YGL075C / MPS2

Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL075C / MPS2

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.55|P-value:6.85E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:-7.48|P-value:3.20E-13 ID:SGTC_75|Compound:0159-0059|FD-Score:-5.35|P-value:1.33E-7 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.33|P-value:6.46E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.45|P-value:4.98E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.30|P-value:8.27E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.60|P-value:2.95E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.57|P-value:3.28E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.80|P-value:2.30E-6 ID:SGTC_264|Compound:promethazine|FD-Score:3.26|P-value:9.42E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.62|P-value:2.79E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:5.11|P-value:5.30E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:3.50|P-value:4.15E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.45|P-value:4.93E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.15|P-value:3.72E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.28|P-value:8.66E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.40|P-value:5.24E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.61|P-value:2.90E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.64|P-value:2.59E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.06|P-value:3.37E-9 ID:SGTC_1629|Compound:st005085|FD-Score:6.24|P-value:1.19E-9 ID:SGTC_1703|Compound:st026983|FD-Score:3.33|P-value:7.48E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.59|P-value:3.09E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.37|P-value:6.62E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.51|P-value:3.55E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.55|P-value:3.55E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:10.30|P-value:3.69E-23 ID:SGTC_2105|Compound:5350118|FD-Score:3.76|P-value:1.63E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.72|P-value:1.90E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.25|P-value:9.56E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.63|P-value:2.62E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.39|P-value:1.39E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.60|P-value:2.93E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.85|P-value:1.03E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.21|P-value:2.95E-5 ID:SGTC_2915|Compound:7971052|FD-Score:-3.68|P-value:1.92E-4 ID:SGTC_2917|Compound:7979103|FD-Score:6.41|P-value:4.35E-10 ID:SGTC_2922|Compound:7999257|FD-Score:-3.76|P-value:1.44E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-8.17|P-value:2.05E-15 ID:SGTC_2925|Compound:9010536|FD-Score:6.65|P-value:9.91E-11 ID:SGTC_2927|Compound:9011802|FD-Score:-3.35|P-value:6.09E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.94|P-value:6.84E-9 ID:SGTC_2973|Compound:9094665|FD-Score:-3.55|P-value:3.09E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.00|P-value:6.77E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.69|P-value:2.17E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.15|P-value:3.64E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.48|P-value:4.58E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.01|P-value:6.36E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:4.55|P-value:6.85E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:-7.48|P-value:3.20E-13 ID:SGTC_75|Compound:0159-0059|FD-Score:-5.35|P-value:1.33E-7 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.33|P-value:6.46E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.45|P-value:4.98E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.30|P-value:8.27E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.60|P-value:2.95E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.57|P-value:3.28E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.80|P-value:2.30E-6 ID:SGTC_264|Compound:promethazine|FD-Score:3.26|P-value:9.42E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.62|P-value:2.79E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:5.11|P-value:5.30E-7 ID:SGTC_526|Compound:4469-0568|FD-Score:3.50|P-value:4.15E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.45|P-value:4.93E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.15|P-value:3.72E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.28|P-value:8.66E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:-3.40|P-value:5.24E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.61|P-value:2.90E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.64|P-value:2.59E-4 ID:SGTC_1626|Compound:st003712|FD-Score:6.06|P-value:3.37E-9 ID:SGTC_1629|Compound:st005085|FD-Score:6.24|P-value:1.19E-9 ID:SGTC_1703|Compound:st026983|FD-Score:3.33|P-value:7.48E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.59|P-value:3.09E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.37|P-value:6.62E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.51|P-value:3.55E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.55|P-value:3.55E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:10.30|P-value:3.69E-23 ID:SGTC_2105|Compound:5350118|FD-Score:3.76|P-value:1.63E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.72|P-value:1.90E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.25|P-value:9.56E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.63|P-value:2.62E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.39|P-value:1.39E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.60|P-value:2.93E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.85|P-value:1.03E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.21|P-value:2.95E-5 ID:SGTC_2915|Compound:7971052|FD-Score:-3.68|P-value:1.92E-4 ID:SGTC_2917|Compound:7979103|FD-Score:6.41|P-value:4.35E-10 ID:SGTC_2922|Compound:7999257|FD-Score:-3.76|P-value:1.44E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-8.17|P-value:2.05E-15 ID:SGTC_2925|Compound:9010536|FD-Score:6.65|P-value:9.91E-11 ID:SGTC_2927|Compound:9011802|FD-Score:-3.35|P-value:6.09E-4 ID:SGTC_2928|Compound:9011484|FD-Score:5.94|P-value:6.84E-9 ID:SGTC_2973|Compound:9094665|FD-Score:-3.55|P-value:3.09E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.00|P-value:6.77E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.69|P-value:2.17E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.19|P-value:3.16E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.15|P-value:3.64E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.48|P-value:4.58E-4 ID:SGTC_3124|Compound:9127567|FD-Score:4.01|P-value:6.36E-5

Top fitness defect scores for YGL075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1926 methyl fluorone black 10.30 53.6 µM 3.69E-23 DNA intercalators 3 4.38E-25 1.91
2 SGTC_2925 9010536 6.65 32.5 µM 9.91E-11 azole & statin 2 1.45E-11 2.24
3 SGTC_2917 7979103 6.41 53.8 µM 4.35E-10 1 7.24E-11 0.82
4 SGTC_1629 st005085 6.24 44.9 µM 1.19E-9 RPP1 & pyrimidine depletion 4 2.16E-10 0.35
5 SGTC_1626 st003712 6.06 1.8 µM 3.37E-9 3 6.73E-10 1.46
6 SGTC_2928 9011484 5.94 9.8 µM 6.84E-9 heme biosynthesis & mitochondrial translocase 10 1.45E-9 0.03
7 SGTC_430 0958-0115 5.11 16.4 µM 5.30E-7 3 1.64E-7 0.21
8 SGTC_145 3737-0113 4.80 38.4 µM 2.30E-6 DNA intercalators 32 8.11E-7 0.06
9 SGTC_9 0092-0002 4.55 10.4 µM 6.85E-6 7 2.66E-6 0.07
10 SGTC_2696 st077691 4.39 74.3 µM 1.39E-5 10 5.74E-6 0.36
11 SGTC_2907 7721985 4.21 69.9 µM 2.95E-5 2 1.30E-5 0.08
12 SGTC_3006 9075424 4.19 71.4 µM 3.16E-5 4 1.40E-5 0.01
13 SGTC_3054 9094397 4.15 49.5 µM 3.64E-5 fatty acid desaturase (OLE1) 7 1.63E-5 0.13
14 SGTC_794 k038-0031 4.15 316.0 µM 3.72E-5 ubiquinone biosynthesis & proteasome 18 1.67E-5 0.02
15 SGTC_3124 9127567 4.01 49.5 µM 6.36E-5 DNA damage response 4 2.99E-5 0.16
16 SGTC_2975 9084847 4.00 53.7 µM 6.77E-5 11 3.20E-5 0.44
17 SGTC_1448 4255-0083 3.88 152.0 µM 1.07E-4 ERG2 3 5.28E-5 0.17
18 SGTC_2105 5350118 3.76 200.0 µM 1.63E-4 7 8.33E-5 0.15
19 SGTC_2133 5320837 3.72 200.0 µM 1.90E-4 ERG2 7 9.83E-5 0.07
20 SGTC_2980 9014342 3.69 25.3 µM 2.17E-4 22 1.14E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 6.24E-41 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.221 1.74E-38 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.213 7.83E-36 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.212 1.42E-35 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.184 8.55E-27 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.181 5.62E-26 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.164 9.39E-22 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.160 1.25E-20 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.159 2.28E-20 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.158 3.06E-20 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.157 5.25E-20 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.155 1.71E-19 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.154 3.50E-19 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.149 3.08E-18 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.148 7.69E-18 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p