Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGL103W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.123 | 8.50E-13 | YGR267C | FOL2 | het | GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |
0.120 | 2.84E-12 | YML003W_p | YML003W_p | hom | Putative protein of unknown function |
0.101 | 4.86E-9 | YHR048W_p | YHK8_p | hom | Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles |
0.099 | 1.03E-8 | YDL235C | YPD1 | het | Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus |
0.091 | 1.10E-7 | YKR050W | TRK2 | hom | Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication |
0.090 | 1.56E-7 | YDL169C | UGX2 | hom | Protein of unknown function, transcript accumulates in response to any combination of stress conditions |
0.090 | 1.84E-7 | YDR541C_p | YDR541C_p | hom | Putative dihydrokaempferol 4-reductase |
0.085 | 8.61E-7 | YGR048W | UFD1 | het | Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) |
0.082 | 1.94E-6 | YLL048C | YBT1 | hom | Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters |
0.082 | 2.03E-6 | YOR113W | AZF1 | hom | Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity |
0.081 | 2.67E-6 | YGL105W | ARC1 | hom | Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress |
0.081 | 2.73E-6 | YOL116W | MSN1 | hom | Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress |
0.079 | 4.12E-6 | YPL240C | HSP82 | hom | Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication |
0.078 | 5.62E-6 | YJL062W-A | COA3 | hom | Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly |
0.078 | 6.12E-6 | YKR081C | RPF2 | het | Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles |