YGL112C / TAF6

Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL112C / TAF6

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.71|P-value:1.82E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.77|P-value:6.06E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.08|P-value:8.02E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.82|P-value:4.90E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:9.30|P-value:3.71E-21 ID:SGTC_363|Compound:0455-0021|FD-Score:3.20|P-value:5.25E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_490|Compound:phenamil|FD-Score:4.44|P-value:3.18E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.20|P-value:5.31E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:7.07|P-value:4.67E-13 ID:SGTC_584|Compound:0986-0246|FD-Score:4.55|P-value:1.86E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.57|P-value:2.35E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.13|P-value:6.81E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.57|P-value:1.70E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.08|P-value:8.10E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.20|P-value:5.26E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.67|P-value:8.91E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.21|P-value:5.08E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.35|P-value:3.10E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.46|P-value:2.96E-6 ID:SGTC_1920|Compound:st075728|FD-Score:5.11|P-value:1.10E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.65|P-value:1.19E-6 ID:SGTC_1943|Compound:st076331|FD-Score:3.57|P-value:1.32E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.22|P-value:4.98E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.32|P-value:3.48E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.25|P-value:4.50E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.18|P-value:9.70E-4 ID:SGTC_2248|Compound:tofa|FD-Score:17.50|P-value:1.27E-69 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.20|P-value:1.50E-7 ID:SGTC_2253|Compound:7938677|FD-Score:3.87|P-value:4.06E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.81|P-value:5.13E-7 ID:SGTC_2329|Compound:6138490|FD-Score:-3.62|P-value:1.98E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.62|P-value:1.11E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-5.20|P-value:1.50E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.72|P-value:7.44E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-3.40|P-value:4.52E-4 ID:SGTC_2854|Compound:9024559|FD-Score:6.09|P-value:3.66E-10 ID:SGTC_2956|Compound:9076196|FD-Score:5.37|P-value:2.64E-8 ID:SGTC_2960|Compound:9079389|FD-Score:-4.34|P-value:1.01E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.66|P-value:1.19E-8 ID:SGTC_2987|Compound:9018338|FD-Score:3.25|P-value:4.51E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.14|P-value:6.65E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.60|P-value:1.17E-4 ID:SGTC_3274|Compound:9138298|FD-Score:6.70|P-value:6.38E-12 ID:SGTC_3283|Compound:9109332|FD-Score:-3.17|P-value:9.92E-4 ID:SGTC_3285|Compound:9112818|FD-Score:5.52|P-value:1.13E-8 ID:SGTC_3293|Compound:9120939|FD-Score:6.44|P-value:3.66E-11 ID:SGTC_127|Compound:0180-0333|FD-Score:3.40|P-value:2.60E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.71|P-value:1.82E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.77|P-value:6.06E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.08|P-value:8.02E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.82|P-value:4.90E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:9.30|P-value:3.71E-21 ID:SGTC_363|Compound:0455-0021|FD-Score:3.20|P-value:5.25E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_490|Compound:phenamil|FD-Score:4.44|P-value:3.18E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.20|P-value:5.31E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:7.07|P-value:4.67E-13 ID:SGTC_584|Compound:0986-0246|FD-Score:4.55|P-value:1.86E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.57|P-value:2.35E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.13|P-value:6.81E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.57|P-value:1.70E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.08|P-value:8.10E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.20|P-value:5.26E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.67|P-value:8.91E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.21|P-value:5.08E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.35|P-value:3.10E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.46|P-value:2.96E-6 ID:SGTC_1920|Compound:st075728|FD-Score:5.11|P-value:1.10E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.65|P-value:1.19E-6 ID:SGTC_1943|Compound:st076331|FD-Score:3.57|P-value:1.32E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.22|P-value:4.98E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.32|P-value:3.48E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.25|P-value:4.50E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.18|P-value:9.70E-4 ID:SGTC_2248|Compound:tofa|FD-Score:17.50|P-value:1.27E-69 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.20|P-value:1.50E-7 ID:SGTC_2253|Compound:7938677|FD-Score:3.87|P-value:4.06E-5 ID:SGTC_2254|Compound:7938975|FD-Score:4.81|P-value:5.13E-7 ID:SGTC_2329|Compound:6138490|FD-Score:-3.62|P-value:1.98E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.62|P-value:1.11E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-5.20|P-value:1.50E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.72|P-value:7.44E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-3.40|P-value:4.52E-4 ID:SGTC_2854|Compound:9024559|FD-Score:6.09|P-value:3.66E-10 ID:SGTC_2956|Compound:9076196|FD-Score:5.37|P-value:2.64E-8 ID:SGTC_2960|Compound:9079389|FD-Score:-4.34|P-value:1.01E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.66|P-value:1.19E-8 ID:SGTC_2987|Compound:9018338|FD-Score:3.25|P-value:4.51E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.14|P-value:6.65E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.60|P-value:1.17E-4 ID:SGTC_3274|Compound:9138298|FD-Score:6.70|P-value:6.38E-12 ID:SGTC_3283|Compound:9109332|FD-Score:-3.17|P-value:9.92E-4 ID:SGTC_3285|Compound:9112818|FD-Score:5.52|P-value:1.13E-8 ID:SGTC_3293|Compound:9120939|FD-Score:6.44|P-value:3.66E-11

Top fitness defect scores for YGL112C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2248 tofa 17.50 1.1 µM 1.27E-69 sphingolipid biosynthesis & PDR1 1 4.28E-69 2.47
2 SGTC_350 k064-0020 9.30 19.8 µM 3.71E-21 heme requiring 3 7.32E-21 4.10
3 SGTC_547 1120-0019 7.07 610.0 nM 4.67E-13 azole & statin 1 7.91E-13 1.01
4 SGTC_3274 9138298 6.70 49.5 µM 6.38E-12 1 1.05E-11 1.23
5 SGTC_3293 9120939 6.44 62.0 µM 3.66E-11 1 5.93E-11 1.24
6 SGTC_2854 9024559 6.09 71.4 µM 3.66E-10 3 5.79E-10 1.39
7 SGTC_3285 9112818 5.52 20.9 µM 1.13E-8 cell wall 5 1.71E-8 0.07
8 SGTC_2956 9076196 5.37 2.5 µM 2.64E-8 1 3.98E-8 0.83
9 SGTC_1920 st075728 5.11 45.7 µM 1.10E-7 2 1.63E-7 0.93
10 SGTC_2254 7938975 4.81 95.2 µM 5.13E-7 4 7.44E-7 0.08
11 SGTC_1929 genistein trimethyl ether 4.65 50.5 µM 1.19E-6 2 1.70E-6 0.48
12 SGTC_1098 clofazimine 4.57 15.1 µM 1.70E-6 heme biosynthesis & mitochondrial translocase 23 2.43E-6 0.21
13 SGTC_584 0986-0246 4.55 15.4 µM 1.86E-6 heme requiring 17 2.65E-6 0.01
14 SGTC_1844 rapamycin 4.46 4.0 nM 2.96E-6 43 4.19E-6 0.03
15 SGTC_490 phenamil 4.44 164.0 µM 3.18E-6 heme requiring 4 4.49E-6 0.57
16 SGTC_2253 7938677 3.87 135.8 µM 4.06E-5 4 5.51E-5 0.45
17 SGTC_299 1273-0059 3.82 1.4 µM 4.90E-5 9 6.64E-5 0.17
18 SGTC_210 3551-0445 3.77 56.8 µM 6.06E-5 15 8.18E-5 0.02
19 SGTC_2615 purpurogallin-4-carboxylic acid 3.72 100.0 µM 7.44E-5 redox potentiating 9 1.00E-4 0.09
20 SGTC_1131 3454-3128 3.67 32.3 µM 8.91E-5 18 1.19E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 2.22E-31 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.195 6.18E-30 YBR198C TAF5 het Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.153 5.60E-19 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.147 1.25E-17 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.146 1.78E-17 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.145 3.36E-17 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.140 3.58E-16 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.139 5.36E-16 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.136 2.12E-15 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.136 2.84E-15 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.132 1.49E-14 YDR167W TAF10 het Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.127 1.32E-13 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.121 1.79E-12 YMR227C TAF7 het TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
0.110 1.57E-10 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.110 1.63E-10 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans