HIPHOP chemogenomics database
YGL080W / FMP37 
Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL080W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.113 | 5.60E-11 | YGL155W | CDC43 | het | Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis |
| 0.109 | 2.21E-10 | YOL019W-A_p | YOL019W-A_p | hom | Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.103 | 2.34E-9 | YJR052W | RAD7 | hom | Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex |
| 0.092 | 1.08E-7 | YLR035C | MLH2 | hom | Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p |
| 0.088 | 3.68E-7 | YOR114W_p | YOR114W_p | hom | Putative protein of unknown function; null mutant is viable |
| 0.088 | 3.69E-7 | YNL319W_d | YNL319W_d | hom | Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 |
| 0.083 | 1.56E-6 | YOL084W | PHM7 | hom | Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress |
| 0.082 | 1.76E-6 | YGR005C | TFG2 | het | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 |
| 0.082 | 1.88E-6 | YDL236W | PHO13 | hom | Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity |
| 0.080 | 3.84E-6 | YKL019W | RAM2 | het | Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor |
| 0.079 | 5.10E-6 | YNR056C | BIO5 | hom | Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis |
| 0.078 | 6.41E-6 | YCR092C | MSH3 | hom | Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability |
| 0.078 | 6.65E-6 | YER155C | BEM2 | hom | Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence |
| 0.078 | 6.95E-6 | YPL160W | CDC60 | het | Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
| 0.075 | 1.30E-5 | YLR230W_d | YLR230W_d | het | Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity |