YGL104C / VPS73

Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL104C / VPS73

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.62|P-value:2.40E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.70|P-value:2.18E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.33|P-value:6.67E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.14|P-value:4.11E-5 ID:SGTC_448|Compound:monastrol|FD-Score:-3.46|P-value:4.23E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.67|P-value:4.36E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.53|P-value:8.06E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:4.95|P-value:1.20E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.58|P-value:6.58E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.71|P-value:1.75E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.55|P-value:3.12E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.60|P-value:3.06E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.28|P-value:7.79E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.05|P-value:5.78E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.07|P-value:5.34E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:5.39|P-value:1.38E-7 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.95|P-value:8.56E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.49|P-value:4.52E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.27|P-value:9.33E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.47|P-value:4.90E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.54|P-value:3.77E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.37|P-value:6.77E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-4.86|P-value:1.48E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.36|P-value:6.97E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.55|P-value:3.04E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.46|P-value:4.97E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.76|P-value:1.72E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.26|P-value:2.53E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-4.01|P-value:5.60E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.18|P-value:3.54E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.92|P-value:7.87E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.42|P-value:4.89E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.40|P-value:5.27E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-4.67|P-value:3.47E-6 ID:SGTC_3067|Compound:9117431|FD-Score:4.39|P-value:1.45E-5 ID:SGTC_3074|Compound:9116018|FD-Score:3.48|P-value:4.67E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.69|P-value:1.89E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.62|P-value:2.40E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.70|P-value:2.18E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.33|P-value:6.67E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.14|P-value:4.11E-5 ID:SGTC_448|Compound:monastrol|FD-Score:-3.46|P-value:4.23E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.67|P-value:4.36E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:4.53|P-value:8.06E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:4.95|P-value:1.20E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:4.58|P-value:6.58E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.71|P-value:1.75E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.55|P-value:3.12E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.60|P-value:3.06E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.28|P-value:7.79E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.05|P-value:5.78E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.07|P-value:5.34E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:5.39|P-value:1.38E-7 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.95|P-value:8.56E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.49|P-value:4.52E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.27|P-value:9.33E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.47|P-value:4.90E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.54|P-value:3.77E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.37|P-value:6.77E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-4.86|P-value:1.48E-6 ID:SGTC_2058|Compound:5236698|FD-Score:3.36|P-value:6.97E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.55|P-value:3.04E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.46|P-value:4.97E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.76|P-value:1.72E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.26|P-value:2.53E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-4.01|P-value:5.60E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.18|P-value:3.54E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.92|P-value:7.87E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.42|P-value:4.89E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.40|P-value:5.27E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-4.67|P-value:3.47E-6 ID:SGTC_3067|Compound:9117431|FD-Score:4.39|P-value:1.45E-5 ID:SGTC_3074|Compound:9116018|FD-Score:3.48|P-value:4.67E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.69|P-value:1.89E-4

Top fitness defect scores for YGL104C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1168 k815-0004 5.39 80.5 µM 1.38E-7 DNA damage response 2 3.45E-8
2 SGTC_533 1222-0222 4.95 6.7 µM 1.20E-6 PDR1 12 3.67E-7
3 SGTC_457 grayanotoxin iii 4.67 135.0 µM 4.36E-6 35 1.50E-6
4 SGTC_582 0987-0078 4.58 156.0 µM 6.58E-6 calcium & mitochondrial duress 45 2.36E-6
5 SGTC_525 k781-2675 4.53 26.7 µM 8.06E-6 redox potentiating 37 2.94E-6
6 SGTC_3067 9117431 4.39 49.5 µM 1.45E-5 4 5.61E-6
7 SGTC_2342 7990637 4.26 118.9 µM 2.53E-5 RNA processing & uracil transport 25 1.03E-5
8 SGTC_2540 epiandrosterone 4.18 100.0 µM 3.54E-5 48 1.48E-5
9 SGTC_208 k072-0098 4.14 12.4 µM 4.11E-5 heme biosynthesis & mitochondrial translocase 38 1.75E-5
10 SGTC_999 4022-0066 4.07 22.7 µM 5.34E-5 Golgi 38 2.32E-5
11 SGTC_806 3966-4455 4.05 5.9 µM 5.78E-5 18 2.54E-5
12 SGTC_1295 1013-0063 3.95 9.8 µM 8.56E-5 10 3.89E-5
13 SGTC_2291 7917025 3.76 104.3 µM 1.72E-4 iron homeostasis 57 8.36E-5
14 SGTC_149 3970-0822 3.70 46.1 µM 2.18E-4 tubulin folding & SWR complex 110 1.08E-4
15 SGTC_639 0833-0042 3.60 114.0 µM 3.06E-4 56 1.57E-4
16 SGTC_1862 st057513 3.54 3.8 µM 3.77E-4 21 1.97E-4
17 SGTC_1325 1431-0015 3.49 227.0 µM 4.52E-4 Golgi 32 2.39E-4
18 SGTC_3074 9116018 3.48 49.5 µM 4.67E-4 RNA processing & uracil transport 25 2.48E-4
19 SGTC_1495 4469-0029 3.47 237.0 µM 4.90E-4 141 2.62E-4
20 SGTC_2265 7929201 3.46 200.0 µM 4.97E-4 33 2.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.23E-13 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.113 6.15E-11 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.104 1.75E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.103 2.43E-9 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.101 4.90E-9 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.093 7.49E-8 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.085 7.69E-7 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.083 1.62E-6 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.083 1.65E-6 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.082 2.27E-6 YKR078W YKR078W hom Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.079 4.10E-6 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.077 7.58E-6 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.077 7.82E-6 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 1.06E-5 YDL084W SUB2 het Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.076 1.18E-5 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication