YGL080W / FMP37

Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL080W / FMP37

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:2.99|P-value:9.59E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.46|P-value:1.50E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.03|P-value:8.34E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.73|P-value:5.55E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:3.41|P-value:2.04E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.46|P-value:1.89E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.25|P-value:3.78E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.99|P-value:1.76E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.75|P-value:4.98E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.16|P-value:5.39E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.06|P-value:7.55E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.05|P-value:8.02E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.15|P-value:7.55E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.39|P-value:2.20E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.15|P-value:5.48E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.87|P-value:2.97E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.42|P-value:1.94E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.13|P-value:5.81E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.08|P-value:7.09E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.80|P-value:4.14E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.59|P-value:9.40E-7 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.11|P-value:1.00E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.48|P-value:1.53E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.02|P-value:8.14E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:5.14E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.14|P-value:5.14E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.14|P-value:5.27E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.01|P-value:8.45E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.69|P-value:5.78E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.09|P-value:6.94E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.31|P-value:3.05E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.45|P-value:1.73E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.77|P-value:4.57E-5 ID:SGTC_2372|Compound:9071633|FD-Score:4.65|P-value:6.90E-7 ID:SGTC_2374|Compound:9071832|FD-Score:-3.45|P-value:1.61E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.41|P-value:2.02E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.51|P-value:1.43E-6 ID:SGTC_2477|Compound:5967686|FD-Score:4.69|P-value:5.56E-7 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.25|P-value:3.85E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.45|P-value:1.91E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:3.17|P-value:5.04E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.08|P-value:1.15E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.01|P-value:9.12E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.72|P-value:1.46E-9 ID:SGTC_2865|Compound:9030313|FD-Score:3.07|P-value:7.46E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.24|P-value:4.69E-11 ID:SGTC_2960|Compound:9079389|FD-Score:-3.20|P-value:4.23E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-4.64|P-value:6.63E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.27|P-value:3.57E-4 ID:SGTC_3116|Compound:9124943|FD-Score:6.40|P-value:1.53E-11 ID:SGTC_3120|Compound:9124077|FD-Score:4.21|P-value:6.25E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.43|P-value:1.87E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:2.99|P-value:9.59E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.46|P-value:1.50E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.03|P-value:8.34E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.73|P-value:5.55E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:3.41|P-value:2.04E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:4.46|P-value:1.89E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.25|P-value:3.78E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.99|P-value:1.76E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.75|P-value:4.98E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.16|P-value:5.39E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.06|P-value:7.55E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.05|P-value:8.02E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.15|P-value:7.55E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.39|P-value:2.20E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.15|P-value:5.48E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.87|P-value:2.97E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.42|P-value:1.94E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.13|P-value:5.81E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.08|P-value:7.09E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.80|P-value:4.14E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.59|P-value:9.40E-7 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.11|P-value:1.00E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.48|P-value:1.53E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.02|P-value:8.14E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.17|P-value:5.14E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.14|P-value:5.14E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.14|P-value:5.27E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.01|P-value:8.45E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.69|P-value:5.78E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.09|P-value:6.94E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.31|P-value:3.05E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.45|P-value:1.73E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.77|P-value:4.57E-5 ID:SGTC_2372|Compound:9071633|FD-Score:4.65|P-value:6.90E-7 ID:SGTC_2374|Compound:9071832|FD-Score:-3.45|P-value:1.61E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.41|P-value:2.02E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.51|P-value:1.43E-6 ID:SGTC_2477|Compound:5967686|FD-Score:4.69|P-value:5.56E-7 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.25|P-value:3.85E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.45|P-value:1.91E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:3.17|P-value:5.04E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.08|P-value:1.15E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.01|P-value:9.12E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:5.72|P-value:1.46E-9 ID:SGTC_2865|Compound:9030313|FD-Score:3.07|P-value:7.46E-4 ID:SGTC_2959|Compound:9079155|FD-Score:6.24|P-value:4.69E-11 ID:SGTC_2960|Compound:9079389|FD-Score:-3.20|P-value:4.23E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-4.64|P-value:6.63E-7 ID:SGTC_2973|Compound:9094665|FD-Score:3.27|P-value:3.57E-4 ID:SGTC_3116|Compound:9124943|FD-Score:6.40|P-value:1.53E-11 ID:SGTC_3120|Compound:9124077|FD-Score:4.21|P-value:6.25E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.43|P-value:1.87E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.52|P-value:1.32E-4

Top fitness defect scores for YGL080W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3116 9124943 6.40 49.5 µM 1.53E-11 1 7.80E-11
2 SGTC_2959 9079155 6.24 11.0 µM 4.69E-11 5 2.21E-10
3 SGTC_2754 granisetron 5.72 64.0 µM 1.46E-9 7 5.37E-9
4 SGTC_2477 5967686 4.69 25.2 µM 5.56E-7 16 1.34E-6
5 SGTC_2372 9071633 4.65 200.0 µM 6.90E-7 5 1.63E-6
6 SGTC_1582 3',3',6'-trihydroxyflavone 4.59 74.0 µM 9.40E-7 5 2.18E-6
7 SGTC_2437 5741531 4.51 144.2 µM 1.43E-6 25 3.21E-6
8 SGTC_259 usnic acid 4.46 108.9 µM 1.89E-6 11 4.16E-6
9 SGTC_2523 spermine 4.45 47.7 µM 1.91E-6 calcium & mitochondrial duress 20 4.21E-6
10 SGTC_3120 9124077 4.21 49.5 µM 6.25E-6 16 1.27E-5
11 SGTC_1587 estradiol valerate 4.11 56.1 µM 1.00E-5 10 1.96E-5
12 SGTC_2623 humulene 4.08 100.0 µM 1.15E-5 17 2.23E-5
13 SGTC_573 3702-0553 3.99 84.7 µM 1.76E-5 13 3.31E-5
14 SGTC_1056 3448-1962 3.87 115.0 µM 2.97E-5 amide catabolism 24 5.40E-5
15 SGTC_1551 6-bromo-3'-methylflavone 3.80 63.5 µM 4.14E-5 22 7.35E-5
16 SGTC_2339 9000433 3.77 200.0 µM 4.57E-5 43 8.06E-5
17 SGTC_622 1348-1566 3.75 26.3 µM 4.98E-5 25 8.72E-5
18 SGTC_155 k072-0202 3.73 43.6 µM 5.55E-5 19 9.65E-5
19 SGTC_3318 9139014 3.52 38.6 µM 1.32E-4 25 2.17E-4
20 SGTC_1074 carmofur 3.51 3.8 µM 1.36E-4 exosome 34 2.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.60E-11 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.109 2.21E-10 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.103 2.34E-9 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.092 1.08E-7 YLR035C MLH2 hom Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p
0.088 3.68E-7 YOR114W_p YOR114W_p hom Putative protein of unknown function; null mutant is viable
0.088 3.69E-7 YNL319W_d YNL319W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14
0.083 1.56E-6 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
0.082 1.76E-6 YGR005C TFG2 het TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
0.082 1.88E-6 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.080 3.84E-6 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.079 5.10E-6 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.078 6.41E-6 YCR092C MSH3 hom Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
0.078 6.65E-6 YER155C BEM2 hom Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
0.078 6.95E-6 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.075 1.30E-5 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity