YGL091C / NBP35

Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL091C / NBP35

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:4.29|P-value:1.80E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.84|P-value:3.64E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.49|P-value:1.68E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:3.02|P-value:1.76E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.98|P-value:2.08E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:2.79|P-value:4.63E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.54|P-value:1.30E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.12|P-value:1.06E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:2.79|P-value:4.70E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.81|P-value:5.85E-9 ID:SGTC_659|Compound:k018-0002|FD-Score:2.87|P-value:3.31E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.97|P-value:2.07E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-2.83|P-value:3.90E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.11|P-value:1.11E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.02|P-value:1.72E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.20|P-value:7.49E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.66|P-value:8.01E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.08|P-value:1.29E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.28|P-value:5.17E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.63|P-value:8.99E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.55|P-value:1.31E-5 ID:SGTC_1695|Compound:st026914|FD-Score:2.88|P-value:3.18E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.74|P-value:4.48E-6 ID:SGTC_1765|Compound:st044815|FD-Score:2.93|P-value:2.52E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.85|P-value:3.72E-4 ID:SGTC_2000|Compound:st075254|FD-Score:2.64|P-value:8.70E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.44|P-value:6.85E-8 ID:SGTC_2056|Compound:5235370|FD-Score:2.83|P-value:4.02E-4 ID:SGTC_2165|Compound:5727197|FD-Score:2.84|P-value:3.87E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.13|P-value:1.01E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.42|P-value:2.55E-5 ID:SGTC_2336|Compound:9001819|FD-Score:2.73|P-value:6.07E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.43|P-value:2.44E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.65|P-value:8.33E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.89|P-value:1.88E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-2.65|P-value:8.19E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.97|P-value:2.11E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.73|P-value:6.06E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.05|P-value:1.53E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.67|P-value:7.54E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.74|P-value:5.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.47|P-value:1.96E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-2.79|P-value:4.54E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-4.37|P-value:1.08E-7 ID:SGTC_2977|Compound:9011197|FD-Score:-3.11|P-value:1.13E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.29|P-value:1.72E-7 ID:SGTC_2987|Compound:9018338|FD-Score:2.89|P-value:3.06E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-2.62|P-value:9.21E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-2.72|P-value:6.05E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-2.63|P-value:8.84E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-2.63|P-value:8.96E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-5.24|P-value:2.51E-10 ID:SGTC_3351|Compound:9150312|FD-Score:-2.84|P-value:3.79E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.91|P-value:2.76E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.29|P-value:1.80E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.84|P-value:3.64E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.49|P-value:1.68E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:3.02|P-value:1.76E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.98|P-value:2.08E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:2.79|P-value:4.63E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.54|P-value:1.30E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.12|P-value:1.06E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:2.79|P-value:4.70E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.81|P-value:5.85E-9 ID:SGTC_659|Compound:k018-0002|FD-Score:2.87|P-value:3.31E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.97|P-value:2.07E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-2.83|P-value:3.90E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.11|P-value:1.11E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.02|P-value:1.72E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.20|P-value:7.49E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.66|P-value:8.01E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.08|P-value:1.29E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.28|P-value:5.17E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.63|P-value:8.99E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.55|P-value:1.31E-5 ID:SGTC_1695|Compound:st026914|FD-Score:2.88|P-value:3.18E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.74|P-value:4.48E-6 ID:SGTC_1765|Compound:st044815|FD-Score:2.93|P-value:2.52E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.85|P-value:3.72E-4 ID:SGTC_2000|Compound:st075254|FD-Score:2.64|P-value:8.70E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.44|P-value:6.85E-8 ID:SGTC_2056|Compound:5235370|FD-Score:2.83|P-value:4.02E-4 ID:SGTC_2165|Compound:5727197|FD-Score:2.84|P-value:3.87E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.13|P-value:1.01E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.42|P-value:2.55E-5 ID:SGTC_2336|Compound:9001819|FD-Score:2.73|P-value:6.07E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.43|P-value:2.44E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.65|P-value:8.33E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.89|P-value:1.88E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-2.65|P-value:8.19E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.97|P-value:2.11E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.73|P-value:6.06E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.05|P-value:1.53E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.67|P-value:7.54E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.74|P-value:5.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.47|P-value:1.96E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-2.79|P-value:4.54E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-4.37|P-value:1.08E-7 ID:SGTC_2977|Compound:9011197|FD-Score:-3.11|P-value:1.13E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.29|P-value:1.72E-7 ID:SGTC_2987|Compound:9018338|FD-Score:2.89|P-value:3.06E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-2.62|P-value:9.21E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-2.72|P-value:6.05E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-2.63|P-value:8.84E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-2.63|P-value:8.96E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-5.24|P-value:2.51E-10 ID:SGTC_3351|Compound:9150312|FD-Score:-2.84|P-value:3.79E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.91|P-value:2.76E-4

Top fitness defect scores for YGL091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_646 4092-0839 4.81 27.3 µM 5.85E-9 plasma membrane duress 3 7.52E-7 0.01
2 SGTC_2035 5154463 4.44 94.6 µM 6.85E-8 8 4.41E-6 0.29
3 SGTC_50 0929-0078 4.29 56.4 µM 1.80E-7 5 8.85E-6 0.01
4 SGTC_1621 st003705 3.55 32.4 µM 1.31E-5 calcium & mitochondrial duress 9 1.96E-4 0.14
5 SGTC_2933 9026794 3.47 32.5 µM 1.96E-5 8 2.61E-4 0.15
6 SGTC_2477 5967686 3.43 25.2 µM 2.44E-5 13 3.06E-4 0.05
7 SGTC_2307 7538926 3.42 6.3 µM 2.55E-5 28 3.16E-4 0.01
8 SGTC_1307 1187-1599 3.28 12.2 µM 5.17E-5 PDR1 10 5.28E-4 0.19
9 SGTC_861 0443-0273 3.20 110.0 µM 7.49E-5 9 6.90E-4 0.22
10 SGTC_422 cantharidin 3.12 155.0 µM 1.06E-4 cell wall signaling 18 8.89E-4 0.06
11 SGTC_2713 st079149 3.05 53.4 µM 1.53E-4 14 0.00116 0.10
12 SGTC_839 0122-0028 3.02 230.0 µM 1.72E-4 RSC complex & mRNA processing 54 0.00126 0.00
13 SGTC_211 3455-0679 3.02 143.5 µM 1.76E-4 12 0.00128 7.64E-4
14 SGTC_840 0245-0196 3.01 390.0 µM 1.81E-4 11 0.00131 0.13
15 SGTC_234 nsc-17383 2.98 10.7 µM 2.08E-4 ERG2 17 0.00145 0.03
16 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 2.97 100.0 µM 2.11E-4 11 0.00147 0.04
17 SGTC_1765 st044815 2.93 90.4 µM 2.52E-4 21 0.00167 0.06
18 SGTC_3352 9151559 2.91 45.6 µM 2.76E-4 9 0.00178 0.07
19 SGTC_2987 9018338 2.89 71.4 µM 3.06E-4 RPP1 & pyrimidine depletion 20 0.00192 0.00
20 SGTC_1695 st026914 2.88 34.5 µM 3.18E-4 16 0.00197 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.11E-19 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.132 2.04E-14 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.112 8.83E-11 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.109 2.19E-10 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.102 3.32E-9 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.100 6.28E-9 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.099 7.96E-9 YNR005C_d YNR005C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 1.07E-8 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.097 1.81E-8 YOL067C RTG1 hom Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
0.094 5.78E-8 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.091 1.43E-7 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.091 1.48E-7 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.089 2.10E-7 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.089 2.25E-7 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.089 2.32E-7 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data