YGL116W / CDC20

Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL116W / CDC20

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.22|P-value:6.85E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:10.00|P-value:7.32E-15 ID:SGTC_23|Compound:0213-0011|FD-Score:5.15|P-value:4.32E-5 ID:SGTC_57|Compound:miconazole|FD-Score:18.60|P-value:1.13E-46 ID:SGTC_59|Compound:0330-0160|FD-Score:4.79|P-value:1.32E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:8.27|P-value:1.16E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.63|P-value:8.85E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:14.80|P-value:1.51E-30 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.04|P-value:7.10E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.43|P-value:2.44E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:7.61|P-value:2.78E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:10.60|P-value:2.33E-16 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.88|P-value:2.04E-12 ID:SGTC_150|Compound:3970-0969|FD-Score:8.63|P-value:1.85E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:5.38|P-value:2.03E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:5.78|P-value:5.18E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:8.88|P-value:4.83E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.81|P-value:7.70E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:6.09|P-value:1.65E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:10.70|P-value:1.27E-16 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.19|P-value:7.40E-4 ID:SGTC_252|Compound:miconazole|FD-Score:5.45|P-value:1.64E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:5.99|P-value:2.41E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:12.80|P-value:3.51E-23 ID:SGTC_262|Compound:fenpropimorph|FD-Score:16.40|P-value:7.03E-37 ID:SGTC_312|Compound:4092-0653|FD-Score:14.90|P-value:8.20E-31 ID:SGTC_315|Compound:k915-0449|FD-Score:8.73|P-value:1.12E-11 ID:SGTC_320|Compound:4092-0846|FD-Score:16.20|P-value:4.01E-36 ID:SGTC_321|Compound:4534-3890|FD-Score:5.09|P-value:5.34E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:4.25|P-value:6.26E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.72|P-value:3.55E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:4.29|P-value:5.59E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.12|P-value:2.86E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.34|P-value:4.92E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.21|P-value:3.56E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-4.19|P-value:4.85E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-9.33|P-value:1.66E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:7.51|P-value:4.46E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:4.72|P-value:1.63E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.95|P-value:9.17E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:10.50|P-value:4.02E-16 ID:SGTC_533|Compound:1222-0222|FD-Score:4.29|P-value:5.60E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:6.14|P-value:1.34E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:22.10|P-value:2.43E-65 ID:SGTC_576|Compound:1073-0113|FD-Score:-4.54|P-value:1.77E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-5.68|P-value:4.20E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:5.10|P-value:5.16E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.39|P-value:4.25E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:9.67|P-value:5.66E-14 ID:SGTC_664|Compound:1222-0054|FD-Score:5.04|P-value:6.26E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.82|P-value:1.22E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.59|P-value:1.53E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:11.70|P-value:1.11E-19 ID:SGTC_704|Compound:1310-0270|FD-Score:4.12|P-value:8.90E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.23|P-value:6.59E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.47|P-value:1.49E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:8.80|P-value:7.32E-12 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.99|P-value:4.40E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.92|P-value:9.76E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:10.20|P-value:1.84E-15 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.54|P-value:1.74E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:26.50|P-value:6.57E-93 ID:SGTC_917|Compound:harmaline|FD-Score:-4.72|P-value:1.03E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.13|P-value:4.61E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:6.30|P-value:7.48E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.88|P-value:2.00E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.05|P-value:3.48E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.62|P-value:2.23E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.48|P-value:3.32E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-6.87|P-value:3.72E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:-7.39|P-value:3.75E-9 ID:SGTC_1055|Compound:3448-0672|FD-Score:7.35|P-value:9.22E-9 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.39|P-value:2.75E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:7.65|P-value:2.35E-9 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.30|P-value:7.36E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:8.01|P-value:4.28E-10 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.19|P-value:7.37E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-5.74|P-value:3.39E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.70|P-value:1.74E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:16.80|P-value:1.51E-38 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.26|P-value:6.06E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-4.58|P-value:1.55E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.22|P-value:6.72E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.24|P-value:1.92E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-4.41|P-value:2.57E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:5.37|P-value:2.15E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.08|P-value:9.81E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.40|P-value:2.64E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.90|P-value:5.79E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-7.23|P-value:7.79E-9 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.52|P-value:2.94E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.75|P-value:9.25E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.29|P-value:5.60E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.20|P-value:1.11E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.19|P-value:1.12E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-4.30|P-value:3.52E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.27|P-value:5.86E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.78|P-value:8.27E-12 ID:SGTC_1750|Compound:st081859|FD-Score:13.70|P-value:3.20E-26 ID:SGTC_1844|Compound:rapamycin|FD-Score:15.20|P-value:7.29E-32 ID:SGTC_1873|Compound:rapamycin|FD-Score:12.20|P-value:2.85E-21 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.50|P-value:4.58E-9 ID:SGTC_1934|Compound:st074720|FD-Score:5.71|P-value:6.53E-6 ID:SGTC_2001|Compound:4023502|FD-Score:-4.26|P-value:3.97E-4 ID:SGTC_2003|Compound:4023581|FD-Score:6.80|P-value:1.01E-7 ID:SGTC_2007|Compound:4011539|FD-Score:-6.35|P-value:3.23E-7 ID:SGTC_2009|Compound:4012297|FD-Score:-5.71|P-value:3.68E-6 ID:SGTC_2021|Compound:4019055|FD-Score:12.50|P-value:4.63E-22 ID:SGTC_2038|Compound:4100038|FD-Score:4.83|P-value:1.19E-4 ID:SGTC_2050|Compound:5263056|FD-Score:6.81|P-value:9.57E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-4.82|P-value:7.62E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.11|P-value:9.06E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-6.13|P-value:7.80E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.98|P-value:7.47E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-4.84|P-value:6.97E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:13.80|P-value:1.75E-26 ID:SGTC_2249|Compound:haloperidol|FD-Score:15.00|P-value:2.67E-31 ID:SGTC_2307|Compound:7538926|FD-Score:9.03|P-value:2.12E-12 ID:SGTC_2322|Compound:7413319|FD-Score:12.00|P-value:1.10E-20 ID:SGTC_2326|Compound:6164455|FD-Score:-3.99|P-value:8.18E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-9.94|P-value:4.43E-15 ID:SGTC_2348|Compound:9022543|FD-Score:-5.86|P-value:2.14E-6 ID:SGTC_2350|Compound:9023895|FD-Score:12.20|P-value:2.43E-21 ID:SGTC_2396|Compound:5342950|FD-Score:-5.10|P-value:3.03E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-5.99|P-value:1.31E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.72|P-value:1.41E-7 ID:SGTC_2430|Compound:5571206|FD-Score:7.66|P-value:2.21E-9 ID:SGTC_2437|Compound:5741531|FD-Score:5.84|P-value:4.07E-6 ID:SGTC_2440|Compound:5628896|FD-Score:5.62|P-value:9.15E-6 ID:SGTC_2447|Compound:5741742|FD-Score:-4.81|P-value:7.76E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-6.35|P-value:3.29E-7 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.04|P-value:7.11E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.33|P-value:3.27E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.25|P-value:4.10E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.90|P-value:2.46E-17 ID:SGTC_2584|Compound:androsterone|FD-Score:7.22|P-value:1.62E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:16.20|P-value:3.22E-36 ID:SGTC_2651|Compound:1327-0036|FD-Score:14.50|P-value:2.56E-29 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.70|P-value:1.71E-19 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.91|P-value:5.63E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.56|P-value:1.68E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:13.90|P-value:4.12E-27 ID:SGTC_2799|Compound:7812892|FD-Score:-4.48|P-value:2.07E-4 ID:SGTC_2814|Compound:7977482|FD-Score:10.00|P-value:8.26E-15 ID:SGTC_2867|Compound:9039098|FD-Score:4.15|P-value:8.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.39|P-value:5.15E-7 ID:SGTC_2913|Compound:7966556|FD-Score:-4.34|P-value:3.11E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.84|P-value:7.02E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-4.32|P-value:3.33E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.40|P-value:2.66E-4 ID:SGTC_2993|Compound:9054257|FD-Score:6.70|P-value:1.53E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-6.21|P-value:5.61E-7 ID:SGTC_3192|Compound:9110362|FD-Score:-4.54|P-value:1.74E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-5.03|P-value:3.83E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-5.17|P-value:2.46E-5 ID:SGTC_3225|Compound:9130819|FD-Score:4.11|P-value:9.11E-4 ID:SGTC_3304|Compound:9125678|FD-Score:9.58|P-value:9.91E-14 ID:SGTC_3311|Compound:9131146|FD-Score:9.42|P-value:2.47E-13 ID:SGTC_3322|Compound:9139058|FD-Score:5.10|P-value:5.06E-5 ID:SGTC_3350|Compound:9150499|FD-Score:6.68|P-value:1.66E-7 ID:SGTC_3351|Compound:9150312|FD-Score:6.92|P-value:6.08E-8 ID:SGTC_8|Compound:0354-0001|FD-Score:4.22|P-value:6.85E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:10.00|P-value:7.32E-15 ID:SGTC_23|Compound:0213-0011|FD-Score:5.15|P-value:4.32E-5 ID:SGTC_57|Compound:miconazole|FD-Score:18.60|P-value:1.13E-46 ID:SGTC_59|Compound:0330-0160|FD-Score:4.79|P-value:1.32E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:8.27|P-value:1.16E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.63|P-value:8.85E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:14.80|P-value:1.51E-30 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.04|P-value:7.10E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.43|P-value:2.44E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:7.61|P-value:2.78E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:10.60|P-value:2.33E-16 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.88|P-value:2.04E-12 ID:SGTC_150|Compound:3970-0969|FD-Score:8.63|P-value:1.85E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:5.38|P-value:2.03E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:5.78|P-value:5.18E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:8.88|P-value:4.83E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.81|P-value:7.70E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:6.09|P-value:1.65E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:10.70|P-value:1.27E-16 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.19|P-value:7.40E-4 ID:SGTC_252|Compound:miconazole|FD-Score:5.45|P-value:1.64E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:5.99|P-value:2.41E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:12.80|P-value:3.51E-23 ID:SGTC_262|Compound:fenpropimorph|FD-Score:16.40|P-value:7.03E-37 ID:SGTC_312|Compound:4092-0653|FD-Score:14.90|P-value:8.20E-31 ID:SGTC_315|Compound:k915-0449|FD-Score:8.73|P-value:1.12E-11 ID:SGTC_320|Compound:4092-0846|FD-Score:16.20|P-value:4.01E-36 ID:SGTC_321|Compound:4534-3890|FD-Score:5.09|P-value:5.34E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:4.25|P-value:6.26E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.72|P-value:3.55E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:4.29|P-value:5.59E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.12|P-value:2.86E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.34|P-value:4.92E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.21|P-value:3.56E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-4.19|P-value:4.85E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-9.33|P-value:1.66E-13 ID:SGTC_513|Compound:4245-1575|FD-Score:7.51|P-value:4.46E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:4.72|P-value:1.63E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.95|P-value:9.17E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:10.50|P-value:4.02E-16 ID:SGTC_533|Compound:1222-0222|FD-Score:4.29|P-value:5.60E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:6.14|P-value:1.34E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:22.10|P-value:2.43E-65 ID:SGTC_576|Compound:1073-0113|FD-Score:-4.54|P-value:1.77E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-5.68|P-value:4.20E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:5.10|P-value:5.16E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.39|P-value:4.25E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:9.67|P-value:5.66E-14 ID:SGTC_664|Compound:1222-0054|FD-Score:5.04|P-value:6.26E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.82|P-value:1.22E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.59|P-value:1.53E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:11.70|P-value:1.11E-19 ID:SGTC_704|Compound:1310-0270|FD-Score:4.12|P-value:8.90E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.23|P-value:6.59E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.47|P-value:1.49E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:8.80|P-value:7.32E-12 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.99|P-value:4.40E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.92|P-value:9.76E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:10.20|P-value:1.84E-15 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.54|P-value:1.74E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:26.50|P-value:6.57E-93 ID:SGTC_917|Compound:harmaline|FD-Score:-4.72|P-value:1.03E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.13|P-value:4.61E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:6.30|P-value:7.48E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.88|P-value:2.00E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.05|P-value:3.48E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.62|P-value:2.23E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.48|P-value:3.32E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-6.87|P-value:3.72E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:-7.39|P-value:3.75E-9 ID:SGTC_1055|Compound:3448-0672|FD-Score:7.35|P-value:9.22E-9 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.39|P-value:2.75E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:7.65|P-value:2.35E-9 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.30|P-value:7.36E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:8.01|P-value:4.28E-10 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.19|P-value:7.37E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-5.74|P-value:3.39E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.70|P-value:1.74E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:16.80|P-value:1.51E-38 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.26|P-value:6.06E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-4.58|P-value:1.55E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.22|P-value:6.72E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.24|P-value:1.92E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-4.41|P-value:2.57E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:5.37|P-value:2.15E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.08|P-value:9.81E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.40|P-value:2.64E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.90|P-value:5.79E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-7.23|P-value:7.79E-9 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.52|P-value:2.94E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.75|P-value:9.25E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.29|P-value:5.60E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:6.20|P-value:1.11E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.19|P-value:1.12E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-4.30|P-value:3.52E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.27|P-value:5.86E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.78|P-value:8.27E-12 ID:SGTC_1750|Compound:st081859|FD-Score:13.70|P-value:3.20E-26 ID:SGTC_1844|Compound:rapamycin|FD-Score:15.20|P-value:7.29E-32 ID:SGTC_1873|Compound:rapamycin|FD-Score:12.20|P-value:2.85E-21 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.50|P-value:4.58E-9 ID:SGTC_1934|Compound:st074720|FD-Score:5.71|P-value:6.53E-6 ID:SGTC_2001|Compound:4023502|FD-Score:-4.26|P-value:3.97E-4 ID:SGTC_2003|Compound:4023581|FD-Score:6.80|P-value:1.01E-7 ID:SGTC_2007|Compound:4011539|FD-Score:-6.35|P-value:3.23E-7 ID:SGTC_2009|Compound:4012297|FD-Score:-5.71|P-value:3.68E-6 ID:SGTC_2021|Compound:4019055|FD-Score:12.50|P-value:4.63E-22 ID:SGTC_2038|Compound:4100038|FD-Score:4.83|P-value:1.19E-4 ID:SGTC_2050|Compound:5263056|FD-Score:6.81|P-value:9.57E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-4.82|P-value:7.62E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.11|P-value:9.06E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-6.13|P-value:7.80E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.98|P-value:7.47E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-4.84|P-value:6.97E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:13.80|P-value:1.75E-26 ID:SGTC_2249|Compound:haloperidol|FD-Score:15.00|P-value:2.67E-31 ID:SGTC_2307|Compound:7538926|FD-Score:9.03|P-value:2.12E-12 ID:SGTC_2322|Compound:7413319|FD-Score:12.00|P-value:1.10E-20 ID:SGTC_2326|Compound:6164455|FD-Score:-3.99|P-value:8.18E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-9.94|P-value:4.43E-15 ID:SGTC_2348|Compound:9022543|FD-Score:-5.86|P-value:2.14E-6 ID:SGTC_2350|Compound:9023895|FD-Score:12.20|P-value:2.43E-21 ID:SGTC_2396|Compound:5342950|FD-Score:-5.10|P-value:3.03E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-5.99|P-value:1.31E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.72|P-value:1.41E-7 ID:SGTC_2430|Compound:5571206|FD-Score:7.66|P-value:2.21E-9 ID:SGTC_2437|Compound:5741531|FD-Score:5.84|P-value:4.07E-6 ID:SGTC_2440|Compound:5628896|FD-Score:5.62|P-value:9.15E-6 ID:SGTC_2447|Compound:5741742|FD-Score:-4.81|P-value:7.76E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-6.35|P-value:3.29E-7 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.04|P-value:7.11E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-4.33|P-value:3.27E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.25|P-value:4.10E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.90|P-value:2.46E-17 ID:SGTC_2584|Compound:androsterone|FD-Score:7.22|P-value:1.62E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:16.20|P-value:3.22E-36 ID:SGTC_2651|Compound:1327-0036|FD-Score:14.50|P-value:2.56E-29 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.70|P-value:1.71E-19 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.91|P-value:5.63E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.56|P-value:1.68E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:13.90|P-value:4.12E-27 ID:SGTC_2799|Compound:7812892|FD-Score:-4.48|P-value:2.07E-4 ID:SGTC_2814|Compound:7977482|FD-Score:10.00|P-value:8.26E-15 ID:SGTC_2867|Compound:9039098|FD-Score:4.15|P-value:8.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.39|P-value:5.15E-7 ID:SGTC_2913|Compound:7966556|FD-Score:-4.34|P-value:3.11E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.84|P-value:7.02E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-4.32|P-value:3.33E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.40|P-value:2.66E-4 ID:SGTC_2993|Compound:9054257|FD-Score:6.70|P-value:1.53E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-6.21|P-value:5.61E-7 ID:SGTC_3192|Compound:9110362|FD-Score:-4.54|P-value:1.74E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-5.03|P-value:3.83E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-5.17|P-value:2.46E-5 ID:SGTC_3225|Compound:9130819|FD-Score:4.11|P-value:9.11E-4 ID:SGTC_3304|Compound:9125678|FD-Score:9.58|P-value:9.91E-14 ID:SGTC_3311|Compound:9131146|FD-Score:9.42|P-value:2.47E-13 ID:SGTC_3322|Compound:9139058|FD-Score:5.10|P-value:5.06E-5 ID:SGTC_3350|Compound:9150499|FD-Score:6.68|P-value:1.66E-7 ID:SGTC_3351|Compound:9150312|FD-Score:6.92|P-value:6.08E-8

Top fitness defect scores for YGL116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_916 4466-0038 26.50 42.0 nM 6.57E-93 cell wall 1 1.41E-154 10.40
2 SGTC_568 1193-0097 22.10 7.5 µM 2.43E-65 ERAD & cell cycle 1 1.97E-108 4.57
3 SGTC_57 miconazole 18.60 162.5 nM 1.13E-46 ergosterol depletion effects on membrane 1 3.50E-77 3.75
4 SGTC_1161 k007-0610 16.80 110.0 µM 1.51E-38 ERAD & cell cycle 2 1.42E-63 2.34
5 SGTC_262 fenpropimorph 16.40 62.5 µM 7.03E-37 ergosterol depletion effects on membrane 2 8.79E-61 9.04
6 SGTC_2619 obliquin 16.20 87.9 µM 3.22E-36 cell wall 3 1.12E-59 3.27
7 SGTC_320 4092-0846 16.20 5.3 µM 4.01E-36 ergosterol depletion effects on membrane 1 1.62E-59 3.51
8 SGTC_1844 rapamycin 15.20 4.0 nM 7.29E-32 3 2.20E-52 0.20
9 SGTC_2249 haloperidol 15.00 116.4 µM 2.67E-31 ergosterol depletion effects on membrane 4 1.93E-51 0.68
10 SGTC_312 4092-0653 14.90 6.8 µM 8.20E-31 ergosterol depletion effects on membrane 1 1.26E-50 1.98
11 SGTC_103 0844-0104 14.80 51.8 µM 1.51E-30 ERAD & cell cycle 4 3.52E-50 0.79
12 SGTC_2651 1327-0036 14.50 5.0 µM 2.56E-29 6 4.00E-48 0.82
13 SGTC_2778 tioconazole 13.90 65.1 nM 4.12E-27 ergosterol depletion effects on membrane 1 1.99E-44 2.33
14 SGTC_2233 sulbentine 13.80 40.4 µM 1.75E-26 5 2.24E-43 1.75
15 SGTC_1750 st081859 13.70 2.4 µM 3.20E-26 endomembrane recycling 1 6.14E-43 1.90
16 SGTC_256 clotrimazole 12.80 625.0 nM 3.51E-23 ergosterol depletion effects on membrane 2 7.56E-38 4.41
17 SGTC_2021 4019055 12.50 173.0 µM 4.63E-22 endomembrane recycling 4 5.66E-36 0.27
18 SGTC_2350 9023895 12.20 38.9 µM 2.43E-21 ergosterol biosynthesis 1 9.06E-35 4.38
19 SGTC_1873 rapamycin 12.20 2.0 nM 2.85E-21 4 1.19E-34 4.06
20 SGTC_2322 7413319 12.00 38.2 µM 1.10E-20 ERAD & cell cycle 2 1.13E-33 1.81

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.452 6.87E-169 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.301 3.41E-71 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.292 3.75E-67 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.287 8.64E-65 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.280 1.99E-61 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.260 3.95E-53 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.249 1.56E-48 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.243 2.42E-46 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.236 1.16E-43 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.235 2.53E-43 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.232 2.10E-42 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.228 6.45E-41 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.225 1.18E-39 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.225 1.13E-39 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.225 1.40E-39 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy