YGL060W / YBP2

Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL060W / YBP2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.22|P-value:7.45E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.43|P-value:3.45E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.92|P-value:5.65E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:3.85|P-value:7.14E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.05|P-value:3.05E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.62|P-value:1.76E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.76|P-value:1.27E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:3.19|P-value:8.08E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-3.45|P-value:3.03E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.53|P-value:2.24E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.86|P-value:6.93E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.28|P-value:6.06E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.88|P-value:6.35E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.97|P-value:1.77E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.33|P-value:4.92E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.38|P-value:6.67E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.53|P-value:2.44E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.35|P-value:4.61E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:6.77|P-value:1.04E-11 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.15|P-value:9.45E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.14|P-value:9.59E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.78|P-value:9.50E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.19|P-value:1.40E-7 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.90|P-value:6.42E-7 ID:SGTC_1605|Compound:st000082|FD-Score:4.39|P-value:6.99E-6 ID:SGTC_1611|Compound:st001856|FD-Score:4.00|P-value:3.91E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.48|P-value:4.61E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.58|P-value:1.98E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.52|P-value:2.53E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.54|P-value:2.32E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.06|P-value:2.95E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.97|P-value:4.40E-7 ID:SGTC_2319|Compound:6033012|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.62|P-value:1.70E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.21|P-value:7.65E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.45|P-value:5.43E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-4.12|P-value:2.15E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:8.61|P-value:8.02E-18 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.00|P-value:3.77E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.79|P-value:8.82E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.35|P-value:4.30E-4 ID:SGTC_2808|Compound:7946468|FD-Score:6.57|P-value:3.88E-11 ID:SGTC_2832|Compound:7992762|FD-Score:5.81|P-value:4.64E-9 ID:SGTC_2836|Compound:9010338|FD-Score:3.32|P-value:5.13E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-5.89|P-value:2.48E-9 ID:SGTC_3050|Compound:9093513|FD-Score:3.50|P-value:2.68E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.14|P-value:2.11E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.29|P-value:5.81E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.63|P-value:2.38E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.22|P-value:7.45E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.43|P-value:3.45E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.92|P-value:5.65E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:3.85|P-value:7.14E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.05|P-value:3.05E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.62|P-value:1.76E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.76|P-value:1.27E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:3.19|P-value:8.08E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-3.45|P-value:3.03E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.53|P-value:2.24E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.86|P-value:6.93E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.28|P-value:6.06E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.88|P-value:6.35E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.49|P-value:2.84E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.97|P-value:1.77E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.23|P-value:1.43E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.33|P-value:4.92E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-4.38|P-value:6.67E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.53|P-value:2.44E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.35|P-value:4.61E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:6.77|P-value:1.04E-11 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.15|P-value:9.45E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.14|P-value:9.59E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.78|P-value:9.50E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.19|P-value:1.40E-7 ID:SGTC_1471|Compound:k673-0312|FD-Score:4.90|P-value:6.42E-7 ID:SGTC_1605|Compound:st000082|FD-Score:4.39|P-value:6.99E-6 ID:SGTC_1611|Compound:st001856|FD-Score:4.00|P-value:3.91E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.48|P-value:4.61E-6 ID:SGTC_1627|Compound:st003713|FD-Score:3.14|P-value:9.50E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.58|P-value:1.98E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.52|P-value:2.53E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.54|P-value:2.32E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.06|P-value:2.95E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.97|P-value:4.40E-7 ID:SGTC_2319|Compound:6033012|FD-Score:3.56|P-value:2.14E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.62|P-value:1.70E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.21|P-value:7.65E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.45|P-value:5.43E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-4.12|P-value:2.15E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:8.61|P-value:8.02E-18 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.00|P-value:3.77E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.79|P-value:8.82E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.35|P-value:4.30E-4 ID:SGTC_2808|Compound:7946468|FD-Score:6.57|P-value:3.88E-11 ID:SGTC_2832|Compound:7992762|FD-Score:5.81|P-value:4.64E-9 ID:SGTC_2836|Compound:9010338|FD-Score:3.32|P-value:5.13E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-5.89|P-value:2.48E-9 ID:SGTC_3050|Compound:9093513|FD-Score:3.50|P-value:2.68E-4 ID:SGTC_3074|Compound:9116018|FD-Score:4.14|P-value:2.11E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.29|P-value:5.81E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.63|P-value:2.38E-6

Top fitness defect scores for YGL060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 8.61 48.7 µM 8.02E-18 cell wall 24 3.80E-18
2 SGTC_1268 0828-0275 6.77 2.5 µM 1.04E-11 2 6.44E-12
3 SGTC_2808 7946468 6.57 45.5 µM 3.88E-11 4 2.46E-11
4 SGTC_1133 3473-0247 5.97 50.0 µM 1.77E-9 RSC complex & mRNA processing 8 1.20E-9
5 SGTC_2832 7992762 5.81 52.0 µM 4.64E-9 8 3.22E-9
6 SGTC_1453 4237-0541 5.19 195.0 µM 1.40E-7 heme biosynthesis & mitochondrial translocase 8 1.04E-7
7 SGTC_2210 7115885 4.97 190.4 µM 4.40E-7 cell wall signaling 20 3.33E-7
8 SGTC_79 0052-0007 4.92 94.1 µM 5.65E-7 17 4.30E-7
9 SGTC_1471 k673-0312 4.90 37.0 µM 6.42E-7 RNA processing & uracil transport 6 4.89E-7
10 SGTC_514 4466-0038 4.76 2.6 nM 1.27E-6 cell wall 119 9.78E-7
11 SGTC_3321 9137793 4.63 26.8 µM 2.38E-6 cell wall 58 1.86E-6
12 SGTC_1621 st003705 4.48 32.4 µM 4.61E-6 calcium & mitochondrial duress 14 3.65E-6
13 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.45 100.0 µM 5.43E-6 9 4.31E-6
14 SGTC_1605 st000082 4.39 49.1 µM 6.99E-6 60S ribosome export 8 5.58E-6
15 SGTC_1145 3546-0597 4.23 10.2 µM 1.43E-5 mitochondrial processes 15 1.16E-5
16 SGTC_3074 9116018 4.14 49.5 µM 2.11E-5 RNA processing & uracil transport 18 1.72E-5
17 SGTC_2178 5812956 4.06 200.0 µM 2.95E-5 14 2.42E-5
18 SGTC_138 0850-0259 4.05 40.9 µM 3.05E-5 cell wall 194 2.51E-5
19 SGTC_2679 rapamycin 4.00 1.0 nM 3.77E-5 143 3.11E-5
20 SGTC_1611 st001856 4.00 99.4 µM 3.91E-5 14 3.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 2.35E-57 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.236 8.15E-44 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.235 3.12E-43 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.229 3.01E-41 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.227 2.45E-40 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.208 2.87E-34 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.207 1.05E-33 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.204 5.10E-33 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.202 4.47E-32 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.193 2.18E-29 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.186 1.99E-27 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.181 3.65E-26 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.177 3.92E-25 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.176 1.03E-24 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.175 1.34E-24 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2