YGL084C / GUP1

Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL084C / GUP1

Click on Significant Values for Screen Details ID:SGTC_126|Compound:0417-1624|FD-Score:4.88|P-value:1.73E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.62|P-value:3.59E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:6.68|P-value:3.46E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.40|P-value:1.02E-6 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.85|P-value:1.86E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.36|P-value:7.33E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.26|P-value:1.32E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.16|P-value:3.92E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.03|P-value:1.11E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.46|P-value:2.83E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.28|P-value:1.61E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:6.37|P-value:1.13E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:4.59|P-value:3.90E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:8.03|P-value:9.77E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:6.57|P-value:5.28E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:8.17|P-value:5.12E-10 ID:SGTC_841|Compound:0251-0215|FD-Score:4.87|P-value:1.76E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:6.04|P-value:3.82E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:5.08|P-value:9.31E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:6.11|P-value:2.96E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:5.20|P-value:6.52E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.99|P-value:4.68E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.85|P-value:7.46E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:4.43|P-value:6.12E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.34|P-value:7.62E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.65|P-value:3.35E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.30|P-value:8.56E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.36|P-value:7.24E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:7.08|P-value:6.73E-8 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.91|P-value:1.54E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.28|P-value:9.13E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.89|P-value:4.41E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.86|P-value:1.84E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.74|P-value:7.01E-5 ID:SGTC_1881|Compound:5652484|FD-Score:4.56|P-value:4.25E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.82|P-value:9.78E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.57|P-value:4.12E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.66|P-value:3.23E-4 ID:SGTC_2064|Compound:5220758|FD-Score:5.44|P-value:3.03E-5 ID:SGTC_2142|Compound:5622915|FD-Score:6.32|P-value:1.39E-6 ID:SGTC_2149|Compound:5554786|FD-Score:5.44|P-value:2.99E-5 ID:SGTC_2289|Compound:7946404|FD-Score:6.37|P-value:1.14E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-5.11|P-value:2.18E-5 ID:SGTC_2350|Compound:9023895|FD-Score:8.04|P-value:9.27E-10 ID:SGTC_2399|Compound:5884133|FD-Score:8.26|P-value:3.28E-10 ID:SGTC_2483|Compound:5729050|FD-Score:-6.28|P-value:2.97E-7 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:7.58|P-value:7.84E-9 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.27|P-value:9.16E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.56|P-value:2.06E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.11|P-value:8.52E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.78|P-value:2.28E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:9.27|P-value:1.78E-12 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.33|P-value:7.96E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.26|P-value:9.52E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.95|P-value:1.38E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.87|P-value:7.04E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-4.32|P-value:2.47E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.27|P-value:5.17E-5 ID:SGTC_2932|Compound:9016711|FD-Score:6.47|P-value:7.91E-7 ID:SGTC_2934|Compound:9036370|FD-Score:6.93|P-value:1.28E-7 ID:SGTC_2938|Compound:9059746|FD-Score:-6.26|P-value:3.30E-7 ID:SGTC_3032|Compound:9089427|FD-Score:4.37|P-value:7.21E-4 ID:SGTC_3058|Compound:9093861|FD-Score:7.07|P-value:7.19E-8 ID:SGTC_3114|Compound:9122766|FD-Score:4.41|P-value:6.32E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.28|P-value:5.07E-5 ID:SGTC_3278|Compound:9139605|FD-Score:4.28|P-value:8.97E-4 ID:SGTC_3284|Compound:9108171|FD-Score:5.55|P-value:2.10E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:4.88|P-value:1.73E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.62|P-value:3.59E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:6.68|P-value:3.46E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.40|P-value:1.02E-6 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.85|P-value:1.86E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.36|P-value:7.33E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.26|P-value:1.32E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.16|P-value:3.92E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.03|P-value:1.11E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.46|P-value:2.83E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.28|P-value:1.61E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:6.37|P-value:1.13E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:4.59|P-value:3.90E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:8.03|P-value:9.77E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:6.57|P-value:5.28E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:8.17|P-value:5.12E-10 ID:SGTC_841|Compound:0251-0215|FD-Score:4.87|P-value:1.76E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:6.04|P-value:3.82E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:5.08|P-value:9.31E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:6.11|P-value:2.96E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:5.20|P-value:6.52E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.99|P-value:4.68E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.85|P-value:7.46E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:4.43|P-value:6.12E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.34|P-value:7.62E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.65|P-value:3.35E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.30|P-value:8.56E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.36|P-value:7.24E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:7.08|P-value:6.73E-8 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.91|P-value:1.54E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.28|P-value:9.13E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.89|P-value:4.41E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.86|P-value:1.84E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-4.74|P-value:7.01E-5 ID:SGTC_1881|Compound:5652484|FD-Score:4.56|P-value:4.25E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.82|P-value:9.78E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.57|P-value:4.12E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.66|P-value:3.23E-4 ID:SGTC_2064|Compound:5220758|FD-Score:5.44|P-value:3.03E-5 ID:SGTC_2142|Compound:5622915|FD-Score:6.32|P-value:1.39E-6 ID:SGTC_2149|Compound:5554786|FD-Score:5.44|P-value:2.99E-5 ID:SGTC_2289|Compound:7946404|FD-Score:6.37|P-value:1.14E-6 ID:SGTC_2295|Compound:7971645|FD-Score:-5.11|P-value:2.18E-5 ID:SGTC_2350|Compound:9023895|FD-Score:8.04|P-value:9.27E-10 ID:SGTC_2399|Compound:5884133|FD-Score:8.26|P-value:3.28E-10 ID:SGTC_2483|Compound:5729050|FD-Score:-6.28|P-value:2.97E-7 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:7.58|P-value:7.84E-9 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.27|P-value:9.16E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.56|P-value:2.06E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.11|P-value:8.52E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.78|P-value:2.28E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:9.27|P-value:1.78E-12 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.33|P-value:7.96E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.26|P-value:9.52E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.95|P-value:1.38E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.87|P-value:7.04E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-4.32|P-value:2.47E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.27|P-value:5.17E-5 ID:SGTC_2932|Compound:9016711|FD-Score:6.47|P-value:7.91E-7 ID:SGTC_2934|Compound:9036370|FD-Score:6.93|P-value:1.28E-7 ID:SGTC_2938|Compound:9059746|FD-Score:-6.26|P-value:3.30E-7 ID:SGTC_3032|Compound:9089427|FD-Score:4.37|P-value:7.21E-4 ID:SGTC_3058|Compound:9093861|FD-Score:7.07|P-value:7.19E-8 ID:SGTC_3114|Compound:9122766|FD-Score:4.41|P-value:6.32E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.28|P-value:5.07E-5 ID:SGTC_3278|Compound:9139605|FD-Score:4.28|P-value:8.97E-4 ID:SGTC_3284|Compound:9108171|FD-Score:5.55|P-value:2.10E-5

Top fitness defect scores for YGL084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2636 apigenin dimethyl ether 9.27 100.0 µM 1.78E-12 5 9.22E-21
2 SGTC_2399 5884133 8.26 200.0 µM 3.28E-10 cell wall signaling 16 7.36E-17
3 SGTC_832 4083-0019 8.17 164.0 µM 5.12E-10 translation 6 1.59E-16
4 SGTC_2350 9023895 8.04 38.9 µM 9.27E-10 ergosterol biosynthesis 4 4.41E-16
5 SGTC_828 2074-0507 8.03 139.0 µM 9.77E-10 RPP1 & pyrimidine depletion 3 4.83E-16
6 SGTC_2550 chrysin dimethyl ether 7.58 71.9 µM 7.84E-9 1 1.75E-14
7 SGTC_1349 flufenamic acid 7.08 69.0 µM 6.73E-8 2 7.11E-13
8 SGTC_3058 9093861 7.07 49.5 µM 7.19E-8 2 7.98E-13
9 SGTC_2934 9036370 6.93 36.9 µM 1.28E-7 5 2.17E-12
10 SGTC_155 k072-0202 6.68 43.6 µM 3.46E-7 2 1.20E-11
11 SGTC_830 4076-0286 6.57 57.8 µM 5.28E-7 translation 8 2.48E-11
12 SGTC_2932 9016711 6.47 44.5 µM 7.91E-7 12 4.99E-11
13 SGTC_221 trifluoperazine 6.40 10.3 µM 1.02E-6 NEO1-PIK1 113 7.76E-11
14 SGTC_708 3448-5400 6.37 146.0 µM 1.13E-6 9 9.18E-11
15 SGTC_2289 7946404 6.37 165.1 µM 1.14E-6 31 9.33E-11
16 SGTC_2142 5622915 6.32 118.5 µM 1.39E-6 1 1.32E-10
17 SGTC_445 e6 berbamine 6.28 66.0 µM 1.61E-6 NEO1-PIK1 23 1.70E-10
18 SGTC_932 2857-0803 6.11 154.0 µM 2.96E-6 6 4.85E-10
19 SGTC_858 0438-0351 6.04 2.8 µM 3.82E-6 copper-dependent oxidative stress 4 7.55E-10
20 SGTC_1012 4112-3522 5.99 18.0 µM 4.68E-6 5 1.07E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 3.65E-25 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.168 1.30E-22 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.138 1.02E-15 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.135 4.17E-15 YJL183W MNN11 hom Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
0.133 1.01E-14 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.128 9.19E-14 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.127 1.65E-13 YEL036C ANP1 hom Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
0.118 6.65E-12 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.118 6.97E-12 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.118 8.37E-12 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.117 9.67E-12 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.114 3.62E-11 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.111 9.79E-11 YDR245W MNN10 hom Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
0.103 2.18E-9 YDR525W_d API2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
0.103 2.57E-9 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress