YGL108C

Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL108C / YGL108C

Click on Significant Values for Screen Details

Top fitness defect scores for YGL108C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_973 1325-0077 5.83 65.9 µM 8.26E-10 1 2.78E-9
2 SGTC_2638 epoxomicin 4.91 18.0 µM 1.96E-7 14 4.64E-7
3 SGTC_1072 oxiconazole 4.74 14.9 nM 4.75E-7 ergosterol depletion effects on membrane 35 1.06E-6
4 SGTC_2960 9079389 4.09 6.0 µM 1.16E-5 25 2.12E-5
5 SGTC_533 1222-0222 4.05 6.7 µM 1.44E-5 PDR1 26 2.60E-5
6 SGTC_2047 4141938 4.01 200.0 µM 1.66E-5 9 2.97E-5
7 SGTC_1633 st005664 3.97 67.9 µM 2.04E-5 29 3.60E-5
8 SGTC_1275 0867-0008 3.96 21.1 µM 2.11E-5 15 3.71E-5
9 SGTC_2850 9015429 3.96 58.4 µM 2.14E-5 11 3.76E-5
10 SGTC_920 mycophenolic acid 3.92 780.4 nM 2.54E-5 31 4.43E-5
11 SGTC_979 1426-2828 3.86 121.0 µM 3.28E-5 21 5.63E-5
12 SGTC_2406 ethylparaben 3.74 405.7 µM 5.64E-5 51 9.36E-5
13 SGTC_2415 st077333 3.72 57.7 µM 6.11E-5 58 1.01E-4
14 SGTC_1636 st007707 3.68 68.9 µM 7.16E-5 56 1.17E-4
15 SGTC_2685 mycophenolic acid 3.62 18.9 µM 9.25E-5 RNA pol III & RNase P/MRP 8 1.49E-4
16 SGTC_1581 himbacine 3.52 57.9 µM 1.37E-4 Golgi 59 2.15E-4
17 SGTC_578 3460-0051 3.48 92.0 µM 1.61E-4 22 2.50E-4
18 SGTC_3315 9136395 3.41 68.5 µM 2.09E-4 21 3.19E-4
19 SGTC_2859 9028643 3.38 45.5 µM 2.43E-4 33 3.69E-4
20 SGTC_196 k015-0023 3.35 18.1 µM 2.68E-4 PDR1 43 4.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.22E-11 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.105 9.57E-10 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.095 3.73E-8 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.094 5.90E-8 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.084 1.11E-6 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.082 1.84E-6 YLR286C CTS1 hom Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
0.081 2.59E-6 YGR148C RPL24B hom Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication
0.081 2.64E-6 YJR021C REC107 hom Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
0.079 4.60E-6 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.079 5.13E-6 YGR264C MES1 het Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
0.077 7.69E-6 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.077 8.72E-6 YOL113W SKM1 hom Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
0.075 1.34E-5 YPL218W SAR1 het GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.075 1.48E-5 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.074 2.00E-5 YCR067C SED4 hom Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p