YGL098W / USE1

Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL098W / USE1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.11|P-value:2.46E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:2.94|P-value:4.89E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:6.55|P-value:9.23E-14 ID:SGTC_41|Compound:0478-0632|FD-Score:2.89|P-value:5.91E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.22|P-value:1.48E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.37|P-value:7.89E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:-2.82|P-value:7.58E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.07|P-value:2.87E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.32|P-value:9.87E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.04|P-value:3.20E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:2.97|P-value:4.22E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:2.92|P-value:5.25E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-3.11|P-value:2.32E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.84|P-value:8.14E-6 ID:SGTC_1687|Compound:st020778|FD-Score:2.81|P-value:8.18E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.83|P-value:8.52E-6 ID:SGTC_1842|Compound:st055362|FD-Score:-3.00|P-value:3.64E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-2.92|P-value:5.14E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-2.89|P-value:5.78E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.17|P-value:1.88E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.27|P-value:1.20E-4 ID:SGTC_2071|Compound:5230951|FD-Score:2.85|P-value:6.89E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-2.94|P-value:4.66E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.46|P-value:2.79E-7 ID:SGTC_2402|Compound:5553605|FD-Score:2.88|P-value:6.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.03|P-value:3.36E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.19|P-value:1.69E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.35|P-value:5.35E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-2.90|P-value:5.40E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.79|P-value:8.81E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.54|P-value:3.38E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-3.35|P-value:8.27E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.02|P-value:3.37E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.72|P-value:1.43E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.93|P-value:5.13E-6 ID:SGTC_2949|Compound:9072542|FD-Score:2.96|P-value:4.54E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.45|P-value:5.35E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.01|P-value:3.52E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-2.82|P-value:7.40E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.11|P-value:2.46E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:2.94|P-value:4.89E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:6.55|P-value:9.23E-14 ID:SGTC_41|Compound:0478-0632|FD-Score:2.89|P-value:5.91E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.22|P-value:1.48E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.37|P-value:7.89E-5 ID:SGTC_647|Compound:0140-0236|FD-Score:-2.82|P-value:7.58E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.07|P-value:2.87E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.32|P-value:9.87E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.04|P-value:3.20E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:2.97|P-value:4.22E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:2.92|P-value:5.25E-4 ID:SGTC_1563|Compound:conessine|FD-Score:-3.11|P-value:2.32E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.84|P-value:8.14E-6 ID:SGTC_1687|Compound:st020778|FD-Score:2.81|P-value:8.18E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.83|P-value:8.52E-6 ID:SGTC_1842|Compound:st055362|FD-Score:-3.00|P-value:3.64E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-2.92|P-value:5.14E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-2.89|P-value:5.78E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.17|P-value:1.88E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.27|P-value:1.20E-4 ID:SGTC_2071|Compound:5230951|FD-Score:2.85|P-value:6.89E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-2.94|P-value:4.66E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.46|P-value:2.79E-7 ID:SGTC_2402|Compound:5553605|FD-Score:2.88|P-value:6.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.03|P-value:3.36E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.19|P-value:1.69E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.35|P-value:5.35E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-2.90|P-value:5.40E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.79|P-value:8.81E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.54|P-value:3.38E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-3.35|P-value:8.27E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-3.02|P-value:3.37E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.72|P-value:1.43E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.93|P-value:5.13E-6 ID:SGTC_2949|Compound:9072542|FD-Score:2.96|P-value:4.54E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.45|P-value:5.35E-5 ID:SGTC_3145|Compound:9085516|FD-Score:-3.01|P-value:3.52E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-2.82|P-value:7.40E-4

Top fitness defect scores for YGL098W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_38 0929-0051 6.55 58.3 µM 9.23E-14 1 2.81E-11 1.31
2 SGTC_2396 5342950 4.46 42.8 µM 2.79E-7 RSC complex & mRNA processing 26 4.13E-6 0.08
3 SGTC_2573 2',4'-dihydroxychalcone 4.35 15.0 µM 5.35E-7 13 6.95E-6 0.35
4 SGTC_2908 7930301 3.93 100.0 µM 5.13E-6 4 4.24E-5 0.08
5 SGTC_1666 st014829 3.84 29.0 µM 8.14E-6 calcium & mitochondrial duress 6 6.14E-5 0.10
6 SGTC_1695 st026914 3.83 34.5 µM 8.52E-6 4 6.38E-5 0.41
7 SGTC_3031 9088762 3.45 49.5 µM 5.35E-5 9 2.79E-4 0.01
8 SGTC_632 0781-2353 3.37 4.7 µM 7.89E-5 Golgi 26 3.80E-4 0.17
9 SGTC_761 k216-0224 3.32 480.0 µM 9.87E-5 10 4.56E-4 0.01
10 SGTC_2056 5235370 3.27 200.0 µM 1.20E-4 11 5.31E-4 0.00
11 SGTC_2506 ethyl hematommate 3.19 54.2 µM 1.69E-4 RPP1 & pyrimidine depletion 11 7.02E-4 0.11
12 SGTC_2052 5265182 3.17 7.1 µM 1.88E-4 17 7.66E-4 0.10
13 SGTC_10 0279-0212 3.11 42.6 µM 2.46E-4 TRP & mitochondrial translation 13 9.49E-4 0.05
14 SGTC_649 1123-0311 3.07 367.0 µM 2.87E-4 endomembrane recycling 22 0.00107 5.50E-4
15 SGTC_765 1319-0117 3.04 244.0 µM 3.20E-4 60S ribosome export 14 0.00117 0.01
16 SGTC_2426 5582046 3.03 32.2 µM 3.36E-4 11 0.00122 0.04
17 SGTC_976 1348-1067 2.97 47.6 µM 4.22E-4 60S ribosome export 16 0.00147 0.01
18 SGTC_2949 9072542 2.96 2.2 µM 4.54E-4 TSC3-RPN4 30 0.00155 0.05
19 SGTC_24 0417-1663 2.94 219.0 µM 4.89E-4 6 0.00165 0.08
20 SGTC_1517 deoxycholic acid methyl ester 2.92 49.2 µM 5.25E-4 10 0.00175 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.71E-20 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.130 5.08E-14 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.128 1.05E-13 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.120 3.74E-12 YLR387C REH1 hom Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
0.106 7.54E-10 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.102 3.57E-9 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.100 6.21E-9 YHR210C_p YHR210C_p hom Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions
0.098 1.28E-8 YLR434C_d YLR434C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
0.095 3.35E-8 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.095 3.82E-8 YIL134C-A_p YIL134C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.094 5.18E-8 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.092 8.02E-8 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
0.089 2.17E-7 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.089 2.63E-7 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.089 2.75E-7 YMR027W_p YMR027W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene