YGL057C / GEP7

Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL057C / GEP7

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:3.27|P-value:7.91E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:6.11|P-value:1.62E-9 ID:SGTC_433|Compound:pimozide|FD-Score:3.55|P-value:3.05E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.32|P-value:6.76E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.93|P-value:6.20E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.58|P-value:2.34E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.39|P-value:9.04E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.45|P-value:4.35E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.98|P-value:6.04E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.54|P-value:2.71E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.59|P-value:4.63E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.22|P-value:9.52E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.49|P-value:7.19E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.81|P-value:1.15E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.93|P-value:9.26E-7 ID:SGTC_1972|Compound:st070201|FD-Score:-3.17|P-value:9.49E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.49|P-value:3.74E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.36|P-value:5.94E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.27|P-value:7.96E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-3.57|P-value:2.44E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.25|P-value:7.24E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.31|P-value:6.08E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.42|P-value:9.75E-6 ID:SGTC_2827|Compound:7993847|FD-Score:-3.47|P-value:3.45E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.42|P-value:4.13E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.33|P-value:6.66E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.52|P-value:2.91E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.27|P-value:7.91E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:6.11|P-value:1.62E-9 ID:SGTC_433|Compound:pimozide|FD-Score:3.55|P-value:3.05E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.32|P-value:6.76E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.93|P-value:6.20E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.58|P-value:2.34E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.39|P-value:9.04E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.45|P-value:4.35E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.98|P-value:6.04E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.54|P-value:2.71E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:4.59|P-value:4.63E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.22|P-value:9.52E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.49|P-value:7.19E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.81|P-value:1.15E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.93|P-value:9.26E-7 ID:SGTC_1972|Compound:st070201|FD-Score:-3.17|P-value:9.49E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.49|P-value:3.74E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.36|P-value:5.94E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.27|P-value:7.96E-4 ID:SGTC_2708|Compound:st078559|FD-Score:-3.57|P-value:2.44E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.25|P-value:7.24E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.31|P-value:6.08E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.42|P-value:9.75E-6 ID:SGTC_2827|Compound:7993847|FD-Score:-3.47|P-value:3.45E-4 ID:SGTC_2839|Compound:9003951|FD-Score:-3.42|P-value:4.13E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.33|P-value:6.66E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.52|P-value:2.91E-4

Top fitness defect scores for YGL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_423 5-fluorouracil 6.11 457.0 µM 1.62E-9 exosome 2 4.86E-10
2 SGTC_1967 st070177 4.93 51.4 µM 9.26E-7 6 4.09E-7
3 SGTC_1549 4'-methoxyflavonol 4.59 74.6 µM 4.63E-6 4 2.26E-6
4 SGTC_1673 st016611 4.49 27.3 µM 7.19E-6 30 3.60E-6
5 SGTC_2824 7998404 4.42 52.0 µM 9.75E-6 26 4.98E-6
6 SGTC_1439 4092-1168 3.98 46.0 µM 6.04E-5 10 3.45E-5
7 SGTC_1681 tripelennamine 3.81 100.0 µM 1.15E-4 26 6.83E-5
8 SGTC_438 sphingosine 3.68 6.7 µM 1.91E-4 31 1.17E-4
9 SGTC_433 pimozide 3.55 108.0 µM 3.05E-4 25 1.93E-4
10 SGTC_1986 st071812 3.49 45.0 µM 3.74E-4 11 2.39E-4
11 SGTC_1364 1653-0028 3.45 37.6 µM 4.35E-4 41 2.81E-4
12 SGTC_2059 5238311 3.36 157.0 µM 5.94E-4 43 3.90E-4
13 SGTC_3143 9086658 3.33 49.5 µM 6.66E-4 79 4.41E-4
14 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.32 8.0 µM 6.76E-4 49 4.48E-4
15 SGTC_129 0088-0017 3.27 176.6 µM 7.91E-4 96 5.30E-4
16 SGTC_2144 5628481 3.27 200.0 µM 7.96E-4 ERG2 51 5.33E-4
17 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.22 85.4 µM 9.52E-4 51 6.45E-4
18 SGTC_437 s-farnesyl-l-cysteine methyl ester 3.18 6.7 µM 0.00109 37 7.46E-4
19 SGTC_2056 5235370 3.16 200.0 µM 0.00116 77 7.94E-4
20 SGTC_795 0685-0265 3.09 78.0 µM 0.00144 excess fatty acid 62 9.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.44E-21 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.160 9.35E-21 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.143 8.16E-17 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.131 2.61E-14 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.129 7.11E-14 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.119 4.20E-12 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.116 1.57E-11 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.097 1.66E-8 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.097 1.67E-8 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.090 1.79E-7 YHR022C-A_p YHR022C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.090 1.96E-7 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.087 3.87E-7 YOR243C PUS7 hom Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria
0.085 1.00E-6 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.083 1.59E-6 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.081 2.88E-6 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W