Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGL068W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.154 | 2.56E-19 | YFL036W | RPO41 | hom | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
0.149 | 4.43E-18 | YOR109W | INP53 | hom | Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains |
0.144 | 5.74E-17 | YDL217C | TIM22 | het | Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported |
0.140 | 3.38E-16 | YCR024C | SLM5 | hom | Mitochondrial asparaginyl-tRNA synthetase |
0.129 | 7.55E-14 | YOR232W | MGE1 | het | Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE |
0.127 | 1.45E-13 | YLR355C | ILV5 | het | Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids |
0.126 | 3.00E-13 | YPL266W | DIM1 | het | Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing |
0.123 | 8.80E-13 | YPL170W | DAP1 | hom | Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis |
0.121 | 1.72E-12 | YNL268W | LYP1 | hom | Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids |
0.120 | 3.68E-12 | YFL016C | MDJ1 | hom | Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones |
0.117 | 1.20E-11 | YNR037C | RSM19 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein |
0.116 | 1.40E-11 | YNL006W | LST8 | het | Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat |
0.113 | 4.52E-11 | YGL064C | MRH4 | hom | Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function |
0.113 | 6.15E-11 | YBR179C | FZO1 | hom | Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system |
0.112 | 7.48E-11 | YKR085C | MRPL20 | hom | Mitochondrial ribosomal protein of the large subunit |