RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL078C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.139 | 6.88E-16 | YLR185W | RPL37A | hom | Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication |
0.121 | 2.03E-12 | YNL043C_d | YNL043C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W |
0.115 | 2.19E-11 | YIR026C | YVH1 | hom | Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases |
0.109 | 2.63E-10 | YDR452W | PPN1 | hom | Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress |
0.106 | 8.07E-10 | YDL063C | SYO1 | hom | Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
0.105 | 1.12E-9 | YLR062C_d | BUD28_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay |
0.102 | 3.76E-9 | YNL067W-B_p | YNL067W-B_p | hom | Putative protein of unknown function |
0.098 | 1.16E-8 | YNL227C | JJJ1 | hom | Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis |
0.097 | 2.00E-8 | YPL101W | ELP4 | hom | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity |
0.096 | 2.37E-8 | YKR057W | RPS21A | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication |
0.093 | 6.56E-8 | YOR312C | RPL20B | hom | Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication |
0.093 | 7.08E-8 | YOR309C_d | YOR309C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 |
0.084 | 9.62E-7 | YGR271C-A | EFG1 | hom | Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus |
0.084 | 9.86E-7 | YGR219W_d | YGR219W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C |
0.084 | 1.02E-6 | YPL125W | KAP120 | hom | Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p |