YGL088W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL088W / YGL088W

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.63|P-value:2.13E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.46|P-value:4.01E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.47|P-value:7.41E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.33|P-value:1.40E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.38|P-value:5.20E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.45|P-value:4.07E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.72|P-value:1.90E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.04|P-value:4.59E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.79|P-value:2.38E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:-5.03|P-value:7.37E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:7.01|P-value:6.24E-12 ID:SGTC_708|Compound:3448-5400|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:6.44|P-value:2.49E-10 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.84|P-value:1.01E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.38|P-value:6.44E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-5.38|P-value:1.35E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.49|P-value:6.79E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.69|P-value:2.18E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-4.11|P-value:4.35E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.99|P-value:6.84E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.96|P-value:7.80E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.35|P-value:1.28E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.25|P-value:9.66E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.72|P-value:1.54E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.19|P-value:9.74E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.29|P-value:8.59E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.35|P-value:5.75E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.36|P-value:1.54E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-3.33|P-value:7.48E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.74|P-value:1.47E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:8.14|P-value:1.92E-15 ID:SGTC_1633|Compound:st005664|FD-Score:3.84|P-value:1.01E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.29|P-value:2.12E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.43|P-value:4.45E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.22|P-value:9.05E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.23|P-value:8.56E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.31|P-value:6.69E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.31|P-value:8.08E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.90|P-value:9.70E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.25|P-value:9.89E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.99|P-value:7.05E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.47|P-value:7.53E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.96|P-value:6.22E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.47|P-value:3.78E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.81|P-value:1.64E-6 ID:SGTC_2819|Compound:7996655|FD-Score:3.30|P-value:6.83E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.33|P-value:1.75E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.50|P-value:3.39E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.85|P-value:9.60E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.34|P-value:6.05E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.53|P-value:5.81E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.21|P-value:9.06E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.09|P-value:3.80E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.63|P-value:2.13E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.46|P-value:4.01E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.47|P-value:7.41E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:4.33|P-value:1.40E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.38|P-value:5.20E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.45|P-value:4.07E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.72|P-value:1.90E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.83|P-value:1.02E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.04|P-value:4.59E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.79|P-value:2.38E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:-5.03|P-value:7.37E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:7.01|P-value:6.24E-12 ID:SGTC_708|Compound:3448-5400|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:6.44|P-value:2.49E-10 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.84|P-value:1.01E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.38|P-value:6.44E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:-5.38|P-value:1.35E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.49|P-value:6.79E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.69|P-value:2.18E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-4.11|P-value:4.35E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.99|P-value:6.84E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.96|P-value:7.80E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.35|P-value:1.28E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:-3.25|P-value:9.66E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.72|P-value:1.54E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.19|P-value:9.74E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.29|P-value:8.59E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.35|P-value:5.75E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.36|P-value:1.54E-5 ID:SGTC_1626|Compound:st003712|FD-Score:-3.33|P-value:7.48E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.74|P-value:1.47E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:8.14|P-value:1.92E-15 ID:SGTC_1633|Compound:st005664|FD-Score:3.84|P-value:1.01E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.29|P-value:2.12E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.43|P-value:4.45E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.22|P-value:9.05E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.23|P-value:8.56E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.31|P-value:6.69E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.31|P-value:8.08E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.90|P-value:9.70E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.25|P-value:9.89E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.99|P-value:7.05E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.47|P-value:7.53E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.96|P-value:6.22E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.47|P-value:3.78E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.81|P-value:1.64E-6 ID:SGTC_2819|Compound:7996655|FD-Score:3.30|P-value:6.83E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.33|P-value:1.75E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.50|P-value:3.39E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.85|P-value:9.60E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.34|P-value:6.05E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.53|P-value:5.81E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.21|P-value:9.06E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.09|P-value:3.80E-5

Top fitness defect scores for YGL088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1631 benzylvanillin 8.14 81.9 µM 1.92E-15 Golgi 1 1.92E-16
2 SGTC_691 1548-0686 7.01 185.0 µM 6.24E-12 1 1.15E-12
3 SGTC_1073 triclabendazole 6.44 3.1 µM 2.49E-10 4 6.05E-11
4 SGTC_2688 kanamycin b 4.81 96.7 µM 1.64E-6 calcium & mitochondrial duress 265 7.63E-7
5 SGTC_3030 9087619 4.53 49.5 µM 5.81E-6 3 2.95E-6
6 SGTC_1246 0422-0085 4.49 105.0 µM 6.79E-6 16 3.49E-6
7 SGTC_362 0310-0100 4.47 9.0 µM 7.41E-6 RPP1 & pyrimidine depletion 21 3.82E-6
8 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.47 15.3 µM 7.53E-6 21 3.89E-6
9 SGTC_1413 3910-0535 4.35 34.4 µM 1.28E-5 7 6.88E-6
10 SGTC_370 0180-0345 4.33 38.7 µM 1.40E-5 DNA intercalators 8 7.59E-6
11 SGTC_3214 9129694 4.09 49.5 µM 3.80E-5 25 2.20E-5
12 SGTC_579 4491-1009 4.04 110.0 µM 4.59E-5 60S ribosome export 21 2.70E-5
13 SGTC_2658 polymyxin b sulfate 3.96 77.0 µM 6.22E-5 NEO1 39 3.73E-5
14 SGTC_2906 7926292 3.85 26.4 µM 9.60E-5 26 5.94E-5
15 SGTC_1141 3253-0389 3.84 52.6 µM 1.01E-4 8 6.24E-5
16 SGTC_1633 st005664 3.84 67.9 µM 1.01E-4 33 6.28E-5
17 SGTC_578 3460-0051 3.83 92.0 µM 1.02E-4 11 6.34E-5
18 SGTC_1627 st003713 3.74 25.6 µM 1.47E-4 calcium & mitochondrial duress 88 9.36E-5
19 SGTC_1438 4092-1045 3.72 4.0 µM 1.54E-4 9 9.83E-5
20 SGTC_1781 st038725 3.67 66.3 µM 1.86E-4 NEO1 113 1.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.86E-12 YPL097W MSY1 hom Mitochondrial tyrosyl-tRNA synthetase
0.116 1.47E-11 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.111 1.17E-10 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.106 6.21E-10 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.104 1.49E-9 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.103 2.46E-9 YGR081C SLX9 hom Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
0.101 4.77E-9 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.100 6.63E-9 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing
0.095 3.63E-8 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.093 6.12E-8 YNL248C RPA49 hom RNA polymerase I subunit A49
0.092 8.07E-8 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.090 1.53E-7 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.089 2.24E-7 YER091C MET6 hom Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.087 4.22E-7 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.087 4.81E-7 YNL096C RPS7B hom Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress