YGL064C / MRH4

Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL064C / MRH4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.23|P-value:2.68E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.55|P-value:3.40E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.27|P-value:2.19E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:5.12|P-value:4.65E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:6.41|P-value:4.06E-10 ID:SGTC_116|Compound:0155-0182|FD-Score:5.63|P-value:3.40E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.18|P-value:3.11E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.34|P-value:1.57E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:14.80|P-value:3.84E-46 ID:SGTC_177|Compound:1327-0068|FD-Score:3.40|P-value:5.67E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.74|P-value:1.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.30|P-value:1.26E-37 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.47|P-value:4.06E-13 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.78|P-value:1.33E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.83|P-value:3.02E-14 ID:SGTC_314|Compound:1671-0008|FD-Score:3.75|P-value:1.68E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.39|P-value:5.41E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.18|P-value:6.73E-19 ID:SGTC_431|Compound:k089-0097|FD-Score:-8.70|P-value:2.95E-17 ID:SGTC_444|Compound:curcumin|FD-Score:-5.81|P-value:1.14E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.32|P-value:6.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.30|P-value:6.98E-16 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.15|P-value:3.55E-7 ID:SGTC_462|Compound:ag-879|FD-Score:3.62|P-value:2.62E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.22|P-value:9.48E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.64|P-value:2.25E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.19|P-value:2.92E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.85|P-value:1.04E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.82|P-value:1.97E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.33|P-value:1.53E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.94|P-value:8.22E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.25|P-value:9.51E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.79|P-value:2.26E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:6.28|P-value:8.93E-10 ID:SGTC_791|Compound:1348-1292|FD-Score:5.12|P-value:4.60E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.27|P-value:8.85E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.28|P-value:8.53E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.31|P-value:6.99E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.30|P-value:8.04E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.46|P-value:4.71E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.78|P-value:4.42E-14 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.32|P-value:6.74E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.57|P-value:4.00E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.76|P-value:1.57E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.55|P-value:3.11E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.35|P-value:1.53E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.60|P-value:2.83E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-4.17|P-value:2.89E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.72|P-value:1.85E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.68|P-value:2.14E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.24|P-value:8.98E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.52|P-value:3.47E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.25|P-value:9.44E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.22|P-value:2.66E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-5.60|P-value:3.49E-8 ID:SGTC_1656|Compound:st012921|FD-Score:-3.59|P-value:2.69E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.34|P-value:6.50E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.33|P-value:6.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.80|P-value:6.31E-35 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.54|P-value:6.09E-6 ID:SGTC_1882|Compound:5615643|FD-Score:4.53|P-value:7.18E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.44|P-value:1.06E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.47|P-value:4.09E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.28|P-value:8.52E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.29|P-value:8.27E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.84|P-value:1.17E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.55|P-value:6.51E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.22|P-value:9.60E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.26|P-value:8.95E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-4.70|P-value:3.01E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.75|P-value:1.53E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.41|P-value:5.55E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.43|P-value:4.64E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.89|P-value:8.76E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.43|P-value:5.09E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.43|P-value:9.90E-6 ID:SGTC_2924|Compound:9010168|FD-Score:-3.85|P-value:1.03E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.73|P-value:1.60E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.56|P-value:3.28E-4 ID:SGTC_3194|Compound:9111903|FD-Score:6.06|P-value:3.24E-9 ID:SGTC_3297|Compound:9117502|FD-Score:3.58|P-value:3.11E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-4.99|P-value:7.69E-7 ID:SGTC_10|Compound:0279-0212|FD-Score:5.23|P-value:2.68E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.55|P-value:3.40E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.27|P-value:2.19E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:5.12|P-value:4.65E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:6.41|P-value:4.06E-10 ID:SGTC_116|Compound:0155-0182|FD-Score:5.63|P-value:3.40E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.18|P-value:3.11E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.34|P-value:1.57E-7 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:14.80|P-value:3.84E-46 ID:SGTC_177|Compound:1327-0068|FD-Score:3.40|P-value:5.67E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.74|P-value:1.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.30|P-value:1.26E-37 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.47|P-value:4.06E-13 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.78|P-value:1.33E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.83|P-value:3.02E-14 ID:SGTC_314|Compound:1671-0008|FD-Score:3.75|P-value:1.68E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.39|P-value:5.41E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.18|P-value:6.73E-19 ID:SGTC_431|Compound:k089-0097|FD-Score:-8.70|P-value:2.95E-17 ID:SGTC_444|Compound:curcumin|FD-Score:-5.81|P-value:1.14E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.32|P-value:6.90E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.30|P-value:6.98E-16 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.15|P-value:3.55E-7 ID:SGTC_462|Compound:ag-879|FD-Score:3.62|P-value:2.62E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.22|P-value:9.48E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.64|P-value:2.25E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.19|P-value:2.92E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.85|P-value:1.04E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.82|P-value:1.97E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.33|P-value:1.53E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.94|P-value:8.22E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.25|P-value:9.51E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:4.79|P-value:2.26E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:6.28|P-value:8.93E-10 ID:SGTC_791|Compound:1348-1292|FD-Score:5.12|P-value:4.60E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.27|P-value:8.85E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:3.28|P-value:8.53E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.31|P-value:6.99E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.30|P-value:8.04E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.46|P-value:4.71E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.78|P-value:4.42E-14 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.32|P-value:6.74E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.57|P-value:4.00E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.76|P-value:1.57E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.55|P-value:3.11E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.35|P-value:1.53E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.60|P-value:2.83E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-4.17|P-value:2.89E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.72|P-value:1.85E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.68|P-value:2.14E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.24|P-value:8.98E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.52|P-value:3.47E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.25|P-value:9.44E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.22|P-value:2.66E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-5.60|P-value:3.49E-8 ID:SGTC_1656|Compound:st012921|FD-Score:-3.59|P-value:2.69E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.34|P-value:6.50E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.33|P-value:6.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.80|P-value:6.31E-35 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.54|P-value:6.09E-6 ID:SGTC_1882|Compound:5615643|FD-Score:4.53|P-value:7.18E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.44|P-value:1.06E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-3.47|P-value:4.09E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.28|P-value:8.52E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.29|P-value:8.27E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.84|P-value:1.17E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.55|P-value:6.51E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.22|P-value:9.60E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.26|P-value:8.95E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-4.70|P-value:3.01E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.75|P-value:1.53E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.41|P-value:5.55E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.43|P-value:4.64E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.89|P-value:8.76E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.43|P-value:5.09E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.43|P-value:9.90E-6 ID:SGTC_2924|Compound:9010168|FD-Score:-3.85|P-value:1.03E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.73|P-value:1.60E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.56|P-value:3.28E-4 ID:SGTC_3194|Compound:9111903|FD-Score:6.06|P-value:3.24E-9 ID:SGTC_3297|Compound:9117502|FD-Score:3.58|P-value:3.11E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-4.99|P-value:7.69E-7

Top fitness defect scores for YGL064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 14.80 2.7 µM 3.84E-46 mitochondrial stress 8 6.30E-50
2 SGTC_236 1509-0011 13.30 5.3 µM 1.26E-37 132 1.09E-40
3 SGTC_1742 st038235 12.80 28.9 µM 6.31E-35 mitochondrial stress 3 9.18E-38
4 SGTC_386 1509-0011 9.18 3.1 µM 6.73E-19 52 2.22E-20
5 SGTC_310 1273-0058 7.83 1.1 µM 3.02E-14 mitochondrial stress 98 2.46E-15
6 SGTC_908 3448-7491 7.78 47.7 µM 4.42E-14 mitochondrial stress 19 3.71E-15
7 SGTC_275 trichlorophene 7.47 5.7 µM 4.06E-13 mitochondrial stress 86 4.11E-14
8 SGTC_70 0141-0289 6.41 43.3 µM 4.06E-10 mitochondrial stress 70 7.35E-11
9 SGTC_778 3456-2434 6.28 196.0 µM 8.93E-10 mitochondrial response to ROS 22 1.73E-10
10 SGTC_3194 9111903 6.06 49.5 µM 3.24E-9 6 6.99E-10
11 SGTC_116 0155-0182 5.63 31.8 µM 3.40E-8 mitochondrial response to ROS 30 8.93E-9
12 SGTC_119 0121-0043 5.34 24.8 µM 1.57E-7 mitochondrial stress 41 4.68E-8
13 SGTC_10 0279-0212 5.23 42.6 µM 2.68E-7 TRP & mitochondrial translation 52 8.37E-8
14 SGTC_791 1348-1292 5.12 225.0 µM 4.60E-7 16 1.50E-7
15 SGTC_68 0986-0284 5.12 82.8 µM 4.65E-7 26 1.52E-7
16 SGTC_520 3584-0023 4.82 682.0 µM 1.97E-6 12 7.26E-7
17 SGTC_629 3448-6466 4.79 76.7 µM 2.26E-6 6 8.45E-7
18 SGTC_2250 alverine citrate 4.55 130.0 µM 6.51E-6 121 2.65E-6
19 SGTC_1882 5615643 4.53 20.0 µM 7.18E-6 TRP & mitochondrial translation 18 2.95E-6
20 SGTC_1883 5-benzylidenerhodanine 4.44 20.0 µM 1.06E-5 TRP & mitochondrial translation 51 4.50E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.550 4.00E-265 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.518 8.44E-230 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.516 4.95E-228 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.516 2.33E-227 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.511 1.48E-222 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.506 1.40E-217 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.502 1.54E-213 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.490 3.49E-202 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.486 1.65E-198 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.486 3.43E-198 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.485 1.39E-197 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.478 5.99E-191 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.478 7.14E-191 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.474 1.36E-187 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.473 5.46E-186 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs