YGL114W_p

Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL114W / YGL114W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-2.98|P-value:3.42E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.31|P-value:7.86E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-2.86|P-value:5.73E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.10|P-value:2.07E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.81|P-value:6.49E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-10.10|P-value:3.13E-31 ID:SGTC_812|Compound:4251-0442|FD-Score:2.98|P-value:3.28E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.70|P-value:9.95E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.18|P-value:1.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.26|P-value:1.04E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.67|P-value:1.45E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.25|P-value:5.93E-7 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.42|P-value:4.52E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.05|P-value:2.42E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.32|P-value:7.81E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.01|P-value:3.06E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-4.69|P-value:4.51E-8 ID:SGTC_1376|Compound:2910-0861|FD-Score:-2.75|P-value:8.86E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.02|P-value:2.90E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.75|P-value:9.95E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-2.77|P-value:8.03E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.26|P-value:1.02E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.46|P-value:3.78E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-5.46|P-value:2.49E-10 ID:SGTC_1943|Compound:st076331|FD-Score:-4.46|P-value:1.91E-7 ID:SGTC_1947|Compound:st076332|FD-Score:-3.14|P-value:1.72E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-2.91|P-value:4.56E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.03|P-value:2.20E-6 ID:SGTC_2062|Compound:5245942|FD-Score:-2.77|P-value:8.10E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.24|P-value:1.05E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.15|P-value:1.66E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.88|P-value:5.33E-4 ID:SGTC_2340|Compound:7987427|FD-Score:2.92|P-value:4.18E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.84|P-value:6.09E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.17|P-value:1.53E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.07|P-value:3.58E-9 ID:SGTC_2605|Compound:digitonin|FD-Score:3.89|P-value:4.47E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:-2.95|P-value:3.92E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.68|P-value:1.36E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.80|P-value:7.07E-6 ID:SGTC_3316|Compound:9136639|FD-Score:-3.15|P-value:1.72E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.20|P-value:7.76E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:-2.98|P-value:3.42E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.31|P-value:7.86E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-2.86|P-value:5.73E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.10|P-value:2.07E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.81|P-value:6.49E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-10.10|P-value:3.13E-31 ID:SGTC_812|Compound:4251-0442|FD-Score:2.98|P-value:3.28E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.70|P-value:9.95E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.18|P-value:1.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.26|P-value:1.04E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.67|P-value:1.45E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.25|P-value:5.93E-7 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.42|P-value:4.52E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.05|P-value:2.42E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.32|P-value:7.81E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.01|P-value:3.06E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-4.69|P-value:4.51E-8 ID:SGTC_1376|Compound:2910-0861|FD-Score:-2.75|P-value:8.86E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.02|P-value:2.90E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.75|P-value:9.95E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-2.77|P-value:8.03E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.26|P-value:1.02E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.46|P-value:3.78E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-5.46|P-value:2.49E-10 ID:SGTC_1943|Compound:st076331|FD-Score:-4.46|P-value:1.91E-7 ID:SGTC_1947|Compound:st076332|FD-Score:-3.14|P-value:1.72E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-2.91|P-value:4.56E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-4.03|P-value:2.20E-6 ID:SGTC_2062|Compound:5245942|FD-Score:-2.77|P-value:8.10E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.24|P-value:1.05E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.15|P-value:1.66E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.88|P-value:5.33E-4 ID:SGTC_2340|Compound:7987427|FD-Score:2.92|P-value:4.18E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.84|P-value:6.09E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.17|P-value:1.53E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:5.07|P-value:3.58E-9 ID:SGTC_2605|Compound:digitonin|FD-Score:3.89|P-value:4.47E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:-2.95|P-value:3.92E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.68|P-value:1.36E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.80|P-value:7.07E-6 ID:SGTC_3316|Compound:9136639|FD-Score:-3.15|P-value:1.72E-4 ID:SGTC_3332|Compound:9141069|FD-Score:4.20|P-value:7.76E-7

Top fitness defect scores for YGL114W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2588 indole-3-carbinol 5.07 100.0 µM 3.58E-9 19 2.04E-7
2 SGTC_1212 0520-0165 4.25 585.0 µM 5.93E-7 21 1.07E-5
3 SGTC_3332 9141069 4.20 11.2 µM 7.76E-7 11 1.31E-5
4 SGTC_2605 digitonin 3.89 300.0 nM 4.47E-6 32 5.10E-5
5 SGTC_3315 9136395 3.80 68.5 µM 7.07E-6 9 7.29E-5
6 SGTC_1916 st067606 3.46 49.2 µM 3.78E-5 63 2.68E-4
7 SGTC_1293 1000-1278 3.42 195.0 µM 4.52E-5 29 3.08E-4
8 SGTC_67 0335-0847 3.31 266.0 µM 7.86E-5 ubiquinone biosynthesis & proteasome 156 4.74E-4
9 SGTC_2065 5221596 3.24 34.3 µM 1.05E-4 35 5.96E-4
10 SGTC_2368 9071271 3.21 200.0 µM 1.21E-4 67 6.64E-4
11 SGTC_1079 idarubicin 3.18 2.4 µM 1.36E-4 DNA damage response 41 7.28E-4
12 SGTC_1296 1068-0102 3.05 11.9 µM 2.42E-4 27 0.00114
13 SGTC_812 4251-0442 2.98 148.0 µM 3.28E-4 36 0.00145
14 SGTC_842 0271-0008 2.92 11.1 µM 4.16E-4 heme biosynthesis & mitochondrial translocase 57 0.00174
15 SGTC_2340 7987427 2.92 183.4 µM 4.18E-4 83 0.00175
16 SGTC_612 0302-0167 2.81 22.4 µM 6.49E-4 copper-dependent oxidative stress 106 0.00246
17 SGTC_1039 k821-0043 2.70 94.0 µM 9.95E-4 Golgi 95 0.00344
18 SGTC_2104 5389443 2.68 200.0 µM 0.00107 92 0.00365
19 SGTC_1033 k072-0102 2.66 21.3 µM 0.00116 60S ribosome export 106 0.00388
20 SGTC_695 3505-6186 2.65 243.0 µM 0.00123 85 0.00405

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.315 2.61E-78 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.250 4.34E-49 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.248 3.02E-48 YDR242W AMD2 hom Putative amidase
0.233 1.96E-42 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.228 6.72E-41 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.218 2.26E-37 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.210 6.44E-35 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.203 1.37E-32 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.179 1.15E-25 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.178 2.12E-25 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.177 3.91E-25 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.176 1.22E-24 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.174 3.26E-24 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.172 1.18E-23 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.170 2.91E-23 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene