YGL111W / NSA1

Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL111W / NSA1

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:3.77|P-value:5.96E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.81|P-value:4.45E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.65|P-value:3.23E-9 ID:SGTC_162|Compound:k030-0015|FD-Score:5.35|P-value:2.23E-8 ID:SGTC_170|Compound:4197-0004|FD-Score:4.02|P-value:2.00E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.27|P-value:3.78E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.45|P-value:2.16E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.85|P-value:4.16E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.68|P-value:8.57E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.46|P-value:2.07E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:8.22|P-value:2.14E-17 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.45|P-value:1.91E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.16|P-value:6.39E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.33|P-value:4.83E-6 ID:SGTC_1862|Compound:st057513|FD-Score:-3.17|P-value:5.44E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.30|P-value:3.39E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.23|P-value:4.93E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.89|P-value:3.56E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.93|P-value:2.97E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.05|P-value:9.36E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.89|P-value:2.91E-7 ID:SGTC_2108|Compound:5365811|FD-Score:-3.29|P-value:3.54E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.12|P-value:7.19E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.03|P-value:9.97E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.58|P-value:1.30E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.14|P-value:1.18E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.71|P-value:7.78E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.10|P-value:1.43E-5 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.31|P-value:3.66E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.73|P-value:6.10E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.54|P-value:7.67E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-3.46|P-value:1.81E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.40|P-value:3.50E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.73|P-value:6.93E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-3.46|P-value:1.82E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.10|P-value:7.73E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.46|P-value:2.09E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.10|P-value:7.03E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.77|P-value:5.96E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.81|P-value:4.45E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.65|P-value:3.23E-9 ID:SGTC_162|Compound:k030-0015|FD-Score:5.35|P-value:2.23E-8 ID:SGTC_170|Compound:4197-0004|FD-Score:4.02|P-value:2.00E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.27|P-value:3.78E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.45|P-value:2.16E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.85|P-value:4.16E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.68|P-value:8.57E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.46|P-value:2.07E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:8.22|P-value:2.14E-17 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.45|P-value:1.91E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.16|P-value:6.39E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.33|P-value:4.83E-6 ID:SGTC_1862|Compound:st057513|FD-Score:-3.17|P-value:5.44E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.30|P-value:3.39E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.23|P-value:4.93E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.89|P-value:3.56E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.93|P-value:2.97E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.05|P-value:9.36E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.89|P-value:2.91E-7 ID:SGTC_2108|Compound:5365811|FD-Score:-3.29|P-value:3.54E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.12|P-value:7.19E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.03|P-value:9.97E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.58|P-value:1.30E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.14|P-value:1.18E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.71|P-value:7.78E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.10|P-value:1.43E-5 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.31|P-value:3.66E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.73|P-value:6.10E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.54|P-value:7.67E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-3.46|P-value:1.81E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.40|P-value:3.50E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.73|P-value:6.93E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-3.46|P-value:1.82E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.10|P-value:7.73E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.46|P-value:2.09E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.10|P-value:7.03E-4

Top fitness defect scores for YGL111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1111 tnp00062 8.22 510.7 nM 2.14E-17 1 1.05E-16 2.35
2 SGTC_2833 9001315 5.54 45.5 µM 7.67E-9 amide catabolism 4 1.55E-8 0.56
3 SGTC_162 k030-0015 5.35 37.8 µM 2.23E-8 iron homeostasis 2 4.31E-8 0.87
4 SGTC_1933 st074711 4.89 15.9 µM 2.91E-7 4 5.02E-7 0.24
5 SGTC_2909 7941780 4.40 10.5 µM 3.50E-6 3 5.42E-6 0.39
6 SGTC_1718 roemerine 4.33 11.9 µM 4.83E-6 redox potentiating 13 7.38E-6 0.28
7 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.14 100.0 µM 1.18E-5 5 1.73E-5 0.01
8 SGTC_2634 4'-methoxyflavone 4.10 100.0 µM 1.43E-5 7 2.08E-5 0.17
9 SGTC_170 4197-0004 4.02 226.0 µM 2.00E-5 3 2.87E-5 0.04
10 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.93 70.1 µM 2.97E-5 6 4.19E-5 0.12
11 SGTC_1913 st060213 3.89 96.1 µM 3.56E-5 2 5.00E-5 0.04
12 SGTC_618 k072-0232 3.85 33.2 µM 4.16E-5 60S ribosome export 5 5.80E-5 0.06
13 SGTC_82 0054-0107 3.77 293.8 µM 5.96E-5 6 8.17E-5 0.05
14 SGTC_3025 9087895 3.73 49.5 µM 6.93E-5 PDR1 5 9.44E-5 0.12
15 SGTC_2603 homopterocarpin 3.71 100.0 µM 7.78E-5 7 1.06E-4 0.08
16 SGTC_745 0469-0705 3.68 296.0 µM 8.57E-5 mitochondrial processes 22 1.16E-4 0.01
17 SGTC_2535 4',4'-dimethoxydalbergione 3.58 51.2 µM 1.30E-4 DNA damage response 5 1.73E-4 0.23
18 SGTC_1104 tacrolimus 3.46 29.8 µM 2.07E-4 11 2.69E-4 0.03
19 SGTC_3124 9127567 3.46 49.5 µM 2.09E-4 DNA damage response 11 2.72E-4 0.10
20 SGTC_578 3460-0051 3.45 92.0 µM 2.16E-4 8 2.81E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.65E-13 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.121 2.17E-12 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.113 4.93E-11 YMR049C ERB1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
0.112 8.94E-11 YDL031W DBP10 het Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
0.105 1.08E-9 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.103 2.23E-9 YDR482C CWC21 hom Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p
0.102 3.61E-9 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.100 6.43E-9 YGR069W_d YGR069W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.099 9.73E-9 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.097 1.83E-8 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.097 1.92E-8 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.097 1.98E-8 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.096 2.88E-8 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.095 3.98E-8 YFL047W RGD2 hom GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.093 6.70E-8 YGR248W SOL4 hom 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication