YGL109W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL109W / YGL109W

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:3.62|P-value:1.09E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.27|P-value:2.53E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.59|P-value:1.29E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.69|P-value:7.49E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.47|P-value:2.38E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.75|P-value:5.89E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-4.24|P-value:2.95E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:4.48|P-value:7.31E-8 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.13|P-value:1.12E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:2.78|P-value:5.55E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.02|P-value:1.87E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:2.97|P-value:2.54E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.13|P-value:1.25E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.08|P-value:7.91E-7 ID:SGTC_802|Compound:4112-3352|FD-Score:3.31|P-value:5.26E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:2.74|P-value:6.61E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.67|P-value:8.19E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.66|P-value:8.22E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.19|P-value:9.06E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.92|P-value:3.17E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.36|P-value:4.17E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.49|P-value:2.17E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.51|P-value:1.89E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.31|P-value:4.89E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.05|P-value:1.62E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.07|P-value:1.50E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.40|P-value:2.49E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.55|P-value:6.51E-15 ID:SGTC_1633|Compound:st005664|FD-Score:-2.83|P-value:4.23E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.44|P-value:2.80E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-2.69|P-value:7.51E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.49|P-value:2.12E-5 ID:SGTC_1990|Compound:st072050|FD-Score:-2.71|P-value:7.05E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.08|P-value:7.91E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-2.90|P-value:3.11E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.98|P-value:2.59E-9 ID:SGTC_2141|Compound:5621638|FD-Score:2.86|P-value:4.10E-4 ID:SGTC_2159|Compound:5658611|FD-Score:2.86|P-value:4.01E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.73|P-value:6.90E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.92|P-value:3.05E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.08|P-value:1.52E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.81|P-value:3.90E-6 ID:SGTC_2389|Compound:9091542|FD-Score:-3.25|P-value:6.39E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.56|P-value:4.44E-8 ID:SGTC_2401|Compound:5128683|FD-Score:-3.71|P-value:6.10E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.93|P-value:3.56E-9 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.96|P-value:2.65E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.83|P-value:7.47E-9 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.33|P-value:1.85E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.72|P-value:6.49E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:7.94|P-value:5.71E-21 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.66|P-value:8.52E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.11|P-value:1.33E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.08|P-value:1.42E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-2.77|P-value:5.52E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.04|P-value:1.68E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.80|P-value:4.84E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.14|P-value:1.10E-4 ID:SGTC_2891|Compound:9063876|FD-Score:2.80|P-value:5.11E-4 ID:SGTC_2892|Compound:9047358|FD-Score:2.68|P-value:8.50E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.92|P-value:2.09E-6 ID:SGTC_2898|Compound:9056270|FD-Score:6.63|P-value:3.57E-15 ID:SGTC_2899|Compound:9053889|FD-Score:3.56|P-value:1.48E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-2.69|P-value:7.52E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-2.68|P-value:7.77E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.27|P-value:2.76E-7 ID:SGTC_3292|Compound:9120825|FD-Score:2.95|P-value:2.73E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.62|P-value:1.09E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.27|P-value:2.53E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:3.59|P-value:1.29E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.69|P-value:7.49E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.47|P-value:2.38E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.75|P-value:5.89E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-4.24|P-value:2.95E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:4.48|P-value:7.31E-8 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.13|P-value:1.12E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:2.78|P-value:5.55E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.02|P-value:1.87E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:2.97|P-value:2.54E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.13|P-value:1.25E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-4.08|P-value:7.91E-7 ID:SGTC_802|Compound:4112-3352|FD-Score:3.31|P-value:5.26E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:2.74|P-value:6.61E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.67|P-value:8.19E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.66|P-value:8.22E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.19|P-value:9.06E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.92|P-value:3.17E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.36|P-value:4.17E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.49|P-value:2.17E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.51|P-value:1.89E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.31|P-value:4.89E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.05|P-value:1.62E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.07|P-value:1.50E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.40|P-value:2.49E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.55|P-value:6.51E-15 ID:SGTC_1633|Compound:st005664|FD-Score:-2.83|P-value:4.23E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.44|P-value:2.80E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-2.69|P-value:7.51E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.49|P-value:2.12E-5 ID:SGTC_1990|Compound:st072050|FD-Score:-2.71|P-value:7.05E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.08|P-value:7.91E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-2.90|P-value:3.11E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.98|P-value:2.59E-9 ID:SGTC_2141|Compound:5621638|FD-Score:2.86|P-value:4.10E-4 ID:SGTC_2159|Compound:5658611|FD-Score:2.86|P-value:4.01E-4 ID:SGTC_2160|Compound:5660466|FD-Score:2.73|P-value:6.90E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.92|P-value:3.05E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.08|P-value:1.52E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.81|P-value:3.90E-6 ID:SGTC_2389|Compound:9091542|FD-Score:-3.25|P-value:6.39E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.56|P-value:4.44E-8 ID:SGTC_2401|Compound:5128683|FD-Score:-3.71|P-value:6.10E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.93|P-value:3.56E-9 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.96|P-value:2.65E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.83|P-value:7.47E-9 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.33|P-value:1.85E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.72|P-value:6.49E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:7.94|P-value:5.71E-21 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.66|P-value:8.52E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.11|P-value:1.33E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.08|P-value:1.42E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-2.77|P-value:5.52E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.04|P-value:1.68E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-2.80|P-value:4.84E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.14|P-value:1.10E-4 ID:SGTC_2891|Compound:9063876|FD-Score:2.80|P-value:5.11E-4 ID:SGTC_2892|Compound:9047358|FD-Score:2.68|P-value:8.50E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.92|P-value:2.09E-6 ID:SGTC_2898|Compound:9056270|FD-Score:6.63|P-value:3.57E-15 ID:SGTC_2899|Compound:9053889|FD-Score:3.56|P-value:1.48E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-2.69|P-value:7.52E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-2.68|P-value:7.77E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.27|P-value:2.76E-7 ID:SGTC_3292|Compound:9120825|FD-Score:2.95|P-value:2.73E-4

Top fitness defect scores for YGL109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2576 guaiol 7.94 23.1 µM 5.71E-21 2 1.01E-15
2 SGTC_2898 9056270 6.63 58.4 µM 3.57E-15 1 1.68E-11
3 SGTC_2125 5246583 4.98 200.0 µM 2.59E-9 tubulin folding & SWR complex 26 3.20E-7
4 SGTC_2410 aloe-emodin-8-o-glycoside 4.93 46.3 µM 3.56E-9 mitochondrial processes 10 4.04E-7
5 SGTC_2563 tomatine 4.83 8.5 µM 7.47E-9 23 6.95E-7
6 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 4.56 200.0 µM 4.44E-8 8 2.57E-6
7 SGTC_532 1548-0774 4.48 215.0 µM 7.31E-8 9 3.70E-6
8 SGTC_2568 diosmetin 4.33 100.0 µM 1.85E-7 19 7.30E-6
9 SGTC_3215 9129942 4.27 49.5 µM 2.76E-7 8 9.81E-6
10 SGTC_2894 9048625 3.92 32.5 µM 2.09E-6 11 4.35E-5
11 SGTC_2373 9071805 3.81 200.0 µM 3.90E-6 15 6.88E-5
12 SGTC_2571 chrysanthemic acid 3.72 100.0 µM 6.49E-6 30 1.00E-4
13 SGTC_162 k030-0015 3.62 37.8 µM 1.09E-5 iron homeostasis 27 1.46E-4
14 SGTC_383 2324-0395 3.59 7.4 µM 1.29E-5 azole & statin 53 1.66E-4
15 SGTC_2899 9053889 3.56 58.4 µM 1.48E-5 17 1.84E-4
16 SGTC_1263 0774-1208 3.51 64.8 µM 1.89E-5 65 2.20E-4
17 SGTC_1989 st071868 3.49 50.2 µM 2.12E-5 21 2.40E-4
18 SGTC_1132 3456-3614 3.49 2.5 µM 2.17E-5 tubulin folding & SWR complex 77 2.44E-4
19 SGTC_522 1273-0010 3.47 11.6 µM 2.38E-5 60S ribosome export 37 2.61E-4
20 SGTC_1742 st038235 3.44 28.9 µM 2.80E-5 mitochondrial stress 143 2.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 3.05E-60 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.276 9.53E-60 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.243 3.63E-46 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.238 1.26E-44 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.229 3.70E-41 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.224 1.45E-39 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.224 2.77E-39 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.212 1.55E-35 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.209 2.72E-34 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.205 2.82E-33 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.203 1.14E-32 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.203 2.81E-32 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.199 3.44E-31 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.195 5.15E-30 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.190 1.12E-28 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity