YGL071W / AFT1

Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL071W / AFT1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:6.30|P-value:5.32E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.71|P-value:2.04E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.79|P-value:1.84E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.40|P-value:4.05E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-6.04|P-value:9.12E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:-6.80|P-value:1.30E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:7.51|P-value:1.88E-6 ID:SGTC_264|Compound:promethazine|FD-Score:5.13|P-value:8.00E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:6.36|P-value:4.57E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.69|P-value:4.27E-8 ID:SGTC_274|Compound:sirtinol|FD-Score:-4.99|P-value:9.86E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.56|P-value:2.86E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:7.74|P-value:9.31E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.34|P-value:2.81E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.67|P-value:2.22E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-5.01|P-value:9.46E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-6.33|P-value:4.45E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.20|P-value:6.31E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-6.33|P-value:4.43E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:5.40|P-value:4.48E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:5.84|P-value:1.63E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:7.56|P-value:1.64E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.97|P-value:4.07E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:5.20|P-value:6.90E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-5.11|P-value:7.73E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-5.72|P-value:1.97E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-6.34|P-value:4.29E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:5.99|P-value:1.13E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:5.27|P-value:6.00E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.81|P-value:1.75E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-9.42|P-value:2.85E-9 ID:SGTC_1054|Compound:3429-0080|FD-Score:6.05|P-value:9.84E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.33|P-value:5.26E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:5.13|P-value:8.02E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:5.91|P-value:1.38E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:8.12|P-value:2.88E-7 ID:SGTC_1209|Compound:2323-2347|FD-Score:5.25|P-value:6.16E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.70|P-value:2.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-8.36|P-value:1.15E-7 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.75|P-value:2.02E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-6.61|P-value:2.11E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.56|P-value:1.62E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:9.17|P-value:7.94E-9 ID:SGTC_1451|Compound:4152-0210|FD-Score:8.79|P-value:3.12E-8 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.74|P-value:2.08E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:5.43|P-value:4.18E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:5.60|P-value:2.84E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:10.10|P-value:2.70E-10 ID:SGTC_1530|Compound:rhein|FD-Score:6.82|P-value:1.35E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:8.51|P-value:8.03E-8 ID:SGTC_1554|Compound:st069299|FD-Score:9.14|P-value:9.00E-9 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:5.33|P-value:5.17E-4 ID:SGTC_1606|Compound:st000094|FD-Score:5.46|P-value:3.91E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.38|P-value:4.68E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-5.35|P-value:4.56E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.05|P-value:8.72E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.44|P-value:3.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-8.56|P-value:5.98E-8 ID:SGTC_1827|Compound:berberine|FD-Score:-6.77|P-value:1.40E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-5.58|P-value:2.71E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.86|P-value:1.08E-5 ID:SGTC_1884|Compound:5633444|FD-Score:6.94|P-value:9.75E-6 ID:SGTC_1950|Compound:st077106|FD-Score:-5.06|P-value:8.49E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-5.35|P-value:4.63E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-6.05|P-value:9.03E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-5.56|P-value:2.87E-4 ID:SGTC_2168|Compound:5727979|FD-Score:5.05|P-value:9.46E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.79|P-value:1.86E-4 ID:SGTC_2189|Compound:6047310|FD-Score:5.24|P-value:6.32E-4 ID:SGTC_2240|Compound:6690706|FD-Score:6.41|P-value:3.95E-5 ID:SGTC_2367|Compound:9070478|FD-Score:6.89|P-value:1.12E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:6.82|P-value:1.33E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-9.37|P-value:3.37E-9 ID:SGTC_2415|Compound:st077333|FD-Score:9.35|P-value:4.25E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:7.35|P-value:2.97E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-7.11|P-value:5.38E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:6.35|P-value:4.60E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.55|P-value:2.94E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:11.30|P-value:1.89E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.24|P-value:5.79E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:5.97|P-value:1.20E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:5.54|P-value:3.29E-4 ID:SGTC_2836|Compound:9010338|FD-Score:5.08|P-value:8.86E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-5.25|P-value:5.66E-4 ID:SGTC_2873|Compound:9040596|FD-Score:6.52|P-value:2.99E-5 ID:SGTC_2875|Compound:9039966|FD-Score:5.14|P-value:7.91E-4 ID:SGTC_2900|Compound:5328528|FD-Score:7.48|P-value:2.08E-6 ID:SGTC_2924|Compound:9010168|FD-Score:5.64|P-value:2.58E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.76|P-value:1.79E-4 ID:SGTC_3054|Compound:9094397|FD-Score:5.40|P-value:4.48E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-10.50|P-value:3.87E-11 ID:SGTC_3170|Compound:9103054|FD-Score:-5.61|P-value:2.58E-4 ID:SGTC_3218|Compound:9131285|FD-Score:8.81|P-value:2.86E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:6.30|P-value:5.32E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.71|P-value:2.04E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:5.79|P-value:1.84E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:6.40|P-value:4.05E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-6.04|P-value:9.12E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:-6.80|P-value:1.30E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:7.51|P-value:1.88E-6 ID:SGTC_264|Compound:promethazine|FD-Score:5.13|P-value:8.00E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:6.36|P-value:4.57E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.69|P-value:4.27E-8 ID:SGTC_274|Compound:sirtinol|FD-Score:-4.99|P-value:9.86E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.56|P-value:2.86E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:7.74|P-value:9.31E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.34|P-value:2.81E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.67|P-value:2.22E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-5.01|P-value:9.46E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-6.33|P-value:4.45E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.20|P-value:6.31E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-6.33|P-value:4.43E-5 ID:SGTC_712|Compound:r015-0009|FD-Score:5.40|P-value:4.48E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:5.84|P-value:1.63E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:7.56|P-value:1.64E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.97|P-value:4.07E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:5.20|P-value:6.90E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:-5.11|P-value:7.73E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:-5.72|P-value:1.97E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-6.34|P-value:4.29E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:5.99|P-value:1.13E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:5.27|P-value:6.00E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.81|P-value:1.75E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-9.42|P-value:2.85E-9 ID:SGTC_1054|Compound:3429-0080|FD-Score:6.05|P-value:9.84E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.33|P-value:5.26E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:5.13|P-value:8.02E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:5.91|P-value:1.38E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:8.12|P-value:2.88E-7 ID:SGTC_1209|Compound:2323-2347|FD-Score:5.25|P-value:6.16E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.70|P-value:2.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-8.36|P-value:1.15E-7 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.75|P-value:2.02E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-6.61|P-value:2.11E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.56|P-value:1.62E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:9.17|P-value:7.94E-9 ID:SGTC_1451|Compound:4152-0210|FD-Score:8.79|P-value:3.12E-8 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.74|P-value:2.08E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:5.43|P-value:4.18E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:5.60|P-value:2.84E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:10.10|P-value:2.70E-10 ID:SGTC_1530|Compound:rhein|FD-Score:6.82|P-value:1.35E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:8.51|P-value:8.03E-8 ID:SGTC_1554|Compound:st069299|FD-Score:9.14|P-value:9.00E-9 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:5.33|P-value:5.17E-4 ID:SGTC_1606|Compound:st000094|FD-Score:5.46|P-value:3.91E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.38|P-value:4.68E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-5.35|P-value:4.56E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.05|P-value:8.72E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.44|P-value:3.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-8.56|P-value:5.98E-8 ID:SGTC_1827|Compound:berberine|FD-Score:-6.77|P-value:1.40E-5 ID:SGTC_1829|Compound:berberine|FD-Score:-5.58|P-value:2.71E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.86|P-value:1.08E-5 ID:SGTC_1884|Compound:5633444|FD-Score:6.94|P-value:9.75E-6 ID:SGTC_1950|Compound:st077106|FD-Score:-5.06|P-value:8.49E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-5.35|P-value:4.63E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-6.05|P-value:9.03E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-5.56|P-value:2.87E-4 ID:SGTC_2168|Compound:5727979|FD-Score:5.05|P-value:9.46E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.79|P-value:1.86E-4 ID:SGTC_2189|Compound:6047310|FD-Score:5.24|P-value:6.32E-4 ID:SGTC_2240|Compound:6690706|FD-Score:6.41|P-value:3.95E-5 ID:SGTC_2367|Compound:9070478|FD-Score:6.89|P-value:1.12E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:6.82|P-value:1.33E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-9.37|P-value:3.37E-9 ID:SGTC_2415|Compound:st077333|FD-Score:9.35|P-value:4.25E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:7.35|P-value:2.97E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-7.11|P-value:5.38E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:6.35|P-value:4.60E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.55|P-value:2.94E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:11.30|P-value:1.89E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.24|P-value:5.79E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:5.97|P-value:1.20E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:5.54|P-value:3.29E-4 ID:SGTC_2836|Compound:9010338|FD-Score:5.08|P-value:8.86E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-5.25|P-value:5.66E-4 ID:SGTC_2873|Compound:9040596|FD-Score:6.52|P-value:2.99E-5 ID:SGTC_2875|Compound:9039966|FD-Score:5.14|P-value:7.91E-4 ID:SGTC_2900|Compound:5328528|FD-Score:7.48|P-value:2.08E-6 ID:SGTC_2924|Compound:9010168|FD-Score:5.64|P-value:2.58E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-5.76|P-value:1.79E-4 ID:SGTC_3054|Compound:9094397|FD-Score:5.40|P-value:4.48E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-10.50|P-value:3.87E-11 ID:SGTC_3170|Compound:9103054|FD-Score:-5.61|P-value:2.58E-4 ID:SGTC_3218|Compound:9131285|FD-Score:8.81|P-value:2.86E-8

Top fitness defect scores for YGL071W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2640 pentamidine 11.30 10.4 µM 1.89E-12 mitochondrial processes 2 9.20E-30
2 SGTC_1479 0549-0158 10.10 134.0 µM 2.70E-10 1 3.59E-24
3 SGTC_2415 st077333 9.35 57.7 µM 4.25E-9 2 4.49E-21
4 SGTC_1450 4112-4260 9.17 37.6 µM 7.94E-9 calcium & mitochondrial duress 6 2.26E-20
5 SGTC_1554 st069299 9.14 38.7 µM 9.00E-9 1 3.13E-20
6 SGTC_3218 9131285 8.81 49.5 µM 2.86E-8 endomembrane recycling 5 6.21E-19
7 SGTC_1451 4152-0210 8.79 104.0 µM 3.12E-8 1 7.75E-19
8 SGTC_273 hydroxyurea 8.69 18.1 mM 4.27E-8 heme biosynthesis & mitochondrial translocase 3 1.74E-18
9 SGTC_1550 gossypolone 8.51 36.6 µM 8.03E-8 1 8.88E-18
10 SGTC_1199 1638-0010 8.12 4.5 µM 2.88E-7 endomembrane recycling 1 2.39E-16
11 SGTC_301 4119-0100 7.74 24.5 µM 9.31E-7 NEO1 21 4.86E-15
12 SGTC_1394 3474-0001 7.56 65.7 µM 1.62E-6 endomembrane recycling 6 2.01E-14
13 SGTC_718 1130-0073 7.56 349.0 µM 1.64E-6 2 2.08E-14
14 SGTC_260 nsc-65238 7.51 4.0 µM 1.88E-6 endomembrane recycling 3 2.96E-14
15 SGTC_2900 5328528 7.48 85.3 µM 2.08E-6 Golgi 6 3.85E-14
16 SGTC_2418 pentamidine 7.35 31.7 µM 2.97E-6 mitochondrial processes 7 9.55E-14
17 SGTC_1884 5633444 6.94 25.0 µM 9.75E-6 redox potentiating 22 2.00E-12
18 SGTC_2367 9070478 6.89 135.4 µM 1.12E-5 cell wall 5 2.84E-12
19 SGTC_2406 ethylparaben 6.82 405.7 µM 1.33E-5 6 4.40E-12
20 SGTC_1530 rhein 6.82 70.4 µM 1.35E-5 3 4.59E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.48E-23 YJL117W PHO86 hom Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress
0.139 7.92E-16 YPR036W VMA13 hom Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
0.138 1.33E-15 YGL054C ERV14 hom COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.132 1.39E-14 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.131 2.90E-14 YDL185W VMA1 hom Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.124 5.08E-13 YLR396C VPS33 hom ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole
0.123 9.01E-13 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.122 1.43E-12 YKL118W_d YKL118W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
0.121 1.86E-12 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.116 1.75E-11 YJL056C ZAP1 hom Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains
0.115 2.21E-11 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.115 2.57E-11 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.114 3.68E-11 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.113 6.64E-11 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.112 8.42E-11 YKL119C VPH2 hom Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)