YGL105W / ARC1

Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL105W / ARC1

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.75|P-value:1.67E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.76|P-value:1.71E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.42|P-value:5.77E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.90|P-value:9.23E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.41|P-value:5.38E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.62|P-value:2.89E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.30|P-value:8.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.61|P-value:5.73E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.27|P-value:8.62E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.60|P-value:2.78E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.20|P-value:3.13E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.35|P-value:1.70E-5 ID:SGTC_698|Compound:k064-0052|FD-Score:3.80|P-value:1.49E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:4.69|P-value:3.88E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:4.38|P-value:1.50E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.05|P-value:5.68E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:5.73|P-value:2.33E-8 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.35|P-value:1.75E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.93|P-value:9.06E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.39|P-value:6.31E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.26|P-value:8.98E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.30|P-value:2.12E-5 ID:SGTC_1904|Compound:st060225|FD-Score:3.89|P-value:1.06E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.60|P-value:3.02E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:2.15E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.69|P-value:2.24E-4 ID:SGTC_2206|Compound:7254556|FD-Score:4.24|P-value:2.72E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.36|P-value:6.91E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.27|P-value:9.24E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.24|P-value:2.68E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.62|P-value:4.22E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.27|P-value:9.37E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.86|P-value:3.30E-14 ID:SGTC_2624|Compound:nerol|FD-Score:3.31|P-value:8.05E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.66|P-value:2.29E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.80|P-value:1.48E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.63|P-value:3.97E-8 ID:SGTC_2838|Compound:9002687|FD-Score:4.14|P-value:4.00E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.29|P-value:8.16E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.27|P-value:9.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.24|P-value:2.50E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.28|P-value:8.28E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-3.95|P-value:7.66E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-3.32|P-value:7.44E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.53|P-value:3.90E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.75|P-value:1.67E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.76|P-value:1.71E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.42|P-value:5.77E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.90|P-value:9.23E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.41|P-value:5.38E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.62|P-value:2.89E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.30|P-value:8.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.61|P-value:5.73E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.27|P-value:8.62E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-3.60|P-value:2.78E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.20|P-value:3.13E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.35|P-value:1.70E-5 ID:SGTC_698|Compound:k064-0052|FD-Score:3.80|P-value:1.49E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:4.69|P-value:3.88E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:4.38|P-value:1.50E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.05|P-value:5.68E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:5.73|P-value:2.33E-8 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.35|P-value:1.75E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.93|P-value:9.06E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.39|P-value:6.31E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.26|P-value:8.98E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.30|P-value:2.12E-5 ID:SGTC_1904|Compound:st060225|FD-Score:3.89|P-value:1.06E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.60|P-value:3.02E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:2.15E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.69|P-value:2.24E-4 ID:SGTC_2206|Compound:7254556|FD-Score:4.24|P-value:2.72E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.36|P-value:6.91E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.27|P-value:9.24E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.24|P-value:2.68E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.62|P-value:4.22E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.27|P-value:9.37E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.86|P-value:3.30E-14 ID:SGTC_2624|Compound:nerol|FD-Score:3.31|P-value:8.05E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.66|P-value:2.29E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.80|P-value:1.48E-4 ID:SGTC_2833|Compound:9001315|FD-Score:5.63|P-value:3.97E-8 ID:SGTC_2838|Compound:9002687|FD-Score:4.14|P-value:4.00E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.29|P-value:8.16E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.27|P-value:9.17E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.24|P-value:2.50E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.28|P-value:8.28E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-3.95|P-value:7.66E-5 ID:SGTC_3349|Compound:9149703|FD-Score:-3.32|P-value:7.44E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.53|P-value:3.90E-4

Top fitness defect scores for YGL105W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2612 dictamnine 7.86 15.5 µM 3.30E-14 RNA pol III & RNase P/MRP 7 1.89E-15
2 SGTC_1182 1222-0449 5.73 220.0 µM 2.33E-8 4 4.91E-9
3 SGTC_2833 9001315 5.63 45.5 µM 3.97E-8 amide catabolism 23 8.81E-9
4 SGTC_2562 3',7'-dimethoxyflavone 5.62 64.9 µM 4.22E-8 7 9.41E-9
5 SGTC_947 3447-0010 4.69 211.0 µM 3.88E-6 6 1.33E-6
6 SGTC_221 trifluoperazine 4.61 10.3 µM 5.73E-6 NEO1-PIK1 181 2.05E-6
7 SGTC_993 3909-8757 4.38 62.7 µM 1.50E-5 17 5.88E-6
8 SGTC_557 1315-0110 4.35 16.2 µM 1.70E-5 Golgi 15 6.72E-6
9 SGTC_1185 1319-0113 4.35 81.3 µM 1.75E-5 DNA damage response 8 6.94E-6
10 SGTC_1497 4476-2978 4.30 41.3 µM 2.12E-5 4 8.56E-6
11 SGTC_2370 9071495 4.24 200.0 µM 2.68E-5 mitochondrial processes 22 1.11E-5
12 SGTC_2206 7254556 4.24 147.0 µM 2.72E-5 60S ribosome export 2 1.12E-5
13 SGTC_276 colchicine 4.20 750.0 µM 3.13E-5 12 1.31E-5
14 SGTC_2838 9002687 4.14 71.4 µM 4.00E-5 fatty acid desaturase (OLE1) 20 1.72E-5
15 SGTC_999 4022-0066 4.05 22.7 µM 5.68E-5 Golgi 39 2.52E-5
16 SGTC_1223 0764-0573 3.93 147.0 µM 9.06E-5 21 4.21E-5
17 SGTC_1904 st060225 3.89 78.0 µM 1.06E-4 21 5.00E-5
18 SGTC_2832 7992762 3.80 52.0 µM 1.48E-4 35 7.18E-5
19 SGTC_698 k064-0052 3.80 127.0 µM 1.49E-4 DNA damage response 4 7.24E-5
20 SGTC_46 0329-0187a 3.76 2.2 µM 1.71E-4 83 8.43E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.45E-10 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.103 2.34E-9 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.102 3.58E-9 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.101 4.77E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.099 1.03E-8 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.096 2.69E-8 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.090 1.70E-7 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.089 2.50E-7 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.087 3.91E-7 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.086 5.89E-7 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.086 6.67E-7 YHL034C SBP1 hom Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
0.082 2.05E-6 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.081 2.67E-6 YGL103W RPL28 het Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
0.081 2.86E-6 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.078 5.53E-6 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress