HIPHOP chemogenomics database

YGL088W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL088W / YGL088W

Click on Significant Values for Screen Details

Top fitness defect scores for YGL088W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1631	benzylvanillin	8.14	81.9 µM	1.92E-15	Golgi	1	1.92E-16
2	SGTC_691	1548-0686	7.01	185.0 µM	6.24E-12		1	1.15E-12
3	SGTC_1073	triclabendazole	6.44	3.1 µM	2.49E-10		4	6.05E-11
4	SGTC_2688	kanamycin b	4.81	96.7 µM	1.64E-6	calcium & mitochondrial duress	265	7.63E-7
5	SGTC_3030	9087619	4.53	49.5 µM	5.81E-6		3	2.95E-6
6	SGTC_1246	0422-0085	4.49	105.0 µM	6.79E-6		16	3.49E-6
7	SGTC_362	0310-0100	4.47	9.0 µM	7.41E-6	RPP1 & pyrimidine depletion	21	3.82E-6
8	SGTC_2577	2',4'-dihydroxy-4-methoxychalcone	4.47	15.3 µM	7.53E-6		21	3.89E-6
9	SGTC_1413	3910-0535	4.35	34.4 µM	1.28E-5		7	6.88E-6
10	SGTC_370	0180-0345	4.33	38.7 µM	1.40E-5	DNA intercalators	8	7.59E-6
11	SGTC_3214	9129694	4.09	49.5 µM	3.80E-5		25	2.20E-5
12	SGTC_579	4491-1009	4.04	110.0 µM	4.59E-5	60S ribosome export	21	2.70E-5
13	SGTC_2658	polymyxin b sulfate	3.96	77.0 µM	6.22E-5	NEO1	39	3.73E-5
14	SGTC_2906	7926292	3.85	26.4 µM	9.60E-5		26	5.94E-5
15	SGTC_1141	3253-0389	3.84	52.6 µM	1.01E-4		8	6.24E-5
16	SGTC_1633	st005664	3.84	67.9 µM	1.01E-4		33	6.28E-5
17	SGTC_578	3460-0051	3.83	92.0 µM	1.02E-4		11	6.34E-5
18	SGTC_1627	st003713	3.74	25.6 µM	1.47E-4	calcium & mitochondrial duress	88	9.36E-5
19	SGTC_1438	4092-1045	3.72	4.0 µM	1.54E-4		9	9.83E-5
20	SGTC_1781	st038725	3.67	66.3 µM	1.86E-4	NEO1	113	1.20E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.121	1.86E-12	YPL097W	MSY1	hom	Mitochondrial tyrosyl-tRNA synthetase
0.116	1.47E-11	YKR057W	RPS21A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.111	1.17E-10	YLL045C	RPL8B	hom	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.106	6.21E-10	YLR048W	RPS0B	hom	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.104	1.49E-9	YJL136C	RPS21B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.103	2.46E-9	YGR081C	SLX9	hom	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
0.101	4.77E-9	YOR293W	RPS10A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.100	6.63E-9	YLR435W	TSR2	hom	Protein with a potential role in pre-rRNA processing
0.095	3.63E-8	YGR271C-A	EFG1	hom	Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.093	6.12E-8	YNL248C	RPA49	hom	RNA polymerase I subunit A49
0.092	8.07E-8	YNL071W	LAT1	hom	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.090	1.53E-7	YPR137W	RRP9	het	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.089	2.24E-7	YER091C	MET6	hom	Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.087	4.22E-7	YGR162W	TIF4631	hom	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.087	4.81E-7	YNL096C	RPS7B	hom	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress