HIPHOP chemogenomics database
YGL091C / NBP35 
Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGL091C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.154 | 3.11E-19 | YGR173W | RBG2 | hom | Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein |
| 0.132 | 2.04E-14 | YKL040C | NFU1 | hom | Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria |
| 0.112 | 8.83E-11 | YPR175W | DPB2 | het | Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate |
| 0.109 | 2.19E-10 | YCR030C | SYP1 | hom | Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization |
| 0.102 | 3.32E-9 | YOL038C-A_p | YOL038C-A_p | hom | Putative protein of unknown function; identified by SAGE analysis |
| 0.100 | 6.28E-9 | YOR057W | SGT1 | het | Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress |
| 0.099 | 7.96E-9 | YNR005C_d | YNR005C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.099 | 1.07E-8 | YGR109C | CLB6 | hom | B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 |
| 0.097 | 1.81E-8 | YOL067C | RTG1 | hom | Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus |
| 0.094 | 5.78E-8 | YDR124W_p | YDR124W_p | hom | Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor |
| 0.091 | 1.43E-7 | YBL065W_d | YBL065W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene |
| 0.091 | 1.48E-7 | YHL006C | SHU1 | hom | Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function |
| 0.089 | 2.10E-7 | YOR329C | SCD5 | het | Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency |
| 0.089 | 2.25E-7 | YLR066W | SPC3 | het | Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 |
| 0.089 | 2.32E-7 | YOL079W_d | YOL079W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |