YGL061C / DUO1

Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL061C / DUO1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.42|P-value:2.91E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-2.76|P-value:4.75E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.05|P-value:9.50E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:2.68|P-value:8.46E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-4.01|P-value:8.10E-7 ID:SGTC_448|Compound:monastrol|FD-Score:2.98|P-value:2.33E-4 ID:SGTC_470|Compound:aa-861|FD-Score:2.65|P-value:9.49E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.57|P-value:9.58E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.76|P-value:4.65E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:5.27|P-value:2.48E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:3.39|P-value:3.40E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.75|P-value:5.10E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:5.72|P-value:7.49E-12 ID:SGTC_587|Compound:k089-0003|FD-Score:2.65|P-value:9.41E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.65|P-value:7.47E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.16|P-value:7.72E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.51|P-value:1.84E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:-2.69|P-value:6.29E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.08|P-value:1.46E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.15|P-value:7.93E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.02|P-value:1.95E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.95|P-value:2.61E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.60|P-value:1.15E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.23|P-value:5.63E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.96|P-value:2.56E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.80|P-value:5.09E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.84|P-value:4.27E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.22|P-value:7.74E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.15|P-value:1.08E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-2.89|P-value:2.69E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.97|P-value:2.45E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.35|P-value:4.10E-5 ID:SGTC_1845|Compound:st056753|FD-Score:5.12|P-value:7.75E-10 ID:SGTC_1861|Compound:st057647|FD-Score:2.80|P-value:5.10E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.11|P-value:1.29E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.91|P-value:3.13E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.07|P-value:8.34E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.37|P-value:1.31E-7 ID:SGTC_2134|Compound:5324836|FD-Score:-2.95|P-value:2.03E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.11|P-value:1.28E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-3.10|P-value:1.02E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.70|P-value:7.58E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.88|P-value:3.56E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.94|P-value:2.83E-4 ID:SGTC_2372|Compound:9071633|FD-Score:2.88|P-value:3.67E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.01|P-value:1.52E-4 ID:SGTC_2386|Compound:9075165|FD-Score:2.92|P-value:3.10E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.46|P-value:1.72E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-2.77|P-value:4.44E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-7.22|P-value:4.07E-18 ID:SGTC_2715|Compound:st079500|FD-Score:-2.97|P-value:1.87E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.91|P-value:2.05E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-2.64|P-value:7.77E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-2.62|P-value:8.24E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.44|P-value:2.61E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.42|P-value:2.91E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-2.76|P-value:4.75E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:4.05|P-value:9.50E-7 ID:SGTC_326|Compound:k292-0812|FD-Score:2.68|P-value:8.46E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-4.01|P-value:8.10E-7 ID:SGTC_448|Compound:monastrol|FD-Score:2.98|P-value:2.33E-4 ID:SGTC_470|Compound:aa-861|FD-Score:2.65|P-value:9.49E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.57|P-value:9.58E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.76|P-value:4.65E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:5.27|P-value:2.48E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:3.39|P-value:3.40E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.75|P-value:5.10E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:5.72|P-value:7.49E-12 ID:SGTC_587|Compound:k089-0003|FD-Score:2.65|P-value:9.41E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.65|P-value:7.47E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.16|P-value:7.72E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.51|P-value:1.84E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:-2.69|P-value:6.29E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.08|P-value:1.46E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.15|P-value:7.93E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.02|P-value:1.95E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.95|P-value:2.61E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.60|P-value:1.15E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.23|P-value:5.63E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.96|P-value:2.56E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.80|P-value:5.09E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.84|P-value:4.27E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.22|P-value:7.74E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.15|P-value:1.08E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-2.89|P-value:2.69E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.97|P-value:2.45E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.35|P-value:4.10E-5 ID:SGTC_1845|Compound:st056753|FD-Score:5.12|P-value:7.75E-10 ID:SGTC_1861|Compound:st057647|FD-Score:2.80|P-value:5.10E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.11|P-value:1.29E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.91|P-value:3.13E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.07|P-value:8.34E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.37|P-value:1.31E-7 ID:SGTC_2134|Compound:5324836|FD-Score:-2.95|P-value:2.03E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.11|P-value:1.28E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-3.10|P-value:1.02E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.70|P-value:7.58E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.88|P-value:3.56E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.94|P-value:2.83E-4 ID:SGTC_2372|Compound:9071633|FD-Score:2.88|P-value:3.67E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.01|P-value:1.52E-4 ID:SGTC_2386|Compound:9075165|FD-Score:2.92|P-value:3.10E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.46|P-value:1.72E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-2.77|P-value:4.44E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-7.22|P-value:4.07E-18 ID:SGTC_2715|Compound:st079500|FD-Score:-2.97|P-value:1.87E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.91|P-value:2.05E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-2.64|P-value:7.77E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-2.62|P-value:8.24E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.44|P-value:2.61E-5

Top fitness defect scores for YGL061C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_542 3381-0244 5.72 89.3 µM 7.49E-12 5 5.39E-9 0.00
2 SGTC_532 1548-0774 5.27 215.0 µM 2.48E-10 2 6.70E-8 0.45
3 SGTC_1845 st056753 5.12 3.0 µM 7.75E-10 TSC3-RPN4 3 1.52E-7 0.57
4 SGTC_2130 NSC 7 4.37 2.5 µM 1.31E-7 copper-dependent oxidative stress 4 6.21E-6 0.63
5 SGTC_2127 5253358 4.07 187.9 µM 8.34E-7 5 2.37E-5 0.11
6 SGTC_172 1112-0046 4.05 2.6 µM 9.50E-7 NEO1 8 2.61E-5 0.01
7 SGTC_2918 7977171 3.91 22.1 µM 2.05E-6 4 4.56E-5 0.19
8 SGTC_537 1334-0398 3.75 209.0 µM 5.10E-6 9 8.85E-5 0.06
9 SGTC_1039 k821-0043 3.60 94.0 µM 1.15E-5 Golgi 6 1.60E-4 0.03
10 SGTC_811 0416-0114 3.51 265.0 µM 1.84E-5 5 2.25E-4 0.09
11 SGTC_3215 9129942 3.44 49.5 µM 2.61E-5 7 2.91E-4 0.05
12 SGTC_45 0kpi-0036 3.42 14.9 µM 2.91E-5 excess fatty acid 9 3.15E-4 0.05
13 SGTC_535 2293-4129 3.39 48.2 µM 3.40E-5 NEO1 16 3.53E-4 0.24
14 SGTC_1788 fluconazole 3.35 20.0 µM 4.10E-5 azole & statin 16 4.05E-4 0.20
15 SGTC_1603 st002045 3.22 67.8 µM 7.74E-5 TSC3-RPN4 4 6.43E-4 0.27
16 SGTC_1606 st000094 3.15 49.2 µM 1.08E-4 60S ribosome export 15 8.22E-4 0.10
17 SGTC_2191 5911152 3.11 200.0 µM 1.28E-4 8 9.31E-4 0.13
18 SGTC_1898 st060199 3.11 18.6 µM 1.29E-4 12 9.36E-4 0.08
19 SGTC_891 0929-0073 3.08 133.0 µM 1.46E-4 10 0.00102 0.04
20 SGTC_953 1188-0045 3.02 9.7 µM 1.95E-4 60S ribosome export 20 0.00127 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.25E-13 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.124 4.53E-13 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.123 1.03E-12 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.121 1.68E-12 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.114 4.30E-11 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.111 1.37E-10 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.102 2.86E-9 YJL047C RTT101 hom Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p
0.101 4.39E-9 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.099 9.86E-9 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
0.098 1.29E-8 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.096 2.17E-8 YOL077W-A ATP19 hom Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
0.095 3.88E-8 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.093 6.31E-8 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.089 2.33E-7 YLR413W_p YLR413W_p hom Putative protein of unknown function; YLR413W is not an essential gene
0.087 4.15E-7 YKR038C KAE1 het Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription