YGL069C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL069C / YGL069C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-4.46|P-value:2.64E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.24|P-value:6.48E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.68|P-value:4.50E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.58|P-value:6.20E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.71|P-value:1.07E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.88|P-value:2.15E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:5.24|P-value:1.12E-6 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.45|P-value:9.39E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.82|P-value:2.90E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.52|P-value:7.64E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.64|P-value:5.27E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.97|P-value:1.73E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.79|P-value:3.16E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.44|P-value:2.81E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.48|P-value:8.68E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.97|P-value:3.70E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-5.62|P-value:1.75E-7 ID:SGTC_1740|Compound:st038286|FD-Score:-4.17|P-value:7.90E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-4.09|P-value:1.02E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.29|P-value:9.12E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.26|P-value:6.08E-5 ID:SGTC_1922|Compound:5578187|FD-Score:5.06|P-value:2.55E-6 ID:SGTC_1923|Compound:st058458|FD-Score:-3.43|P-value:9.23E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.29|P-value:5.43E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.85|P-value:2.59E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-5.35|P-value:6.33E-7 ID:SGTC_2072|Compound:5231554|FD-Score:3.81|P-value:2.99E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.04|P-value:1.34E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.22|P-value:7.05E-5 ID:SGTC_2534|Compound:helenine|FD-Score:3.97|P-value:1.70E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.73|P-value:3.87E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.77|P-value:8.33E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.56|P-value:6.14E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.33|P-value:7.74E-7 ID:SGTC_3055|Compound:9094636|FD-Score:4.95|P-value:4.05E-6 ID:SGTC_3062|Compound:9077494|FD-Score:4.06|P-value:1.25E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.94|P-value:1.93E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.82|P-value:6.28E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.46|P-value:2.64E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.24|P-value:6.48E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:3.68|P-value:4.50E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.58|P-value:6.20E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:4.71|P-value:1.07E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.88|P-value:2.15E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:5.24|P-value:1.12E-6 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.45|P-value:9.39E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.82|P-value:2.90E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.52|P-value:7.64E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.64|P-value:5.27E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.97|P-value:1.73E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.79|P-value:3.16E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.44|P-value:2.81E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.48|P-value:8.68E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.97|P-value:3.70E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-5.62|P-value:1.75E-7 ID:SGTC_1740|Compound:st038286|FD-Score:-4.17|P-value:7.90E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-4.09|P-value:1.02E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.29|P-value:9.12E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.26|P-value:6.08E-5 ID:SGTC_1922|Compound:5578187|FD-Score:5.06|P-value:2.55E-6 ID:SGTC_1923|Compound:st058458|FD-Score:-3.43|P-value:9.23E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.29|P-value:5.43E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.85|P-value:2.59E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-5.35|P-value:6.33E-7 ID:SGTC_2072|Compound:5231554|FD-Score:3.81|P-value:2.99E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.04|P-value:1.34E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.22|P-value:7.05E-5 ID:SGTC_2534|Compound:helenine|FD-Score:3.97|P-value:1.70E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.73|P-value:3.87E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.77|P-value:8.33E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.56|P-value:6.14E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.33|P-value:7.74E-7 ID:SGTC_3055|Compound:9094636|FD-Score:4.95|P-value:4.05E-6 ID:SGTC_3062|Compound:9077494|FD-Score:4.06|P-value:1.25E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.94|P-value:1.93E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.82|P-value:6.28E-6

Top fitness defect scores for YGL069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2912 7964298 5.33 10.9 µM 7.74E-7 cell wall 26 5.02E-8 0.09
2 SGTC_1743 st037606 5.29 46.4 µM 9.12E-7 3 6.13E-8 0.66
3 SGTC_372 0155-0182 5.24 15.9 µM 1.12E-6 mitochondrial response to ROS 4 7.86E-8 0.36
4 SGTC_1922 5578187 5.06 25.0 µM 2.55E-6 TRP & mitochondrial translation 5 2.14E-7 0.58
5 SGTC_1373 2887-0003 4.97 58.5 µM 3.70E-6 Golgi 6 3.37E-7 0.65
6 SGTC_3055 9094636 4.95 49.5 µM 4.05E-6 3 3.76E-7 0.63
7 SGTC_2562 3',7'-dimethoxyflavone 4.77 64.9 µM 8.33E-6 5 9.04E-7 0.01
8 SGTC_331 k048-0133 4.71 24.5 µM 1.07E-5 RSC & ERG11 7 1.23E-6 0.04
9 SGTC_1952 st077036 4.29 64.1 µM 5.43E-5 10 8.82E-6 0.11
10 SGTC_1785 bathophenanthroline 4.26 24.0 µM 6.08E-5 heme requiring 19 1.01E-5 0.05
11 SGTC_119 0121-0043 4.24 24.8 µM 6.48E-5 mitochondrial stress 16 1.09E-5 0.09
12 SGTC_2418 pentamidine 4.22 31.7 µM 7.05E-5 mitochondrial processes 13 1.21E-5 0.39
13 SGTC_3062 9077494 4.06 49.5 µM 1.25E-4 mitochondrial response to ROS 6 2.43E-5 0.01
14 SGTC_2381 9035592 4.04 200.0 µM 1.34E-4 7 2.64E-5 0.32
15 SGTC_2534 helenine 3.97 20.1 µM 1.70E-4 RSC complex & mRNA processing 21 3.53E-5 0.07
16 SGTC_1172 0370-0043 3.97 85.0 µM 1.73E-4 4 3.60E-5 0.02
17 SGTC_3143 9086658 3.94 49.5 µM 1.93E-4 15 4.11E-5 0.03
18 SGTC_1985 st071382 3.85 65.5 µM 2.59E-4 3 5.88E-5 0.20
19 SGTC_966 1300-0360 3.82 30.2 µM 2.90E-4 heme requiring 20 6.75E-5 0.01
20 SGTC_2072 5231554 3.81 129.0 µM 2.99E-4 2 6.98E-5 0.20

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.46E-11 YAL001C TFC3 het Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
0.113 5.80E-11 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.110 1.90E-10 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.102 3.11E-9 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.096 2.16E-8 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.095 3.47E-8 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.091 1.31E-7 YGL207W SPT16 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
0.086 5.22E-7 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.086 1.01E-6 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.085 8.64E-7 YBR078W ECM33 hom GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
0.083 1.59E-6 YPL080C_d YPL080C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.081 2.81E-6 YDR062W LCB2 het Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.078 5.53E-6 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.077 7.48E-6 YOL119C MCH4 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.076 1.12E-5 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis