YGL102C_d

Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL102C / YGL102C

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.80|P-value:1.45E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:5.34|P-value:2.54E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:1.10E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.01|P-value:6.57E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.46|P-value:1.37E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.43|P-value:5.33E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.36|P-value:8.19E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.34|P-value:7.13E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.38|P-value:7.65E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.67|P-value:2.85E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.01|P-value:8.28E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:6.38|P-value:9.49E-10 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.27|P-value:3.02E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.64|P-value:3.12E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:3.68|P-value:2.73E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.35|P-value:8.32E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.77|P-value:1.99E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.42|P-value:6.78E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.38|P-value:7.70E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.84|P-value:1.54E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.03|P-value:7.79E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.63|P-value:3.27E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.32|P-value:9.32E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.14|P-value:5.11E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.39|P-value:7.39E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.80|P-value:1.45E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:5.34|P-value:2.54E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:1.10E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.01|P-value:6.57E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:4.46|P-value:1.37E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.81|P-value:1.72E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.43|P-value:5.33E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.36|P-value:8.19E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.34|P-value:7.13E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.38|P-value:7.65E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.67|P-value:2.85E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.01|P-value:8.28E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:6.38|P-value:9.49E-10 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.27|P-value:3.02E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.64|P-value:3.12E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:3.68|P-value:2.73E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.35|P-value:8.32E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.77|P-value:1.99E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.42|P-value:6.78E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.38|P-value:7.70E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.84|P-value:1.54E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.03|P-value:7.79E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.63|P-value:3.27E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.32|P-value:9.32E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.14|P-value:5.11E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.39|P-value:7.39E-4

Top fitness defect scores for YGL102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1259 0671-0132 6.38 43.0 µM 9.49E-10 1 9.09E-11 1.25
2 SGTC_53 0973-0023 5.34 40.0 µM 2.54E-7 RNA processing & uracil transport 4 4.70E-8 0.32
3 SGTC_245 methotrexate 4.46 289.6 µM 1.37E-5 11 4.07E-6 0.35
4 SGTC_1262 0737-0114 4.27 49.6 µM 3.02E-5 2 9.85E-6 0.54
5 SGTC_3000 9075062 4.14 71.4 µM 5.11E-5 5 1.77E-5 0.03
6 SGTC_2907 7721985 4.03 69.9 µM 7.79E-5 5 2.84E-5 0.11
7 SGTC_1093 fluphenazine 4.01 8.0 µM 8.28E-5 5 3.04E-5 0.30
8 SGTC_2813 7971799 3.84 71.4 µM 1.54E-4 8 6.06E-5 0.05
9 SGTC_285 1486-1325 3.81 46.0 µM 1.72E-4 5 6.90E-5 0.07
10 SGTC_1999 st074831 3.77 12.5 µM 1.99E-4 plasma membrane duress 13 8.12E-5 0.01
11 SGTC_1555 citronellol 3.68 128.0 µM 2.73E-4 2 1.15E-4 0.06
12 SGTC_757 1066-0008 3.67 322.0 µM 2.85E-4 Golgi 4 1.21E-4 0.01
13 SGTC_1282 0886-0010 3.64 32.4 µM 3.12E-4 endomembrane recycling 17 1.34E-4 0.10
14 SGTC_2913 7966556 3.63 36.6 µM 3.27E-4 60S ribosome export 10 1.41E-4 0.19
15 SGTC_2484 5809818 3.42 12.0 µM 6.78E-4 5 3.19E-4 0.01
16 SGTC_3210 9128157 3.39 49.5 µM 7.39E-4 20 3.51E-4 0.11
17 SGTC_543 3844-1095 3.38 191.0 µM 7.65E-4 ERG2 11 3.64E-4 0.02
18 SGTC_2750 bromebric acid 3.38 70.2 µM 7.70E-4 10 3.67E-4 0.03
19 SGTC_479 n-linoleoylglycine 3.36 10.0 µM 8.19E-4 3 3.94E-4 0.14
20 SGTC_1723 st034307 3.35 2.5 µM 8.32E-4 mitochondrial processes 25 4.00E-4 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.34E-21 YGR154C GTO1 hom Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
0.137 1.67E-15 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.126 2.86E-13 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.112 7.69E-11 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.110 1.42E-10 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.100 7.47E-9 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.093 6.12E-8 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.092 1.07E-7 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.090 1.84E-7 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.087 3.90E-7 YOR151C RPB2 het RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
0.087 4.23E-7 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.086 5.26E-7 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.085 7.53E-7 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.082 1.88E-6 YBL008W HIR1 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
0.080 3.15E-6 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation