YGL072C_d

Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL072C / YGL072C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.28|P-value:1.22E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.67|P-value:8.27E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.99|P-value:3.11E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.13|P-value:1.98E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.65|P-value:3.32E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.81|P-value:5.40E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.19|P-value:1.60E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.31|P-value:1.07E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.76|P-value:6.25E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.60|P-value:1.23E-31 ID:SGTC_232|Compound:clozapine|FD-Score:4.59|P-value:4.09E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.07|P-value:2.42E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:10.60|P-value:4.83E-20 ID:SGTC_304|Compound:1310-0298|FD-Score:4.03|P-value:2.69E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:9.02|P-value:4.79E-15 ID:SGTC_315|Compound:k915-0449|FD-Score:4.28|P-value:1.18E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.75|P-value:3.47E-9 ID:SGTC_354|Compound:2783-3500|FD-Score:5.68|P-value:5.37E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:4.52|P-value:5.28E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.54|P-value:4.96E-5 ID:SGTC_433|Compound:pimozide|FD-Score:5.40|P-value:1.78E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.13|P-value:1.88E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:7.68|P-value:2.16E-11 ID:SGTC_443|Compound:clozapine|FD-Score:4.95|P-value:1.07E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.20|P-value:3.22E-10 ID:SGTC_447|Compound:ml7|FD-Score:4.04|P-value:2.64E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.08|P-value:8.55E-8 ID:SGTC_462|Compound:ag-879|FD-Score:3.69|P-value:7.61E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.77|P-value:5.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.72|P-value:2.51E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.81|P-value:5.36E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:5.05|P-value:7.24E-6 ID:SGTC_573|Compound:3702-0553|FD-Score:3.80|P-value:5.54E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.84|P-value:4.91E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.44|P-value:6.98E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.65|P-value:3.33E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-4.32|P-value:9.99E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.60|P-value:3.89E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.02|P-value:8.36E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:-3.72|P-value:6.87E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.62|P-value:3.60E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.28|P-value:1.20E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.49|P-value:1.22E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:5.05|P-value:7.37E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:4.99|P-value:9.07E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:4.19|P-value:1.61E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:8.65|P-value:5.59E-14 ID:SGTC_928|Compound:2764-0428|FD-Score:4.00|P-value:2.94E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.61|P-value:9.90E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.01|P-value:2.89E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.65|P-value:3.31E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.68|P-value:2.13E-11 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.13|P-value:1.99E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:5.36|P-value:2.14E-6 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.72|P-value:7.13E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.22|P-value:1.46E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:5.28|P-value:2.90E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.79|P-value:5.77E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.62|P-value:3.61E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.11|P-value:2.13E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.51|P-value:5.51E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.93|P-value:3.72E-4 ID:SGTC_1706|Compound:st031321|FD-Score:4.06|P-value:2.46E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.83|P-value:2.78E-7 ID:SGTC_1754|Compound:st042065|FD-Score:7.03|P-value:7.93E-10 ID:SGTC_1760|Compound:st045453|FD-Score:10.70|P-value:2.61E-20 ID:SGTC_1773|Compound:st048542|FD-Score:4.75|P-value:2.26E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.77|P-value:3.15E-9 ID:SGTC_1801|Compound:st050089|FD-Score:5.64|P-value:6.34E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.30|P-value:2.64E-6 ID:SGTC_1831|Compound:st055328|FD-Score:6.12|P-value:7.29E-8 ID:SGTC_1833|Compound:st055984|FD-Score:4.37|P-value:8.73E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.93|P-value:1.79E-7 ID:SGTC_1854|Compound:st056233|FD-Score:3.87|P-value:4.48E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.42|P-value:1.60E-6 ID:SGTC_1885|Compound:st057546|FD-Score:5.17|P-value:4.46E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.72|P-value:2.58E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.78|P-value:5.90E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.88|P-value:1.40E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.88|P-value:4.32E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.73|P-value:2.45E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.20|P-value:5.11E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.63|P-value:9.23E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.39|P-value:2.09E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.26|P-value:8.95E-16 ID:SGTC_2414|Compound:st077232|FD-Score:-3.85|P-value:4.61E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:5.09|P-value:6.35E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.89|P-value:1.35E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.18|P-value:1.67E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.12|P-value:5.47E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.62|P-value:9.41E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.36|P-value:9.25E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.34|P-value:2.29E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:4.14|P-value:1.90E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.95|P-value:3.45E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.34|P-value:1.49E-10 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.24|P-value:1.39E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.39|P-value:8.36E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.68|P-value:8.00E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.40|P-value:8.02E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.91|P-value:3.97E-4 ID:SGTC_2887|Compound:9044784|FD-Score:5.08|P-value:6.51E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.00|P-value:2.96E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.67|P-value:8.10E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.72|P-value:7.04E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.11|P-value:7.91E-8 ID:SGTC_3152|Compound:9099253|FD-Score:4.92|P-value:1.21E-5 ID:SGTC_3279|Compound:9140807|FD-Score:4.27|P-value:1.22E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.44|P-value:6.92E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.99|P-value:9.11E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.90|P-value:4.03E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.19|P-value:1.60E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.81|P-value:5.37E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.28|P-value:1.22E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.67|P-value:8.27E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.99|P-value:3.11E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.13|P-value:1.98E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.65|P-value:3.32E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.81|P-value:5.40E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.19|P-value:1.60E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.31|P-value:1.07E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.76|P-value:6.25E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.60|P-value:1.23E-31 ID:SGTC_232|Compound:clozapine|FD-Score:4.59|P-value:4.09E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.07|P-value:2.42E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:10.60|P-value:4.83E-20 ID:SGTC_304|Compound:1310-0298|FD-Score:4.03|P-value:2.69E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:9.02|P-value:4.79E-15 ID:SGTC_315|Compound:k915-0449|FD-Score:4.28|P-value:1.18E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.75|P-value:3.47E-9 ID:SGTC_354|Compound:2783-3500|FD-Score:5.68|P-value:5.37E-7 ID:SGTC_360|Compound:0957-0399|FD-Score:4.52|P-value:5.28E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.54|P-value:4.96E-5 ID:SGTC_433|Compound:pimozide|FD-Score:5.40|P-value:1.78E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.13|P-value:1.88E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:7.68|P-value:2.16E-11 ID:SGTC_443|Compound:clozapine|FD-Score:4.95|P-value:1.07E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.20|P-value:3.22E-10 ID:SGTC_447|Compound:ml7|FD-Score:4.04|P-value:2.64E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.08|P-value:8.55E-8 ID:SGTC_462|Compound:ag-879|FD-Score:3.69|P-value:7.61E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.77|P-value:5.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.72|P-value:2.51E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.81|P-value:5.36E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:5.05|P-value:7.24E-6 ID:SGTC_573|Compound:3702-0553|FD-Score:3.80|P-value:5.54E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.84|P-value:4.91E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.44|P-value:6.98E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.65|P-value:3.33E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-4.32|P-value:9.99E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.60|P-value:3.89E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.02|P-value:8.36E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:-3.72|P-value:6.87E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.62|P-value:3.60E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.28|P-value:1.20E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.49|P-value:1.22E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:5.05|P-value:7.37E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:4.99|P-value:9.07E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:4.19|P-value:1.61E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:8.65|P-value:5.59E-14 ID:SGTC_928|Compound:2764-0428|FD-Score:4.00|P-value:2.94E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.61|P-value:9.90E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.01|P-value:2.89E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.65|P-value:3.31E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:7.68|P-value:2.13E-11 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.13|P-value:1.99E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:5.36|P-value:2.14E-6 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.72|P-value:7.13E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.22|P-value:1.46E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:5.28|P-value:2.90E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.79|P-value:5.77E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.62|P-value:3.61E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.11|P-value:2.13E-4 ID:SGTC_1661|Compound:st013063|FD-Score:4.51|P-value:5.51E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.93|P-value:3.72E-4 ID:SGTC_1706|Compound:st031321|FD-Score:4.06|P-value:2.46E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.83|P-value:2.78E-7 ID:SGTC_1754|Compound:st042065|FD-Score:7.03|P-value:7.93E-10 ID:SGTC_1760|Compound:st045453|FD-Score:10.70|P-value:2.61E-20 ID:SGTC_1773|Compound:st048542|FD-Score:4.75|P-value:2.26E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.77|P-value:3.15E-9 ID:SGTC_1801|Compound:st050089|FD-Score:5.64|P-value:6.34E-7 ID:SGTC_1803|Compound:st050068|FD-Score:5.30|P-value:2.64E-6 ID:SGTC_1831|Compound:st055328|FD-Score:6.12|P-value:7.29E-8 ID:SGTC_1833|Compound:st055984|FD-Score:4.37|P-value:8.73E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.93|P-value:1.79E-7 ID:SGTC_1854|Compound:st056233|FD-Score:3.87|P-value:4.48E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.42|P-value:1.60E-6 ID:SGTC_1885|Compound:st057546|FD-Score:5.17|P-value:4.46E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.72|P-value:2.58E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.78|P-value:5.90E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.88|P-value:1.40E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.88|P-value:4.32E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.73|P-value:2.45E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.20|P-value:5.11E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.63|P-value:9.23E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.39|P-value:2.09E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.26|P-value:8.95E-16 ID:SGTC_2414|Compound:st077232|FD-Score:-3.85|P-value:4.61E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:5.09|P-value:6.35E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.89|P-value:1.35E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.18|P-value:1.67E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.12|P-value:5.47E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.62|P-value:9.41E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.36|P-value:9.25E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.34|P-value:2.29E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:4.14|P-value:1.90E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.95|P-value:3.45E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.34|P-value:1.49E-10 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.24|P-value:1.39E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.39|P-value:8.36E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.68|P-value:8.00E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.40|P-value:8.02E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.91|P-value:3.97E-4 ID:SGTC_2887|Compound:9044784|FD-Score:5.08|P-value:6.51E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.00|P-value:2.96E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.67|P-value:8.10E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.72|P-value:7.04E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.11|P-value:7.91E-8 ID:SGTC_3152|Compound:9099253|FD-Score:4.92|P-value:1.21E-5 ID:SGTC_3279|Compound:9140807|FD-Score:4.27|P-value:1.22E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.44|P-value:6.92E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.99|P-value:9.11E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.90|P-value:4.03E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.19|P-value:1.60E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.81|P-value:5.37E-4

Top fitness defect scores for YGL072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 13.60 10.3 µM 1.23E-31 NEO1-PIK1 29 3.62E-42
2 SGTC_1760 st045453 10.70 10.4 µM 2.61E-20 NEO1-PIK1 29 7.43E-27
3 SGTC_301 4119-0100 10.60 24.5 µM 4.83E-20 NEO1 15 1.71E-26
4 SGTC_2408 sulbentine 9.26 18.4 µM 8.95E-16 7 9.91E-21
5 SGTC_313 3474-0040 9.02 5.0 µM 4.79E-15 NEO1-PIK1 4 9.53E-20
6 SGTC_916 4466-0038 8.65 42.0 nM 5.59E-14 cell wall 9 2.63E-18
7 SGTC_1130 3454-2858 7.68 15.9 µM 2.13E-11 NEO1 24 7.93E-15
8 SGTC_439 amiodarone 7.68 34.4 µM 2.16E-11 NEO1-PIK1 26 8.09E-15
9 SGTC_2679 rapamycin 7.34 1.0 nM 1.49E-10 49 1.09E-13
10 SGTC_445 e6 berbamine 7.20 66.0 µM 3.22E-10 NEO1-PIK1 16 3.09E-13
11 SGTC_1754 st042065 7.03 16.1 µM 7.93E-10 NEO1-PIK1 72 1.04E-12
12 SGTC_1781 st038725 6.77 66.3 µM 3.15E-9 NEO1 43 6.66E-12
13 SGTC_351 caspofungin 6.75 25.0 nM 3.47E-9 cell wall 31 7.57E-12
14 SGTC_2257 7960413 6.39 200.0 µM 2.09E-8 NEO1-PIK1 9 8.51E-11
15 SGTC_2249 haloperidol 6.20 116.4 µM 5.11E-8 ergosterol depletion effects on membrane 42 2.83E-10
16 SGTC_1831 st055328 6.12 12.0 µM 7.29E-8 heme biosynthesis & mitochondrial translocase 4 4.56E-10
17 SGTC_3037 9091026 6.11 49.5 µM 7.91E-8 NEO1-PIK1 48 5.09E-10
18 SGTC_1844 rapamycin 5.93 4.0 nM 1.79E-7 91 1.52E-9
19 SGTC_1712 st032288 5.83 53.4 µM 2.78E-7 calcium & mitochondrial duress 83 2.75E-9
20 SGTC_354 2783-3500 5.68 4.9 µM 5.37E-7 cell wall 21 6.67E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.457 3.64E-173 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.423 1.45E-145 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.405 3.68E-132 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.399 3.33E-128 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.394 9.92E-125 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.384 1.20E-118 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.378 1.57E-114 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.364 4.25E-105 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.343 1.91E-93 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.340 1.38E-91 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.330 8.39E-86 YNL079C TPM1 hom Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication
0.326 8.61E-84 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.319 4.44E-80 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.316 1.12E-78 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.312 1.08E-76 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription