YGL095C / VPS45

Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL095C / VPS45

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-5.87|P-value:3.89E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.67|P-value:7.59E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:8.48|P-value:7.17E-9 ID:SGTC_57|Compound:miconazole|FD-Score:-7.54|P-value:1.99E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.86|P-value:1.31E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:5.17|P-value:2.81E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.03|P-value:3.98E-8 ID:SGTC_98|Compound:0074-0023|FD-Score:5.81|P-value:5.29E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.29|P-value:2.06E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.65|P-value:8.09E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.79|P-value:6.92E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.31|P-value:1.95E-4 ID:SGTC_232|Compound:clozapine|FD-Score:7.90|P-value:6.52E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.50|P-value:1.20E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.96|P-value:4.74E-4 ID:SGTC_264|Compound:promethazine|FD-Score:12.10|P-value:3.51E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.40|P-value:1.57E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.06|P-value:3.67E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.72|P-value:5.93E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.17|P-value:2.50E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:6.87|P-value:2.23E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:7.65|P-value:1.60E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:7.40|P-value:3.81E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.76|P-value:3.13E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:5.63|P-value:8.67E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.97|P-value:4.21E-8 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.46|P-value:1.34E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.90|P-value:4.83E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.43|P-value:8.72E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:4.94|P-value:4.97E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.62|P-value:1.78E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:5.95|P-value:3.57E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:5.94|P-value:3.66E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:5.12|P-value:3.20E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:5.14|P-value:3.01E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:5.19|P-value:2.70E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.98|P-value:1.58E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.91|P-value:5.24E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:6.79|P-value:2.85E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:5.44|P-value:1.40E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:6.53|P-value:6.45E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:7.14|P-value:9.12E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:4.98|P-value:4.45E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.85|P-value:6.08E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.42|P-value:1.48E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.44|P-value:1.43E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.87|P-value:5.81E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:5.03|P-value:3.97E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.08|P-value:2.42E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.88|P-value:4.34E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.89|P-value:6.61E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:7.37|P-value:4.28E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:6.28|P-value:1.37E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:7.20|P-value:7.42E-7 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.33|P-value:4.91E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.64|P-value:8.40E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:5.46|P-value:1.33E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.29|P-value:1.34E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.68|P-value:7.44E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:9.83|P-value:2.48E-11 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.08|P-value:1.10E-6 ID:SGTC_1665|Compound:st014639|FD-Score:8.79|P-value:2.11E-9 ID:SGTC_1666|Compound:st014829|FD-Score:10.20|P-value:4.61E-12 ID:SGTC_1672|Compound:st016598|FD-Score:11.90|P-value:8.49E-16 ID:SGTC_1679|Compound:4130-1276|FD-Score:11.20|P-value:2.95E-14 ID:SGTC_1687|Compound:st020778|FD-Score:5.63|P-value:8.68E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.93|P-value:3.71E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.79|P-value:6.99E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.21|P-value:2.53E-4 ID:SGTC_1826|Compound:st055655|FD-Score:13.70|P-value:2.72E-20 ID:SGTC_1827|Compound:berberine|FD-Score:-5.08|P-value:3.11E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.90|P-value:3.58E-5 ID:SGTC_1830|Compound:st055982|FD-Score:5.18|P-value:2.75E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.90|P-value:4.13E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.50|P-value:7.15E-6 ID:SGTC_1891|Compound:st059073|FD-Score:7.02|P-value:1.37E-6 ID:SGTC_1892|Compound:st058411|FD-Score:-6.04|P-value:2.37E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-7.23|P-value:5.72E-7 ID:SGTC_1901|Compound:st060216|FD-Score:6.83|P-value:2.53E-6 ID:SGTC_1904|Compound:st060225|FD-Score:5.64|P-value:8.42E-5 ID:SGTC_1933|Compound:st074711|FD-Score:7.02|P-value:1.39E-6 ID:SGTC_1939|Compound:st074455|FD-Score:-6.11|P-value:1.97E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-5.36|P-value:1.53E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.75|P-value:7.59E-4 ID:SGTC_2036|Compound:5160441|FD-Score:8.69|P-value:3.11E-9 ID:SGTC_2038|Compound:4100038|FD-Score:-5.82|P-value:4.51E-5 ID:SGTC_2077|Compound:5212015|FD-Score:6.40|P-value:9.66E-6 ID:SGTC_2151|Compound:5563267|FD-Score:4.83|P-value:6.37E-4 ID:SGTC_2188|Compound:6126565|FD-Score:4.80|P-value:6.91E-4 ID:SGTC_2200|Compound:6600604|FD-Score:7.34|P-value:4.65E-7 ID:SGTC_2223|Compound:6903751|FD-Score:-5.49|P-value:1.09E-4 ID:SGTC_2242|Compound:6630449|FD-Score:11.60|P-value:4.07E-15 ID:SGTC_2352|Compound:9027995|FD-Score:6.59|P-value:5.45E-6 ID:SGTC_2385|Compound:9074692|FD-Score:6.03|P-value:2.81E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.57|P-value:8.80E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:7.27|P-value:6.03E-7 ID:SGTC_2431|Compound:5490079|FD-Score:7.32|P-value:4.94E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-5.64|P-value:7.21E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-5.22|P-value:2.19E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:12.50|P-value:3.36E-17 ID:SGTC_2526|Compound:patulin|FD-Score:9.89|P-value:1.83E-11 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.51|P-value:2.57E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:5.74|P-value:6.37E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.77|P-value:5.90E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:10.60|P-value:6.44E-13 ID:SGTC_2694|Compound:st077685|FD-Score:5.55|P-value:1.06E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:10.70|P-value:3.56E-13 ID:SGTC_2699|Compound:st077704|FD-Score:6.48|P-value:7.44E-6 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.80|P-value:6.92E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.64|P-value:4.65E-6 ID:SGTC_2802|Compound:7925815|FD-Score:5.22|P-value:2.45E-4 ID:SGTC_2873|Compound:9040596|FD-Score:10.10|P-value:7.38E-12 ID:SGTC_2909|Compound:7941780|FD-Score:-4.69|P-value:7.89E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-5.53|P-value:9.70E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-5.55|P-value:9.35E-5 ID:SGTC_2981|Compound:9013952|FD-Score:9.71|P-value:4.22E-11 ID:SGTC_3062|Compound:9077494|FD-Score:5.87|P-value:4.50E-5 ID:SGTC_3105|Compound:9121040|FD-Score:-5.07|P-value:3.17E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.90|P-value:5.40E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.83|P-value:4.93E-5 ID:SGTC_3225|Compound:9130819|FD-Score:8.02|P-value:4.18E-8 ID:SGTC_3237|Compound:9133362|FD-Score:5.34|P-value:1.81E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.81|P-value:5.98E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-8.11|P-value:2.45E-8 ID:SGTC_3287|Compound:9117173|FD-Score:-5.74|P-value:5.57E-5 ID:SGTC_3292|Compound:9120825|FD-Score:4.77|P-value:7.27E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-7.51|P-value:2.20E-7 ID:SGTC_3295|Compound:9122362|FD-Score:-4.74|P-value:7.03E-4 ID:SGTC_3314|Compound:9135860|FD-Score:5.93|P-value:3.73E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.87|P-value:3.89E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.67|P-value:7.59E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:8.48|P-value:7.17E-9 ID:SGTC_57|Compound:miconazole|FD-Score:-7.54|P-value:1.99E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.86|P-value:1.31E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:5.17|P-value:2.81E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:8.03|P-value:3.98E-8 ID:SGTC_98|Compound:0074-0023|FD-Score:5.81|P-value:5.29E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.29|P-value:2.06E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.65|P-value:8.09E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:4.79|P-value:6.92E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.31|P-value:1.95E-4 ID:SGTC_232|Compound:clozapine|FD-Score:7.90|P-value:6.52E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.50|P-value:1.20E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.96|P-value:4.74E-4 ID:SGTC_264|Compound:promethazine|FD-Score:12.10|P-value:3.51E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.40|P-value:1.57E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.06|P-value:3.67E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.72|P-value:5.93E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.17|P-value:2.50E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:6.87|P-value:2.23E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:7.65|P-value:1.60E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:7.40|P-value:3.81E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.76|P-value:3.13E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:5.63|P-value:8.67E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.97|P-value:4.21E-8 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.46|P-value:1.34E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.90|P-value:4.83E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.43|P-value:8.72E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:4.94|P-value:4.97E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.62|P-value:1.78E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:5.95|P-value:3.57E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:5.94|P-value:3.66E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:5.12|P-value:3.20E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:5.14|P-value:3.01E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:5.19|P-value:2.70E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:6.98|P-value:1.58E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.91|P-value:5.24E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:6.79|P-value:2.85E-6 ID:SGTC_887|Compound:0885-0007|FD-Score:5.44|P-value:1.40E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:6.53|P-value:6.45E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:7.14|P-value:9.12E-7 ID:SGTC_954|Compound:1189-0853|FD-Score:4.98|P-value:4.45E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.85|P-value:6.08E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:5.42|P-value:1.48E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.44|P-value:1.43E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.87|P-value:5.81E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:5.03|P-value:3.97E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.08|P-value:2.42E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.88|P-value:4.34E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.89|P-value:6.61E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:7.37|P-value:4.28E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:6.28|P-value:1.37E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:7.20|P-value:7.42E-7 ID:SGTC_1394|Compound:3474-0001|FD-Score:7.33|P-value:4.91E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.64|P-value:8.40E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:5.46|P-value:1.33E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.29|P-value:1.34E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:5.68|P-value:7.44E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:9.83|P-value:2.48E-11 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.08|P-value:1.10E-6 ID:SGTC_1665|Compound:st014639|FD-Score:8.79|P-value:2.11E-9 ID:SGTC_1666|Compound:st014829|FD-Score:10.20|P-value:4.61E-12 ID:SGTC_1672|Compound:st016598|FD-Score:11.90|P-value:8.49E-16 ID:SGTC_1679|Compound:4130-1276|FD-Score:11.20|P-value:2.95E-14 ID:SGTC_1687|Compound:st020778|FD-Score:5.63|P-value:8.68E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.93|P-value:3.71E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.79|P-value:6.99E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.21|P-value:2.53E-4 ID:SGTC_1826|Compound:st055655|FD-Score:13.70|P-value:2.72E-20 ID:SGTC_1827|Compound:berberine|FD-Score:-5.08|P-value:3.11E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.90|P-value:3.58E-5 ID:SGTC_1830|Compound:st055982|FD-Score:5.18|P-value:2.75E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.90|P-value:4.13E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.50|P-value:7.15E-6 ID:SGTC_1891|Compound:st059073|FD-Score:7.02|P-value:1.37E-6 ID:SGTC_1892|Compound:st058411|FD-Score:-6.04|P-value:2.37E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-7.23|P-value:5.72E-7 ID:SGTC_1901|Compound:st060216|FD-Score:6.83|P-value:2.53E-6 ID:SGTC_1904|Compound:st060225|FD-Score:5.64|P-value:8.42E-5 ID:SGTC_1933|Compound:st074711|FD-Score:7.02|P-value:1.39E-6 ID:SGTC_1939|Compound:st074455|FD-Score:-6.11|P-value:1.97E-5 ID:SGTC_1949|Compound:st076024|FD-Score:-5.36|P-value:1.53E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.75|P-value:7.59E-4 ID:SGTC_2036|Compound:5160441|FD-Score:8.69|P-value:3.11E-9 ID:SGTC_2038|Compound:4100038|FD-Score:-5.82|P-value:4.51E-5 ID:SGTC_2077|Compound:5212015|FD-Score:6.40|P-value:9.66E-6 ID:SGTC_2151|Compound:5563267|FD-Score:4.83|P-value:6.37E-4 ID:SGTC_2188|Compound:6126565|FD-Score:4.80|P-value:6.91E-4 ID:SGTC_2200|Compound:6600604|FD-Score:7.34|P-value:4.65E-7 ID:SGTC_2223|Compound:6903751|FD-Score:-5.49|P-value:1.09E-4 ID:SGTC_2242|Compound:6630449|FD-Score:11.60|P-value:4.07E-15 ID:SGTC_2352|Compound:9027995|FD-Score:6.59|P-value:5.45E-6 ID:SGTC_2385|Compound:9074692|FD-Score:6.03|P-value:2.81E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.57|P-value:8.80E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:7.27|P-value:6.03E-7 ID:SGTC_2431|Compound:5490079|FD-Score:7.32|P-value:4.94E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-5.64|P-value:7.21E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-5.22|P-value:2.19E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:12.50|P-value:3.36E-17 ID:SGTC_2526|Compound:patulin|FD-Score:9.89|P-value:1.83E-11 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.51|P-value:2.57E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:5.74|P-value:6.37E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.77|P-value:5.90E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:10.60|P-value:6.44E-13 ID:SGTC_2694|Compound:st077685|FD-Score:5.55|P-value:1.06E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:10.70|P-value:3.56E-13 ID:SGTC_2699|Compound:st077704|FD-Score:6.48|P-value:7.44E-6 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.80|P-value:6.92E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.64|P-value:4.65E-6 ID:SGTC_2802|Compound:7925815|FD-Score:5.22|P-value:2.45E-4 ID:SGTC_2873|Compound:9040596|FD-Score:10.10|P-value:7.38E-12 ID:SGTC_2909|Compound:7941780|FD-Score:-4.69|P-value:7.89E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-5.53|P-value:9.70E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-5.55|P-value:9.35E-5 ID:SGTC_2981|Compound:9013952|FD-Score:9.71|P-value:4.22E-11 ID:SGTC_3062|Compound:9077494|FD-Score:5.87|P-value:4.50E-5 ID:SGTC_3105|Compound:9121040|FD-Score:-5.07|P-value:3.17E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.90|P-value:5.40E-4 ID:SGTC_3219|Compound:9131112|FD-Score:5.83|P-value:4.93E-5 ID:SGTC_3225|Compound:9130819|FD-Score:8.02|P-value:4.18E-8 ID:SGTC_3237|Compound:9133362|FD-Score:5.34|P-value:1.81E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.81|P-value:5.98E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-8.11|P-value:2.45E-8 ID:SGTC_3287|Compound:9117173|FD-Score:-5.74|P-value:5.57E-5 ID:SGTC_3292|Compound:9120825|FD-Score:4.77|P-value:7.27E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-7.51|P-value:2.20E-7 ID:SGTC_3295|Compound:9122362|FD-Score:-4.74|P-value:7.03E-4 ID:SGTC_3314|Compound:9135860|FD-Score:5.93|P-value:3.73E-5

Top fitness defect scores for YGL095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1826 st055655 13.70 41.6 µM 2.72E-20 ERG2 4 6.69E-43
2 SGTC_2514 salinomycin 12.50 42.7 µM 3.36E-17 3 4.66E-36
3 SGTC_264 promethazine 12.10 12.5 mM 3.51E-16 DNA intercalators 6 8.36E-34
4 SGTC_1672 st016598 11.90 6.5 µM 8.49E-16 endomembrane recycling 5 5.90E-33
5 SGTC_2242 6630449 11.60 61.3 µM 4.07E-15 Golgi 5 1.88E-31
6 SGTC_1679 4130-1276 11.20 6.7 µM 2.95E-14 Golgi 6 1.50E-29
7 SGTC_2697 mebhydrolin 10.70 72.4 µM 3.56E-13 NEO1 14 3.69E-27
8 SGTC_2689 tacrolimus 10.60 100.0 µM 6.44E-13 3 1.36E-26
9 SGTC_1666 st014829 10.20 29.0 µM 4.61E-12 calcium & mitochondrial duress 3 1.05E-24
10 SGTC_2873 9040596 10.10 71.4 µM 7.38E-12 2 2.96E-24
11 SGTC_2526 patulin 9.89 37.6 µM 1.83E-11 9 2.19E-23
12 SGTC_1581 himbacine 9.83 57.9 µM 2.48E-11 Golgi 8 4.28E-23
13 SGTC_2981 9013952 9.71 39.0 µM 4.22E-11 3 1.38E-22
14 SGTC_1665 st014639 8.79 11.4 µM 2.11E-9 NEO1 1 7.59E-19
15 SGTC_2036 5160441 8.69 105.0 µM 3.11E-9 NEO1 23 1.78E-18
16 SGTC_52 0329-0193 8.48 875.0 nM 7.17E-9 TSC3-RPN4 3 1.12E-17
17 SGTC_70 0141-0289 8.03 43.3 µM 3.98E-8 mitochondrial stress 41 4.80E-16
18 SGTC_3225 9130819 8.02 49.5 µM 4.18E-8 amide catabolism 2 5.35E-16
19 SGTC_232 clozapine 7.90 119.0 µM 6.52E-8 NEO1 20 1.42E-15
20 SGTC_1306 1185-0270 7.89 9.0 µM 6.61E-8 Golgi 19 1.46E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.360 3.19E-103 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.350 3.38E-97 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.302 1.00E-71 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.299 3.99E-70 YKR001C VPS1 hom Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
0.296 1.46E-68 YGL054C ERV14 hom COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.291 2.53E-66 YLR148W PEP3 hom Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
0.268 2.86E-56 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.256 4.30E-51 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.253 5.32E-50 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.252 1.59E-49 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.244 1.31E-46 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.244 1.73E-46 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.244 1.85E-46 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.240 5.53E-45 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.233 1.58E-42 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion