YGL067W / NPY1

NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL067W / NPY1

Click on Significant Values for Screen Details ID:SGTC_202|Compound:3594-0513|FD-Score:-3.19|P-value:3.58E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-2.97|P-value:1.09E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.51|P-value:6.14E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:2.93|P-value:1.15E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-2.93|P-value:1.34E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.62|P-value:5.62E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.16|P-value:3.66E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:2.96|P-value:1.01E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.93|P-value:1.18E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.59|P-value:6.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.89|P-value:5.48E-10 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.40|P-value:2.04E-8 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.67|P-value:4.46E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.75|P-value:2.72E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.73|P-value:3.07E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.11|P-value:5.34E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.59|P-value:5.71E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.66|P-value:4.58E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-2.51|P-value:9.13E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.59|P-value:3.38E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:-2.86|P-value:1.84E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.73|P-value:1.68E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.86|P-value:1.87E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.01|P-value:7.67E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.08|P-value:1.54E-7 ID:SGTC_1554|Compound:st069299|FD-Score:3.40|P-value:9.64E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.12|P-value:4.52E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.18|P-value:3.34E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-2.93|P-value:1.35E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-2.96|P-value:1.17E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.62|P-value:5.68E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.45|P-value:8.54E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.08|P-value:6.32E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-2.90|P-value:1.52E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.58|P-value:4.19E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-3.79|P-value:1.13E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-2.68|P-value:4.31E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-2.56|P-value:7.10E-4 ID:SGTC_3172|Compound:9105863|FD-Score:-2.81|P-value:2.31E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.80|P-value:2.41E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:-3.19|P-value:3.58E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-2.97|P-value:1.09E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.51|P-value:6.14E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:2.93|P-value:1.15E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-2.93|P-value:1.34E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.62|P-value:5.62E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.16|P-value:3.66E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:2.96|P-value:1.01E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.93|P-value:1.18E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.59|P-value:6.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.89|P-value:5.48E-10 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.40|P-value:2.04E-8 ID:SGTC_969|Compound:1313-0238|FD-Score:-2.67|P-value:4.46E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.75|P-value:2.72E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.73|P-value:3.07E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.11|P-value:5.34E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.59|P-value:5.71E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.66|P-value:4.58E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-2.51|P-value:9.13E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.59|P-value:3.38E-6 ID:SGTC_1355|Compound:1499-0035|FD-Score:-2.86|P-value:1.84E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.73|P-value:1.68E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.86|P-value:1.87E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.01|P-value:7.67E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.08|P-value:1.54E-7 ID:SGTC_1554|Compound:st069299|FD-Score:3.40|P-value:9.64E-6 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.12|P-value:4.52E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.18|P-value:3.34E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-2.93|P-value:1.35E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-2.96|P-value:1.17E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.62|P-value:5.68E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.45|P-value:8.54E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.08|P-value:6.32E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-2.90|P-value:1.52E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.58|P-value:4.19E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-3.79|P-value:1.13E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-2.68|P-value:4.31E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-2.56|P-value:7.10E-4 ID:SGTC_3172|Compound:9105863|FD-Score:-2.81|P-value:2.31E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.80|P-value:2.41E-4

Top fitness defect scores for YGL067W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1552 6-methylflavone 4.08 10.6 µM 1.54E-7 superoxide 14 2.24E-5
2 SGTC_1312 1218-2183 3.59 165.0 µM 3.38E-6 14 1.67E-4
3 SGTC_1554 st069299 3.40 38.7 µM 9.64E-6 39 3.31E-4
4 SGTC_1741 st038134 3.18 10.2 µM 3.34E-5 71 7.45E-4
5 SGTC_656 4090-1979 3.16 187.0 µM 3.66E-5 49 7.91E-4
6 SGTC_1560 lithocholic acid 3.12 53.1 µM 4.52E-5 13 9.10E-4
7 SGTC_1520 flindersine 3.01 88.0 µM 7.67E-5 75 0.00129
8 SGTC_669 0108-0021 2.96 26.2 µM 1.01E-4 fatty acid desaturase (OLE1) 153 0.00154
9 SGTC_353 1988-1175 2.93 58.3 µM 1.15E-4 unfolded protein response 72 0.00168
10 SGTC_940 3232-1287 2.93 54.8 µM 1.18E-4 NEO1 89 0.00171
11 SGTC_988 1497-1057 2.75 103.0 µM 2.72E-4 61 0.00296
12 SGTC_1043 0916-0009 2.73 19.3 µM 3.07E-4 102 0.00320
13 SGTC_1177 0983-0204 2.59 23.6 µM 5.71E-4 85 0.00482
14 SGTC_2159 5658611 2.36 73.8 µM 0.00150 92 0.00911
15 SGTC_2057 5236571 2.31 38.3 µM 0.00180 RPP1 & pyrimidine depletion 199 0.01030
16 SGTC_1359 1582-0056 2.29 520.0 nM 0.00201 167 0.01110
17 SGTC_697 0508-1955 2.29 564.0 µM 0.00202 183 0.01110
18 SGTC_2930 9013230 2.24 14.9 µM 0.00247 heme biosynthesis & mitochondrial translocase 202 0.01270
19 SGTC_1974 st069448 2.22 26.9 µM 0.00265 135 0.01330
20 SGTC_1553 gossypol 2.20 38.6 µM 0.00283 72 0.01390

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 5.43E-28 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.170 4.65E-23 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.163 2.04E-21 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.159 1.98E-20 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.147 1.36E-17 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.144 5.71E-17 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.72E-16 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.138 1.14E-15 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.133 1.06E-14 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.133 1.10E-14 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.132 2.08E-14 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.130 4.32E-14 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.126 2.27E-13 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.126 2.39E-13 YDR321W ASP1 hom Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively
0.126 3.20E-13 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner