YGL056C / SDS23

One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL056C / SDS23

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.35|P-value:5.18E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.47|P-value:3.26E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.31|P-value:5.73E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.60|P-value:2.11E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.38|P-value:4.36E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.32|P-value:5.35E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.23|P-value:7.53E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.69|P-value:1.41E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-4.01|P-value:4.32E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:4.59|P-value:3.27E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:-3.20|P-value:8.64E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.31|P-value:6.03E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.93|P-value:5.51E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.78|P-value:1.32E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:5.54|P-value:2.58E-8 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.51|P-value:3.06E-8 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.47|P-value:5.92E-6 ID:SGTC_1518|Compound:st038567|FD-Score:3.63|P-value:1.76E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-4.22|P-value:1.79E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-3.86|P-value:7.89E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.35|P-value:5.25E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.29|P-value:6.08E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.16|P-value:9.90E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.29|P-value:6.08E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.42|P-value:4.06E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.66|P-value:2.92E-11 ID:SGTC_2507|Compound:purpurin|FD-Score:4.78|P-value:1.31E-6 ID:SGTC_2623|Compound:humulene|FD-Score:6.17|P-value:6.50E-10 ID:SGTC_2701|Compound:st077767|FD-Score:3.59|P-value:2.10E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.18|P-value:9.24E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.21|P-value:1.49E-7 ID:SGTC_2859|Compound:9028643|FD-Score:-3.24|P-value:7.52E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.17|P-value:9.68E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.17|P-value:2.09E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.24|P-value:7.53E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.32|P-value:5.51E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.26|P-value:6.60E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.30|P-value:5.85E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.35|P-value:5.18E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.47|P-value:3.26E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.31|P-value:5.73E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.60|P-value:2.11E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.38|P-value:4.36E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.32|P-value:5.35E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.23|P-value:7.53E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.69|P-value:1.41E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-4.01|P-value:4.32E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:4.59|P-value:3.27E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:-3.20|P-value:8.64E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.31|P-value:6.03E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.93|P-value:5.51E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.78|P-value:1.32E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:5.54|P-value:2.58E-8 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.51|P-value:3.06E-8 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.47|P-value:5.92E-6 ID:SGTC_1518|Compound:st038567|FD-Score:3.63|P-value:1.76E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-4.22|P-value:1.79E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-3.86|P-value:7.89E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.35|P-value:5.25E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.29|P-value:6.08E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.16|P-value:9.90E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.29|P-value:6.08E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.42|P-value:4.06E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.66|P-value:2.92E-11 ID:SGTC_2507|Compound:purpurin|FD-Score:4.78|P-value:1.31E-6 ID:SGTC_2623|Compound:humulene|FD-Score:6.17|P-value:6.50E-10 ID:SGTC_2701|Compound:st077767|FD-Score:3.59|P-value:2.10E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.18|P-value:9.24E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.21|P-value:1.49E-7 ID:SGTC_2859|Compound:9028643|FD-Score:-3.24|P-value:7.52E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.17|P-value:9.68E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.17|P-value:2.09E-5 ID:SGTC_3076|Compound:9116187|FD-Score:-3.24|P-value:7.53E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.32|P-value:5.51E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.26|P-value:6.60E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.30|P-value:5.85E-4

Top fitness defect scores for YGL056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2498 4'-Methoxychalcone 6.66 54.6 µM 2.92E-11 RPP1 & pyrimidine depletion 2 1.34E-11
2 SGTC_2623 humulene 6.17 100.0 µM 6.50E-10 2 3.32E-10
3 SGTC_1205 4161-2785 5.54 76.0 µM 2.58E-8 8 1.51E-8
4 SGTC_1425 4048-4433 5.51 7.3 µM 3.06E-8 copper-dependent oxidative stress 14 1.80E-8
5 SGTC_2852 9023854 5.21 52.0 µM 1.49E-7 16 9.25E-8
6 SGTC_2507 purpurin 4.78 79.7 µM 1.31E-6 copper-dependent oxidative stress 22 8.81E-7
7 SGTC_1193 1488-0126 4.78 41.5 µM 1.32E-6 13 8.90E-7
8 SGTC_719 2810-4230 4.59 27.3 µM 3.27E-6 5 2.26E-6
9 SGTC_3068 9116768 4.17 49.5 µM 2.09E-5 15 1.54E-5
10 SGTC_1189 1431-2119 3.93 7.3 µM 5.51E-5 29 4.21E-5
11 SGTC_640 3381-0960 3.69 37.1 µM 1.41E-4 18 1.11E-4
12 SGTC_1518 st038567 3.63 90.8 µM 1.76E-4 20 1.40E-4
13 SGTC_2701 st077767 3.59 14.7 µM 2.10E-4 60 1.68E-4
14 SGTC_149 3970-0822 3.47 46.1 µM 3.26E-4 tubulin folding & SWR complex 127 2.65E-4
15 SGTC_1936 st074407 3.44 74.3 µM 3.53E-4 DNA damage response 55 2.88E-4
16 SGTC_313 3474-0040 3.38 5.0 µM 4.36E-4 NEO1-PIK1 96 3.58E-4
17 SGTC_362 0310-0100 3.32 9.0 µM 5.35E-4 RPP1 & pyrimidine depletion 64 4.42E-4
18 SGTC_3083 9117465 3.32 49.5 µM 5.51E-4 46 4.56E-4
19 SGTC_150 3970-0969 3.31 77.2 µM 5.73E-4 95 4.75E-4
20 SGTC_3316 9136639 3.30 10.6 µM 5.85E-4 34 4.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.51E-9 YLR422W_p YLR422W_p hom Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
0.098 1.25E-8 YPR127W YPR127W hom Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.097 1.99E-8 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.091 1.24E-7 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.089 2.08E-7 YJL103C GSM1 hom Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
0.086 5.54E-7 YGL196W DSD1 hom D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate
0.079 5.06E-6 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.079 5.25E-6 YOL136C PFK27 hom 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
0.078 5.61E-6 YKL217W JEN1 hom Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
0.077 7.32E-6 YDR092W UBC13 hom Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
0.077 7.69E-6 YEL041W YEF1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication
0.075 1.32E-5 YHR062C RPP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.075 1.50E-5 YPL270W MDL2 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.074 1.62E-5 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases
0.073 2.50E-5 YIR027C DAL1 hom Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression