID:SGTC_1830|Compound:st055982|FD-Score:3.86|P-value:1.46E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.99|P-value:1.37E-6 ID:SGTC_1936|Compound:st074407|FD-Score:3.74|P-value:2.26E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.87|P-value:1.01E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.94|P-value:1.12E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.99|P-value:9.20E-5 ID:SGTC_1999|Compound:st074831|FD-Score:9.27|P-value:1.06E-18 ID:SGTC_2006|Compound:4011487|FD-Score:4.51|P-value:1.14E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.68|P-value:4.51E-8 ID:SGTC_2028|Compound:5153890|FD-Score:3.57|P-value:4.13E-4 ID:SGTC_2038|Compound:4100038|FD-Score:8.94|P-value:1.62E-17 ID:SGTC_2047|Compound:4141938|FD-Score:3.42|P-value:6.88E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.89|P-value:1.31E-4 ID:SGTC_2050|Compound:5263056|FD-Score:22.60|P-value:1.41E-101 ID:SGTC_2105|Compound:5350118|FD-Score:6.65|P-value:1.88E-10 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.93|P-value:1.82E-6 ID:SGTC_2239|Compound:6685329|FD-Score:4.17|P-value:4.60E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.03|P-value:7.74E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.26|P-value:3.23E-5 ID:SGTC_2385|Compound:9074692|FD-Score:7.55|P-value:5.30E-13 ID:SGTC_2440|Compound:5628896|FD-Score:3.48|P-value:5.53E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.61|P-value:3.66E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.89|P-value:1.34E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:11.30|P-value:1.08E-26 ID:SGTC_2725|Compound:haloperidol|FD-Score:13.80|P-value:3.04E-39 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.41|P-value:6.97E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:9.17|P-value:2.57E-18 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-4.64|P-value:4.51E-6 ID:SGTC_2792|Compound:7535235|FD-Score:4.32|P-value:2.54E-5 ID:SGTC_2825|Compound:7998094|FD-Score:8.13|P-value:8.94E-15 ID:SGTC_2838|Compound:9002687|FD-Score:6.90|P-value:3.84E-11 ID:SGTC_2880|Compound:9042983|FD-Score:9.95|P-value:2.87E-21 ID:SGTC_2887|Compound:9044784|FD-Score:9.44|P-value:2.47E-19 ID:SGTC_2893|Compound:9048488|FD-Score:5.12|P-value:7.39E-7 ID:SGTC_2910|Compound:7948405|FD-Score:7.41|P-value:1.40E-12 ID:SGTC_2938|Compound:9059746|FD-Score:5.12|P-value:7.44E-7 ID:SGTC_2952|Compound:9073731|FD-Score:4.06|P-value:6.95E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.97|P-value:1.53E-6 ID:SGTC_2993|Compound:9054257|FD-Score:19.60|P-value:3.96E-77 ID:SGTC_3027|Compound:9089541|FD-Score:5.44|P-value:1.57E-7 ID:SGTC_3033|Compound:9090887|FD-Score:7.06|P-value:1.44E-11 ID:SGTC_3041|Compound:9091929|FD-Score:5.70|P-value:4.05E-8 ID:SGTC_3045|Compound:9092950|FD-Score:3.38|P-value:7.69E-4 ID:SGTC_3054|Compound:9094397|FD-Score:8.41|P-value:1.05E-15 ID:SGTC_3056|Compound:9094900|FD-Score:4.67|P-value:5.75E-6 ID:SGTC_3071|Compound:9117417|FD-Score:14.40|P-value:1.02E-42 ID:SGTC_3081|Compound:9117243|FD-Score:11.00|P-value:1.94E-25 ID:SGTC_3126|Compound:9127922|FD-Score:18.00|P-value:4.16E-65 ID:SGTC_3145|Compound:9085516|FD-Score:5.44|P-value:1.57E-7 ID:SGTC_3155|Compound:9099265|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.86|P-value:2.44E-6 ID:SGTC_3214|Compound:9129694|FD-Score:4.95|P-value:1.62E-6 ID:SGTC_3310|Compound:9130229|FD-Score:4.39|P-value:1.89E-5 ID:SGTC_3334|Compound:9142812|FD-Score:7.49|P-value:8.18E-13 ID:SGTC_3335|Compound:9143315|FD-Score:3.58|P-value:4.05E-4

Top fitness defect scores for YGL055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2050 5263056 22.60 171.0 µM 1.41E-101 fatty acid desaturase (OLE1) 1 4.13E-113 9.61
2 SGTC_2993 9054257 19.60 71.4 µM 3.96E-77 fatty acid desaturase (OLE1) 1 7.02E-86 6.79
3 SGTC_3126 9127922 18.00 49.5 µM 4.16E-65 fatty acid desaturase (OLE1) 1 1.73E-72 3.07
4 SGTC_1026 k007-1105 15.60 30.6 µM 1.27E-49 ERAD & cell cycle 3 3.10E-55 4.23
5 SGTC_1165 k072-0275 14.50 30.3 µM 4.28E-43 1 5.83E-48 5.99
6 SGTC_3071 9117417 14.40 49.5 µM 1.02E-42 fatty acid desaturase (OLE1) 1 1.54E-47 7.14
7 SGTC_103 0844-0104 14.10 51.8 µM 1.29E-40 ERAD & cell cycle 5 3.38E-45 1.03
8 SGTC_2725 haloperidol 13.80 53.2 µM 3.04E-39 plasma membrane duress 2 1.15E-43 3.42
9 SGTC_1750 st081859 11.80 2.4 µM 4.36E-29 endomembrane recycling 2 2.41E-32 1.38
10 SGTC_887 0885-0007 11.50 9.6 µM 8.41E-28 endomembrane recycling 2 6.53E-31 1.79
11 SGTC_2721 ifenprodil 11.30 61.4 µM 1.08E-26 plasma membrane duress 1 1.13E-29 5.22
12 SGTC_3081 9117243 11.00 49.5 µM 1.94E-25 fatty acid desaturase (OLE1) 1 2.81E-28 1.49
13 SGTC_258 haloperidol 10.00 50.8 µM 1.43E-21 fatty acid desaturase (OLE1) 1 5.80E-24 1.55
14 SGTC_2880 9042983 9.95 58.4 µM 2.87E-21 fatty acid desaturase (OLE1) 1 1.26E-23 2.78
15 SGTC_1343 1487-0095 9.58 224.0 µM 7.26E-20 1 4.63E-22 5.93
16 SGTC_2887 9044784 9.44 58.4 µM 2.47E-19 fatty acid desaturase (OLE1) 1 1.82E-21 0.82
17 SGTC_1999 st074831 9.27 12.5 µM 1.06E-18 plasma membrane duress 1 9.25E-21 2.53
18 SGTC_1160 4092-0570 9.24 10.5 µM 1.33E-18 plasma membrane duress 1 1.19E-20 2.10
19 SGTC_2757 clomiphene 9.17 4.2 µM 2.57E-18 fatty acid desaturase (OLE1) 1 2.47E-20 4.05
20 SGTC_706 4262-0057 9.00 46.9 µM 9.80E-18 fatty acid desaturase (OLE1) 2 1.10E-19 2.18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.475 3.91E-188 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.379 6.05E-115 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.303 3.38E-72 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.264 1.98E-54 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.261 3.67E-53 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.259 1.61E-52 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.241 1.67E-45 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.238 2.71E-44 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.231 1.04E-41 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
0.230 2.26E-41 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.227 2.22E-40 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.223 4.85E-39 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.221 3.10E-38 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.212 2.36E-35 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.203 1.41E-32 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W