YGL100W / SEH1

Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL100W / SEH1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.80|P-value:2.86E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:9.14|P-value:7.42E-17 ID:SGTC_56|Compound:0957-0365|FD-Score:3.48|P-value:7.94E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.20|P-value:3.86E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:5.69|P-value:1.33E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:4.51|P-value:2.23E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.84|P-value:5.88E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.49|P-value:7.73E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.53|P-value:2.83E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:3.68|P-value:4.26E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.25|P-value:2.76E-11 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.88|P-value:2.17E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.45|P-value:8.84E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-4.40|P-value:3.93E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.63|P-value:5.71E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.52|P-value:7.90E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.99|P-value:1.50E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.82|P-value:6.57E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.03|P-value:1.30E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.92|P-value:1.93E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.82|P-value:2.69E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.97|P-value:1.84E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.65|P-value:1.60E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.37|P-value:4.32E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:6.01|P-value:2.69E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:3.94|P-value:1.77E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.85|P-value:2.43E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.14|P-value:8.81E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.63|P-value:4.98E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.18|P-value:7.72E-5 ID:SGTC_918|Compound:glabranin|FD-Score:7.03|P-value:1.08E-10 ID:SGTC_1045|Compound:1348-1485|FD-Score:6.81|P-value:3.83E-10 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.63|P-value:5.07E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.33|P-value:6.98E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.55|P-value:7.24E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.03|P-value:1.51E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.23|P-value:7.37E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.07|P-value:1.13E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.62|P-value:5.19E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-3.55|P-value:7.22E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.99|P-value:1.50E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.05|P-value:1.21E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.41|P-value:9.95E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.11|P-value:1.89E-6 ID:SGTC_1754|Compound:st042065|FD-Score:10.20|P-value:2.18E-20 ID:SGTC_1760|Compound:st045453|FD-Score:7.45|P-value:8.17E-12 ID:SGTC_1781|Compound:st038725|FD-Score:5.57|P-value:2.33E-7 ID:SGTC_1800|Compound:st050079|FD-Score:5.21|P-value:1.23E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.53|P-value:2.87E-7 ID:SGTC_1818|Compound:st052136|FD-Score:4.36|P-value:4.01E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.54|P-value:2.00E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.27|P-value:9.24E-7 ID:SGTC_1910|Compound:st062352|FD-Score:3.77|P-value:3.18E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.78|P-value:3.09E-4 ID:SGTC_1942|Compound:st076330|FD-Score:6.27|P-value:7.04E-9 ID:SGTC_1947|Compound:st076332|FD-Score:3.44|P-value:9.07E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.79|P-value:7.25E-6 ID:SGTC_2273|Compound:7815444|FD-Score:4.28|P-value:5.33E-5 ID:SGTC_2278|Compound:7948257|FD-Score:6.75|P-value:5.17E-10 ID:SGTC_2292|Compound:7671323|FD-Score:4.11|P-value:9.82E-5 ID:SGTC_2296|Compound:7971656|FD-Score:5.45|P-value:4.13E-7 ID:SGTC_2297|Compound:7971671|FD-Score:3.88|P-value:2.20E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.02|P-value:1.55E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.91|P-value:2.02E-4 ID:SGTC_2375|Compound:9072683|FD-Score:5.11|P-value:1.88E-6 ID:SGTC_2379|Compound:9035213|FD-Score:3.57|P-value:6.12E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.14|P-value:8.91E-5 ID:SGTC_2388|Compound:9080168|FD-Score:-3.68|P-value:4.87E-4 ID:SGTC_2390|Compound:9097792|FD-Score:4.19|P-value:7.54E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.46|P-value:8.44E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.94|P-value:3.97E-8 ID:SGTC_2401|Compound:5128683|FD-Score:4.62|P-value:1.45E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.47|P-value:2.60E-5 ID:SGTC_2455|Compound:5377712|FD-Score:4.40|P-value:3.45E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.60|P-value:5.48E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.93|P-value:1.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.12|P-value:1.84E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-5.97|P-value:4.10E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:5.03|P-value:2.61E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.28|P-value:6.04E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.30|P-value:5.22E-21 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.46|P-value:8.44E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.17|P-value:7.83E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-5.02|P-value:3.21E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.27|P-value:5.54E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.68|P-value:4.90E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.87|P-value:5.52E-8 ID:SGTC_3166|Compound:9102297|FD-Score:6.30|P-value:6.06E-9 ID:SGTC_3173|Compound:9105693|FD-Score:4.56|P-value:1.81E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-4.33|P-value:5.12E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.63|P-value:4.95E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.59|P-value:6.39E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.80|P-value:2.86E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:9.14|P-value:7.42E-17 ID:SGTC_56|Compound:0957-0365|FD-Score:3.48|P-value:7.94E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.20|P-value:3.86E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:5.69|P-value:1.33E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:4.51|P-value:2.23E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.84|P-value:5.88E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.49|P-value:7.73E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.53|P-value:2.83E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:3.68|P-value:4.26E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.25|P-value:2.76E-11 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.88|P-value:2.17E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.45|P-value:8.84E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-4.40|P-value:3.93E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.63|P-value:5.71E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.52|P-value:7.90E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.99|P-value:1.50E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.82|P-value:6.57E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.03|P-value:1.30E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.92|P-value:1.93E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.82|P-value:2.69E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.97|P-value:1.84E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.65|P-value:1.60E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.37|P-value:4.32E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:6.01|P-value:2.69E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:3.94|P-value:1.77E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.85|P-value:2.43E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.14|P-value:8.81E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.63|P-value:4.98E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.18|P-value:7.72E-5 ID:SGTC_918|Compound:glabranin|FD-Score:7.03|P-value:1.08E-10 ID:SGTC_1045|Compound:1348-1485|FD-Score:6.81|P-value:3.83E-10 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.63|P-value:5.07E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.33|P-value:6.98E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.55|P-value:7.24E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.03|P-value:1.51E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.23|P-value:7.37E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.07|P-value:1.13E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.62|P-value:5.19E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:-3.55|P-value:7.22E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.99|P-value:1.50E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.05|P-value:1.21E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.41|P-value:9.95E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.11|P-value:1.89E-6 ID:SGTC_1754|Compound:st042065|FD-Score:10.20|P-value:2.18E-20 ID:SGTC_1760|Compound:st045453|FD-Score:7.45|P-value:8.17E-12 ID:SGTC_1781|Compound:st038725|FD-Score:5.57|P-value:2.33E-7 ID:SGTC_1800|Compound:st050079|FD-Score:5.21|P-value:1.23E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.53|P-value:2.87E-7 ID:SGTC_1818|Compound:st052136|FD-Score:4.36|P-value:4.01E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.54|P-value:2.00E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.27|P-value:9.24E-7 ID:SGTC_1910|Compound:st062352|FD-Score:3.77|P-value:3.18E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.78|P-value:3.09E-4 ID:SGTC_1942|Compound:st076330|FD-Score:6.27|P-value:7.04E-9 ID:SGTC_1947|Compound:st076332|FD-Score:3.44|P-value:9.07E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.79|P-value:7.25E-6 ID:SGTC_2273|Compound:7815444|FD-Score:4.28|P-value:5.33E-5 ID:SGTC_2278|Compound:7948257|FD-Score:6.75|P-value:5.17E-10 ID:SGTC_2292|Compound:7671323|FD-Score:4.11|P-value:9.82E-5 ID:SGTC_2296|Compound:7971656|FD-Score:5.45|P-value:4.13E-7 ID:SGTC_2297|Compound:7971671|FD-Score:3.88|P-value:2.20E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.02|P-value:1.55E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.91|P-value:2.02E-4 ID:SGTC_2375|Compound:9072683|FD-Score:5.11|P-value:1.88E-6 ID:SGTC_2379|Compound:9035213|FD-Score:3.57|P-value:6.12E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.14|P-value:8.91E-5 ID:SGTC_2388|Compound:9080168|FD-Score:-3.68|P-value:4.87E-4 ID:SGTC_2390|Compound:9097792|FD-Score:4.19|P-value:7.54E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.46|P-value:8.44E-4 ID:SGTC_2398|Compound:5228213|FD-Score:5.94|P-value:3.97E-8 ID:SGTC_2401|Compound:5128683|FD-Score:4.62|P-value:1.45E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.47|P-value:2.60E-5 ID:SGTC_2455|Compound:5377712|FD-Score:4.40|P-value:3.45E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.60|P-value:5.48E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.93|P-value:1.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.12|P-value:1.84E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-5.97|P-value:4.10E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:5.03|P-value:2.61E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.28|P-value:6.04E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.30|P-value:5.22E-21 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.46|P-value:8.44E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.17|P-value:7.83E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-5.02|P-value:3.21E-6 ID:SGTC_2920|Compound:7982904|FD-Score:4.27|P-value:5.54E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.68|P-value:4.90E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.87|P-value:5.52E-8 ID:SGTC_3166|Compound:9102297|FD-Score:6.30|P-value:6.06E-9 ID:SGTC_3173|Compound:9105693|FD-Score:4.56|P-value:1.81E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-4.33|P-value:5.12E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.63|P-value:4.95E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.59|P-value:6.39E-4

Top fitness defect scores for YGL100W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 10.30 5.0 µM 5.22E-21 21 2.49E-25
2 SGTC_1754 st042065 10.20 16.1 µM 2.18E-20 NEO1-PIK1 23 1.44E-24
3 SGTC_46 0329-0187a 9.14 2.2 µM 7.42E-17 10 3.07E-20
4 SGTC_1760 st045453 7.45 10.4 µM 8.17E-12 NEO1-PIK1 63 4.56E-14
5 SGTC_221 trifluoperazine 7.25 10.3 µM 2.76E-11 NEO1-PIK1 98 2.02E-13
6 SGTC_58 0957-0393 7.20 9.0 µM 3.86E-11 cell wall 157 3.04E-13
7 SGTC_918 glabranin 7.03 770.7 nM 1.08E-10 2 1.07E-12
8 SGTC_1045 1348-1485 6.81 165.0 µM 3.83E-10 2 5.04E-12
9 SGTC_2278 7948257 6.75 134.3 µM 5.17E-10 3 7.27E-12
10 SGTC_3166 9102297 6.30 49.5 µM 6.06E-9 Golgi 11 1.47E-10
11 SGTC_1942 st076330 6.27 65.2 µM 7.04E-9 2 1.76E-10
12 SGTC_690 glyoxal 6.01 20.3 µM 2.69E-8 42 9.04E-10
13 SGTC_2398 5228213 5.94 48.8 µM 3.97E-8 iron homeostasis 9 1.46E-9
14 SGTC_3037 9091026 5.87 49.5 µM 5.52E-8 NEO1-PIK1 52 2.18E-9
15 SGTC_59 0330-0160 5.69 1.3 µM 1.33E-7 45 6.39E-9
16 SGTC_642 0335-0876 5.65 158.0 µM 1.60E-7 ubiquinone biosynthesis & proteasome 14 7.94E-9
17 SGTC_1781 st038725 5.57 66.3 µM 2.33E-7 NEO1 63 1.26E-8
18 SGTC_201 4262-0159 5.53 12.8 µM 2.83E-7 ergosterol depletion effects on membrane 19 1.60E-8
19 SGTC_1803 st050068 5.53 52.4 µM 2.87E-7 NEO1-PIK1 96 1.62E-8
20 SGTC_2296 7971656 5.45 126.5 µM 4.13E-7 17 2.54E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.261 2.34E-53 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.253 4.57E-50 YGR057C LST7 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.250 6.28E-49 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.248 3.43E-48 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.230 2.12E-41 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.228 9.11E-41 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.227 1.88E-40 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.226 5.07E-40 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.224 1.77E-39 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.223 4.00E-39 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.218 1.84E-37 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.215 2.60E-36 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.210 9.81E-35 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.207 9.50E-34 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.206 2.56E-33 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO