YGL082W_p

Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL082W / YGL082W

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:2.80|P-value:9.40E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:2.90|P-value:6.43E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.80|P-value:1.90E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.84|P-value:1.08E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.22|P-value:2.47E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-2.86|P-value:9.94E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.19|P-value:4.85E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:3.22|P-value:1.74E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.17|P-value:2.14E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.90|P-value:6.38E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.46|P-value:4.10E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:3.22|P-value:1.72E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.12|P-value:2.71E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-2.97|P-value:6.64E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.43|P-value:7.27E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.03|P-value:3.84E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.02|P-value:3.97E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.90|P-value:7.98E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.09|P-value:3.01E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.32|P-value:1.65E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.01|P-value:4.16E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.83|P-value:1.63E-5 ID:SGTC_2281|Compound:7943571|FD-Score:2.83|P-value:8.11E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.91|P-value:6.11E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.83|P-value:1.10E-5 ID:SGTC_2387|Compound:9077560|FD-Score:-3.83|P-value:1.64E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.10|P-value:2.93E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.19|P-value:4.39E-12 ID:SGTC_2480|Compound:5767542|FD-Score:3.38|P-value:8.93E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.57|P-value:2.22E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.25|P-value:2.15E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.30|P-value:1.76E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.01|P-value:4.12E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.96|P-value:2.35E-11 ID:SGTC_2804|Compound:7954240|FD-Score:3.61|P-value:3.09E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.95|P-value:6.23E-6 ID:SGTC_2990|Compound:9074105|FD-Score:-3.47|P-value:8.73E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.98|P-value:7.77E-6 ID:SGTC_2993|Compound:9054257|FD-Score:-3.24|P-value:2.24E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.17|P-value:1.93E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.05|P-value:3.50E-4 ID:SGTC_3331|Compound:9141060|FD-Score:7.28|P-value:5.29E-16 ID:SGTC_3333|Compound:9141820|FD-Score:-5.39|P-value:2.29E-9 ID:SGTC_3334|Compound:9142812|FD-Score:4.02|P-value:4.32E-6 ID:SGTC_25|Compound:0118-0223|FD-Score:2.80|P-value:9.40E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:2.90|P-value:6.43E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.80|P-value:1.90E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.84|P-value:1.08E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.22|P-value:2.47E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-2.86|P-value:9.94E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.19|P-value:4.85E-9 ID:SGTC_759|Compound:3486-0358|FD-Score:3.22|P-value:1.74E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.17|P-value:2.14E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:2.90|P-value:6.38E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:4.46|P-value:4.10E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:3.22|P-value:1.72E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.12|P-value:2.71E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-2.97|P-value:6.64E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.22|P-value:1.78E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.43|P-value:7.27E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.03|P-value:3.84E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.02|P-value:3.97E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.90|P-value:7.98E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.09|P-value:3.01E-4 ID:SGTC_1837|Compound:st055472|FD-Score:-3.32|P-value:1.65E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.01|P-value:4.16E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.83|P-value:1.63E-5 ID:SGTC_2281|Compound:7943571|FD-Score:2.83|P-value:8.11E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.91|P-value:6.11E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.83|P-value:1.10E-5 ID:SGTC_2387|Compound:9077560|FD-Score:-3.83|P-value:1.64E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.10|P-value:2.93E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.19|P-value:4.39E-12 ID:SGTC_2480|Compound:5767542|FD-Score:3.38|P-value:8.93E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.57|P-value:2.22E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.25|P-value:2.15E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.30|P-value:1.76E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.01|P-value:4.12E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.96|P-value:2.35E-11 ID:SGTC_2804|Compound:7954240|FD-Score:3.61|P-value:3.09E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.95|P-value:6.23E-6 ID:SGTC_2990|Compound:9074105|FD-Score:-3.47|P-value:8.73E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.98|P-value:7.77E-6 ID:SGTC_2993|Compound:9054257|FD-Score:-3.24|P-value:2.24E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.17|P-value:1.93E-6 ID:SGTC_3328|Compound:9140624|FD-Score:3.05|P-value:3.50E-4 ID:SGTC_3331|Compound:9141060|FD-Score:7.28|P-value:5.29E-16 ID:SGTC_3333|Compound:9141820|FD-Score:-5.39|P-value:2.29E-9 ID:SGTC_3334|Compound:9142812|FD-Score:4.02|P-value:4.32E-6

Top fitness defect scores for YGL082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3331 9141060 7.28 2.0 µM 5.29E-16 cell wall 6 1.71E-13
2 SGTC_2479 5617353 6.19 43.9 µM 4.39E-12 6 3.07E-10
3 SGTC_2757 clomiphene 5.96 4.2 µM 2.35E-11 fatty acid desaturase (OLE1) 7 1.24E-9
4 SGTC_669 0108-0021 5.19 26.2 µM 4.85E-9 fatty acid desaturase (OLE1) 33 1.04E-7
5 SGTC_2514 salinomycin 4.57 42.7 µM 2.22E-7 29 2.48E-6
6 SGTC_859 0439-0102 4.46 54.6 µM 4.10E-7 redox potentiating 11 4.14E-6
7 SGTC_3212 9128307 4.17 49.5 µM 1.93E-6 39 1.50E-5
8 SGTC_3334 9142812 4.02 21.9 µM 4.32E-6 28 2.93E-5
9 SGTC_2989 9073649 3.95 71.4 µM 6.23E-6 40 3.98E-5
10 SGTC_1828 st055811 3.90 49.0 µM 7.98E-6 9 4.89E-5
11 SGTC_297 0986-0032 3.84 24.0 µM 1.08E-5 60S ribosome export 8 6.26E-5
12 SGTC_2386 9075165 3.83 157.4 µM 1.10E-5 11 6.36E-5
13 SGTC_2804 7954240 3.61 19.5 µM 3.09E-5 47 1.51E-4
14 SGTC_1715 st032160 3.43 10.2 µM 7.27E-5 61 3.07E-4
15 SGTC_2480 5767542 3.38 37.2 µM 8.93E-5 25 3.65E-4
16 SGTC_862 0452-0056 3.22 10.2 µM 1.72E-4 azole & statin 54 6.31E-4
17 SGTC_759 3486-0358 3.22 89.3 µM 1.74E-4 40 6.35E-4
18 SGTC_1260 0700-1617 3.22 7.8 µM 1.78E-4 calcium & mitochondrial duress 64 6.48E-4
19 SGTC_762 1165-0429 3.17 115.0 µM 2.14E-4 TSC3-RPN4 50 7.55E-4
20 SGTC_1125 tnp00248 3.12 1.3 µM 2.71E-4 93 9.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 7.14E-23 YIL059C_d YIL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
0.116 1.91E-11 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.110 1.58E-10 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.104 1.62E-9 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.102 3.88E-9 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.101 5.20E-9 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.099 8.86E-9 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.097 2.03E-8 YGR009C SEC9 het t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
0.097 2.12E-8 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.095 3.19E-8 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.095 3.87E-8 YMR075W RCO1 hom Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.093 5.93E-8 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.092 8.20E-8 YKL006C-A SFT1 het Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.090 1.52E-7 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.090 1.52E-7 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2