YGL097W / SRM1

Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL097W / SRM1

Click on Significant Values for Screen Details ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.01|P-value:9.22E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.36|P-value:2.49E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.37|P-value:3.08E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.89|P-value:5.98E-10 ID:SGTC_816|Compound:0325-0417|FD-Score:3.25|P-value:3.79E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.40|P-value:2.19E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.00|P-value:9.99E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.06|P-value:7.60E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:-3.18|P-value:5.13E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:10.30|P-value:8.22E-27 ID:SGTC_1690|Compound:st023502|FD-Score:-3.22|P-value:4.52E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.23|P-value:4.17E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.38|P-value:2.44E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.03|P-value:8.44E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.38|P-value:2.30E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.00|P-value:9.46E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.20|P-value:4.65E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.32|P-value:3.96E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.15|P-value:5.53E-4 ID:SGTC_2810|Compound:7959871|FD-Score:2.99|P-value:9.69E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.81|P-value:3.25E-7 ID:SGTC_2874|Compound:9043904|FD-Score:3.50|P-value:1.46E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.05|P-value:8.01E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.20|P-value:4.65E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.08|P-value:7.58E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.28|P-value:3.40E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.45|P-value:1.78E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.63|P-value:8.55E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.33|P-value:2.92E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.01|P-value:9.22E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.36|P-value:2.49E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.37|P-value:3.08E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.89|P-value:5.98E-10 ID:SGTC_816|Compound:0325-0417|FD-Score:3.25|P-value:3.79E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.40|P-value:2.19E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.00|P-value:9.99E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.06|P-value:7.60E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:-3.18|P-value:5.13E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:10.30|P-value:8.22E-27 ID:SGTC_1690|Compound:st023502|FD-Score:-3.22|P-value:4.52E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.23|P-value:4.17E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.38|P-value:2.44E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.03|P-value:8.44E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.38|P-value:2.30E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.00|P-value:9.46E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.20|P-value:4.65E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.32|P-value:3.96E-6 ID:SGTC_2800|Compound:7887935|FD-Score:3.15|P-value:5.53E-4 ID:SGTC_2810|Compound:7959871|FD-Score:2.99|P-value:9.69E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.46|P-value:1.71E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.81|P-value:3.25E-7 ID:SGTC_2874|Compound:9043904|FD-Score:3.50|P-value:1.46E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.05|P-value:8.01E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.20|P-value:4.65E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.30|P-value:3.15E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.08|P-value:7.58E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.28|P-value:3.40E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.45|P-value:1.78E-4 ID:SGTC_3275|Compound:9138069|FD-Score:3.63|P-value:8.55E-5

Top fitness defect scores for YGL097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1557 sumaresinolic acid 10.30 42.3 µM 8.22E-27 1 3.38E-25 2.53
2 SGTC_2830 7992007 4.81 71.4 µM 3.25E-7 5 7.63E-7 0.02
3 SGTC_503 tyrphostin 8 4.37 294.0 µM 3.08E-6 TSC3-RPN4 7 6.27E-6 0.03
4 SGTC_2789 5281112 4.32 71.4 µM 3.96E-6 5 7.95E-6 0.06
5 SGTC_3275 9138069 3.63 49.5 µM 8.55E-5 3 1.42E-4 0.52
6 SGTC_2874 9043904 3.50 71.4 µM 1.46E-4 4 2.34E-4 0.23
7 SGTC_2942 9052777 3.48 62.2 µM 1.55E-4 11 2.48E-4 0.05
8 SGTC_2826 7992541 3.46 19.5 µM 1.71E-4 5 2.72E-4 0.27
9 SGTC_3273 9137859 3.45 49.5 µM 1.78E-4 6 2.82E-4 0.08
10 SGTC_1119 parthenolide 3.40 318.5 nM 2.19E-4 TSC3-RPN4 13 3.43E-4 0.15
11 SGTC_2301 7769476 3.38 200.0 µM 2.30E-4 20 3.58E-4 0.18
12 SGTC_448 monastrol 3.36 171.0 µM 2.49E-4 3 3.86E-4 0.25
13 SGTC_2979 9012552 3.30 45.5 µM 3.15E-4 4 4.82E-4 0.25
14 SGTC_3207 9114163 3.28 49.5 µM 3.40E-4 20 5.18E-4 0.05
15 SGTC_816 0325-0417 3.25 81.3 µM 3.79E-4 12 5.73E-4 0.20
16 SGTC_1929 genistein trimethyl ether 3.23 50.5 µM 4.17E-4 10 6.26E-4 0.28
17 SGTC_2722 naftopidil 3.20 47.2 µM 4.65E-4 6 6.94E-4 0.16
18 SGTC_2947 9072639 3.20 7.7 µM 4.65E-4 tubulin folding & SWR complex 17 6.95E-4 0.01
19 SGTC_2800 7887935 3.15 81.8 µM 5.53E-4 RPP1 & pyrimidine depletion 18 8.16E-4 0.02
20 SGTC_1447 4239-0816 3.06 81.9 µM 7.60E-4 17 0.00110 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 8.59E-15 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.120 3.67E-12 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
0.115 2.17E-11 YDR034C LYS14 hom Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
0.113 6.34E-11 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.106 7.64E-10 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.105 9.37E-10 YNL132W KRE33 het Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.104 1.58E-9 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.104 1.69E-9 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.104 1.69E-9 YKR046C PET10 hom Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
0.103 2.23E-9 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.099 1.05E-8 YLR387C REH1 hom Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
0.094 5.29E-8 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.093 7.28E-8 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.090 1.53E-7 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.089 2.37E-7 YPL102C_d YPL102C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4