YGL115W / SNF4

Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL115W / SNF4

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.76|P-value:3.82E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.57|P-value:3.57E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:6.05|P-value:3.55E-8 ID:SGTC_110|Compound:0850-0284|FD-Score:5.61|P-value:2.86E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:7.95|P-value:8.14E-13 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.51|P-value:4.15E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.89|P-value:3.56E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.08|P-value:2.94E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.63|P-value:5.72E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.13|P-value:1.12E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.80|P-value:4.72E-4 ID:SGTC_442|Compound:cape|FD-Score:3.57|P-value:7.06E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.52|P-value:2.70E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.59|P-value:2.06E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:8.02|P-value:5.22E-13 ID:SGTC_577|Compound:r071-0003|FD-Score:4.87|P-value:7.07E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:4.58|P-value:2.16E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.92|P-value:2.31E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.96|P-value:1.98E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.79|P-value:3.54E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.68|P-value:4.88E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.81|P-value:8.81E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.47|P-value:9.34E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:6.18|P-value:1.90E-8 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.46|P-value:3.37E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.43|P-value:3.81E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.53|P-value:7.96E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.94|P-value:2.11E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:6.66|P-value:1.60E-9 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.71|P-value:4.57E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.25|P-value:7.40E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.06|P-value:1.40E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.58|P-value:6.76E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.46|P-value:9.57E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.75|P-value:3.91E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.69|P-value:4.77E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.64|P-value:5.66E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.90|P-value:9.34E-6 ID:SGTC_1769|Compound:st044406|FD-Score:3.50|P-value:8.69E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.66|P-value:5.24E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.98|P-value:1.87E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.38|P-value:4.64E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.01|P-value:3.98E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-4.72|P-value:1.92E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.62|P-value:6.00E-4 ID:SGTC_2057|Compound:5236571|FD-Score:8.80|P-value:2.79E-15 ID:SGTC_2094|Compound:5332512|FD-Score:6.16|P-value:2.13E-8 ID:SGTC_2106|Compound:5357045|FD-Score:4.57|P-value:2.29E-5 ID:SGTC_2179|Compound:6298986|FD-Score:5.43|P-value:6.57E-7 ID:SGTC_2191|Compound:5911152|FD-Score:3.52|P-value:8.00E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.50|P-value:8.54E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.89|P-value:2.50E-4 ID:SGTC_2438|Compound:5259590|FD-Score:7.70|P-value:3.84E-12 ID:SGTC_2442|Compound:5158906|FD-Score:3.64|P-value:5.62E-4 ID:SGTC_2446|Compound:5162541|FD-Score:7.89|P-value:1.18E-12 ID:SGTC_2448|Compound:5185112|FD-Score:9.59|P-value:8.48E-18 ID:SGTC_2452|Compound:5863136|FD-Score:-3.85|P-value:4.00E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.10|P-value:1.23E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.85|P-value:2.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.69|P-value:4.76E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.73|P-value:1.22E-5 ID:SGTC_2789|Compound:5281112|FD-Score:4.06|P-value:1.40E-4 ID:SGTC_2953|Compound:9074162|FD-Score:5.93|P-value:6.58E-8 ID:SGTC_2970|Compound:9090938|FD-Score:3.52|P-value:8.18E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.95|P-value:2.03E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.77|P-value:3.77E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.77|P-value:3.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.43|P-value:3.86E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.66|P-value:5.31E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.76|P-value:3.82E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.57|P-value:3.57E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:6.05|P-value:3.55E-8 ID:SGTC_110|Compound:0850-0284|FD-Score:5.61|P-value:2.86E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:7.95|P-value:8.14E-13 ID:SGTC_117|Compound:lucigenin|FD-Score:-4.51|P-value:4.15E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.89|P-value:3.56E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:5.08|P-value:2.94E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.63|P-value:5.72E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.13|P-value:1.12E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.80|P-value:4.72E-4 ID:SGTC_442|Compound:cape|FD-Score:3.57|P-value:7.06E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.52|P-value:2.70E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.59|P-value:2.06E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:8.02|P-value:5.22E-13 ID:SGTC_577|Compound:r071-0003|FD-Score:4.87|P-value:7.07E-6 ID:SGTC_616|Compound:4092-0450|FD-Score:4.58|P-value:2.16E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.92|P-value:2.31E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.96|P-value:1.98E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.79|P-value:3.54E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.68|P-value:4.88E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.81|P-value:8.81E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.47|P-value:9.34E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:6.18|P-value:1.90E-8 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.46|P-value:3.37E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.43|P-value:3.81E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.53|P-value:7.96E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.94|P-value:2.11E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:6.66|P-value:1.60E-9 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.71|P-value:4.57E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.25|P-value:7.40E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:4.06|P-value:1.40E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.58|P-value:6.76E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.46|P-value:9.57E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.75|P-value:3.91E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.69|P-value:4.77E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.64|P-value:5.66E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.90|P-value:9.34E-6 ID:SGTC_1769|Compound:st044406|FD-Score:3.50|P-value:8.69E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.66|P-value:5.24E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.98|P-value:1.87E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.38|P-value:4.64E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.01|P-value:3.98E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-4.72|P-value:1.92E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.62|P-value:6.00E-4 ID:SGTC_2057|Compound:5236571|FD-Score:8.80|P-value:2.79E-15 ID:SGTC_2094|Compound:5332512|FD-Score:6.16|P-value:2.13E-8 ID:SGTC_2106|Compound:5357045|FD-Score:4.57|P-value:2.29E-5 ID:SGTC_2179|Compound:6298986|FD-Score:5.43|P-value:6.57E-7 ID:SGTC_2191|Compound:5911152|FD-Score:3.52|P-value:8.00E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.50|P-value:8.54E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.89|P-value:2.50E-4 ID:SGTC_2438|Compound:5259590|FD-Score:7.70|P-value:3.84E-12 ID:SGTC_2442|Compound:5158906|FD-Score:3.64|P-value:5.62E-4 ID:SGTC_2446|Compound:5162541|FD-Score:7.89|P-value:1.18E-12 ID:SGTC_2448|Compound:5185112|FD-Score:9.59|P-value:8.48E-18 ID:SGTC_2452|Compound:5863136|FD-Score:-3.85|P-value:4.00E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.10|P-value:1.23E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.85|P-value:2.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.69|P-value:4.76E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.73|P-value:1.22E-5 ID:SGTC_2789|Compound:5281112|FD-Score:4.06|P-value:1.40E-4 ID:SGTC_2953|Compound:9074162|FD-Score:5.93|P-value:6.58E-8 ID:SGTC_2970|Compound:9090938|FD-Score:3.52|P-value:8.18E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.95|P-value:2.03E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.77|P-value:3.77E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.77|P-value:3.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.43|P-value:3.86E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.66|P-value:5.31E-4

Top fitness defect scores for YGL115W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2448 5185112 9.59 27.2 µM 8.48E-18 1 4.21E-22
2 SGTC_2057 5236571 8.80 38.3 µM 2.79E-15 RPP1 & pyrimidine depletion 3 6.73E-19
3 SGTC_571 k831-0106 8.02 44.2 µM 5.22E-13 2 5.22E-16
4 SGTC_114 0364-0001 7.95 490.3 µM 8.14E-13 4 9.18E-16
5 SGTC_2446 5162541 7.89 200.0 µM 1.18E-12 1 1.48E-15
6 SGTC_2438 5259590 7.70 200.0 µM 3.84E-12 1 6.59E-15
7 SGTC_1320 1313-0481 6.66 95.3 µM 1.60E-9 1 1.39E-11
8 SGTC_1032 k061-1018 6.18 98.7 µM 1.90E-8 1 3.20E-10
9 SGTC_2094 5332512 6.16 191.7 µM 2.13E-8 6 3.69E-10
10 SGTC_108 0509-0257 6.05 621.1 µM 3.55E-8 13 7.05E-10
11 SGTC_2953 9074162 5.93 66.5 µM 6.58E-8 5 1.54E-9
12 SGTC_110 0850-0284 5.61 111.6 µM 2.86E-7 8 9.84E-9
13 SGTC_103 0844-0104 5.57 51.8 µM 3.57E-7 ERAD & cell cycle 85 1.30E-8
14 SGTC_2179 6298986 5.43 200.0 µM 6.57E-7 heme requiring 6 2.82E-8
15 SGTC_120 rhodamine 6G 5.08 52.3 µM 2.94E-6 mitochondrial processes 13 1.87E-7
16 SGTC_1894 3',6'-dihydroxyflavone 5.01 78.7 µM 3.98E-6 6 2.74E-7
17 SGTC_577 r071-0003 4.87 38.6 µM 7.07E-6 fatty acid desaturase (OLE1) 29 5.63E-7
18 SGTC_928 2764-0428 4.81 58.7 µM 8.81E-6 cell wall 33 7.44E-7
19 SGTC_2584 androsterone 4.73 48.7 µM 1.22E-5 cell wall 89 1.12E-6
20 SGTC_568 1193-0097 4.59 7.5 µM 2.06E-5 ERAD & cell cycle 108 2.17E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 7.37E-24 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.141 3.02E-16 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.126 2.18E-13 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.115 2.73E-11 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.114 3.82E-11 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.113 5.76E-11 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.112 8.87E-11 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.110 1.43E-10 YNR021W_p YNR021W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
0.107 5.13E-10 YEL044W IES6 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
0.101 4.03E-9 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.100 6.16E-9 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.100 7.88E-9 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.096 2.77E-8 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.095 3.89E-8 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.093 6.23E-8 YOR111W_p YOR111W_p hom Putative protein of unknown function