YGL076C / RPL7A

Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL076C / RPL7A

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.45|P-value:3.28E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.13|P-value:2.40E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.70|P-value:2.33E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.49|P-value:8.73E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_459|Compound:nigericin|FD-Score:-3.52|P-value:4.43E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.32|P-value:5.12E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.32|P-value:8.84E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.01|P-value:3.93E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.31|P-value:8.86E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.47|P-value:3.01E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.98|P-value:5.30E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.88|P-value:6.64E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.29|P-value:5.70E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.19|P-value:8.12E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.40|P-value:3.98E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.92|P-value:7.04E-7 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.92|P-value:1.05E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.33|P-value:4.96E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.71|P-value:2.75E-11 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.25|P-value:1.48E-5 ID:SGTC_1554|Compound:st069299|FD-Score:-3.47|P-value:5.24E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.49|P-value:4.85E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.56|P-value:2.20E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.18|P-value:1.95E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.34|P-value:8.07E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.16|P-value:8.71E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.13|P-value:2.38E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.37|P-value:4.29E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.56|P-value:3.89E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.21|P-value:7.60E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.67|P-value:2.56E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.88|P-value:6.75E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:-4.74|P-value:3.39E-6 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.22|P-value:7.21E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.48|P-value:2.99E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.30|P-value:5.60E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.64|P-value:2.94E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.65|P-value:1.60E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.45|P-value:3.28E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.13|P-value:2.40E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.70|P-value:2.33E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.49|P-value:8.73E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.56|P-value:2.19E-4 ID:SGTC_459|Compound:nigericin|FD-Score:-3.52|P-value:4.43E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.32|P-value:5.12E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.32|P-value:8.84E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.01|P-value:3.93E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.31|P-value:8.86E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.47|P-value:3.01E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.98|P-value:5.30E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.88|P-value:6.64E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.41|P-value:3.76E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.29|P-value:5.70E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.19|P-value:8.12E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.72|P-value:1.22E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.40|P-value:3.98E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.92|P-value:7.04E-7 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.92|P-value:1.05E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.33|P-value:4.96E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:6.71|P-value:2.75E-11 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.25|P-value:1.48E-5 ID:SGTC_1554|Compound:st069299|FD-Score:-3.47|P-value:5.24E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.24|P-value:6.82E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.49|P-value:4.85E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.56|P-value:2.20E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.18|P-value:1.95E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.34|P-value:8.07E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.16|P-value:8.71E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_2150|Compound:5556613|FD-Score:4.13|P-value:2.38E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.37|P-value:4.29E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.56|P-value:3.89E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.21|P-value:7.60E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.67|P-value:2.56E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.88|P-value:6.75E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:-4.74|P-value:3.39E-6 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.22|P-value:7.21E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.48|P-value:2.99E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.30|P-value:5.60E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.64|P-value:2.94E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.65|P-value:1.60E-4

Top fitness defect scores for YGL076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1534 6-azauridine 6.71 81.6 µM 2.75E-11 RNA pol III & RNase P/MRP 4 9.62E-12
2 SGTC_957 1187-1561 4.98 14.1 µM 5.30E-7 9 3.25E-7
3 SGTC_1221 2958-7315 4.92 257.0 µM 7.04E-7 8 4.38E-7
4 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.25 61.9 µM 1.48E-5 11 1.08E-5
5 SGTC_1695 st026914 4.18 34.5 µM 1.95E-5 12 1.45E-5
6 SGTC_2150 5556613 4.13 200.0 µM 2.38E-5 18 1.78E-5
7 SGTC_118 0083-0097 4.13 135.3 µM 2.40E-5 translation 115 1.80E-5
8 SGTC_800 3448-7362 4.01 155.0 µM 3.93E-5 translation 156 3.02E-5
9 SGTC_966 1300-0360 3.88 30.2 µM 6.64E-5 heme requiring 26 5.24E-5
10 SGTC_2512 diallyl trisulfide 3.88 49.2 µM 6.75E-5 9 5.33E-5
11 SGTC_1204 4049-0315 3.72 18.3 µM 1.22E-4 37 9.89E-5
12 SGTC_3269 9137823 3.65 49.5 µM 1.60E-4 60S ribosome export 23 1.32E-4
13 SGTC_454 lyso-paf C-16 3.56 6.7 µM 2.19E-4 32 1.83E-4
14 SGTC_1692 fluoroquinolonic acid 3.56 71.0 µM 2.20E-4 11 1.84E-4
15 SGTC_2970 9090938 3.48 41.9 µM 2.99E-4 RNA processing & uracil transport 67 2.54E-4
16 SGTC_939 1165-0479 3.47 45.3 µM 3.01E-4 52 2.55E-4
17 SGTC_33 0986-0033 3.45 35.8 µM 3.28E-4 calcium & mitochondrial duress 29 2.80E-4
18 SGTC_1064 honokiol 3.41 6.8 µM 3.76E-4 39 3.22E-4
19 SGTC_2299 7976368 3.41 114.9 µM 3.78E-4 49 3.24E-4
20 SGTC_1205 4161-2785 3.40 76.0 µM 3.98E-4 53 3.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 6.57E-15 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.122 1.14E-12 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.120 2.71E-12 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.116 1.81E-11 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.111 1.10E-10 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.110 1.41E-10 YJR055W HIT1 hom Protein of unknown function, required for growth at high temperature
0.108 4.08E-10 YPR047W MSF1 hom Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase
0.106 8.76E-10 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.103 2.58E-9 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.102 2.72E-9 YPR116W RRG8 hom Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.102 3.70E-9 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.101 3.88E-9 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.101 4.64E-9 YCR028C-A RIM1 hom Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
0.100 5.87E-9 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.100 6.66E-9 YLR185W RPL37A hom Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication