YGL094C / PAN2

Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL094C / PAN2

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.36|P-value:1.40E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.94|P-value:8.82E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.65|P-value:3.91E-6 ID:SGTC_229|Compound:benomyl|FD-Score:5.91|P-value:6.78E-9 ID:SGTC_375|Compound:3970-0961|FD-Score:3.32|P-value:7.22E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.12|P-value:3.36E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.01|P-value:5.85E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.23|P-value:8.82E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.93|P-value:7.96E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.19|P-value:2.89E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-6.17|P-value:1.25E-9 ID:SGTC_999|Compound:4022-0066|FD-Score:4.49|P-value:7.98E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.96|P-value:6.26E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:-6.76|P-value:3.35E-11 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.17|P-value:2.74E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.31|P-value:5.52E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.46|P-value:7.98E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.05|P-value:5.97E-7 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.75|P-value:1.61E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:7.53|P-value:2.17E-13 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.54|P-value:3.01E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.29|P-value:1.85E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.22|P-value:9.05E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.72|P-value:1.60E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.71|P-value:1.66E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.72|P-value:1.87E-8 ID:SGTC_1801|Compound:st050089|FD-Score:6.43|P-value:3.18E-10 ID:SGTC_1803|Compound:st050068|FD-Score:4.84|P-value:1.66E-6 ID:SGTC_1866|Compound:st057638|FD-Score:-3.89|P-value:8.43E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:44.70|P-value:0 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.43|P-value:9.14E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.47|P-value:4.33E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.36|P-value:5.63E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.41|P-value:5.29E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.40|P-value:1.20E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.78|P-value:1.40E-4 ID:SGTC_2174|Compound:5790901|FD-Score:9.94|P-value:5.59E-22 ID:SGTC_2319|Compound:6033012|FD-Score:7.04|P-value:6.20E-12 ID:SGTC_2352|Compound:9027995|FD-Score:3.74|P-value:1.64E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.46|P-value:4.56E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.25|P-value:8.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.62|P-value:4.43E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.45|P-value:4.59E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-4.66|P-value:3.31E-6 ID:SGTC_3095|Compound:9117207|FD-Score:-3.47|P-value:3.89E-4 ID:SGTC_3333|Compound:9141820|FD-Score:4.18|P-value:2.92E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:4.36|P-value:1.40E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.94|P-value:8.82E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.65|P-value:3.91E-6 ID:SGTC_229|Compound:benomyl|FD-Score:5.91|P-value:6.78E-9 ID:SGTC_375|Compound:3970-0961|FD-Score:3.32|P-value:7.22E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.12|P-value:3.36E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.01|P-value:5.85E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.23|P-value:8.82E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.93|P-value:7.96E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:4.19|P-value:2.89E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-6.17|P-value:1.25E-9 ID:SGTC_999|Compound:4022-0066|FD-Score:4.49|P-value:7.98E-6 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.96|P-value:6.26E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:-6.76|P-value:3.35E-11 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.17|P-value:2.74E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.31|P-value:5.52E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.46|P-value:7.98E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.05|P-value:5.97E-7 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.75|P-value:1.61E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:7.53|P-value:2.17E-13 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.54|P-value:3.01E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.29|P-value:1.85E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.22|P-value:9.05E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.72|P-value:1.60E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.71|P-value:1.66E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.72|P-value:1.87E-8 ID:SGTC_1801|Compound:st050089|FD-Score:6.43|P-value:3.18E-10 ID:SGTC_1803|Compound:st050068|FD-Score:4.84|P-value:1.66E-6 ID:SGTC_1866|Compound:st057638|FD-Score:-3.89|P-value:8.43E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:44.70|P-value:0 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.43|P-value:9.14E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.47|P-value:4.33E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.36|P-value:5.63E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.41|P-value:5.29E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.40|P-value:1.20E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.78|P-value:1.40E-4 ID:SGTC_2174|Compound:5790901|FD-Score:9.94|P-value:5.59E-22 ID:SGTC_2319|Compound:6033012|FD-Score:7.04|P-value:6.20E-12 ID:SGTC_2352|Compound:9027995|FD-Score:3.74|P-value:1.64E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.46|P-value:4.56E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.25|P-value:8.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.62|P-value:4.43E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.45|P-value:4.59E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-4.66|P-value:3.31E-6 ID:SGTC_3095|Compound:9117207|FD-Score:-3.47|P-value:3.89E-4 ID:SGTC_3333|Compound:9141820|FD-Score:4.18|P-value:2.92E-5

Top fitness defect scores for YGL094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1875 nocodazole 44.70 6.0 µM 0 tubulin folding & SWR complex 1 0
2 SGTC_2174 5790901 9.94 200.0 µM 5.59E-22 tubulin folding & SWR complex 11 1.43E-23
3 SGTC_1326 1431-2094 7.53 10.8 µM 2.17E-13 tubulin folding & SWR complex 10 2.54E-14
4 SGTC_2319 6033012 7.04 152.6 µM 6.20E-12 tubulin folding & SWR complex 11 9.38E-13
5 SGTC_1801 st050089 6.43 28.4 µM 3.18E-10 NEO1-PIK1 45 6.51E-11
6 SGTC_229 benomyl 5.91 22.9 µM 6.78E-9 tubulin folding & SWR complex 18 1.76E-9
7 SGTC_1800 st050079 5.72 29.1 µM 1.87E-8 NEO1-PIK1 46 5.24E-9
8 SGTC_1287 0971-0001 5.05 34.6 µM 5.97E-7 sphingolipid biosynthesis & PDR1 30 2.18E-7
9 SGTC_1803 st050068 4.84 52.4 µM 1.66E-6 NEO1-PIK1 122 6.55E-7
10 SGTC_221 trifluoperazine 4.65 10.3 µM 3.91E-6 NEO1-PIK1 177 1.65E-6
11 SGTC_2752 diclazuril 4.62 33.1 µM 4.43E-6 88 1.88E-6
12 SGTC_999 4022-0066 4.49 22.7 µM 7.98E-6 Golgi 27 3.54E-6
13 SGTC_2141 5621638 4.40 7.7 µM 1.20E-5 tubulin folding & SWR complex 27 5.51E-6
14 SGTC_43 0570-0105 4.36 72.5 µM 1.40E-5 ERG2 79 6.50E-6
15 SGTC_1643 st009866 4.29 20.2 µM 1.85E-5 31 8.76E-6
16 SGTC_996 3970-0799 4.19 1.8 µM 2.89E-5 76 1.41E-5
17 SGTC_3333 9141820 4.18 12.1 µM 2.92E-5 13 1.43E-5
18 SGTC_423 5-fluorouracil 4.01 457.0 µM 5.85E-5 exosome 21 3.02E-5
19 SGTC_640 3381-0960 3.93 37.1 µM 7.96E-5 14 4.21E-5
20 SGTC_2145 5634607 3.78 200.0 µM 1.40E-4 9 7.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.488 5.70E-200 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.386 1.17E-119 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.355 5.06E-100 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.339 5.29E-91 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.329 1.34E-85 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.322 7.08E-82 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.321 2.63E-81 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.317 4.10E-79 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.312 1.78E-76 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.307 4.43E-74 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.289 1.54E-65 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.287 1.14E-64 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.282 1.47E-62 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.281 6.32E-62 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.279 6.95E-61 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2