HIPHOP chemogenomics database

YGL093W / SPC105

Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components

Zygosity: Heterozygous strain

fixedexpanded
Profile for YGL093W / SPC105

Click on Significant Values for Screen Details

Top fitness defect scores for YGL093W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_3059	1327-0034	26.40	3.0 µM	3.73E-93		2	1.91E-153	19.70
2	SGTC_3063	1327-0034	21.10	4.0 µM	2.88E-60		2	8.68E-99	15.10
3	SGTC_3060	1327-0027	19.80	12.5 µM	1.26E-53		2	9.37E-88	13.40
4	SGTC_2429	5902844	19.00	64.4 µM	2.20E-49		2	1.03E-80	13.30
5	SGTC_1294	1000-1494	18.80	117.0 µM	1.76E-48		2	3.26E-79	6.31
6	SGTC_1968	st069590	16.80	43.6 µM	4.22E-39		2	1.22E-63	4.18
7	SGTC_294	k038-0071	16.00	157.0 µM	1.15E-35	ubiquinone biosynthesis & proteasome	1	6.16E-58	5.29
8	SGTC_1239	0337-0584	15.50	35.4 µM	1.83E-33	unfolded protein response	2	2.78E-54	0.15
9	SGTC_635	k038-0028	15.40	24.7 µM	2.98E-33	ubiquinone biosynthesis & proteasome	1	6.23E-54	4.84
10	SGTC_107	0358-0022	15.30	2.7 µM	6.44E-33	SWF1 & branched chain AA biosynthesis	1	2.23E-53	7.73
11	SGTC_142	0335-0849	15.00	62.7 µM	1.15E-31	ubiquinone biosynthesis & proteasome	3	2.68E-51	1.45
12	SGTC_1652	st011932	14.70	78.0 µM	3.03E-30	RSC complex & mRNA processing	6	6.04E-49	0.70
13	SGTC_64	000l-0018	14.50	272.1 µM	1.12E-29	ubiquinone biosynthesis & proteasome	8	5.28E-48	2.27
14	SGTC_2912	7964298	14.10	10.9 µM	2.65E-28	cell wall	4	1.01E-45	0.02
15	SGTC_200	k038-0079	12.90	37.5 µM	7.02E-24	ubiquinone biosynthesis & proteasome	2	2.15E-38	5.45
16	SGTC_2111	5486399	12.80	200.0 µM	1.91E-23		5	1.13E-37	0.82
17	SGTC_3064	1327-0027	12.40	10.0 µM	2.37E-22		2	7.36E-36	7.29
18	SGTC_1374	2889-5571	12.40	141.0 µM	2.55E-22	RSC complex & mRNA processing	7	8.29E-36	0.10
19	SGTC_216	k038-0035	12.00	28.4 µM	8.43E-21	ubiquinone biosynthesis & proteasome	2	2.72E-33	2.69
20	SGTC_1679	4130-1276	12.00	6.7 µM	8.50E-21	Golgi	2	2.76E-33	0.05

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.766	0	YPR107C	YTH1	het	Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.484	3.89E-196	YFR007W	YFH7	hom	Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.453	2.62E-169	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.451	1.78E-167	YER041W	YEN1	hom	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.442	9.14E-161	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.420	2.70E-143	YDR537C_d	YDR537C_d	hom	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.405	3.06E-132	YCL014W	BUD3	hom	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.404	6.74E-132	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.388	6.50E-121	YNR016C	ACC1	het	Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.386	1.46E-119	YLR033W	RSC58	het	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.382	2.91E-117	YJR129C_p	YJR129C_p	hom	Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.367	1.66E-107	YJL193W_p	YJL193W_p	hom	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.365	3.68E-106	YER165W	PAB1	het	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.353	2.67E-99	YFR037C	RSC8	het	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.342	1.04E-92	YML034W	SRC1	hom	Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance